Use of Graph Database for the Integration of Heterogeneous Biological Data by Byoung-Ha Yoon, Seon-Kyu Kim, Seon-Young Kim

“…We collected various biological data (protein-protein interaction, drug-target, gene-disease, etc.) from several existing sources, removed duplicate and redundant data, and finally constructed a graph database containing 114,550 nodes and 82,674,321 relationships. …”
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The molecular receptor NKBB enhances the persistence and anti-hepatocellular carcinoma activity of GPC3 CAR-T cells by Minghao Sui, Tiantian Liu, Xuanli Song, Ji Li, Han Ding, Yuqian Liu, Xinyu Wang, Huimin Liu, Yuchan Xue, Jianni Qi, Miao Zhang, Songbo Zhao, Qiang Zhu

“…Therefore, to treat HCC more effectively, we connected the molecular receptor NKBB to a second-generation glypican-3 (GPC3) CAR to construct GC3328z-NKBB CAR-T cells, which have double specific targets of GPC3 and NKG2DLs (natural killer group 2, member D ligands), dual co-stimulation of CD28 and 41BB, and a single CD3ζ chain. …”
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Assessing the Impact of Waterfront Environments on Public Well-Being Through Digital Twin Technology by Junjie Luo, Zheng Yuan, Lingzi Xu, Wenhui Xu

“…A high-precision 3-D virtual replica of a suburban park was constructed using UAV oblique photogrammetry and handheld lidar scanning technologies. …”
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Gene Expression Profiling of the Sciatic Nerve in Streptozotocin-Induced Diabetic Rats with Peripheral Neuropathy by Yiji Tu, Zenggan Chen, Feng Zhang, Zhenglin Di, Junhui Zhang, Li Cai

“…Experimental DPN rats were successfully constructed, presenting significantly decreased withdrawal threshold and motor nerve conduction velocity, and typical histological changes in the sciatic nerve. 597 DEGs (186 up- and 411 downregulated) were identified in DPN rats. …”
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Assessment of Flood Mitigation Strategies: A Case Study of the Aït Athmane Center in the Errachidia Region by Kadiri Abdelhakim, Essafraoui Badre, Messaoudi Badre, Aït Lahssaine Ismail, Ait Said Brahim, El Ouali Mohamed, Kabiri Lahcen

“…These primarily involve simple mechanical adjustments such as constructing gabion weirs, raising retaining walls along the Wadi's banks, and creating crossing structures.…”
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Gene signatures derived from transcriptomic-causal networks stratify colorectal cancer patients for effective targeted therapy by Akram Yazdani, Heinz-Josef Lenz, Gianluigi Pillonetto, Raul Mendez-Giraldez, Azam Yazdani, Hanna Sanoff, Reza Hadi, Esmat Samiei, Alan P. Venook, Mark J. Ratain, Naim Rashid, Benjamin G. Vincent, Xueping Qu, Yujia Wen, Michael Kosorok, William F. Symmans, John Paul Y. C. Shen, Michael S. Lee, Scott Kopetz, Andrew B. Nixon, Monica M. Bertagnolli, Charles M. Perou, Federico Innocenti

“…This study aimed to uncover such signatures in metastatic colorectal cancer (CRC) patients to aid treatment decisions. Methods We constructed transcriptomic-causal networks and integrated gene interconnectivity into overall survival (OS) analysis to control for confounding genes. …”
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Psychometric properties of the Turkish version of the respectful maternity care scale https://nmcjournal.zums.ac.ir/article-1-935-en.html by Sule Gokyildiz Surucu, Gunes Arslan, Burcu Avcibay Vurgec, Ebru Gozuyesil, Ephrem Daniel Sheferaw

“…Researchers studied the RMC scale for the reliability of language, content, construct, validity, and internal consistency. The validity analysis of the scale was examined using Confirmatory factor analysis (CFA). …”
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Personalized treatment strategies for breast adenoid cystic carcinoma: A machine learning approach by Sakhr Alshwayyat, Mahmoud Bashar Abu Al Hawa, Mustafa Alshwayyat, Tala Abdulsalam Alshwayyat, Siya sawan, Ghaith Heilat, Hanan M. Hammouri, Sara Mheid, Batool Al Shweiat, Hamdah Hanifa

“…To identify the prognostic variables, we conducted Cox regression analysis and constructed prognostic models using five Machine Learning (ML) algorithms to predict the 5-year survival. …”
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Polydopamine grafting polyether ether ketone to stabilize growth factor for efficient osteonecrosis repair by Yi Sun, Jingyun Liu, Kaijia Chen, Nannan Zhong, Chengpeng He, Xinming Luan, Xiaobei Zang, Jianbo Sun, Ning Cao, Wenbo Wang, Qiang Ren

“…A range of PEEK composite materials, including sulfonated polyether ether ketone (SPEEK), polydopamine-sulfonated polyether ether ketone (SPEEK-PDA), bone-forming peptide-poly-dopamine-sulfonated polyether ether ketone (SPEEK-PDA-BFP), and vascular endothelial growth factor-poly-dopamine-sulfonated polyether ether ketone (SPEEK-PDA-VEGF), were constructed by concentrated sulfuric acid sulfonation, polydopamine modification and grafting of bioactive factors. …”
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TCR transgenic clone selection guided by immune receptor analysis and single-cell RNA expression of polyclonal responders by Nincy Debeuf, Sahine Lameire, Manon Vanheerswynghels, Julie Deckers, Caroline De Wolf, Wendy Toussaint, Rein Verbeke, Kevin Verstaen, Hamida Hammad, Stijn Vanhee, Bart N Lambrecht

“…To overcome this detection problem, adoptive transfer of a cohort of T cells purified from T cell receptor (TCR) transgenic donors has been extensively used but is not readily available for emerging pathogens. Constructing TCR transgenic mice from T cell hybridomas is a labor-intensive and sometimes erratic process, since the best clones are selected based on antigen-induced CD69 upregulation or IL-2 production in vitro, and TCR chains are polymerase chain reaction (PCR)-cloned into expression vectors. …”
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A Dual-Type L2 11-88 Peptide from HPV Types 16/18 Formulated in Montanide ISA 720 Induced Strong and Balanced Th1/Th2 Immune Responses, Associated with High Titers of Broad Spectru... by Farhad Motavalli Khiavi, Arash Arashkia, Majid Golkar, Maryam Nasimi, Farzin Roohvand, Kayhan Azadmanesh

“…Herein, three dual-type- (DT-) HPV L2 fusion peptides comprising the three head-to-tail tandem repeats (multimers) of either HPV 16 epitope “17-36” or “69-81” or one copy (monomer) of 11-88 fused to the same residues of HPV 18 were constructed and expressed in E. coli. SDS-PAGE and Western blot analyses indicated the proper expression and stability of the E. coli-derived DT peptides. …”
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Structural and functional connectivity coupling as an imaging marker for bone metastasis pain in lung cancer patients by Jiahui Zheng, Chengfang Wang, Xiaoyu Zhou, Yu Tang, Lin Tang, Yong Tan, Jing Zhang, Hong Yu, Jiuquan Zhang, Daihong Liu

“…Subsequently, individualized SC-FC coupling networks were constructed based on the Euclidean distance metric. …”
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Validity and reliability of the Malay language Perception Towards Smoking Questionnaire (BM-PTSQ) among secondary school adolescents: Further validation using Confirmatory Factor A... by Kuang Hock Lim, Yoon Ling Cheong, Hui Li Lim, Kee Chee Cheong, Mohd Hazilas Mat Hashim, Ali Aman Marine, Yong Kang Cheah, Jia Hui Lim, Sumarni Mohd Ghazali

“…In addition, we also employed EFA, confirmatory factor analyses (CFA), and Cronbach's alpha to evaluate the construct validity and reliability of the BM-PTSQ. …”
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Exploration of the diagnostic and prognostic roles of decreased autoantibodies in lung cancer by Ying Ye, Ying Ye, Yi Huang, Yi Huang, Jianbo Pan, Jianbo Pan

“…Diagnosing malignant small lung nodules (≤3cm) in CT scans remains a challenge in clinical practice.MethodsIn this study, we applied the HuProt array and the bioinformatics analysis to assess the diagnostic values of the decreased autoantibodies in lung cancers.ResultsIn total, 15 types of decreased autoantibodies were identified, and 6 of them were constructed into a predictive model for early lung cancer, reaching a sensitivity of 76.19% and a specificity of 55.74%. …”
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SFDA-MEF: An Unsupervised Spacecraft Feature Deformable Alignment Network for Multi-Exposure Image Fusion by Qianwen Xiong, Xiaoyuan Ren, Huanyu Yin, Libing Jiang, Canyu Wang, Zhuang Wang

“…We introduce a deformable convolution in the feature deformable alignment module and construct an alignment loss function to preserve its shape with minimal distortion. …”
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Structural safety assessment procedure of plastic single-span greenhouses considering semi-rigid clamp joints by Byung-Hun Seo, Sangik Lee, Do-Kyung Kim, Jong-Hyuk Lee, Dong-Su Kim, Dong-Woo Kim, Yerim Jo, Won Choi

“…This result highlights the potential structural vulnerability of low-cost greenhouses constructed exclusively with SW joints. The nonlinear finite element method (FEM) results identified side rafter pipes as the most vulnerable members due to excessive stress redistributed from semi-rigid joints, while the columns were found to contribute minimally to structural performance. …”
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Novel metabolic prognostic score for predicting survival in patients with cancer by Jinyu Shi, Chenan Liu, Xin Zheng, Yue Chen, Heyang Zhang, Tong Liu, Qi Zhang, Li Deng, Hanping Shi

“…Finally, nomogram prognostic models and corresponding calculators were constructed and evaluated using the areas under the receiver operating characteristic curves (AUC), decision curve analysis (DCA), and calibration curves. …”
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Assessing groundwater quality and suitability in Qatar: Strategic insights for sustainable water management and environmental protection by Sarra Aloui, Adel Zghibi, Annamaria Mazzoni, Ahmad S. Abushaikha, Adel Elomri

“…Suitability for use was assessed using the drinking water quality index (DWQI) and a novel integrated irrigation water quality index (IWQI), constructed upon seven standard indices. Results revealed predominantly high salinity in coastal and southern parts, suggesting extensive saltwater intrusion. …”
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A New Global Ionospheric Electron Density Model Based on Grid Modeling Method by Huijun Le, Tingwei Han, Qiaoling Li, Libo Liu, Yiding Chen, Hui Zhang

“…Abstract Based on nearly 4.6 million radio occultation (RO) ionospheric profile data from Constellation Observing System for Meteorology, Ionosphere, and Climate satellites in 2006–2020, a global three‐dimensional ionospheric electron density model was constructed with a new concept. The global 3D ionosphere structure was divided into total 338,661 grids with longitude intervals of 10°, latitude intervals of 2°, and height intervals of 5 km. …”
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Bushen Huoxue formula protects against renal fibrosis and pyroptosis in chronic kidney disease by inhibiting ROS/NLRP3-mediated inflammasome activation by Lin Liao, Pengyu Tao, Qiming Xu, Jie Chen, Weiwei Liu, Jing Hu, Jianrao Lu

“…However, its mechanisms of action remain unclear.Methods and results In this study, a rat model of renal fibrosis was constructed by 5/6 nephrectomy in vivo, and histopathological changes were analyzed using hematoxylin-eosin and Masson’s trichrome staining. …”
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