Multimodal data-based longitudinal prognostic model for predicting atrial fibrillation recurrence after catheter ablation in patients with patent foramen ovale and paroxysmal atria... by Shoupeng Duan, Xujun Li, Jun Wang, Yuhong Wang, Tianyou Xu, Fuding Guo, Yijun Wang, Lingpeng Song, Zeyan Li, Xiaomeng Yang, Xiaoyu Shi, Hengyang Liu, Liping Zhou, Yueyi Wang, Hong Jiang, Lilei Yu

“…Results The dataset was partitioned into the development cohort (n = 102) and the validation cohort (n = 43) using a 7:3 ratio. The constructed nomogram included four clinical variables: age, diabetes mellitus, lipoprotein (a), and right ventricular diameter. …”
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Psychometric evaluation of the exercise-related cognitive errors questionnaire among Chinese emerging adults by Mengyao Guo, Jin Kuang, Ting Wang, Fabian Herold, Alyx Taylor, Jonathan Leo Ng, Jonathan Leo Ng, M. Mahbub Hossain, M. Mahbub Hossain, Arthur F. Kramer, Arthur F. Kramer, Robert Schinke, Zhihui Cheng, Liye Zou

“…In accordance with the literature, we also observed positive associations between the six dimensions of E-CEQ-C and the constructs of the CD-Quest-C, which provided concurrent validity evidence for the E-CEQ-C.ConclusionThis study showed that E-CEQ-C is a psychometrically sound measure to assess exercise-related cognitive errors in Chinese-speaking populations.…”
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T-cell receptor beta variable gene polymorphism predicts immune-related adverse events during checkpoint blockade immunotherapy by Linghua Wang, Siqing Fu, Aung Naing, Funda Meric-Bernstam, Carl Morrison, Joud Hajjar, Mingxuan Xu, Anas Alshawa, Bettzy Stephen, Ying Yuan, Jordi Rodon Ahnert, Abdulrazzak Zarifa, Shrutii Sarda, Timothy Looney, Sapna P Patel, Geoffrey M Lowman, Dzifa Yawa Duose, Jeffrey M Conroy, Evan Kwiatkowski

“…Resultant amplicons were sequenced via the Ion Torrent and TRBV allele profiles constructed for each individual was correlated with irAE annotations to identify haplotypes associated with severe irAEs (≥ grade 3).Results Our study included 81 patients who had irAEs when treated with immunotherapy for cancer. …”
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Application of information-based closed-loop management in optimizing surgical process (基于信息化的闭环管理优化手术流程的设计与实践) by ZHOU Liheng (周立恒), ZHU Xiaodong (朱小东), CHEN Qiannan (陈倩楠), LI Amin (李阿敏)

“…A surgical closed loop suitable for hospital was constructed by means of information technology. The closed-loop of the whole surgical process based on PDA can optimize and standardize the surgical process, effectively extend the preoperative, intraoperative and postoperative medical services for patients, and has important significance for the fine management of surgery and the overall monitoring and management of hospitals. …”
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Fecal microbiome change in patients with ulcerative colitis after fecal microbiota transplantation by A. Y. Tikunov, V. V. Morozov, A. N. Shvalov, A. V. Bardasheva, E. V. Shrayner, O. A. Maksimova, I. O. Voloshina, V. V. Morozova, V. V. Vlasov, N. V. Tikunova

“…The main method is a comparative analysis of 16S ribosomal RNA sequence libraries constructed using fecal samples obtained from patients with ulcerative colitis before and after FT and sequenced on the Illumina MiSeq platform. …”
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Systematic multiomics analysis and in vitro experiments suggest that ITGA5 could serve as a promising therapeutic target for ccRCC by Xiangxian Che, Xi Tian, Zhenda Wang, Shuxuan Zhu, Shiqi Ye, Yue Wang, Yihan Chen, Yiyun Huang, Aihetaimujiang Anwaier, Peifeng Yao, Yijia Chen, Keting Wu, Yifei Liu, Wenhao Xu, Hailiang Zhang, Dingwei Ye

“…Bioinformatic analysis was performed to explain the comprehensive effect of ITGA5 on the TME and drug sensitivity. Results We constructed a machine learning model to elaborate the prognostic implication of ITGA5. …”
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Right ventricular myocardial work: proof-of-concept for the assessment of pressure-strain loops of patients with pre-capillary pulmonary hypertension by Bárbara Lacerda Teixeira, Francisco Albuquerque, Raquel Santos, André Ferreira, Ricardo Carvalheiro, João Reis, Luis Almeida Morais, Tânia Mano, Pedro Rio, Ana Teresa Timoteo, Rui Cruz Ferreira, Ana Galrinho

“…From RVGWI, RV global constructive work (RVGCW), RV global wasted work (RVGWW), and RV global work efficiency (RVGWE) were estimated. …”
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Inferior outcome of stand-alone short versus long tibial stem in revision total knee arthroplasty. A retrospective comparative study with minimum 2 year follow-up by Abdelatif Elsayed Ahmed, Abu Mukh Assala, Elsaid Ahmed Nady Saleh, Youssef Ahmed Omar, Foissey Constant, Servien Elvire, Lustig Sebastien

“…To obtain the benefits of short stem and improve the longevity of the construct; adjuvant zone II (metaphyseal) fixation might be the clue.…”
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Structure and metabolic function of spatiotemporal pit mud microbiome by Zhihua Li, Chi Zhao, Zhenyu Mao, Fengju Zhang, Ling Dong, Chuan Song, Yao Chen, Xin Fu, Zonghua Ao, Yanfei Xiong, Qin Hui, Weizhi Song, Petri Penttinen, Suyi Zhang

“…We identified 178 medium- and high-quality non-redundant metagenome-assembled genomes (MAGs), and constructed their phylogenetic tree, depicting their roles in the carbon, nitrogen, and sulfur cycles. …”
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Linkage Analysis between Solid-Fluid Coupling and the Strength Reduction Method for Karst Cave Water Inrush in Mines by Yanlin Zhao, Jian Liao, Qiang Liu, Yang Li, Jianchao Cheng

“…Combining the nonlinear seepage-pipe coupling model with the strength reduction method, the linkage analysis of fluid solid coupling and strength reduction method are constructed to study the whole process of confined Karst cave water inrush. …”
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Mixed reality infrastructure based on deep learning medical image segmentation and 3D visualization for bone tumors using DCU-Net by Kun Wang, Yong Han, Yuguang Ye, Yusi Chen, Daxin Zhu, Yifeng Huang, Ying Huang, Yijie Chen, Jianshe Shi, Bijiao Ding, Jianlong Huang

“…Conclusion: The deep learning DCU-Net algorithm model can improve the performance of tumor CT image segmentation, and the reconstructed fine model can better reflect the actual situation of individual tumors; the MR system constructed based on this model enhances clinicians’ understanding of tumor morphology and spatial relationships. …”
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Early risk assessment in paediatric and adult household contacts of confirmed tuberculosis cases by novel diagnostic tests (ERASE-TB): protocol for a prospective, non-interventiona... by Ursula Panzner, Katharina Kranzer, Tsitsi Bandason, Kuda Mutasa, Sandra Rukobo, Charles Sandy, Bariki Mtafya, Andrea Rachow, Norbert Heinrich, Michael Hoelscher, Judith Bruchfeld, Olena Ivanova, Nyanda Elias Ntinginya, Doreen Pamba, Laura Olbrich, Issa Sabi, Simeon Mwanyonga, Elmar Saathoff, Willyhelmina Olomi, Junior Mutsvangwa, Hazel M Dockrell, Edson Tawanda Marambire, Denise Banze, Alfred Mfinanga, Theodora D Mbunda, Khosa Celso, Gunilla Kallenius, Claire J Calderwood, Christof Geldmacher, Kathrin Held, Tejaswi Appalarowthu, Friedrich Rieß, Anna Shepherd, Christopher Sundling, Mishelle Mugava, Martha Chipinduro, Lwitiho Sudi, Antelmo Haule, Emmanuel Sichone, Paschal Qwaray, Harrieth Mwambola, Lilian Minja, Peter Edwin, Dogo Ngalison, Stella Luswema, Celina Nhamuave, António Machiana, Carla Madeira, Emelva Manhiça, Nádia Sitoe, Jorge Ribeiro

“…Statistical analyses will include assessment of diagnostic accuracy by constructing receiver operating curves and calculation of sensitivity and specificity.Ethics and dissemination ERASE-TB has been approved by regulatory and ethical committees in each African country and by each partner organisation. …”
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Modulation of local immunity by the vaginal microbiome is associated with triggering spontaneous preterm birth by Yijia Liang, Yijia Liang, Yijia Liang, Changying Zhao, Yan Wen, Dashuang Sheng, Tiantian Wei, Tianqi Hu, Junhui Dai, Guoping Zhao, Guoping Zhao, Guoping Zhao, Sijie Yang, Sijie Yang, Qinghua Wang, Lei Zhang, Lei Zhang

“…Bidirectional mediation analysis was employed to construct a network of mediating roles, and preliminary in vitro validation of the Microbial-Cytokine-Preterm Birth pathway was performed to explore the effects of microbial and immune characteristics on vaginal epithelial cell function.ResultsPregnant women were categorized into three immune subtypes based on local immune status. …”
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Risk-based triage strategy by extended HPV genotyping for women with ASC-US cytology by Xuan Rao, Yue-Han Wang, Rui-Zhe Chen, Qian-Qian Wu, Xiao-Fei Zhang, Yun-Feng Fu, Xin-Yu Wang, Xiao Li

“…Compared with conventional strategy, this new risk-based strategy not only had higher specificity (CIN2+: p = .00; CIN3+: p = .01) and positive predictive value (CIN2+: p = .00; CIN3+: p = .03) for detecting CIN2+/3+, but also needed fewer colposcopies to identify each CIN2+/3+.Conclusions A new triage strategy for ASC-US women was successfully constructed based on CIN2+/3+ risks of 14 high-risk and 4 intermediate-risk HPVs, which could significantly reduce unnecessary colposcopies.…”
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Development of a latency model for HIV-1 subtype C and the impact of long terminal repeat element genetic variation on latency reversal by Shreyal Maikoo, Robert-Jan Palstra, Krista L. Dong, Tokameh Mahmoudi, Thumbi Ndung'u, Paradise Madlala

“…To address this scientific gap, we constructed a minimal genome retroviral vector expressing HIV-1C consensus transactivator of transcription protein (Tat) and green fluorescent protein (GFP) under the control of either HIV-1C consensus LTR (C731CC) or the transmitted/founder (T/F) LTRs derived from PLWH (CT/F731CC), produced corresponding LTR pseudotyped viruses using a vesicular stomatitis virus (VSV-G) pseudotyped Envelope vector and the pCMVΔR8.91 packaging vector containing HIV-1 accessory and rev genes. …”
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Predicting positive Clostridioides difficile test results using large-scale longitudinal data of demographics and medication history by Anh Pham, Robert El-Kareh, Frank Myers, Lucila Ohno-Machado, Tsung-Ting Kuo

“…Three models (Logistic Regression, Random Forest, and Ensemble) were constructed using hyper-parameters selected through 10-fold cross-validation. …”
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On the tracks of an uninvited guest, the Asian tiger mosquito, Aedes albopictus in Cyprus by Riccardo Piccinno, Giulia Fiorenza, Marlen Ines Vasquez, Jeremy Bouyer, Gregoris Notarides, Ludvik Marcus Gomulski, Soteris Meletiou, Mustafa Akiner, Antonios Michaelakis, Federico Forneris, Giovanni Maga, Giuliano Gasperi, Anna Rodolfa Malacrida

“…Methods We applied highly polymorphic simple sequence repeat (SSR) markers to the Ae. albopictus mosquitoes collected in Cyprus and to specimens from Italy, France, Switzerland, the Balkans, Greece and Turkey to construct an SSR individual genotype dataset that would enable the invasion pattern of Ae. albopictus in Cyprus to be traced. …”
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Remote sensing-based maize growth process parameters revel the maize yield: a comparison of field- and regional-scale by Minghan Cheng, Xiuliang Jin, Chenwei Nie, Kaihua Liu, Tianao Wu, Yuping Lv, Shuaibing Liu, Xun Yu, Yi Bai, Yadong Liu, Lin Meng, Xiao Jia, Yuan Liu, Lili Zhou, Fei Nan

“…These parameters were used to construct a maize yield estimation model applicable at both regional and field scales. …”
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Prognostic factors for transplant-free survival in patients with secondary sclerosing cholangitis associated with critical illness by Christoph Schramm, Hartmut Schmidt, Christian Gerges, Alisan Kahraman, Christian M Lange, Jassin Rashidi-Alavijeh, Katharina Willuweit, Georgios Konstantis, Dorsa Ghaffar Loy Moghadam, Alexandra Frey, Nargiz Nuruzade, Moritz Passenberg

“…A multivariable Cox regression model was constructed using Lasso regularisation and validated with Bootstrap resampling. …”
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Evaluation of ecological geological environment carrying capacity and analysis of driving mechanisms based on normal cloud model and geodetector model by Rongkun Dai, Changlai Xiao, Xiujuan Liang, Lin Jia, Yi Jia, Jiarui Yao, Weifei Yang, Jiang Zhang, Linzuo Zhang, Weifeng Li

“…In order to realize the sustainable development of the region in this fragile ecological-geological environment, it is necessary to study its Ecological Geological Environmental Carrying Capacity (EGECC) to better serve the regional ecological-geological environment restoration and management work. This study constructs an indicator system encompassing three subsystems: Geological Environment (GE), Social Environment (SE), and Ecological Environment (EE). …”
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