Prediction models for cognitive impairment in middle-aged patients with cerebral small vessel disease by Wei Zheng, Xiaoyan Qin, Ronghua Mu, Peng Yang, Bingqin Huang, Bingqin Huang, Zhixuan Song, Xiqi Zhu, Xiqi Zhu

“…Additionally, decision curve analysis (DCA) was conducted to justify the clinical relevance of the study, and the DeLong test was utilized to compare the areas under two correlated receiver operating characteristic (ROC) curves.ResultsNine texture features of the hippocampus were selected to construct radiomics model. The AUC values of the brain volume, radiomics, and combined models in the test set were 0.593, 0.843, and 0.817, respectively. …”
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The Application of FT-IR Spectroscopy for Quality Control of Flours Obtained from Polish Producers by Katarzyna Sujka, Piotr Koczoń, Alicja Ceglińska, Magdalena Reder, Hanna Ciemniewska-Żytkiewicz

“…The calibration data set was used to construct calibration models with use of the CSR and the PLS with the leave one-out, cross-validation techniques. …”
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Over-Dimension and Over-Load (ODOL) truck in highways: Prevalence and modeling intention to operate ODOL truck, lesson learned from Indonesia by Ari Widyanti, Justin Mulya Gananda, Titah Yudhistira, Widyarini Weningtyas, Ludfi Pratiwi Bowo, Sinung Nugoroho

“…The questionnaire items used in this study are developed from constructs derived from the Theory of Planned Behavior (TPB), the Health Belief Model (HBM), Legal Sanctions, and Non-legal Sanctions. …”
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Detection of Bovine IgG Isotypes in a PPA-ELISA for Johne's Disease Diagnosis in Infected Herds by Bárbara Fernández, Liliana Rosa Gilardoni, Ana Jolly, Silvia Beatriz Colavecchia, Fernando Alberto Paolicchi, Silvia Leonor Mundo

“…Receiver-operating characteristic (ROC) curves of isotypes/PPA-ELISAs were constructed and areas under the curves were compared to evaluate the performance of each test. …”
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Multi-omics analysis reveals that neutrophil extracellular traps related gene TIMP1 promotes CRC progression and influences ferroptosis by Yuzhao Jin, Luyu Liao, Qianping Chen, Bufu Tang, Jin Jiang, Ji Zhu, Minghua Bai

“…Result We screened out three major NETs Genes: TIMP1, F3, and CRISPLD2 based on machine learning. The NETs score constructed based on this not only predicts the prognosis of CRC patients but also shows significant differences in MSI status, chenckpoints expression, and predicted efficacy of PD-L1 targeted therapy. …”
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Comparison of chicoric acid, and its metabolites caffeic acid and caftaric acid: In vitro protection of biological macromolecules and inflammatory responses in BV2 microglial cells by Qian Liu, Fan Liu, Liling Zhang, Yajie Niu, Zhigang Liu, Xuebo Liu

“…To compare the protective effects of CA and its metabolites on biomolecules and inflammatory responses, oxidative damage induced by free radicals in vitro and microglial inflammation triggered by lipopolysaccharide in BV2 cells were constructed. Results showed that CA, CTA and CFA all significantly inhibited protein degradation and carbonylation induced by hydroxyl radicals and alcoxyl radicals, and suppressed hemin/nitrite/H2O2 triggered-nitration. …”
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Single-cell transcriptomes of dissecting the intra-tumoral heterogeneity of breast cancer microenvironment by Peixian Chen, Kaifeng Liang, Xiaofan Mao, Qiuyuan Wu, Zhiyan Chen, Yabin Jin, Kairong Lin, Tiancheng He, Shuqing Yang, Huiqi Huang, Guolin Ye, Juntao Gao, Dan Zhou, Zhihao Zeng

“…The changes of lipid metabolism pathways in macrophages are closely related to the microenvironment of breast cancer. Conclusion We constructed a comprehensive single-cell transcriptome atlas of 54,055 cells from 4 malignant and 4 nonmalignant patients, providing insights into the mechanisms underlying breast cancer progression and the development of potential therapeutic strategies in breast cancer.…”
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Tongue-LiteSAM: A Lightweight Model for Tongue Image Segmentation With Zero-Shot by Daiqing Tan, Hao Zang, Xinyue Zhang, Han Gao, Ji Wang, Zaijian Wang, Xing Zhai, Huixia Li, Yan Tang, Aiqing Han

“…Existing deep learning-based tongue image segmentation models face issues such as poor versatility and insufficient expressiveness in zero-shot tasks. This study aims to construct an efficient model with zero-shot suitable for tongue image segmentation in TCM. …”
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Optimizing Polar Air Traffic: Strategies for Mitigating the Effects of Space Weather‐Induced Communication Failures Poleward of 82°N by Dabin Xue, Zhizhao Liu, Donghe Zhang, Cheng‐Lung Wu, Jian Yang

“…With the background of the anticipated solar maximum in 2025 and a growing number of polar flights, it is indispensable to have a comprehensive understanding of the space weather effects on aviation communication and develop constructive strategies from an Air Traffic Management (ATM) perspective. …”
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Recurrent Falls in People with Parkinson’s Disease without Cognitive Impairment: Focusing on Modifiable Risk Factors by Lorena R. S. Almeida, Guilherme T. Valença, Nádja N. Negreiros, Elen B. Pinto, Jamary Oliveira-Filho

“…We evaluated 171 patients, collecting demographic and clinical data, including standardized assessments with the Unified Parkinson’s Disease Rating Scale (UPDRS), activities of daily living (ADL) and motor sections, modified Hoehn and Yahr Scale, Schwab and England, eight-item Parkinson’s Disease Questionnaire, Activities-specific Balance Confidence Scale, Falls Efficacy Scale-International (FES-I), Berg Balance Scale, Dynamic Gait Index, Functional Reach, and Timed Up and Go. ROC curves were constructed to determine the cutoff scores for all measures. …”
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PdRu bimetallic nanoalloys with improved photothermal effect for amplified ROS-mediated tumor therapy by Yujia Liang, Shufang Ning, Mekhrdod S. Kurboniyon, Khaiyom Rahmonov, Zhengmin Cai, Shirong Li, Jinling Mai, Xiaojing He, Lijuan Liu, Liping Tang, Litu Zhang, Chen Wang

“…In response, the PdRu@PEI bimetallic nanoalloys were constructed with well-catalytic activities and effective separation of charges, which can catalyze hydrogen peroxide (H2O2) to toxic hydroxyl radical (·OH) under near-infrared laser stimulation. …”
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Alpha-Linolenic Acid Attenuates Inflammatory Response in LPS-stimulated Macrophages by Regulating TLR4/MyD88/NF-κB Signaling Pathway by Ruixin CAI, Xiaodie CHEN, Haibin ZHU, Yushun QIAN, Jianhua XIE, Mingyue SHEN

“…In order to elucidate its anti-inflammatory mechanism in vitro, lipopolysaccharide (LPS) was used to stimulate macrophages to construct an inflammatory model. The levels of monocyte chemotactic protein (MCP-1), interleukin4 (IL-4), interleukin13 (IL-13), the production of reactive oxygen species (ROS) and the expression of related proteins in inflammatory signaling pathways were determined to explore the mechanism of α-linolenic acid in alleviating LPS-induced inflammatory response. …”
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JiuZhou: open foundation language models and effective pre-training framework for geoscience by Zhou Chen, Ming Lin, Mingrun Zang, Zimeng Wang, Juanzi Li, Yuqi Bai

“…In this study, we introduce JiuZhou, a powerful open foundational language model used in geoscience. First, we construct the large-scale, diverse, and high-quality JiuZhou-Corpus and the JiuZhou-Framework specifically designed for training geoscience large language models (LLMs). …”
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Using computer modeling to find new LRRK2 inhibitors for parkinson’s disease by María C. García, Sebastián A. Cuesta, José R. Mora, Jose L. Paz, Yovani Marrero-Ponce, Frank Alexis, Edgar A. Márquez

“…An ensemble modeling approach was employed to screen the DrugBank database, aiming to repurpose approved medications as potential treatments for Parkinson’s disease (PD). The dataset was constructed using pIC50 values of various compounds targeting the inhibition of leucine-rich repeat kinase 2 (LRRK2). …”
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Asynchronous Distributed Coordinated Hybrid Precoding in Multi-Cell mmWave Wireless Networks by Meesam Jafri, Suraj Srivastava, Sunil Kumar, Aditya K. Jagannatham, Lajos Hanzo

“…Subsequently, a Bayesian learning (BL) technique is harnessed for decomposing the FD beamformer into its analog and baseband components and construct a hybrid transmit precoder (TPC). However, the centralized TPC design requires global channel state information (CSI), hence it results in a high signaling overhead. …”
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Modeling Radiation Belt Electrons With Information Theory Informed Neural Networks by Simon Wing, Drew L. Turner, Aleksandr Y. Ukhorskiy, Jay R. Johnson, Thomas Sotirelis, Romina Nikoukar, Giuseppe Romeo

“…The model is operational from L* = 3 to 6.5. The model is constructed with neural networks assisted by information theory. …”
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A High-Precision Real-Time PWV Grid Model for the China Region and Its Preliminary Performance in WRF Assimilation by Pengfei Xia, Biyan Chen, Ning Huang, Xin Xie, Qinglan Zhang

“…This study demonstrates the potential of GNSS and surface meteorological data in constructing high-resolution, real-time PWV models. The developed model provides valuable insights into atmospheric moisture variations and enhances the accuracy of weather forecasting and climate research in the China region.…”
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Research of the microwave generator and antenna emitters for hyperthermia of oncological diseases by V. V. Fedyanin

“…With the help of simulation modeling, magnetic field strength distributions for the developed antennas are constructed. It is established that the maximum radiated power occurs when the oscillation frequency is equal to the natural frequency of the antennas. …”
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A Turbo‐Charging System‐Like Contrast Agent for MRI‐Guided STING Pathway‐Activated Cancer Immunotherapy by Bin Ren, Sihua Yan, Zongheng Li, Ya Huang, Haobin Cai, Jing Yang, Qingdeng Fan, Chunmei Chen, Fanchao Que, Guochao Wu, Lin Huang, Ruilong Zhou, Jiaoyang Zhu, Chenggong Yan, Gang Liu, Zheyu Shen, Shipeng Ning

“…Abstract To overcome the problems of Gd‐based contrast agents (GBCAs) (nephrotoxicity and brain deposition) and stimulator of interferon genes (STING) agonists (poor stability, low delivery efficiency, and potential toxicity), in this study, a Turbo‐charging system‐like GBCA is designed and constructed for magnetic resonance imaging (MRI) guided STING pathway‐activated cancer immunotherapy. …”
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Vimentin-Rab7a Pathway Mediates the Migration of MSCs and Lead to Therapeutic Effects on ARDS by Kai Wang, Boxiang Du, Yan Zhang, Congyou Wu, Xiuli Wang, Xu Zhang, Liwei Wang

“…While the mechanism of MSC migration to the lungs remains unclear, the role of MSCs is of great clinical significance. To this end, we constructed vimentin knockout mice, extracted bone MSCs from the mice, and used them for the treatment of LPS-induced ARDS. …”
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