Integrated bioinformatics analysis of the effects of chronic pain on patients with spinal cord injury by Jinlong Zhang, Jinlong Zhang, Longju Qi, Yuyu Sun, Yuyu Sun, Shiyuan Chen, Jinyi Liu, Jiaxi Chen, Fangsu Yan, Wenqi Wang, Qinghua Wang, Liang Chen

“…Additionally, we conducted an in-depth examination of immune infiltration in SCI to elucidate its correlation with chronic pain.ResultsAnalyzing 101 DEGs associated with SCI and chronic pain, we constructed a protein interaction network and identified 15 hub genes. …”
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Deep learning model based prediction of vehicle CO2 emissions with eXplainable AI integration for sustainable environment by Gazi Mohammad Imdadul Alam, Sharia Arfin Tanim, Sumit Kanti Sarker, Yutaka Watanobe, Rashedul Islam, M. F. Mridha, Kamruddin Nur

“…This study used deep learning techniques to construct a CO2 emission prediction model, specifically a light multilayer perceptron (MLP) architecture called CarbonMLP. …”
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High-altitude hypoxia aggravated neurological deficits in mice induced by traumatic brain injury via BACH1 mediating astrocytic ferroptosis by Peng Zou, Tianjing Li, Zixuan Cao, Erwan Yang, Mingdong Bao, Haofuzi Zhang, Zhuoyuan Zhang, Dan Liu, Min Zhang, Xiangyu Gao, Junmiao Ge, Xiaofan Jiang, Zhicheng Tian, Peng Luo

“…In order to deeply investigate this scientific issue, we constructed a high-altitude hypoxic TBI model at different altitudes and used animal behavioral assessments (Modified neurological severity score, rotarod test, elevated plus maze test) as well as histopathological analyses (brain gross specimens, brain water content, Evans blue content, hypoxia inducible factor-1α, Hematoxylin-Eosin staining and ROS detection) to reveal its underlying principles and characteristics. …”
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Cross-cultural adaptation and validation of the Spanish version of the Prevent for Work questionnaire by Julia Blasco-Abadía, Pablo Bellosta-López, Víctor Doménech-García, Thorvaldur Skuli Palsson, Steffan Wittrup McPhee Christensen, Steffan Wittrup McPhee Christensen, Morten Hoegh, Pedro Berjano, Francesco Langella

“…Additionally, good internal consistency and construct validity were found. This translated version of the questionnaire can therefore be considered acceptable for use by workers with and without history of disabling musculoskeletal pain.…”
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Controlled lattice deformation for high-mobility two-dimensional MoTe2 growth by Ruishan Li, Mengyu Hong, Wei Shangguan, Yanzhe Zhang, Yihe Liu, He Jiang, Huihui Yu, Li Gao, Xiankun Zhang, Zheng Zhang, Yue Zhang

“…Meanwhile, the lowest Gibbs free energy change of the chemical reaction results in an impressive 2H-MoTe2 growth rate of 8.07 μm/min. The constructed 2H-MoTe2 field-effect transistor array from MoO3 precursor showcases record-high hole mobility of 85 cm2·V-1·s-1, competitive on-off ratio of 3×104, and outstanding uniformity. …”
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Aquaponics model can provide better productivity: Microorganisms affect the growth and health of tilapia by Dingyue Fan, Huimin Xu, Shunlong Meng, Limin Fan, Chao Song, Liping Qiu, Dandan Li, Longxiang Fang, Zhuping Liu, Xuwen Bing

“…In the present study, three aquaponics systems were established, and three same sized recirculating aquaculture systems (RAS) were constructed to act as controls. To evaluate bacterial community diversity and compositions across different microhabitats in the two systems, we used amplicon-based high-throughput sequencing technique targeting the 16S rRNA gene. …”
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Structural damage-driven brain compensation among near-centenarians and centenarians without dementia by Hui Tang, Haichao Zhao, Hao Liu, Jiyang Jiang, Nicole Kochan, Jing Jing, Henry Brodaty, Wei Wen, Perminder S. Sachdev, Tao Liu

“…We examined a cohort of near-centenarians and centenarians without dementia (aged 95-103 years, n=44). We constructed a structural disconnection matrix based on the disruption of white matter pathways caused by white matter hyperintensities (WMHs), aiming to explore the relationship between functional connections, cognitive preservation and white matter damage. …”
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Streptococcus halichoeri: Comparative Genomics of an Emerging Pathogen by Kirsi Aaltonen, Ravi Kant, Marjut Eklund, Mirja Raunio-Saarnisto, Lars Paulin, Olli Vapalahti, Thomas Grönthal, Merja Rantala, Tarja Sironen

“…A phylogenetic tree was constructed using the genes of the core genome. Virulence factors were assessed using the Virulence Factor Database (VFDB) concentrating on the previously confirmed streptococcal factors. …”
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Dual-stream disentangled model for microvascular extraction in five datasets from multiple OCTA instruments by Xiaoyang Hu, Xiaoyang Hu, Jinkui Hao, Quanyong Yi, Yitian Zhao, Jiong Zhang

“…By introducing vascular structure as a prior constraint and constructing auxiliary information, the network achieves disentangled representation learning, effectively minimizing the interference of noise and artifacts. …”
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A novel homozygous intronic variant in CDT1 that alters splicing causes Meier–Gorlin syndrome, and a review of published mutations and growth hormone treatments by Qing Li, Yichi Wu, Fucheng Meng, Zhuxi Li, Di Zhan, Xiaoping Luo

“…Whole-exome sequencing (WES) and bioinformatic analysis were performed to identify any variants and predict their pathogenicity. Minigene constructs were generated and transfected into HEK-293T cells for in vitro splicing assays. …”
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Exploring the role of splicing in TP53 variant pathogenicity through predictions and minigene assays by Cristina Fortuno, Inés Llinares-Burguet, Daffodil M. Canson, Miguel de la Hoya, Elena Bueno-Martínez, Lara Sanoguera-Miralles, Sonsoles Caldes, Paul A. James, Eladio A. Velasco-Sampedro, Amanda B. Spurdle

“…Methods We conducted splicing analyses using a minigene construct containing TP53 exons 2 to 9 transfected into human breast cancer SKBR3 cells, and compared results against different splice prediction methods, including correlation with the SpliceAI-10k calculator. …”
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An integrated approach to flood risk assessment using multi-criteria decision analysis and geographic information system. A case study from a flood-prone region of Pakistan by Muhammad Ibrahim, Aidi Huo, Aidi Huo, Aidi Huo, Waheed Ullah, Safi Ullah, Zhao Xuantao

“…Selecting average precipitation, peak river flow, and historical flood frequency as indicators, the weights of the three are 0.4, 0.3, and 0.3 respectively, an indicator system for predicting flood disasters was constructed. The results categorised the study area into four hazard zones: very high, high, medium, and low, based on their susceptibility to flood hazards. …”
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Development of Virus-Like Particles (VLPs) for Hepatitis C Virus genotype 4: a novel approach for vaccine development in Egypt by Ahmed A. Ali, Rasha A. M. Azouz, Nahla A. Hussein, Reem El-Shenawy, Naiera M. Helmy, Yasmine S. El-Abd, Ashraf A. Tabll

“…Methods Lentiviral-based vectors were constructed and employed to integrate the full-length sequence of Core, E1, E2, and P7 genes of HCV genotype 4 into the genome of Human Embryonic Kidney cells (HEK293T). …”
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Prediction of Soil Organic Carbon Content in <italic>Spartina alterniflora</italic> by Using UAV Multispectral and LiDAR Data by Jiannan He, Yongbin Zhang, Mingyue Liu, Lin Chen, Weidong Man, Hua Fang, Xiang Li, Xuan Yin, Jianping Liang, Wenke Bai, Fuping Li

“…The results show that the following. 1) The prediction accuracy is improved by classifying the data into three types: unlodging <italic>S. alterniflora</italic> (ULSA), lodging <italic>S. alterniflora</italic> (LSA), and mudflats. 2) XGBoost outperformed RF and SVM in accurately predicting SOC content, with <italic>R</italic>²; values of 0.743 for ULSA, 0.731 for LSA, and 0.705 for mudflats; 3) In the XGBoost models constructed for ULSA, LSA, and mudflats, spectral features contributed 75.7&#x0025;, 73.1&#x0025;, and 63.1&#x0025;, respectively, with the normalized difference vegetation index emerging as the most critical spectral feature. …”
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The Accuracy of the Passive Leg Raising Test Using the Perfusion Index to Identify Preload Responsiveness—A Single Center Study in a Resource-Limited Setting by Marialessia Casazzo, Luigi Pisani, Rabiul Alam Md Erfan Uddin, Abdus Sattar, Rashed Mirzada, Abu Shahed Mohammad Zahed, Shoman Sarkar, Anupam Barua, Sujat Paul, Mohammad Abul Faiz, Abdullah Abu Sayeed, Stije J. Leopold, Sue J. Lee, Mavuto Mukaka, Mohammed Abul Hassan Chowdhury, Ketsanee Srinamon, Marja Schilstra, Asok Kumar Dutta, Salvatore Grasso, Marcus J. Schultz, Aniruddha Ghose, Arjen Dondorp, Katherine Plewes

“…Receiver operating characteristic (ROC) curves were constructed. <b>Results:</b> The study included 34 patients admitted for sepsis with signs of hypoperfusion and 10 patients admitted for severe malaria. …”
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Modeling factors related to earthquake preparedness: a structural equation modeling approach by Azadeh Fatehpanah, Elham Maraghi, Anthony Coetzer-Liversage, Mahmood Karimy, Amir H. Pakpour, Majed Maripour, Nematollah Jaafarzadeh Haghighi Fard, Marzieh Araban

“…Structural equation modeling (SEM) was employed to analyze TPB constructs, including attitudes, subjective norms, perceived behavioral control, and intentions, in relation to earthquake preparedness behaviors. …”
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Efficient recovery of rare metal lanthanum from water by MOF-modified biochar: DFT calculation and dynamic adsorption by Qilan Huang, Qianru Zhang, Shuwen Zhao, Chuchen Zhang, Huixin Guan, Jianqiao Liu

“…Density functional theory (DFT) computations allowed for rationally constructing the adsorption model. According to DFT calculations, the primary processes involved in the adsorption of La3+ were π–π interaction and ligand exchange, wherein the surface hydroxyl group played a crucial role. …”
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Predicting patient outcomes with gene-expression biomarkers from colorectal cancer organoids and cell lines by Alexandra Razumovskaya, Mariia Silkina, Mariia Silkina, Mariia Silkina, Andrey Poloznikov, Timur Kulagin, Maria Raigorodskaya, Nina Gorban, Anna Kudryavtseva, Maria Fedorova, Boris Alekseev, Alexander Tonevitsky, Alexander Tonevitsky, Alexander Tonevitsky, Sergey Nikulin, Sergey Nikulin, Sergey Nikulin

“…The main goal of this study was to find the genes connected to the resistance to the aforementioned drugs and to construct a predictive gene expression-based classifier to separate responders and non-responders.MethodsIn this study, we analyzed gene expression profiles of seven patient-derived CRC organoids and performed correlation analyses between gene expression and IC50 values for the three standard-of-care chemotherapeutic drugs. …”
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Filamented hydrogels as tunable conduits for guiding neurite outgrowth by Hao Liu, Anna Puiggalí-Jou, Parth Chansoria, Jakub Janiak, Marcy Zenobi-Wong

“…FLight employs optical modulation instability (OMI) to rapidly and safely (<5 s) fabricate hydrogel constructs with precise microfilament alignment. The tunability of FLight matrices was demonstrated by adjusting four key parameters: stiffness, porosity, growth factor release, and incorporation of biological cues. …”
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SCUBADive. I. JWST+ALMA Analysis of 289 Submillimeter Galaxies in COSMOS-web by Jed McKinney, Caitlin M. Casey, Arianna S. Long, Olivia R. Cooper, Sinclaire M. Manning, Maximilien Franco, Hollis Akins, Erini Lambrides, Elaine Gammon, Camila Silva, Fabrizio Gentile, Jorge A. Zavala, Aristeidis Amvrosiadis, Irham Andika, Malte Brinch, Jaclyn B. Champagne, Nima Chartab, Nicole E. Drakos, Andreas L. Faisst, Seiji Fujimoto, Steven Gillman, Ghassem Gozaliasl, Thomas R. Greve, Santosh Harish, Christopher C. Hayward, Michaela Hirschmann, Olivier Ilbert, Boris S. Kalita, Jeyhan S. Kartaltepe, Anton M. Koekemoer, Vasily Kokorev, Daizhong Liu, Georgios Magdis, Henry Joy McCracken, Jason Rhodes, Brant E. Robertson, Margherita Talia, Francesco Valentino, Aswin P. Vijayan

“…JWST has enabled detecting and spatially resolving the heavily dust-attenuated stellar populations of submillimeter galaxies, revealing detail that was previously inaccessible. In this work, we construct a sample of 289 submillimeter galaxies with joint Atacama Large Millimeter/submillimeter Array (ALMA) and JWST constraints in the COSMOS field. …”
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