A Hemodynamic-Based Evaluation of Applying Different Types of Coronary Artery Bypass Grafts to Coronary Artery Aneurysms by Haoran Wang, Hitomi Anzai, Youjun Liu, Aike Qiao, Jinsheng Xie, Makoto Ohta

“…To do this, eight three-dimensional models were constructed, representing application of SVGs and LIMA grafts to CAAs (whether ligated or not) with diameters two, three, and five times the normal diameter, to perform computational fluid dynamics (CFD) simulation. …”
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Insights gained through real-time monitoring of porcine reproductive and respiratory syndrome virus and description of temporal trends based on laboratory data in Ontario, Canada by Tatiana Petukhova, Maria Spinato, Tanya Rossi, Michele T. Guerin, Cathy A. Bauman, Pauline Nelson-Smikle, Davor Ojkic, Zvonimir Poljak

“…The final optimized, aggregated, and anonymized datasets were exported to the Tableau server and were used to design dynamic real-time visualizations with Tableau Desktop v.2021.4. Constructed dashboards were: (1) monthly number of submissions and positive submissions over the last 10 years; (2) number of submissions and positive submissions over the last 3 years, interactively displayed at weekly, monthly, quarterly and yearly intervals; (3) monthly number of PRRSV restriction fragment length polymorphism pattern (RFLP) types at the submission level over the last 5 years; (4) weekly number of tested farms and positive farms over the last 6 Years; (5) monthly number of tested farms and positive farms over the last 6 Years; (6) indicators of the epidemiological data quality in each month; and (7) contextual information. …”
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Preparation, Reliability, and Validity of a Japanese Version of the “Satisfaction of Treatment among Caregivers of Dependent Type 2 Diabetic Patients” Questionnaire by Satoshi Ida, Ryutaro Kaneko, Kanako Imataka, Kaoru Okubo, Yoshitaka Shirakura, Kentaro Azuma, Ryoko Fujiwara, Hiroka Takahashi, Kazuya Murata

“…Exploratory factor analyses were performed to assess construct validity, and Pearson’s correlation coefficients between STCD2-J score and HbA1c as well as the degree of satisfaction with patients’ blood glucose levels, depression, and negative self-assessment of nursing care were calculated to assess criterion-related validity. …”
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Enhancing furcation involvement classification on panoramic radiographs with vision transformers by Xuan Zhang, Enting Guo, Xu Liu, Hong Zhao, Jie Yang, Wen Li, Wenlei Wu, Weibin Sun

“…Methods A total of 1,568 tooth images obtained from 506 panoramic radiographs were used to construct the database and evaluate the models. This study developed and assessed a ViT model for classifying FI from panoramic radiographs, and compared its performance with traditional models, including Multi-Layer Perceptron (MLP), Visual Geometry Group (VGG)Net, and GoogLeNet. …”
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Development and external validation of a dynamic nomogram for predicting the risk of functional outcome after 90 days in patients with acute intracerebral hemorrhage by Shaojie Li, Hongjian Li, Jiani Chen, Baofang Wu, Jiayin Wang, Chaocan Hong, Changhu Yan, Weizhi Qiu, Yasong Li, Hongzhi Gao

“…Later, least absolute shrinkage and selection operator (LASSO) regression and multifactorial logistic regression were used to screen the variables and construct a nomogram. Next, the evaluation was performed using the Receiver Operating Characteristic (ROC) curve, calibration curve, and decision curve analysis. …”
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Molecular and biological characterization of infectious full-length cDNA clones of two viruses in Paris yunnanensis, including a novel potyvirus by Pingxiu Lan, Peng He, Aiqiu Mu, Mengji Cao, Yun Wang, Guohua Zhou, Xiaojiao Chen, Hong Cai, Fan Li

“…To characterize their biological features, two infectious clones, representing the two viruses, have been constructed through homologous recombination or yeast homologous recombination, and inoculated to several species plants, respectively. …”
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Designing a broad-spectrum multi-epitope subunit vaccine against leptospirosis using immunoinformatics and structural approaches by Guneswar Sethi, Guneswar Sethi, Young Kyu Kim, Su-Cheol Han, Jeong Ho Hwang, Jeong Ho Hwang

“…These epitopes were fused with a heparin-binding hemagglutinin (HBHA) adjuvant and appropriate linkers to construct the broad-spectrum vaccine. The physicochemical properties of the vaccine were assessed, including antigenicity, immunogenicity, allergenicity, and conservation. …”
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Mesenchymal Stem Cell Therapy for Diabetic Kidney Disease: A Review of the Studies Using Syngeneic, Autologous, Allogeneic, and Xenogeneic Cells by Christian Sávio-Silva, Stephany Beyerstedt, Poliana E. Soinski-Sousa, Expedito B. Casaro, Maria Theresa A. Balby-Rocha, Antônio Simplício-Filho, Jamille Alves-Silva, Érika B. Rangel

“…Importantly, the bench to bedside pathway has been constructed in the last decade for assessing the therapeutic potential of MSCs in the DM setting. …”
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Quasi-weekly oscillation of regional PM_2.5 transport over China driven by the synoptic-scale disturbance of the East Asian winter monsoon circulation by Y. Bai, T. Zhao, K. Meng, Y. Zhou, J. Xiong, X. Sun, L. Shen, Y. Yue, Y. Zhu, W. Hu, J. Yao

“…Therefore, this study is targeted at the quasi-weekly oscillation (QWO) of regional PM<span class="inline-formula">_2.5</span> transport over central and eastern China (CEC) with the influence of synoptic-scale disturbance of the East Asian winter monsoon (EAWM) circulation. By constructing the data of daily PM<span class="inline-formula">_2.5</span> transport flux in CEC in the winters of 2015–2019, we utilize the extended empirical orthogonal function (EEOF) decomposition and other statistical methods to extract the moving spatial distribution of regional PM<span class="inline-formula">_2.5</span> transport over CEC, recognizing the QWO in regional PM<span class="inline-formula">_2.5</span> transport with the spatial–temporal variations over CEC. …”
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Association of immune-related adverse events with the outcomes of immune checkpoint inhibitors in patients with dMMR/MSI-H metastatic colorectal cancer by Chiara Cremolini, Sara Lonardi, Filippo Pietrantonio, Francesca Corti, Elisabetta Fenocchio, Massimiliano Salati, Margherita Ambrosini, Michael J Overman, Lisa Salvatore, Rossana Intini, Priya Jayachandran, Javier Ros, Maria Elena Elez, Marwan Fakih, Aakash Tushar Shah, Rosalba Miceli, Monica Niger, Vincenzo Nasca, Giacomo Mazzoli, Francesco Barretta

“…Of note, the irAEs were summarized using a ‘burden score’ constructed in a way that the same score value could be obtained by cumulating many low-grade irAEs or few high-grade irAEs; as a result, the lower the burden the better. …”
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Trends in palliative care utilization among older adult decedents with and without cancer in Taiwan: a population-based comparative studyResearch in context by Yu-Tai Lo, Tzu-Jung Chuang, Yu-Tung Huang, Yi-Lin Wu, Yi-Ching Yang, Chung-Yi Li

“…Multivariable logistic regression models were constructed to analyze cancer, and non-cancer causes of death associated with palliative care utilization. …”
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Immunogenicity and protective efficacy of a multi-antigenic adenovirus-based vaccine candidate against Mycobacterium tuberculosis by Jin-Seung Yun, Jin-Seung Yun, Eunkyung Shin, Young-Ran Lee, Jung-Ah Lee, Hyeokjin Lee, Jong-Seok Kim, Sung Jae Shin, Sang-Jun Ha, Sang-Won Lee, Dokeun Kim, Jung-Sik Yoo, Hye-Sook Jeong

“…In this study, we aimed to evaluate the efficacy of a multi-antigenic recombinant Ad5 vectored vaccine and determine the optimal immunization route for enhanced immune response against Mycobacterium tuberculosis.MethodsWe constructed a multi-antigenic recombinant Ad5 vectored vaccine expressing four antigens (Ag85B-ESAT6-MPT64-Rv2660c) of M. tuberculosis (rAd-TB4), immunized with rAd-TB4 (5 × 107 infectious virus units/mouse) twice at an interval of 4 weeks starting at 10 weeks after BCG priming, and evaluated its boosting efficacy in a BCG-primed mouse model, and determined the optimal immunization route.ResultsCompared with the BCG-only (2 × 105 colony forming units/mouse), subcutaneous injection of rAd-TB4 (1 × 107 infectious virus units/mL; two doses) elicited a T-cell response and cytokine production in lung lymphocytes and splenocytes. rAd-TB4 immunization significantly reduced bacterial loads and inflamed lung areas compared to BCG immunization (p &lt; 0.01) and protected against the H37Rv challenge performed at 17 weeks of BCG priming. …”
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Mesenchymal Stem Cells Carrying Viral Fusogenic Protein p14 to Treat Solid Tumors by Inducing Cell–Cell Fusion and Immune Activation by Yao Wang, Xunlei Pang, Ruirui Li, Jiuzhou Chen, Chen Wen, Huihuang Zhu, Tingyu Long, Jianjie Li, Lijun Zheng, Youcai Deng, Junnian Zheng, Bo Xu

“…Therefore, cell–cell fusion as a cell-killing mechanism might develop a novel cytotherapy aimed at improving the efficacy against solid tumors. Methods: We constructed a fusogenic protein, fusion-associated small transmembrane (FAST) p14 of reptilian reovirus, into cancer cells and mesenchymal stem cells (MSCs), which cocultured with various colon cancer cells and melenoma cells to validate its ability to induce cell fusion and syncytia formation. …”
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Carboplatin-resistance-related DNA damage repair prognostic gene signature and its association with immune infiltration in breast cancer by Shuwen Dong, Anqi Li, Ruixin Pan, Jin Hong, Zheng Wang, Kunwei Shen

“…This study aimed to identify the DDR genes involved in carboplatin resistance and to elucidate their effects on prognosis, immune infiltration, and drug sensitivity in breast cancer patients.MethodsA 3D-culture model resistant to carboplatin was constructed and sequenced. Co-expressed DDR genes were analyzed to develop a predictive model. …”
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<i>Rubus idaeus RiACS1</i> Gene Is Involved in Ethylene Synthesis and Accelerates Fruit Ripening in <i>Solanum lycopersicum</i> by Tiemei Li, Wenjiao Xin, Hang Zhang, Jiarong Jiang, Kunmiao Ding, Mengyu Liu, Nanyan Li, Guohui Yang

“…The <i>RiACS1</i> gene overexpression vector was constructed and transformed into tomato plants using the <i>Agrobacterium tumefaciens</i> infection method to verify its function in their reproductive development. …”
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Baseline [18F]FDG PET/CT radiomics for predicting interim efficacy in follicular lymphoma treated with first-line R-CHOP by Zeying Wen, Xiaohe Gao, Qingxia Wu, Jianwei Yang, Jian Sun, Keliu Wu, Hongfei Zhao, Ruihua Wang, Yanmei Li

“…Seven clinical risk factors and ten radiomics features associated with interim efficacy were selected to construct the clinical, radiomics, and radiomics-clinical combined models. …”
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TransferBAN-Syn: a transfer learning-based algorithm for predicting synergistic drug combinations against echinococcosis by Haitao Li, Haitao Li, Yuanyuan Chu, Yuanyuan Chu, Liyuan Jiang, Liyuan Jiang, Lei Li, Lei Li, GuoDong Lv, Yuansheng Liu, Chunhou Zheng, Chunhou Zheng, Yansen Su, Yansen Su

“…Specifically, TransferBAN-Syn contains a drug interaction feature representation module, a disease feature representation module, and a prediction module, where the bilinear attention network is employed in the drug interaction feature representation module to deeply extract the fusion feature of drug combinations. Besides, we construct a special dataset with multi-source information and drug combinations for parasitic diseases, including 21 parasitic diseases and echinococcosis. …”
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CSNK1E is involved in TGF-β1 induced epithelial mesenchymal transformationas and related to melanoma immune heterogeneity by Wangbing Hong, Xin Wang, Xinyu Huang, Pengfei Chen, Yifan Liu, Ziying Zheng, Xin You, Yinghua Chen, Zengxin Xie, Gongnan Zhan, Heping Huang

“…The Least Absolute Shrinkage and Selection Operator (LASSO) algorithm was then applied to refine the gene set and construct a 13-gene prognostic model. We validated the model at multiple time points to assess its predictive performance. …”
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Unsupervised machine learning model for phenogroup-based stratification in acute type A aortic dissection to identify postoperative acute gastrointestinal injury by Yuhu Ma, Xiaofang Yang, Chenxiang Weng, Xiaoqing Wang, Baoping Zhang, Ying Liu, Rui Wang, Zhenxing Bao, Peining Yang, Hong Zhang, Yatao Liu

“…Logistic regression was used to analyze the high-risk factors for AGI in each phenogroups and random forest (RF) algorithms were used to construct diagnostic models for AGI in different phenogroups.ResultsA total of 188 patients were included, with 166 males and 22 females. …”
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Association of player position and functional connectivity alterations in collegiate American football players: an fMRI study by Owen Griffith, Xiaoxiao Bai, Alexa E. Walter, Michael Gay, Jon Kelly, Wayne Sebastianelli, Linda Papa, Semyon Slobounov

“…Second, 10 DMN ROIs were constructed by overlaying an anatomical map over regions of positive correlation from one-sample t-tests of pre-season and post-season. …”
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