Core Outcome Set development for LEPtospirosis trials (COS-LEP): a study protocol to develop a core outcome set for the evaluation of clinical therapeutic interventions for human l... by Nathaniel Lee, Chris Smith, Robin Bailey, Koya Ariyoshi, Sarah Smith, Nick Black, Tansy Edwards

“…Establishing a COS will contribute to harmonizing Leptospirosis treatment research and will be instrumental in constructing a high-quality evidence base to feed into a planned future rigorous international clinical trial on leptospirosis. …”
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Decomposition and comparative analysis of urban-rural disparity in attitude towards advance care planning among Chinese adults: A nationwide study by Xue Wang, Yibo Wu, Lina Ge, Meizhen Zhao, Yi Ma, Shuang Zang

“…Methods Data were derived from Psychology and Behavior Investigation of Chinese Residents (PBICR) including 19,738 participants, representative of Chinese adults. We constructed multivariate linear regression models to investigate the primary factors influencing the attitudes toward ACP among Chinese adults. …”
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Study on needle anatomical structure and drought resistance of 15 spruce species by ZHAO Li, BAO Xiulan, WANG Fude, FU Sheng, LIU Lijie, HUO Kaiyu

“…[Conclusion] The needle anatomical structure of the 15 spruce species can adapt to the environment in various forms. By constructing the developed cuticle, epidermal cells, mesophyll cells, and stele tissues, the water storage and water use efficiency can be improved, so that they can survive in arid environment.…”
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Identifying core symptom clusters based on symptom distress levels in patients with maintenance hemodialysis: a cross-sectional network analysis by Yaxin Chang, Ke Wang, Mengjia Liu, Zhifang Zhang, Huiwen Ma, Xinping Gao, Zhaoxia Yang

“…Background To explore the symptom clusters of patients undergoing maintenance hemodialysis and construct a symptom network to identify the core symptoms and core symptom clusters, to provide reference for precise symptom management.Methods Conveniently selected 354 patients with maintenance hemodialysis were surveyed cross-sectionally using the general information questionnaire, the Dialysis Symptom Index and the Kidney Disease Questionnaire. …”
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Variants of the Sliding Mode Control in Presence of External Disturbance for Quadrotor by Irfan Ahmad, Muwaida Liaquat, Fahad Mumtaz Malik, Hameed Ullah, Usman Ali

“…The control objective is to construct a controller such that would force the state trajectories to approach the sliding surface with an exponential policy. …”
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Development of an Efficient and Generalized MTSCAM Model to Predict Liquid Chromatography Retention Times of Organic Compounds by Mengdie Fan, Chenhui Sang, Hua Li, Yue Wei, Bin Zhang, Yang Xing, Jing Zhang, Jie Yin, Wei An, Bing Shao

“…In this study, a dataset for 10,905 compounds was constructed including their retention times. Next, an innovative classification system was implemented, classifying 10,905 compounds into a 3-tier hierarchy across 141 classes, based on functional group weighting. …”
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Urban Surface Water Mapping from VHR Images Based on Superpixel Segmentation and Target Detection by Qingwei Liu, Yugang Tian, Lihao Zhang, Bo Chen

“…The method includes three steps: clustering water bodies into sparse targets at the object level by an improved scale-adaptive simple non-iterative clustering (SA-SNIC) superpixel segmentation; generating new bands with additional spectral, spatial, and derived features, to increase the dimensions of original data and enhance the separability between water bodies and background covers; and constructing a positive-negative constrained energy minimization multitarget sparse detector to highlight the water bodies while suppressing shadows. …”
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ADMNet: adaptive deformable convolution large model combining multi-level progressive fusion for Building Change Detection by Liye Mei, Haonan Yu, Zhaoyi Ye, Chuan Xu, Cheng Lei, Wei Yang

“…Second, we utilize a large model semantically driven to enhance model context awareness and construct long-range feature dependencies from multi-scale edge information, which are then integrated with locally adaptive edge structure features to achieve accurate edge localization. …”
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Tryptophan metabolism-related gene CYP1B1 serves as a shared biomarker for both Parkinson’s disease and insomnia by Xin-Yu Li, Wen-Kai Yu, Jing-Hao Wu, Wen-Jun He, Yu-Nan Cheng, Kai Gao, Yi-Han Wei, Yu-Sheng Li

“…Additionally, gene interaction, Drug-mRNA, Transcription Factor (TF)-mRNA, and competing endogenous RNA (ceRNA) networks centered on these hub genes were constructed to explore regulatory mechanisms and potential drug interactions. …”
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Development of a clinical prediction model for benign and malignant pulmonary nodules with a CTR ≥ 50% utilizing artificial intelligence-driven radiomics analysis by Wensong Shi, Yuzhui Hu, Guotao Chang, He Qian, Yulun Yang, Yinsen Song, Zhengpan Wei, Liang Gao, Hang Yi, Sikai Wu, Kun Wang, Huandong Huo, Shuaibo Wang, Yousheng Mao, Siyuan Ai, Liang Zhao, Xiangnan Li, Huiyu Zheng

“…Using R programming, Lasso regression with 10-fold cross-validation filtered features, followed by univariate and multivariate logistic regression to construct the model. Its efficacy was evaluated by ROC, DCA curves and calibration plots. …”
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ZBiotics ameliorates T2DM-induced histopathological damage in liver, kidney and adipose tissues by modulating the NOD-like receptor signaling in Wistar rats by Mohammed Esawie, Marwa Matboli, Mariam Sameh Bushra, Amany H. Hasanin, Eman Kamal Habib, Reham Hussein Mohamed, Hebatalla Said Ali

“…In silico analysis was performed to construct a genetic-epigenetic network linked to STING-NOD pathway and autophagy signaling. …”
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Optimizing Reversible Phase‐Transformation of FeS2 Anode via Atomic‐Interface Engineering Toward Fast‐Charging Sodium Storage: Theoretical Predication and Experimental Validation... by Wenxi Zhao, Yanbing Zhou, Hao Zhou, Xinqin Wang, Shengjun Sun, Xun He, Yongsong Luo, Binwu Ying, Yongchao Yao, Xiaoqing Ma, Xuping Sun

“…Abstract Sodium‐storage performance of pyrite FeS2 is greatly improved by constructing various FeS2‐based nanostructures to optimize its ion‐transport kinetics and structural stability. …”
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Development of a 50K SNP array for whole-genome analysis and its application in the genetic localization of eggplant (Solanum melongena L.) fruit shape by Chuying Yu, Qihong Yang, Weiliu Li, Yaqin Jiang, Guiyun Gan, Liangyu Cai, Xinchun Li, Zhiqiang Li, Wenjia Li, Min Zou, Yang Yang, Yikui Wang

“…The 50K SNP liquid-phase array was used to perform bulked- segregant analysis combined with whole-genome resequencing (BSA-seq) of fruit shape in the F2 population, which consisted of 1435 lines constructed with E421 as the maternal parent and 145 as the paternal parent. …”
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Reconstructing the genetic structure of the Kazakh from clan distribution data by M. K. Zhabagin, О. Е. Balanovsky, Zh. M. Sabitov, A. Z. Temirgaliyev, A. T. Agdzhoyan, S. M. Koshel, Е. М. Ramankulov, E. V. Balanovska

“…The analysis included three steps: the isonymy method, which is standard for quasigenetic markers, comparing frequencies of quasigenetic markers, and comparing the quasigenetic and genetic datasets. We constructed 50 maps of frequency of the distribution of each clan and revealed that these maps correlate with the maps of genetic distances. …”
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Assessing Prevention Protocols by a Brief Questionnaire in the Infectious Respiratory Diseases Pandemics: An Application in Pedestrian Population in COVID-19 Pandemic by Ali Jafari-Khounigh, Alireza Razzaghi, Hamid Sharifi, Shahram Habibzadeh, Seyed Taghi Heydari, Rasool Entezarmahdi, Mostafa Farahbakhsh, Alireza Ansari Moghaddam, Mahdi Rezaei, Mohammad Saadati, Ehsan Sarbazi, Morteza Haghighi, Mina Golestani, Homayoun Sadeghi-Bazargani

“…This cross-sectional study was conducted using convenience sampling method in May and June 2021. Construct validity of the questionnaire was assessed using Exploratory Factor Analysis (EFA). …”
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Rational design of a triple-type HPV53/56/66 vaccine with one preferable base particle incorporating two identified immunodominant sites by Ciying Qian, Jie Chen, Yurou Yang, Yihan Lu, Tianyu Ren, Yanan Jiang, Yang Huang, Xin Chi, Shuyue Zhang, Chengzong Zhang, Kewei Li, Jingjia Shen, Sibo Zhang, Daning Wang, Lizhi Zhou, Tingting Li, Qingbing Zheng, Hai Yu, Ying Gu, Ningshao Xia, Shaowei Li

“…By incorporating two identified immunodominant sites into the preferable base particle, the study constructed a triple-type chimera H66-56HI-53FG, which could efficiently self-assemble into VLPs in vitro that closely resembled the wild-type HPV66 VLP and, induced balanced triple-type neutralization titers (~ 3 log unites), as contrast to none observable HPV53 neutralization titer and lower HPV56 titer elicited by the immunization of the wild-type HPV66 alone. …”
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Long-Term Assessment of Soil Salinization Patterns in the Yellow River Delta Using Landsat Imagery from 2003 to 2021 by Yu Fu, Pengyu Wang, Wengeng Cao, Shiqian Fu, Juanjuan Zhang, Xiangzhi Li, Jiju Guo, Zhiquan Huang, Xidong Chen

“…Accurately determining the spatial distribution of soil salinization in the YRD is vital for regional salinity management and agricultural development. In this study, we constructed and evaluated three soil salinization indices—NDSI, SI, and S5—using measured soil conductivity data and three machine learning methods: Random Forest, Support Vector Machine, and XGBoost. …”
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A Novel Lactococcal Vaccine Expressing a Peptide from the M2 Antigen of H5N2 Highly Pathogenic Avian Influenza A Virus Prolongs Survival of Vaccinated Chickens by Kaleb A. Reese, Christopher Lupfer, Rudd C. Johnson, Georgi M. Mitev, Valerie M. Mullen, Bruce L. Geller, Manoj Pastey

“…Current influenza vaccines for poultry are expensive and subtype specific, and therefore there is an urgent need to develop a universal avian influenza vaccine. We have constructed a live bacterial vaccine against avian influenza by expressing a conserved peptide from the ectodomain of M2 antigen (M2e) on the surface of Lactococcus lactis (LL). …”
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Identification of circRNA/miRNA/mRNA regulatory network involving (+)-catechin ameliorates diabetic nephropathy mice by Chao Chen, Dina Zhu, Shuai Zhang, Wensheng Zhang

“…The ceRNA regulatory network was constructed and analyzed using bioinformatics software and public databases (Cytoscape, ClueGO, MiRWalk, STRING, et al.). …”
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Tomato Stem and Leaf Segmentation and Phenotype Parameter Extraction Based on Improved Red Billed Blue Magpie Optimization Algorithm by Lina Zhang, Ziyi Huang, Zhiyin Yang, Bo Yang, Shengpeng Yu, Shuai Zhao, Xingrui Zhang, Xinying Li, Han Yang, Yixing Lin, Helong Yu

“…In this study, an efficient and adaptive intelligent optimization framework was constructed, which is capable of optimizing data processing strategies to achieve efficient and accurate processing of tomato point cloud data. …”
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