Late-stage diversification strategy for the synthesis of peptide acids and amides using hydrazides by Shoko Tanaka, Mizuki Kanno, Yosuke Tashiro, Tetsuo Narumi, Nobuyuki Mase, Kohei Sato

“…Aim: Modification of the C-terminus of a peptide to improve its properties, particularly after constructing the peptide chain, has great promise in the development of peptide therapeutics. …”
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Machine learning-based identification and validation of amino acid metabolism related genes as novel biomarkers in chronic kidney disease by Guoqing Zhang, Hongyan Luo, Xiaohua Lu, Yonghua Liu, Mei Wang, Bo Li, Haixia Lu, Yali Zheng

“…Methods: We filtered the key genes associated with AA metabolism based on the least absolute shrinkage and selection operator (LASSO) and SVM algorithm. Then, we constructed logistic regression models and evaluated the accuracy and specificity by nomogram analysis and DCA. …”
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Paleoclimatic and paleoenvironmental constraints on organic matter enrichment in the Paleocene strata in the Lishui Sag, East China Sea Shelf Basin by Shiyan Yin, Chuang Lei, Jiaren Ye, Jingfu Wu, Yu Wang, Ying Zhang, Xiaoying Han

“…The Yueguifeng Formation has greater hydrocarbon-generating potential than the Lingfeng and Mingyuefeng formations. Constructing the developmental models of organic-rich mudstones based on the covariation in the paleoclimatic and paleoenvironmental conditions represents a valid method for understanding the hydrocarbon-generating potential of these source rocks.…”
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A Study of Molecular Mimicry and Immunological Cross-reactivity between Hepatitis B Surface Antigen and Myelin Mimics by Dimitrios-Petrou Bogdanos, Heather Smith, Yun Ma, Harold Baum, Giorgina Mieli-Vergani, Diego Vergani

“…Twenty-mer peptides spanning 4 SHBsAg/MOG and 1 SHBsAg/MBP mimicking pairs, were constructed and tested by ELISA as targets of cross-reactive responses. …”
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Mitochondria-targeted photothermal-chemodynamic therapy enhances checkpoint blockade immunotherapy on colon cancer by Benchao Zheng, Hongbo Wang, Shiyi Zhai, Jiangsheng Li, Kuangda Lu

“…We propose that mitochondria-targeted PTT may better synergize with immunotherapy. Herein, we constructed a multifunctional nanoplatform that enables mitochondria-targeted photothermal-chemodynamic combination therapy by conjugating indocyanine green-thiol (ICG-SH) and mercaptoethyl-triphenylphosphonium (TPP-SH) onto polyvinyl pyrrolidone (PVP)-coated gold-copper nanoparticles (AIT). …”
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Non-pharmacological interventions for primary hypertension: a systematic review and network meta-analysis protocol by Tao Xu, Fan-rong Liang, Qifu Li, Taipin Guo, Ziwen Chen, Yun-Jie Shu, Xueli Zhou

“…It will also provide recommendations for integrating these interventions into community-based chronic disease management.Methods and analysis To identify potentially relevant randomised controlled trials, a reverse search strategy will be employed to ascertain all non-pharmacological interventions for PH. A well-constructed search strategy will be applied across nine academic databases (Web of Science, Embase, PubMed, PsycINFO, CENTRAL, AMED, CNKI, WF and VIP database) and three clinical trial registries (WHO ICTRP, ClinicalTrials.gov and ChiCTR) for studies conducted between 1 January 2014 and 1 August 2024. …”
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Self-reported determinants for subjective financial distress: a qualitative interview study with German cancer patients by Eva Winkler, Katja Mehlis, Bastian Surmann, Wolfgang Greiner, Andrea Züger, Viktoria Mathies, Sophie Pauge, Luise Richter, Thomas Ernst, Natalja Menold

“…The interviews were audiorecorded, transcribed verbatim and analysed using qualitative content analysis.Setting Participants were recruited from two German academic cancer centres, that is, the National Center for Tumor Diseases Heidelberg and Jena University Hospital.Participants 18 patients who had undergone cancer-related therapy for at least 2 months were interviewed (10 females).Results Based on the results of the qualitative content analysis, we developed a multicomponent construct of determinants that could influence subjective financial distress. …”
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Cluster Candidates with Massive Quiescent Galaxies at z ∼ 2 by Tomokazu Kiyota, Makoto Ando, Masayuki Tanaka, Alexis Finoguenov, Sadman Shariar Ali, Jean Coupon, Guillaume Desprez, Stephen Gwyn, Marcin Sawicki, Rhythm Shimakawa

“…In this paper, we report a discovery of seven cluster candidates with massive quiescent galaxies at z  ∼ 2 in the 3.5 deg ^2 area of the XMM Large Scale Structure field, roughly doubling the known cluster sample at this frontier redshift if confirmed. We construct a photometric redshift catalog based on deep ( i  ∼ 26, K _s  ∼ 24) multiwavelength photometry from the u * band to the K band gathered from the Hyper Suprime-Cam Subaru Strategic Program and other collaborative/public surveys. …”
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A self-assembled nanoparticle vaccine elicits effective neutralizing antibody response against EBV infection by Ping Li, Ping Li, Ziyi Jiang, Jingjing Shi, Haochuan Sha, Zihang Yu, Yan Zhao, Sanyang Han, Lan Ma, Lan Ma, Lan Ma

“…Most importantly, the L350–ferritin nanoparticle induced efficient neutralizing antibodies to block EBV-GFP infection in AKATA cells and also constructed a strong antigen-specific B-cell memory in immunized mice. …”
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Increased pro-SFTPB in HDL promotes the pro-inflammatory transition of HDL and represents a sign of poor prognosis in ARDS patients by Liu Yang, Zhuo Xu, Zhenyan Wang, Fangping Ding, Zhipeng Wu, Xiaoqian Shi, Jing Wang, Yingmin Ma, Jiawei Jin

“…Luminex assessed the levels of 38 plasma cytokines and chemokines. The in vitro constructed pro-SFTPB enriched HDL was applied to confirm the effect on M1 polarization of THP1-derived macrophage. …”
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Identification of Co-Expression Modules of Cotton Plant Height-Related Genes Based on Weighted Gene Co-Expression Network Analysis by Qian Huang, Li Liu, Hang Li, Xuwen Wang, Aijun Si, Liangrong He, Yu Yu

“…A co-expression network comprising 20,409 valid genes was constructed and visualized using Cytoscape 3.9.1. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses indicated that these modules are associated with biologically significant pathways, including oxidoreductase activity, transcriptional regulator activity, catalytic activity, and phosphate hydrolase activity. …”
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High-Performance Photocatalytic Multifunctional Material Based on Bi₄Ti₃O₁₂-Supported Ag and Ti₃C₂T_x for Organic D... by Kexi Zhang, Bingdong Yan, Xiaohong Wang, Yang Cao, Wanjun Hao, Jinchun Tu

“…In this study, BTO/Ag/Ti₃C₂T_x biomultifunctional materials were constructed by combining BTO with Ag and Ti₃C₂T_x. …”
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Symptom Network and Subgroup Analysis in Patients with Exacerbation of Chronic Obstructive Pulmonary Disease: A Cross-Sectional Study by Yu C, Xu M, Pang X, Zhang Y, Cao X, Xu Y, Huang S, Zhao H, Chen C

“…Chunchun Yu,1 Mengying Xu,1 Xinyue Pang,2 Yuting Zhang,3 Xinmei Cao,2 Yixin Xu,1 Shuai Huang,1 Hongjun Zhao,4 Chengshui Chen1,3,4 1Key Laboratory of Interventional Pulmonology of Zhejiang Province, Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, People’s Republic of China; 2Zhejiang Province, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, People’s Republic of China; 3Cixi Biomedical Research Institute, Wenzhou Medical University, Wenzhou, Zhejiang, 315302, People’s Republic of China; 4Zhejiang Province Engineering Research Center for Endoscope Instruments and Technology Development, Department of Pulmonary and Critical Care Medicine, Quzhou People’s Hospital, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou, 324000, People’s Republic of ChinaCorrespondence: Hongjun Zhao; Chengshui Chen, Zhejiang Province Engineering Research Center for Endoscope Instruments and Technology Development, Department of Pulmonary and Critical Care Medicine, Quzhou People’s Hospital, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou, 324000, People’s Republic of China, Email zhaohongjun@wmu.edu.cn; chenchengshui@wmu.edu.cnPurpose: This study aims to construct a contemporaneous symptom network of inpatients with Exacerbation of Chronic Obstructive Pulmonary Disease (ECOPD) based on the symptom cluster, identify core and bridge symptoms, and patient subgroups with different symptom clusters based on individual differences in the intensity of patient symptom experiences.Patients and Methods: This study used convenience sampling to collect demographic, symptom, auxiliary examination, and prognosis information of 208 inpatients with ECOPD from April 2022 to October 2023. …”
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What is the relationship between exposure to environmental pollutants and severe mental disorders? A systematic review on shared biological pathways by Pierluigi Catapano, Mario Luciano, Salvatore Cipolla, Daniela D'Amico, Alessandra Cirino, Maria Chiara Della Corte, Gaia Sampogna, Andrea Fiorillo

“…Severe mental disorders are multi-dimensional constructs, resulting from the interaction of genetic, biological, psychosocial, and environmental factors. …”
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Experimental Investigations of Offshore Sand Production Monitoring Based on the Analysis of Vibration in Response to Weak Shocks by Yichen Li, Gang Liu, Zongwen Jia, Min Qin, Gang Wang, Yinan Hu, Jialin He, Kai Wang

“…Based on this knowledge, a real-time calculation model of sand production in offshore oil wells is constructed, and the effectiveness of this model is verified. …”
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Identification and verification of autophagy-related gene signatures and their association with immune infiltration and drug responsiveness in epilepsy by Han-han He, Xiao-ge Zhang, Fen-fang Chen

“…Subsequently, protein–protein interaction, transcription factors and miRNAs networks were constructed. Additionally, the functional enrichment analysis of Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) were applied. …”
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Fractional-order PID feedback synthesis controller including some external influences on insulin and glucose monitoring by Kottakkaran Sooppy Nisar, Muhammad Farman, Khadija Jamil, Saba Jamil, Evren Hincal

“…At the end comparison of numerical simulations is constructed to show the efficiency, convergence, and accuracy of proposed techniques at different fractional values with power law and exponential kernels. …”
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Issues of International and Interchurch Relations in the Work of Holy Council 1917–1918 of the Orthodox Russian Church by A. I. Mramornov

“…The efforts of some historians and publicists shaping contemporary discourse in Russia depict the restoration of the Patriarchate in the Russian Church as the only important act of the Council are challenged by the material presented in this article, which shows how the Council constructed the future position of Russian Orthodoxy in dialogue with the non-Orthodox churches, in its presence abroad and its missions in non-Christian countries. …”
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Development and validation of a prediction model for acute kidney injury following cardiac valve surgery by Xiaotong Jia, Jun Ma, Zeyou Qi, Dongni Zhang, Junwei Gao

“…Using binary logistic stepwise regression analysis, we identified independent AKI risk factors after cardiac valve surgery. Lastly, we constructed a nomogram and conducted external validation in a validation cohort comprising 200 patients. …”
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Development and approval of a Lasso score based on nutritional and inflammatory parameters to predict prognosis in patients with glioma by Huixian Li, Hui Hong, Jinling Zhang

“…The Least Absolute Shrinkage and Selection Operator (Lasso) was employed to select relevant hematological indicators and generate a Lasso score. A nomogram was constructed utilizing Cox regression and Lasso variable selection. …”
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