Determining the association of hyperoxia while on extracorporeal life support with mortality in neonates following Norwood operation by Beshish Asaad G., Aljiffry Alaa, Xiang Yijin, Evans Sean, Scheel Amy, Harriott Ashley, Patel Shayli, Amedi Alan, Harding Amanda, Davis Joel, Shashidharan Subhadra, Kwiatkowski David M.

“…Background: Patients requiring extracorporeal life support (ECLS) support post-Norwood operation constitute an extremely high-risk group. Materials and methods: We retrospectively aimed to evaluate the relationship of hyperoxia with mortality and other clinical outcomes in patients who required ECLS following Norwood operation between January/2010 and December/2020 in a large volume center. …”
Get full text

Buffalo genetic improvement program in Vene- zuela by José A. Aranguren-Méndez, Rafael M. Román-Bravo, Ricardo A. Briceño-Rojas, Mauricio G. Briceño-Rojas, Luis A. Pacheco-Díaz

“…Since many of the selection plans in this species have been directed to production traits (milk, solids in milk, and meat), reproduction needs to be included to avoid a reduction in fertility since poor reproductive ability, long age at first calving, calving intervals, and a low conception rate, constituting these elements as one of the main drawbacks of buffalo livestock. …”
Get full text

Quality of life among residents of informal urban settlements during the COVID-19 pandemic in Salvador, Brazil by Albert I Ko, Federico Costa, Hammed Mogaji, Nivison Nery, Hernan D Argibay, Jaqueline S Cruz, Ianei O Carneiro, Ricardo Lustosa, Mike Begon, Hussein Khalil

“…Background Disadvantaged populations, especially those living in rural and informal settlements, constitute the most affected during the COVID-19 pandemic. …”
Get full text

Identification of a 5-Gene-Based Scoring System by WGCNA and LASSO to Predict Prognosis for Rectal Cancer Patients by He Huang, Shilei Xu, Aidong Chen, Fen Li, Jiezhong Wu, Xusheng Tu, Kunpeng Hu

“…Five DEGs (ASB2, GPR15, PRPH, RNASE7, and TCL1A) in these two modules constituted the optimal prognosis signature panel. Kaplan-Meier curve analysis showed that patients in the high-risk group had a poorer prognosis than those in the low-risk group. …”
Get full text

Provide a Framework for the Application of Open Policy Making in Parliament of Iran by Mohsen Eynali, Seyed Abbas Ebrahimi, Mohsen Farhadinejad, Hasan Danaeefard

“…Grounded theory and Maxqda10 software were used for data analysis in the qualitative part, while the structural equation modeling approach was applied in the quantitative part.ResultsData analysis identified the general dimensions and preconditions of the open policy model, along with the components and elements constituting its main dimensions, including understanding the problem, developing solutions, compiling, and evaluating. …”
Get full text

Online patients questions regarding reverse total shoulder arthroplasty pertain to timeline of recovery, specific activities, and limitations by Kyle K. Obana, MD, Dane R.G. Lind, BA, Andrew J. Luzzi, MD, Michaela J. O’Connor, MD, Matthew R. LeVasseur, MD, William N. Levine, MD

“…Government websites had the highest JAMA score (3.11 ± 1.01) and constituted 55.9% of all websites with a score of 4/4. …”
Get full text

Anti-Methanogenic Potential of Seaweeds and Impact on Feed Fermentation and Rumen Microbiome In Vitro by Pradeep Kumar Malik, Atul Purshottam Kolte, Shraddha Trivedi, Govindan Tamilmani, Archit Mohapatra, Shalini Vaswani, Johnson Belevendran, Artabandhu Sahoo, Achamveetil Gopalakrishnan, Raghavendra Bhatta

“…The prevalence of <i>Methanobrevibacter</i> was similar across treatments, constituting the majority (~79%) of the archaeal community. …”
Get full text

Legal Disputes of Emigrant Periodical Publishers from the End of the 19th Century to 1904 by Remigijus Misiūnas

“…As the role of the press grew within the community, clergy, who constituted the majority of the right-wing leadership, found themselves losing the unchallenged authority they had in Lithuania and were unable to compensate for it through their own press and polemics against other factions. …”
Get full text

Designing a model of institutionalization of organizational culture based on synergy in the tourism holding of Parsian Hotels Group by Behnam Rahemi, Majid Jahangirfard, Farshad Hajalian

“…The findings showed that all the factors constituting the organizational culture institutionalization model based on synergy in the tourism holding of Parsian Hotels Group (team building, cohesion, structure, innovation, support, motivation, participation and performance) are significant at the 95% confidence level, and as a result, the overall fit of the model GOF was equal to 0.65, which shows the usefulness of the model. …”
Get full text

Association of different insulin resistance surrogates with all-cause and cardiovascular mortality among the population with cardiometabolic multimorbidity by Hongqiang Zhang, Zhixin Tu, Sihua Liu, Jumei Wang, Jie Shi, Xingyu Li, Rongdongqing Shi, Minghui Chen, Tong Yue, Sihui Luo, Yu Ding, Xueying Zheng

“…Conclusions This study emphasizes the prognostic significance of IR surrogates, particularly the TyG index, in predicting mortality among individuals with CMM. The TyG index constitutes a crucial element in the development of management and intervention strategies for these patients. …”
Get full text

Targeting deubiquitinase USP7-mediated stabilization of XPO1 contributes to the anti-myeloma effects of selinexor by Junying Wang, Mengping Chen, Jinxing Jiang, Yike Wan, Xin Li, Minyue Zhang, Fei Xiao, Lu Zhong, Hua Zhong, Zhaoyu Qin, Jian Hou

“…However, intrinsic and acquired drug resistance constitute great challenges. SEL has been reported to promote the degradation of XPO1 protein in tumor cells. …”
Get full text

TP53 germline testing and hereditary cancer: how somatic events and clinical criteria affect variant detection rate by Paula Rofes, Carmen Castillo-Manzano, Mireia Menéndez, Álex Teulé, Sílvia Iglesias, Elisabet Munté, Mireia Ramos-Muntada, Carolina Gómez, Eva Tornero, Esther Darder, Eva Montes, Laura Valle, Gabriel Capellá, Marta Pineda, Joan Brunet, Lidia Feliubadaló, Jesús del Valle, Conxi Lázaro

“…Variant origin was elucidated in 39 of these: 72% patients had a constitutional PV, 10% were mosaics, and 18% had CHIP-associated PVs. …”
Get full text

IQUB mutation induces radial spoke 1 deficiency causing asthenozoospermia with normal sperm morphology in humans and mice by Tingwenyi Hu, Xiangrong Tang, Tiechao Ruan, Shunhua Long, Guicen Liu, Jing Ma, Xueqi Li, Ruoxuan Zhang, Guoning Huang, Ying Shen, Tingting Lin

“…More importantly, we identified twelve critical components of RS1 in humans and mice, among which RSPH3, RSPH6A, RSPH9 and DYDC1 constituting the head, DYDC1, NME5, DNAJB13 and PPIL6 assembling into the head-neck complex, AK8, ROPN1L, RSPH14, DYNLL1, and IQUB forming the stalk of RS1. …”
Get full text

Evaluating CNN Architectures for the Automated Detection and Grading of Modic Changes in MRI: A Comparative Study by Li‐peng Xing, Gang Liu, Hao‐chen Zhang, Lei Wang, Shan Zhu, Man Du La Hua Bao, Yan‐ni Wang, Chao Chen, Zhi Wang, Xin‐yu Liu, Shuai Zhang, Qiang Yang

“…Of the 139 patients, MRIs from 109 patients were acquired using Philips scanners from June 2020 to June 2021, constituting Dataset 1. The remaining 30 patients had MRIs obtained from both Philips and United Imaging scanners from June 2022 to March 2023, forming Dataset 2. …”
Get full text

Secular trend and projection of overweight and obesity among Chinese children and adolescents aged 7–18 years from 1985 to 2019: Rural areas are becoming the focus of investment by Jiajia Dang, Yunfei Liu, Shan Cai, Panliang Zhong, Di Shi, Ziyue Chen, Yihang Zhang, Yanhui Dong, Jun Ma, Yi Song, Jing Ni, Xuehong Zhang

“…We analyzed data from seven rounds of the Chinese National Survey on Students Constitution and Health (CNSSCH) conducted from 1985 to 2019, focusing on school-age children and adolescents aged 7–18 years. …”
Get full text

Identification and validation of a prognostic signature of drug resistance and mitochondrial energy metabolism-related differentially expressed genes for breast cancer by Tiankai Xu, Chu Chu, Shuyu Xue, Tongchao Jiang, Ying Wang, Wen Xia, Huanxin Lin

“…Abstract Background Drug resistance constitutes one of the principal causes of poor prognosis in breast cancer patients. …”
Get full text

The contrasted impacts of grasshoppers on soil microbial activities in function of primary production and herbivore diet by Ibanez, Sébastien, Foulquier, Arnaud, Brun, Charles, Colace, Marie-Pascale, Piton, Gabin, Bernard, Lionel, Gallet, Christiane, Clément, Jean-Christophe

“…The most productive sites were constituted by exploitative plant species which depleted N resources in the soil, and by microbes producing relatively few extracellular enzymes, leading to a lower PNM. …”
Get full text

HIV self-testing positivity rate and linkage to confirmatory testing and care: a telephone survey in Côte d’Ivoire, Mali, and Senegal by Kra, Arsène Kouassi, Fotso, Arlette Simo, Rouveau, Nicolas, Maheu-Giroux, Mathieu, Boily, Marie-Claude, Silhol, Romain, d’Elbée, Marc, Vautier, Anthony, Larmarange, Joseph

“…However, if confirmed HIV-positive, almost all initiated treatment. HIVST constitutes a relevant complementary tool to existing screening services. …”
Get full text

Therapeutic depletion of CCR8+ tumor-infiltrating regulatory T cells elicits antitumor immunity and synergizes with anti-PD-1 therapy by James Dooley, Bart Neyns, Elizabeth Allen, Frank Tacke, Louis Boon, Damya Laoui, Julia Katharina Schwarze, Helena Van Damme, Bruno Dombrecht, Máté Kiss, Heleen Roose, Eva Van Overmeire, Daliya Kancheva, Liesbet Martens, Aleksandar Murgaski, Pauline Madeleine Rachel Bardet, Gillian Blancke, Maude Jans, Evangelia Bolli, Maria Solange Martins, Yvon Elkrim, Kiavash Movahedi, Niels Vandamme, Sebahat Ocak, Isabelle Scheyltjens, Lars Vereecke, Frank Aboubakar Nana, Pascal Merchiers, Jo Agnes Van Ginderachter

“…Background Modulation and depletion strategies of regulatory T cells (Tregs) constitute valid approaches in antitumor immunotherapy but suffer from severe adverse effects due to their lack of selectivity for the tumor-infiltrating (ti-)Treg population, indicating the need for a ti-Treg specific biomarker.Methods We employed single-cell RNA-sequencing in a mouse model of non-small cell lung carcinoma (NSCLC) to obtain a comprehensive overview of the tumor-infiltrating T-cell compartment, with a focus on ti-Treg subpopulations. …”
Get full text

Biological activities of Usnea lethariiformis lichen extracts and UHPLC-ESI-QTOF-MS analysis of their secondary metabolites by Mauricio Piñeiro, Mauricio Piñeiro, Sofía Manrique, Jessica Gómez, Jessica Gómez, Juan Manuel Rodriguez, Patricia Barrera, Duilio Caballero, Miguel A. Sosa, Gabriel Vargas-Arana, Gabriel Vargas-Arana, Alejandro Tapia, Beatriz Lima, Beatriz Lima, Mario J. Simirgiotis

“…The results indicated that U. lethariiformis may constitute a potential source of diverse bioactivities with application in the food, pharmaceutical, and agronomic industries.…”
Get full text