Identification of Differentially Expressed Genes and Signaling Pathways in Acute Myocardial Infarction Based on Integrated Bioinformatics Analysis by Da-Qiu Chen, Xiang-Sheng Kong, Xue-Bin Shen, Mao-Zhi Huang, Jian-Ping Zheng, Jing Sun, Shang-Hua Xu

“…In order to explore the correlation between these DEGs, the interaction network of protein-protein internet (PPI) was constructed using the STRING database. Utilizing the MCODE plug-in of Cytoscape, the module analysis was performed. …”
Get full text

Developing a ceRNA-based lncRNA-miRNA-mRNA regulatory network to uncover roles in skeletal muscle development by Wang Wenlun, Wang Wenlun, Yu Chaohang, Huang Yan, Li Wenbin, Zhou Nanqing, Hu Qianmin, Wu Shengcai, Yuan Qing, Yu Shirui, Zhang Feng, Zhu Lingyun

“…Based on the ceRNA theory, we constructed and visualized the lncRNA-miRNA-mRNA regulatory network using ggalluvial among other R packages. …”
Get full text

Assessment of prognosis and responsiveness to immunotherapy in colorectal cancer patients based on the level of immune cell infiltration by Kaili Liao, Minqi Zhu, Lei Guo, Zijun Gao, Jinting Cheng, Bing Sun, Yihui Qian, Bingying Lin, Jingyan Zhang, Tingyi Qian, Yixin Jiang, Yanmei Xu, Qionghui Zhong, Xiaozhong Wang

“…Prognosis-related genes were screened and models were constructed using LASSO-Cox analysis. The models were validated by survival analysis. …”
Get full text

Development and assessment of the health-related quality of life scale for children with hearing loss in China by Jie Liu, Yu-Xiao Wang, Jing Li, Dahong Wu, Guang-xian Zeng, Jing Cheng, Jia-yi Wang, Jian-Zhong Zheng, Lu He

“…We sought to develop a reliable and valid measure of health-related QoL in children with hearing loss. Methods We constructed a conceptual framework to assess the QoL of children with hearing loss based on the Pediatric Quality of Life Inventory™ Version 4.0 child quality of life scale and World Health Organization Quality of Life Brief Version disability general version. …”
Get full text

Organizational readiness and implementation of colorectal cancer screening evidence-based interventions in federally qualified health centers: A cross-sectional study by Emanuelle M. Dias, Timothy J. Walker, Bijal A. Balasubramanian, Paula M. Cuccaro, Lauren Workman, Abraham Wandersman, Maria E. Fernandez

“…Conclusion: This study guides researchers in prioritizing organizational structure and selecting specific implementation strategies to improve this construct to implement CRC screening-related EBIs. …”
Get full text

ALDH2 Overexpression Alleviates High Glucose-Induced Cardiotoxicity by Inhibiting NLRP3 Inflammasome Activation by Ruiping Cao, Dian Fang, Jiahui Wang, Ying Yu, Hongwei Ye, Pinfang Kang, Zhenghong Li, Hongju Wang, Qin Gao

“…Mitochondrial ALDH2 overexpression cardiac cell line was constructed. The results showed in high glucose condition that ALDH2 overexpression significantly increased H9C2 cardiac cell viability, increased mitochondrial ALDH2 activity and protein expression, and reduced mitochondrial reactive oxygen species (ROS) production, 4-hydroxynonenal (4-HNE), and lactate dehydrogenase (LDH) levels; meanwhile, the pyroptosis key components—NLRP3 inflammasome-related proteins, apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC), cysteine-containing aspartate specific protease 1 (Caspase-1), and interleukin-18 (IL-18) protein expressions—were significantly decreased, and IL-18 and interleukin-1β (IL-1β) levels were also decreased. …”
Get full text

Establishment of a metabolite diagnostic model for the risk of diabetic nephropathy in type 2 diabetic population: Based on a cross-sectional study in China by Jing-Yang Su, Yong-Jie Chen, Wei Zhang, Rui Zhang, Tong-Feng Liu, Wei-Ming Luo, Xi-Lin Yang, Zhong-Ze Fang

“…Introduction: This study aimed to investigate the correlation between various plasma metabolites and the likelihood of developing diabetic nephropathy (DN) and construct a diagnostic model for DN in Chinese patients with type 2 diabetes mellitus (T2DM). …”
Get full text

Achilles Tendon Repair by Decellularized and Engineered Xenografts in a Rabbit Model by Marta Bottagisio, Daniele D’Arrigo, Giuseppe Talò, Matilde Bongio, Marco Ferroni, Federica Boschetti, Matteo Moretti, Arianna B. Lovati

“…In conclusion, this in vivo study suggests a potential use of the proposed tissue-engineered constructs for tendon reconstruction.…”
Get full text

MP-LLAVRec: an agricultural product recommendation algorithm based on LLAVA and user modal preference by Peishan Li, Peishan Li, Peishan Li, Lutao Gao, Lutao Gao, Lutao Gao, Lilian Zhang, Lilian Zhang, Lilian Zhang, Lin Peng, Lin Peng, Lin Peng, Chunhui Bai, Chunhui Bai, Chunhui Bai, Linnan Yang, Linnan Yang, Linnan Yang

“…It consisted of three main components: (1) LLAVA data enhancement, which introduced a multimodal macromodel to improve the understanding of node attributes; (2) agricultural product association relationship fusion, which constructed and improved the complex association network structure among products to ensure that the system can better understand the substitution relationship, complementary relationship, and implied consumption logic among products; (3) user modal preference feature extraction block, which deeply mined the interaction data between consumers and products, and advanced the effective user feature information from the correspondence between global user representations and local modal user representations.Results and DiscussionWe conduct experiments on a real dataset from Amazon's large-scale e-commerce platform to verify the effectiveness of MP-LLAVRec. …”
Get full text

Risk factors for multidrug resistance in pulmonary tuberculosis patients with diabetes mellitus by Lianpeng Wu, Lianpeng Wu, Na Chen, Na Chen, Dandan Xia, Dandan Xia, Xiangao Jiang, Xiangao Jiang

“…Multivariate logistic regression analysis was used to identify independent risk factors for MDR, and receiver operating characteristic (ROC) curves were constructed to evaluate the predictive value of these factors.ResultsA total of 318 patients were analyzed, with 253 in the non-MDR group and 65 in the MDR group. …”
Get full text

Development and validation of a predictive model and tool for functional recovery in patients after postero-lateral interbody fusion by Shuai Zhou, Zhenbang Yang, Wei Zhang, Shihang Liu, Qian Xiao, Guangzhao Hou, Rui Chen, Nuoman Han, Jiao Guo, Miao Liang, Qi Zhang, Yingze Zhang, Hongzhi Lv

“…The pooled variables were subsequently included in binary logistic regression analyses, construct risk prediction models, and plot nomograms. …”
Get full text

Sustainability of healthcare system improvements, programmes and interventions in acute care settings: protocol for a mixed methods systematic review by Franz E Babl, Sandy Middleton, Julie Cowie, Catherine Wilson, Peter Wilson, Pauline Campbell, Emma Tavender, Lisa Kuhn, Nicola Straiton, Victoria Ramsden, Elizabeth McInnes

“…Facilitators and barriers will be mapped to the Consolidated Framework for Sustainability Constructs in Healthcare and a narrative approach will be used to present key findings.Ethics and dissemination No primary data will be collected so formal ethical approval is not required. …”
Get full text

Intratumoral and peritumoral radiomics using multi-phase contrast-enhanced CT for diagnosis of renal oncocytoma and chromophobe renal cell carcinoma: a multicenter retrospective st... by Yongsong Ye, Bei Weng, Yan Guo, Lesheng Huang, Shanghuang Xie, Guimian Zhong, Wenhui Feng, Wenxiang Lin, Zhixuan Song, Huanjun Wang, Tianzhu Liu

“…PurposeTo construct diagnostic models that distinguish renal oncocytoma (RO) from chromophobe renal cell carcinoma (CRCC) using intratumoral and peritumoral radiomic features from the corticomedullary phase (CMP) and nephrographic phase (NP) of computed tomography, and compare model results with manual and radiological results.MethodsThe RO and CRCC cases from five centers were split into a training set (70%) and a validation set (30%). …”
Get full text

Evidence that transverse variability of critical current density can greatly mitigate screening current stress in high field REBCO magnets by Jeseok Bang, Jonathan Lee, Griffin Bradford, Kwangmin Kim, Xinbo Hu, Dmytro Abraimov, Jan Jaroszynski, Anatolii Polyanskii, So Noguchi, Seungyong Hahn, David C. Larbalestier

“…Reasons for this slit edge orientation-dependent damage mitigation having not yet been presented, we made it the central issue of this new Little Big Coil (LBC4). Accordingly, we constructed and tested LBC4 by replicating LBC3, except that only single-slit tapes were used and every slit edge pointed inward towards the magnet center. …”
Get full text

Machine learning identification of a novel vasculogenic mimicry-related signature and FOXM1’s role in promoting vasculogenic mimicry in clear cell renal cell carcinoma by Chao Xu, Sujing Zhang, Jingwei Lv, Yilong Cao, Yao Chen, Hao Sun, Shengtao Dai, Bowei Zhang, Meng Zhu, Yuepeng Liu, Junfei Gu

“…Conclusion: This study constructed a VM-related signature and revealed that FOXM1 promotes VM formation in renal cell carcinoma through the PYCR1-PI3K/AKT/mTOR signaling axis, serving as a prognostic indicator and potential therapeutic target.…”
Get full text

Resuscitative Endovascular Balloon occlusion of the aorta in Impending Traumatic arrest: Is It Effective? by Jae Sik Chung, Oh Hyun Kim, Seongyup Kim, Ji Young Jang, Gyo Jin An, Pil Young Jung

“…Therefore, appropriate protocols, including pre-hospital REBOA, should be constructed to demonstrate the effectiveness of REBOA in reducing mortality in arrest or impending arrest patients.…”
Get full text

Enhanced Electrochemical Performance of Dual-Ion Batteries with T-Nb₂O₅/Nitrogen-Doped Three-Dimensional Porous Carbon Composites by Chen Qi, Duo Ying, Cheng Ma, Wenming Qiao, Jitong Wang, Licheng Ling

“…Herein, a nitrogen-doped three-dimensional porous carbon (RMF) was prepared for loading niobium pentoxide to construct a composite system with excellent electrochemical performance. …”
Get full text

Identification and Pathogenicity of <i>Fusarium</i> Species from Herbaceous Plants on Grassland in Qiaojia County, China by Yanzhu Gao, Zhixiao Zhang, Mei Ji, Sangzi Ze, Haodong Wang, Bin Yang, Lianrong Hu, Ning Zhao

“…Through morphological means and based on ITS, <i>RPB2</i>, and <i>TEF-1</i> gene sequences, we compared and constructed polygenic phylogenetic trees to classify and identify the <i>Fusarium</i> species. …”
Get full text

Drug Efficacy Recommendation System of Glioblastoma (GBM) Using Deep Learning by Sajid Naveed, Mujtaba Husnain, Ali Samad, Amna Ikram, Hina Afreen, Ghulam Gilanie, Najah Alsubaie

“…A drug efficacy recommendation system was constructed using a deep learning method that combines gene expression, drug Simplified Molecular Input Line Entry System (SMILES), and inhibitory concentration features. …”
Get full text

Measurement properties of the Traumatic Brain Injury Quality of Life (TBI-QoL) and Spinal Cord Injury Quality of Life (SCI-QoL) measurement systems: a systematic review by Rebecca Ataman, Rehab Alhasani, Line Auneau-Enjalbert, Adria Quigley, Henry Ukachukwu Michael, Sara Ahmed

“…Both measurement systems have sufficient content validity, structural validity, internal consistency and construct validity across nearly all domains (GRADE: high). …”
Get full text