Empowering Stroke Survivors: developing a patient version of guidelines to facilitate patient rehabilitation nursing of stroke patients with limb dysfunction in China by Dan Yang, Jingyuan Zhang, Meiqi Meng, Xuejing Li, Lijiao Yan, Jiaxin Fang, Ziyan Wang, Sihan Chen, Xiaoyan Zhang, Yufang Hao, Fang Wang

“…ObjectiveTo develop a patient version of guidelines (PVG) for rehabilitation nursing (RN) in stroke patients with limb dysfunction, aiming to enhance patients’ awareness, self-management skills, and adherence to rehabilitation programs.MethodsThis guideline was developed based on the cultural and healthcare context of China, and was guided on the Minimum standards for the Development Process, Content and Governance of Patient-Directed Knowledge Tools and the PVG tool book of the Guidelines International Network. The guideline was constructed through a normative process involving clarifying priority questions, assessing and integrating evidence, detailing and contextualizing recommendations, and evaluating the prototype of PVG.ResultsFifteen priority RN issues were identified, and eight articles (four guidelines and four evidence summaries) were included, all demonstrating robust methodological quality. …”
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A genome-wide association study of high-sensitivity C-reactive protein in a large Korean population highlights its genetic relationship with cholesterol metabolism by Kwangyeon Oh, Minju Yuk, Soyoun Yang, Jiyeong Youn, Qian Dong, Zhaoming Wang, Nan Song

“…A phenome-wide association study was performed based on a polygenic risk score (PRS) constructed using 69 hsCRP-associated SNPs. Notably, the alleles associated with higher hsCRP levels appeared to be associated with lower low-density lipoprotein cholesterol levels (P = 1.69 × 10–33, β = -1.47) and higher γ -glutamyl transpeptidase (P = 8.30 × 10–8, β = 0.84). …”
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Intervention effect and mechanism of Dracocephalum moldavica L. extract on bleomycin-induced pulmonary fibrosis in rats by Xiaoyu SUN, Li CHEN, Ruifang GAO, Hui YU, Min JIN

“…A protein-protein interaction (PPI) was constructed using the Search Tool for the Retrieval of Interacting Genes (STRING) database and Cytoscape software. …”
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Integrated Framework and Technical Path for Multi-level Nested Assessment of Landscape Character by Yuncai WANG, Qizhen DONG

“…By combining multi-scale segmentation and spatial clustering techniques of deep learning, a technical path for multi-level nested landscape character assessment is constructed as a new idea for characterizing the local characteristics of landscape at multiple scales.ConclusionIn the process of developing landscape character assessment systems, there have been numerous methodological systems. …”
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Spectroscopic (FT-IR and FT-Raman) and quantum chemical study on monomer and dimer of benznidazole from DFT and molecular docking approaches by Tirth Raj Paneru, Manoj Kumar Chaudhary, Poonam Tandon, Bhawani Datt Joshi, Beatriz Pinheiro Bezerra, Alejandro Pedro Ayala

“…The structure with minimum energy was taken as a monomer and dimer is constructed based on intermolecular hydrogen bonding N−H…O. …”
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Engineered CAF-cancer cell hybrid membrane biomimetic dual-targeted integrated platform for multi-dimensional treatment of ovarian cancer by Yuwei Yao, Jiarui Zhang, Kexin Huang, Yingying Peng, Shuangshuang Cheng, Shuangge Liu, Ting Zhou, Jinhua Chen, Haojia Li, Yingchao Zhao, Hongbo Wang

“…Additionally, poor targeting and insufficient tissue penetration are important constraints in ovarian cancer treatment. Result We constructed PH20-overexpressing cancer-associated fibroblast (CAF)-cancer hybrid-cell membrane vesicles (PH20/CCM) for the dual-targeted delivery of carboplatin (CBP) and siRNA targeting p65 (sip65) loaded on the poly (dimethyl diallyl ammonium chloride) (PDDA)-modified MXene (PMXene), named PMXene@CBP-sip65 (PMCS). …”
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Predicting high sensitivity C-reactive protein levels and their associations in a large population using decision tree and linear regression by Somayeh Ghiasi Hafezi, Toktam Sahranavard, Alireza Kooshki, Marzieh Hosseini, Amin Mansoori, Elham Amir Fakhrian, Helia Rezaeifard, Mark Ghamsary, Habibollah Esmaily, Majid Ghayour-Mobarhan

“…We utilized a data mining approach to construct a predictive model of hs-CRP measurements, employing the DT methodology. …”
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Dynamic biomechanical effects of medial meniscus tears on the knee joint: a finite element analysis by Zuming Mao, Qiang Yang, Xiangyu Meng, Dong Jiang, Feng Zhao

“…Methods Seven finite element models of the knee joint were constructed, including the intact medial meniscus (IMM), radial stable tears in the anterior, middle, and posterior one-third regions of the medial meniscus (RSTA, RSTM, RSTP), and the corresponding unstable tears (RUTA, RUTM, RUTP). …”
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Early amiodarone or lidocaine administration during in-hospital cardiac arrest caused by shockable rhythms by Rafael C. Paganoni, Jack C. Pluenneke, Adham M. Mohamed, Charles H. Hayes, III, Carole E. Freiberger-O’Keefe, Paul S. Chan

“…A multivariable logistic regression model was constructed to evaluate the association between (1) time to drug administration and (2) drug administration prior to the second defibrillator shock on both survival outcomes. …”
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Radiomics-based biomarker for PD-1 status and prognosis analysis in patients with HCC by Gulizaina Hapaer, Feng Che, Qing Xu, Qian Li, Ailin Liang, Zhou Wang, Jituome Ziluo, Xin Zhang, Yi Wei, Yuan Yuan, Bin Song, Bin Song

“…Radiomics score was built for each patient and was integrated with independent clinic radiologic predictors into the radiomics model using multivariable logistic regression analysis.ResultsSeventeen radiomics features were finally selected to construct the radiomics score. In multivariate analysis, serum creatine and peritumoral enhancement were significant independent factors for PD-1 prediction. …”
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Long-term correction of hemophilia A via integration of a functionally enhanced FVIII gene into the AAVS1 locus by nickase in patient-derived iPSCs by Do-Hun Kim, Sang-Hwi Choi, Jin Jea Sung, Sieun Kim, Hanui Yi, Sanghyun Park, Chan Wook Park, Young Woo Oh, Jungil Lee, Dae-Sung Kim, Jong-Hoon Kim, Chul-Yong Park, Dong-Wook Kim

“…However, the low expression level and short half-life of FVIII still remain significant limiting factors in the efficacy of these approaches in HA. Here, we constructed a functionally enhanced FVIII variant, F309S/E1984V-mutated B domain-deleted (BDD)-FVIII (FE-FVIII), with increased activity and stability. …”
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Production of Hydrophobic Microparticles at Safe-To-Inject Sizes for Intravascular Administration by Francisca L. Gomes, Francisco Conceição, Liliana Moreira Teixeira, Jeroen Leijten, Pascal Jonkheijm

“…<b>Background/Objectives:</b> Hydrophobic microparticles are one of the most versatile structures in drug delivery and tissue engineering. These constructs offer a protective environment for hydrophobic or water-sensitive compounds (e.g., drugs, peroxides), providing an optimal solution for numerous biomedical purposes, such as drug delivery or oxygen therapeutics. …”
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Global sensitivity analysis and uncertainty quantification for a mathematical model of dry anaerobic digestion in plug-flow reactors by Daniele Bernardo Panaro, Andrea Trucchia, Vincenzo Luongo, Maria Rosaria Mattei, Luigi Frunzo

“…A surrogate model was constructed to investigate the relation between input and output parameters without running demanding simulations from scratch. …”
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What drives consumers’ intention towards fairness-oriented products purchasing? An emotion-extended model of theory of planned behaviour by Antonella Samoggia, Giulia Rossi, Andrea Fantini, Evangelia Mouchtaropoulou, Notis Argiriou

“…Data elaboration includes a Structural Equation Modeling to explore the complex relationships between the extended TPB constructs and their influence on consumer purchasing intentions. …”
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Bioactive Coatings on 3D Printed Polycaprolactone Scaffolds for Bone Regeneration: A Novel Murine Femur Defect Model for Examination of the Biomaterial Capacity for Repair by Karen M. Marshall, Jonathan P. Wojciechowski, Vineetha Jayawarna, Abshar Hasan, Cécile Echalier, Sebastien J. P. Callens, Tao Yang, Janos M. Kanczler, Jonathan I. Dawson, Alvaro Mata, Manuel Salmeron‐Sanchez, Molly M. Stevens, Richard O. C. Oreffo

“…In summary, Laponite/BMP‐2 coated PCL‐TMA900 scaffolds offer a biodegradable, osteogenic construct for bone augmentation with potential for development into a large scale polymer scaffold for clinical translation.…”
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Characteristics of multiple emulsions stabilized by myosin from bighead carp (Aristichthys nobilis) by Yuhe Ma, Jianxiong Hou, Yin Cao, Wuyin Weng, Linfan Shi, Zhongyang Ren

“…This study may be helpful for the development of multiple emulsions constructed using fish proteins.…”
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Impact of Undetected Comorbidity on Treatment and Outcomes of Breast Cancer by Robert I. Griffiths, Michelle L. Gleeson, José M. Valderas, Mark D. Danese

“…Two comorbidity indices were constructed: the National Cancer Institute index, using 12 months of claims before cancer, and a second index for previously undetected conditions, using three months after cancer. …”
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Cadophora species from marine glaciers in the Qinghai-Tibet Plateau: an example of unsuspected hidden biodiversity by Bingqian Zhang, Xiaoguang Li, Guojie Li, Qi-Ming Wang, Manman Wang

“…Two phylogenetic trees were constructed: one was based on the partial large subunit nrDNA (LSU) to infer taxonomic placement of our isolates and the other was based on multi-locus sequences of LSU, ITS, TUB and TEF-1α to investigate more exact phylogenetic relationships between Cadophora and allied genera. …”
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Implicit link prediction based on extended social graph by Ling Xing, Jinxin Liu, Qi Zhang, Honghai Wu, Huahong Ma, Xiaohui Zhang

“…Subsequently, an extended social graph is constructed based on user attribute relations, social relations, and discourse interaction relations, enriching user nodes with comprehensive representational information. …”
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Validity of E-PASS Score for Evaluating Perioperative Minor Complications Associated with Carotid Endarterectomy by Yutaka MORISHIMA, Masahito KAWABORI, Yoichi ITO, Masayuki GEKKA, Koji FURUKAWA, Yoshimasa NIIYA, Miki FUJIMURA

“…Sensitivity and specificity were used to construct a receiver operating characteristic curve, and the area under the curve (AUC) was calculated for accuracy. …”
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