HDAC and MEK inhibition synergistically suppresses HOXC6 and enhances PD-1 blockade efficacy in BRAFV600E-mutant microsatellite stable colorectal cancer by Xin Li, Peng Yang, Jin Gu, Nan Chen, Dengbo Ji, Jinhong Xia, Jinying Jia, Zhuang Sun, Mengyuan Shi, Hanyang Wang, Zhaoya Gao

“…Background B-Raf proto-oncogene, serine/threonine kinase (BRAF)V600E-mutant microsatellite stable (MSS) colorectal cancer (CRC) constitutes a distinct CRC subgroup, traditionally perceived as minimally responsive to standard therapies. …”
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Club Cell Protein 16 Attenuates CD16brightCD62dim Immunosuppressive Neutrophils in Damaged Tissue upon Posttraumatic Sepsis-Induced Lung Injury by Nils Becker, Philipp Störmann, Andrea Janicova, Kernt Köhler, Klemens Horst, Ildiko Rita Dunay, Claudia Neunaber, Ingo Marzi, Jan Tilmann Vollrath, Borna Relja

“…Since CC16 affects both the distribution of PMNL subsets and apoptosis in tissues after trauma, it may constitute as a novel target to beneficially shape the posttraumatic tissue microenvironment and homeostasis to improving outcomes.…”
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Compliance with the Municipal Agro-Environmental Legislation in Francisco de Orellana, Ecuador by E. Pozo, J. Pozo, A. Bonilla, J. Jimenez

“… The Decentralized Autonomous Municipal Government of the Francisco de Orellana canton is made up of the following rural parishes: Alejandro Labaka, Armenia, Dayuma, El Dorado, El Edén, García Moreno, Guayusa, Inés Arango, La Belleza, Nuevo Paraiso, Taracoa and the Urban Parish of El Coca. The Constitution of the Republic of Ecuador (2008) establishes the rights of nature and protects the biodiversity of the Amazon ecosystem. …”
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CHARACTERISTICS OF CYTOPROTECTIVE EFFECT ON THE GASTRIC MUCOSA OF CRYOPRESERVED PLACENTA EXTRACT UNDER WATER-IMMOBILIZATION STRESS by Illia Koshurba, Fedir Hladkykh, Mykola Chyzh

“…The study of the activity of constitutive (cNOS) and inducible (iNOS) isoforms of NOS showed that at the pathobiochemical level against the background of stress-induced ulcerogenesis in the tissues of the central nervous system there is a statistically significant (p<0.001) increase in iNOS activity in 5.2 times was 0.89±0.01 NADPH2/min´g protein. …”
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ALKBH5, an m6A demethylase, attenuates tumor growth and inhibits metastasis in papillary thyroid carcinoma by Yong Zhuang, Qingyan Cai, Xin Hu, Huibin Huang

“…Moreover, effective inhibition of m6A modification of ALKBH5 might constitute a potential treatment strategy for PTC.…”
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Assessment of out-of-pocket (OOP) expenditures on essential medicines for acute and chronic illness: a comparative study across regional and socioeconomic groups in India by Ranjit Kumar Dehury, Imteyaz Ahmad, Manas Ranjan Behera, Janmejaya Samal, Varalakshmi Manchana, Jalal Mohammed, Parthsarathi Dehury, Deepanjali Behera, Nafisa Vaz e Desouza, Abhishek Dondapati

“…Wealthy households constituted most of the OOP expenditure (81 wealthy households), whereas 33 poor households also contributed to the OOP expenditure. …”
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Le français dans la géopolitique méditerranéenne by Raymond Renard

“…Ce principe s’avère en effet d’autant plus porteur qu’ainsi conçue, la langue française, non certes de par sa nature mais par son histoire, véhicule des valeurs éthiques (qui souvent, comme en témoigne la création lexicale, ont d’abord été désignées et définies en français) et a des moyens d’expression répondant aux besoins de la res publica. Le libellé de la Constitution française est explicite à cet égard – Le français est la langue de la République (non d’un territoire ou de l’État) –, et fait ainsi « référence à un type précis de rapport » (Klinkenberg) entre langue et conception de société. …”
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Development of a new data management system for the study of the gut microbiome of children who are small for their gestational age by Felix Manske, Magdalena Durda-Masny, Norbert Grundmann, Jan Mazela, Monika Englert-Golon, Marta Szymankiewicz-Bręborowicz, Joanna Ciomborowska-Basheer, Izabela Makałowska, Anita Szwed, Wojciech Makałowski

“…By providing users with the MetagenomicsDB backend which constitutes the major part of the system, we ensure that custom development can be finished in a reasonable amount of time. …”
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Genome-wide identification, characterization and expression analysis of WRKY transcription factors under abiotic stresses in Carthamus tinctorius L by Zhengwei Tan, Dandan Lu, Yongliang Yu, Lei Li, Lanjie Xu, Wei Dong, Qing Yang, Chunming Li, Xiufu Wan, Huizhen Liang

“…Abstract Background WRKY transcription factors constitute one of the largest families of plant transcriptional regulators, playing pivotal roles in plant responses to biotic and abiotic stresses, as well as in hormonal signaling and secondary metabolism regulation. …”
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Rat Model of Cystic Neutrophilic Granulomatous Mastitis by Corynebacterium Kroppenstedtii by Wang M, Zeng Y, Liu M, Zhang D, Zhao D, Wang J, Liu Y, Zhao W

“…Developing an appropriate animal model will help further study the pathogenesis of CNGM.Methods: Seventy-two rats were randomly assigned to seven groups: group A (n=12, tissue suspension 0.2mL), group B (n=12, 1× 10^8 CFU/mL Corynebacterium kroppenstedtii (CK) suspension 0.1mL), group C (n=12, 1× 10^9 CFU/mL CK suspension 0.1mL), group D (n=12, tissue suspension 0.1mL + 1× 10^8 CFU/mL CK suspension 0.1mL), group E (n=12, tissue suspension 0.1mL + 1× 10^9 CFU/mL CK suspension 0.1mL), group F (n=6, phosphate buffer saline solution 0.1mL), and group G (n=6, physiological saline 0.1mL + Complete Freund’s adjuvant suspension 0.1mL). Groups A to E constitute the experimental groups with 12 rats each, while groups F and G served as control groups with 6 rats each. …”
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Plaider la « bonne gouvernance sécuritaire » au Maroc : Domestiquer les savoirs de réforme en régime de contrainte consensuelle by Irene Lizzola

“…If, on the one hand, this reformist lexicon promotes NGOs’ depoliticized commitment and the institutional construction of a liberal appearance, on the other, it constitutes a tool in the hands of professionalized and internationalized NGOs, which allows them to keep the discussion open with the authorities around the security issue. …”
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Tratamento Diretamente Observado para a Tuberculose na Atenção Primária à Saúde: discursos e práticas by Ingrid Gabriel Grigorio, Kalyta Michaelly Silva Glória, Milena de Oliveira Simões, Katiuscia Cardoso Rodrigues, Flávia Rodrigues Pereira

“…Conclusion: Definitions of Directly Observed Treatment encompassed not only medication intake supervised by a health professional but also other actions that constitute TB patient care and its limitations within the Primary Health Care setting, as a shared care model with Secondary Care. …”
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Improving the representation of major Indian crops in the Community Land Model version 5.0 (CLM5) using site-scale crop data by K. N. Reddy, S. Baidya Roy, S. S. Rabin, D. L. Lombardozzi, D. L. Lombardozzi, G. V. Varma, R. Biswas, D. C. Naik

“…<p>Accurate representation of croplands is essential for simulating terrestrial water, energy, and carbon fluxes over India because croplands constitute more than 50 % of the Indian land mass. Wheat and rice are the two major crops grown in India, covering more than 80 % of the agricultural land. …”
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Le temple polygonal de la rue Lecointre à Reims/Durocortorum by Sébastien Péchart, Frédéric Poupon

“…The northern zone of the ancient city seems to have been understood from the outset as the site of monumental and funerary complexes, even if it also housed spaces devoted to domestic and artisanal activities. The site constitutes the first glimpse of spaces within Durocortorum dedicated to worship for the early Gallo-Roman and Alto-Imperial transitional periods. …”
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Nano-Zinc Oxide Can Enhance the Tolerance of Apple Rootstock M9-T337 Seedlings to Saline Alkali Stress by Initiating a Variety of Physiological and Biochemical Pathways by Jietao Zhai, Xulin Xian, Zhongxing Zhang, Yanxiu Wang

“…Soil salinization severely restricts the growth and development of crops globally, especially in the northwest Loess Plateau, where apples constitute a pillar industry. Nanomaterials, leveraging their unique properties, can facilitate the transport of nutrients to crops, thereby enhancing plant growth and development under stress conditions. …”
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Morphological evaluations in buffaloes (Bubal- us bubalis) in Venezuela by Luis Alfredo Pacheco-Díaz, José Atilio Aranguren-Méndez, Rafael Román-Bravo, Sharon Rivero-Hernández, Luis Edgardo Tovar-Briceño

“…This information would include the genetic evaluation using the BLUP methodology and the morphological characterization of the breeds present in Venezuela, constituting a starting point in the genetic programs. …”
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Comparison of search and rescue operations involving emergency physicians in devastating earthquakes in Turkey: a 24-year experience study by Mustafa Ferudun Celikmen, Gülbin Aydoğdu Umaç, Melih Imamoglu, Mümin Murat Yazici, Elif Çiğdem Keleş, Sarper Yilmaz

“…Conclusion The 24 years of experience and expertise gained by EPs who served in Türkiye in these operations constitute a valuable global resource. Disseminating this knowledge is crucial not only for managing earthquakes but also for preparing for other catastrophic events that could cause widespread destruction. …”
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A Systematic Review on Poisoned Patients as Potential Organ Donors by Kattamreddy Ananth Rupesh, Anirudh Suseel Nalumaru, Mohit Kumar Moses Thathapudi, Omkarnath Sivarchaka, Deekshitha Alla

“…Background: Organ failure constitutes a significant global health crisis, with millions of individuals awaiting organ transplants at any given time. …”
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Noninvasive Oral Hyperspectral Imaging–Driven Digital Diagnosis of Heart Failure With Preserved Ejection Fraction: Model Development and Validation Study by Xiaomeng Yang, Zeyan Li, Lei Lei, Xiaoyu Shi, Dingming Zhang, Fei Zhou, Wenjing Li, Tianyou Xu, Xinyu Liu, Songyun Wang, Quan Yuan, Jian Yang, Xinyu Wang, Yanfei Zhong, Lilei Yu

“…Subsequently, from August 2024 to September 2024, an additional 35 patients were enrolled from Three Gorges University and Yichang Central People’s Hospital to constitute the external testing group. After preprocessing to ensure image quality, spectral and textural features were extracted from the images. …”
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Teaching healthy eating habits to children, to maintain good health throughout life through Greek primary school textbooks 1975-2020. [Enseigner de saines habitudes alimentaires au... by Archontia VASILOPOULOU

“…The books of primary school, including physical sciences subjects, constituted the body of the study, edited from 1975-2020, since they are the main source of nutritional information for students. …”
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