Development and validation of a hyperlipidemia risk prediction model for middle-aged and older adult Chinese using 2015 CHARLS data by Li-xiang Zhang, Shan-Bing Hou, Fang-fang Zhao, Ting-ting Wang, Ying Jiang, Xiao-juan Zhou, Jiao-yu Cao

“…From these findings, a nomogram prediction model was constructed to estimate the risk of hyperlipidemia for middle-aged and older adult individuals. …”
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Comparative Analysis of Carbon Density Simulation Methods in Grassland Ecosystems: A Case Study from Gansu Province, China by Luyao Wu, Jiaqiang Du, Xinying Liu, Lijuan Li, Xiaoqian Zhu, Xiya Chen, Yue Gong, Yushuo Li

“…Inversion models were constructed for four components of the grassland ecosystem: aboveground (AGBC) and belowground biomass carbon density (BGBC), dead organic matter carbon density (DOMC), and soil organic carbon density (SOC). …”
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Bioassays for the evaluation of the attractiveness of attractive targeted sugar bait (ATSB) against Anopheles mosquitoes in controlled semi-field systems by Frank S. C. Tenywa, Ummi A. Kibondo, Julian Entwistle, Osward Dogan, Mapipi Haruna, Restuta P. Phisoo, Jason Moore, Jane J. Machange, Haji Makame, Frederic Tripet, Pie Müller, Mathias Mondy, Derric Nimmo, Jennifer C. Stevenson, Sarah J. Moore

“…Method Experiments were conducted in 2 × 5 × 2-m cages constructed within the semi-field systems (SFS) at Ifakara Health Institute, Bagamoyo, Tanzania. …”
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Screening and Identification of Cold-Tolerant Phosphorus and Potassium Solubilizing Bacteria and Their Growth-Promoting Effects on Soybean in Cold Regions by Hao Yan, Tianyi Wang, Haocheng Wang, Nan Sun, Xuebing Wang, Xingbo Zhao, Zhongbao Yao, Hao Tian, Shengjie Chen, Songyan Tang, Chenyang Li

“…This study screened cold-tolerant phosphorus-solubilizing and potassium-solubilizing bacteria by gradient-cooling-directed screening and constructed mixed bacterial agents. We analyzed the strain’s phosphorus/potassium solubilizing capacity, as well as its organic acid secretion ability, to reveal its mechanism of detoxification of phosphorus and potassium. …”
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The transcription factor combination MEF2 and KLF7 promotes axonal sprouting in the injured spinal cord with functional improvement and regeneration-associated gene expression by Callan L. Attwell, Inés Maldonado-Lasunción, Ruben Eggers, Bastiaan A. Bijleveld, Ward M. Ellenbroek, Natascha Siersema, Lotte Razenberg, Dédé Lamme, Nitish D. Fagoe, Ronald E. van Kesteren, August B. Smit, Joost Verhaagen, Matthew R. J. Mason

“…Gene expression profiling revealed that unexpectedly, the MEF2-VP16 construct used had little transcriptional activity in vivo, suggesting additional steps may be required to achieve full MEF2 activity. …”
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CREB3L1 facilitates pancreatic tumor progression and reprograms intratumoral tumor-associated macrophages to shape an immunotherapy-resistance microenvironment by Yu Wang, Haiyan Xu, Li Cai, Yang Sun, Liwei Wang, Ming Yue, Xiaofei Zhang, Yanling Wang, Shumin Li, Shengbai Xue, Jingyu Ma, Tiebo Mao, Weiyu Ge, Daiyuan Shentu, Wenxin Lu, Yongchao Wang, Jiong Hu, Jiujie Cui

“…Then, we established gene-modified cells to determine whether CREB3L1 functions in cell proliferation and migration capacity. Besides, we constructed subcutaneously and orthotopically transplanted mice models to verify their progrowing function and pulmonary metastasis models to prove their proinvasion role. …”
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HA198 mutations in H9N2 avian influenza: molecular dynamics insights into receptor binding by Rui Zhu, Rui Zhu, Rui Zhu, Jie Wu, Ruiying Chen, Mo Zhou, Mo Zhou, Mo Zhou, Shinuo Cao, Shinuo Cao, Shinuo Cao, Zhi Wu, Zhi Wu, Zhi Wu, Ligang Wang, Lei Zhang, Shanyuan Zhu, Shanyuan Zhu, Shanyuan Zhu

“…This study explores the molecular mechanisms by which mutations at the HA 198 site affect the antigenicity, receptor specificity, and binding affinity of the H9N2 virus.MethodsUsing the sequence of the A/Chicken/Jiangsu/WJ57/2012 strain, we constructed recombinant H9N2 viruses, including rWJ57, rWJ57/HA198A, and rWJ57/HA198T, using reverse genetics. …”
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LncRNA LUCAT1 offers protection against human coronary artery endothelial cellular oxidative stress injury through modulating hsa-miR-6776-5p/LRRC25 axis and activating autophagy f... by Yanjun Wang, Xin Zhang, Mengmeng Ren, Shu He, Hengjie Bie, Mengyang Duan, Zhiyuan Chen, Qiaowei Jia, Boyu Chi, Xiongkang Gan, Chengcheng Li, Yahong Fu, Hanxiao Zhou, Sheng Zhang, Qian Zhang, Fenghui An, Xiumei Chen, Enzhi Jia

“…Methods (1) Autophagy-related proteins including LC3, p62, Beclin1, ATG5, and ATG7 were immunohistochemical stained in coronary specimens; (2) The levels and function of autophagy in the HCAEC oxidative stress model were evaluated using western blot (WB), transmission electron microscopy (TEM), and mRFP-GFP-LC3 adenovirus transfection experiments; (3) The competing endogenous RNA (ceRNA) network of lncRNA LUCAT1/hsa-miR-6776-5p/LRRC25 axis was constructed and validated; (4) The expression levels of above autophagy-related RNAs in peripheral blood mononuclear cells (PBMCs) were verified by qPCR, and their diagnostic performance was subsequently analyzed using receiver operating characteristic (ROC) analysis. …”
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XCL1-secreting CEA CAR-T cells enhance endogenous CD8+ T cell responses to tumor neoantigens to confer a long-term antitumor immunity by Kun Chen, Fei Zhao, Hong Zhao, Dongmei Wang, Chunfeng Qu, Zhiyuan Wu, Feifei Wang, Xing-Ning Li, Ruochan Zhang, Chentong Xiao, Yuliang Ran

“…We modified CEA-specific CAR-T cells, aiming to stimulate endogenous CD8+ T cell responses against neoantigens that were derived from CEA-positive tumors destroyed by the CAR T cells.Methods In a conventional CEA CAR (reg-CAR), we modified it to express lymphotactin XCL1 and interleukin (IL)-7 genes, constructing a modified 7XCL1-CAR. By generating the CEA-specific 7XCL1-CAR T cells, we assessed their antitumor efficacy against CRC cells with varying levels of CEA expression, both in cell-cultures and in two strains of tumor-bearing syngeneic mice.Results Following retroviral transduction, 7XCL1-CAR T cells and reg-CAR T cells exhibited similar positive proportions of CEA-CAR and CD4:CD8 ratios. …”
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Molecular mapping and validation of quantitative trait loci for content of micronutrients in wheat grain by Xiangdong Chen, Junchao You, Nannan Dong, Di Wu, Die Zhao, Rui Yong, Wenjing Hu

“…A recombinant inbred lines (RIL) population derived from Yangmai 4/Yanzhan 1 (YM4/YZ1) with wheat 55K single nucleotide polymorphism (SNP) arrays and micronutrient content of two environments was used to construct a genetic linkage map and dissect the quantitative trait loci (QTL) for the content of Mn, Fe, Cu, Zn, and Se in wheat. …”
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Integrated bioinformatics analysis to explore potential therapeutic targets and drugs for small cell carcinoma of the esophagus by Maofei Zhu, Maofei Zhu, Yueming Chu, Yueming Chu, Qiang Yuan, Qiang Yuan, Junfeng Li, Silin Chen, Lin Li, Lin Li, Lin Li

“…The STRING database was employed to conduct protein-protein interaction (PPI) analysis of differentially expressed onco/tumor suppressor genes, the network was further constructed in Cytoscape, and hub genes of the network were obtained through the Cytohubba plugin. …”
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PD-L1/TLR7 dual-targeting nanobody-drug conjugate mediates potent tumor regression via elevating tumor immunogenicity in a host-expressed PD-L1 bias-dependent way by Wei Huang, Ji Zhou, Jia Li, Yakun Wan, Chao Hu, Meng Liu, Pan Xu, Feng Tang, Jianhua Sun, Xiaolu Yu, Yiru Long, Binfan Chen, Yongliang Tong, Mengwen Shan, Xiaomin Jia, Henglei Lu, Runqiu Chen, Jin Ren, Guangyi Jin, Likun Gong

“…Immune activation and PD-L1-inducing of TLR7 agonists were evaluated in diverse innate cell models. We constructed PD-L1/TLR7 dual-targeting NDCs by chemically coupling PD-L1 nanobodies and TLR7 agonists. …”
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Social vulnerability and genetic service utilization among unaffected BRIDGE trial patients with inherited cancer susceptibility by Jemar R. Bather, Melody S. Goodman, Adrian Harris, Guilherme Del Fiol, Rachel Hess, David W. Wetter, Daniel Chavez-Yenter, Lingzi Zhong, Lauren Kaiser-Jackson, Rachelle Chambers, Richard Bradshaw, Wendy Kohlmann, Sarah Colonna, Whitney Espinel, Rachel Monahan, Saundra S. Buys, Ophira Ginsburg, Kensaku Kawamoto, Kimberly A. Kaphingst, on behalf of the BRIDGE research team

“…We merged zip codes from the EHR to construct census tract-weighted social measures of the Social Vulnerability Index. …”
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Whole lung radiomic features are associated with overall survival in patients with locally advanced non-small cell lung cancer treated with definitive radiotherapy by Meng Yan, Zhen Zhang, Jia Tian, Jiaqi Yu, Andre Dekker, Dirk de Ruysscher, Leonard Wee, Lujun Zhao

“…Three models based on a tumor RS, and a lung RS separately and their combinations were constructed. The Harrell concordance index (C-index) and calibration curves were used to evaluate the discrimination and calibration performance. …”
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NL-Augmenter: A Framework for Task-Sensitive Natural Language Augmentation by Kaustubh Dhole, Varun Gangal, Sebastian Gehrmann, Aadesh Gupta, Zhenhao Li, Saad Mahamood, Abinaya Mahadiran, Simon Mille, Ashish Shrivastava, Samson Tan, Tongshang Wu, Jascha Sohl-Dickstein, Jinho Choi, Eduard Hovy, Ondřej Dušek, Sebastian Ruder, Sajant Anand, Nagender Aneja, Rabin Banjade, Lisa Barthe, Hanna Behnke, Ian Berlot-Attwell, Connor Boyle, Caroline Brun, Marco Antonio Sobrevilla Cabezudo, Samuel Cahyawijaya, Emile Chapuis, Wanxiang Che, Mukund Choudhary, Christian Clauss, Pierre Colombo, Filip Cornell, Gautier Dagan, Mayukh Das, Tanay Dixit, Thomas Dopierre, Paul-Alexis Dray, Suchitra Dubey, Tatiana Ekeinhor, Marco Di Giovanni, Tanya Goyal, Rishabh Gupta, Louanes Hamla, Sang Han, Fabrice Harel-Canada, Antoine Honoré, Ishan Jindal, Przemysław Joniak, Denis Kleyko, Venelin Kovatchev, Kalpesh Krishna, Ashutosh Kumar, Stefan Langer, Seungjae Ryan Lee, Corey James Levinson, Hualou Liang, Kaizhao Liang, Zhexiong Liu, Andrey Lukyanenko, Vukosi Marivate, Gerard de Melo, Simon Meoni, Maxine Meyer, Afnan Mir, Nafise Sadat Moosavi, Niklas Meunnighoff, Timothy Sum Hon Mun, Kenton Murray, Marcin Namysl, Maria Obedkova, Priti Oli, Nivranshu Pasricha, Jan Pfister, Richard Plant, Vinay Prabhu, Vasile Pais, Libo Qin, Shahab Raji, Pawan Kumar Rajpoot, Vikas Raunak, Roy Rinberg, Nicholas Roberts, Juan Diego Rodriguez, Claude Roux, Vasconcellos Samus, Ananya Sai, Robin Schmidt, Thomas Scialom, Tshephisho Sefara, Saqib Shamsi, Xudong Shen, Yiwen Shi, Haoyue Shi, Anna Shvets, Nick Siegel, Damien Sileo, Jamie Simon, Chandan Singh, Roman Sitelew, Priyank Soni, Taylor Sorensen, William Soto, Aman Srivastava, Aditya Srivatsa, Tony Sun, Mukund Varma, A Tabassum, Fiona Tan, Ryan Teehan, Mo Tiwari, Marie Tolkiehn, Athena Wang, Zijian Wang, Zijie Wang, Gloria Wang, Fuxuan Wei, Bryan Wilie, Genta Indra Winata, Xinyu Wu, Witold Wydmanski, Tianbao Xie, Usama Yaseen, Michael Yee, Jing Zhang, Yue Zhang

“…The transformations incorporate noise, intentional and accidental human mistakes, socio-linguistic variation, semantically-valid style, syntax changes, as well as artificial constructs that are unambiguous to humans. We demonstrate the efficacy of NL-Augmenter by using its transformations to analyze the robustness of popular language models. …”
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Association of glucose to lymphocyte ratio with the risk of death in patients with atherosclerotic cardiovascular disease by Jinglin Lei, Wentao Duan, Xiaoxi Yao, Zheng Hu, Huihui Fan, Yifan Liu, Wenjian Zhong, Haipeng Li

“…Restricted cubic spline (RCS) curves were used to display the relationship between GLR and all-cause mortality visually, and two-segment Cox proportional hazards models were constructed on either side of the inflection points. …”
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The association between metabolomic profiles of lifestyle and the latent phase of incident chronic kidney disease in the UK Population by Tingting Jin, Yunqi Wu, Siyi Zhang, Ya Peng, Yao Lin, Saijun Zhou, Hongyan Liu, Pei Yu

“…The study enrolled approximately 500,000 participants from the UK Biobank (UKB) between 2006 and 2010, excluding 447,163 individuals with missing data for any metabolite in the NMR metabolomics, any biomarker in the blood chemistry (including eGFR, albumin, or cystatin C), any factor required for constructing the lifestyle score, or a baseline diagnosis of CKD. …”
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Establishing a radiomics model using contrast-enhanced ultrasound for preoperative prediction of neoplastic gallbladder polyps exceeding 10 mm by Dong Jiang, Yi Qian, Yijun Gu, Ru Wang, Hua Yu, Zhenmeng Wang, Hui Dong, Dongyu Chen, Yan Chen, Haozheng Jiang, Yiran Li

“…Significant features were identified using the Mann–Whitney U test and further refined with a least absolute shrinkage and selection operator (LASSO) regression model to construct radiomic features. By integrating clinical characteristics, a radiomics nomogram was developed. …”
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Enhanced fibrotic potential of COL1A1hiNR4A1low fibroblasts in ischemic heart revealed by transcriptional dynamics heterogeneity analysis at both bulk and single-cell levels by Cheng Luo, Cheng Luo, Cheng Luo, Baoping Tan, Luoxiang Chu, Liqiang Chen, Xinglong Zhong, Yangyang Jiang, Yuluan Yan, Fanrui Mo, Hong Wang, Fan Yang, Fan Yang

“…Through machine learning, ten feature genes from COL1A1hiNR4A1low FB were selected to construct a diagnostic tool for IHD. The robustness of this new tool was validated using an independent cohort and heart failure rats.ConclusionCOL1A1hiNR4A1low FB possess heightened capability in promoting cardiac fibrosis. …”
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Factors associated with physical fitness and disparities in population segments among older adults: A cross-sectional study by Yuqin Rao, Jingjing Wang, Kai Li, Fanhui Zheng, Ying Chen, Bo Zhai, Jintao Hong, Chen Wang, Bao Liu, Dao Wang

“…A profile analysis model was constructed by feature extraction, label design and clustering using principal component analysis and k-prototypes. …”
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