Establishing primary care physician commitment in Canadian long-term care homes: a protocol for a modified e-Delphi study by Andrew P Costa, Aaron Jones, Darly Dash, Paula Rochon, Patrick Quail, Rachel D Savage, Henry Yu-Hin Siu, Lisa M McCarthy, Nathan Stall, Dee Tripp, Maya Potter, Paul Katz, Samantha Peck

“…A literature review will generate a candidate list of statements constituting PCP commitment. The first round evaluates the relevance and feasibility of candidate statements through an online questionnaire. …”
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Experimental study on monitoring microwave ablation efficacy by real-time shear wave elastography in ex vivo porcine brain by Rui Li, Yukang Zhang, Linggang Cheng, Shuai Zheng, Hongbing Li, Hongxia Zhang, Lijuan Du, Wen He, Wei Zhang

“…Objective: Glioma constitutes the most common primary malignant tumor in the central nervous system. …”
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Risk Factors Associated with Leishmaniasis in the Most Affected Provinces by Leishmania infantum in Morocco by Maryam Hakkour, Asmae Hmamouch, Mohamed Mahmoud El Alem, Abdelhakim Bouyahya, Abdelaali Balahbib, Abdelhak EL Khazraji, Hajiba Fellah, Abderrahim Sadak, Faiza Sebti

“…Human leishmaniasis, both visceral and cutaneous, has been reported in Morocco for centuries and constitutes a serious public health problem. However, the evolution of this pathology depends on several factors such as ecological, socioeconomic, and climatic conditions. …”
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Impact of Obstructive Sleep Apnea on In-Stent Restenosis in Coronary Heart Disease Patients after Elective Drug-Eluting Stenting by Wenjie Yang, Zhuoshan Huang, Ke Yang, Dinghui Liu, Junpeng Xiao, Zhen Wu, Ling Jiang, Shan Cao, Xujing Xie, Shujie Yu

“…Results: This study enrolled 206 individuals who were diagnosed with CHD, with a mean age of 62.01 ± 10.27 years, and males constituted 76.2% of the patient population. After a median follow-up period of 15 months following DES implantation, there was a significant increase in the incidence of ISR among patients with moderate to severe OSA, increasing from 10.9% to 31.3% (p < 0.001). …”
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Analysis of population structure and genetic diversity in a Southern African soybean collection based on single nucleotide polymorphism markers by A. Tsindi, J. S. Y. Eleblu, E. Gasura, H. Mushoriwa, P. Tongoona, E. Y. Danquah, L. Mwadzingeni, M. Zikhali, E. Ziramba, G. Mabuyaye, J. Derera

“…The UPMGA tree showed that the first sub-cluster is composed of three genotypes, the second cluster has two genotypes, while the rest of the genotypes constituted the third cluster. The third cluster revealed low variation among most genotypes. …”
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Investigation of calonysterone and 20-hydroxyecdysone effects in high-fat, high-sugar diet-induced obesity rat model by Alaa AM. Osman, Dávid Laczkó, Máté Vágvölgyi, Adrienn Seres-Bokor, Anita Sztojkov-Ivanov, Kata Kira Kemény, Attila Hunyadi, Eszter Ducza

“…Similarly, the incidence of obesity among adolescents has increased fourfold. Overweight constitutes a significant health and social issue in developed nations globally. …”
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Primary multiple cancer in practice of urological oncologist by M. D. Ter-Ovanesov, D. M. Yagudaev, A. A. Gritskevich, E. V. Anikanova, K. I. Medvedev

“…Total of 58,217 PMMs were detected for the first time in our country in 2021, which constitutes 10.0 % of all newly diagnosed malignant neoplasms. …”
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Vesicoureteral Reflux in Children with Accidental Diagnosis of Unilateral Small Size Kidney by Mohsen Mohammadi, Khadijeh Ebrahimi, Soraya Khafri, Maryam Nikpour, Hadi Sorkhi

“…This suggests that VUR may constitute a significant etiological factor in the development of small-size kidneys. …”
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Cerebral Microhemorrhages in Children With Congenital Heart Disease: Prevalence, Risk Factors, and Association With Neurodevelopmental Outcomes by Kristen N. Andersen, Sicong Yao, Brian R. White, Marin Jacobwitz, Jake Breimann, Jharna Jahnavi, Alexander Schmidt, Wesley B. Baker, Tiffany S. Ko, J. William Gaynor, Arastoo Vossough, Rui Xiao, Daniel J. Licht, Evelyn K. Shih

“…Cerebral microhemorrhages (CMH) are frequently seen after surgery, but whether they are benign or constitute injury is unknown. Methods and Results One hundred ninety‐two infants with congenital heart disease undergoing cardiac surgery with cardiopulmonary bypass were evaluated with pre‐ (n=183) and/or postoperative (n=162) magnetic resonance imaging. …”
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Sedimentary architecture of the microbial mound–shoal complex: a case study of the Ediacaran Dengying Formation, Sichuan Basin, China by Qinyu Xia, Zhenhua Guo, Fei Zhang, Lin Zhang, Rui Xu, Xue Wang, Wenzheng Li, Shuyuan Shi, Haijun Yan, Yuyang Liu

“…Various composite MMSCs are isolated from each other by sediments formed under low hydrodynamic conditions, constituting distinct connectivity units. Compared to isolated MMSCs, superimposed and migratory MMSCs exhibit superior reservoir conditions. …”
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Significance of Glioma Stem-Like Cells in the Tumor Periphery That Express High Levels of CD44 in Tumor Invasion, Early Progression, and Poor Prognosis in Glioblastoma by Masahiro Nishikawa, Akihiro Inoue, Takanori Ohnishi, Shohei Kohno, Shiro Ohue, Shirabe Matsumoto, Satoshi Suehiro, Daisuke Yamashita, Saya Ozaki, Hideaki Watanabe, Hajime Yano, Hisaaki Takahashi, Riko Kitazawa, Junya Tanaka, Takeharu Kunieda

“…Here, we investigated the existence and functions of GSCs in the tumor periphery, which is considered to constitute the invasion niche for GSCs in GBM, by analyzing expression of stem cell markers and stem cell-related molecules and measuring particular activities of cultured GSCs. …”
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Constant Dizziness Versus Episodic Vertigo in Ménière’s Disease: Health-Related Quality of Life, Cognitive Dissonance, and Postural Problems by Ilmari Pyykkö, Jing Zou, Vinaya Manchaiah

“…Conclusion: We emphasize that constant dizziness in MD constitutes a long-term maladaptation to a vestibular and visual cognitive function causing cognitive dissonance. …”
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Oridonin ameliorates renal fibrosis in diabetic nephropathy by inhibiting the Wnt/β-catenin signaling pathway by Jushuang Li, Lan Shu, Qianqian Jiang, Baohong Feng, Zhimin Bi, Geli Zhu, Yanxia Zhang, Xiangyou Li, Jun Wu

“…Diabetic nephropathy (DN) is one of the most serious and frequent complications among diabetes patients and presently constitutes vast the cases of end-stage renal disease worldwide. …”
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Effects of nanoencapsulated essential oil blend in diet of Lohmann Brown hens on posture percentage, quality and egg oxidative stability by Gilmar Mendoza–Ordoñez, Miguel Callacná–Custodio, Vanessa Armas–Azabache, Bruno Loyaga–Cortéz, Roberto Ybañez–Julca, Daniel Asunción–Alvarez, Hugo Saavedra–Sarmiento, Aníbal Rodriguez–Vargas

“…In conclusion, diets with N–EOs constitute a promising option that favors feed conversion, laying percentage, and greater shell thickness of the eggs of laying hens. …”
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The Influence of Gastric Microbiota and Probiotics in <i>Helicobacter pylori</i> Infection and Associated Diseases by Jagriti Verma, Md Tanveer Anwar, Bodo Linz, Steffen Backert, Suneesh Kumar Pachathundikandi

“…While the development of <i>H. pylori</i>-associated intestinal metaplasia is accompanied by an increase in Bacteroides, the stomachs of GC patients are dominated by Firmicutes such as <i>Lactobacillus</i> and <i>Veillonella</i>, constituting up to 40% of the total microbiota, and by Bacteroidetes such as <i>Prevotella</i>, whereas the numbers of <i>H. pylori</i> are decreasing. …”
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Clinical findings of acute necrotizing esophagitis complicated by diabetic ketoacidosis by Yuichiro Iwamoto, Tomohiko Kimura, Takashi Itoh, Shigehito Mori, Taku Sasaki, Mana Ohnishi, Haruka Takenouchi, Hideyuki Iwamoto, Junpei Sanada, Yoshiro Fushimi, Yukino Katakura, Fuminori Tatsumi, Masashi Shimoda, Shuhei Nakanishi, Tomoatsu Mune, Kohei Kaku, Hideaki Kaneto

“…Seven patients in this study presented with ANE, forming the ANE group. The remaining 23 constituted the non-ANE group. We compared the clinical parameters and computed tomography (CT) between the groups. …”
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Structure- and machine learning-guided engineering demonstrate that a non-canonical disulfide in an anti-PD-1 rabbit antibody does not impede antibody developability by Wei-Ching Liang, Hongkang Xi, Dawei Sun, Luigi D’Ascenzo, Jonathan Zarzar, Nicole Stephens, Ryan Cook, Yinyin Li, Zhengmao Ye, Marissa Matsumoto, Jian Payandeh, Matthieu Masureel, Yan Wu

“…Our case study thus indicates that, while the non-canonical inter-CDR disulfide bond found in rabbit antibodies does not necessarily constitute an obstacle to therapeutic antibody development, combining structure- and ML-guided approaches can provide a fast and efficient way to improve antibody properties and remove potential liabilities.…”
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Advances in Cell and Immune Therapies for Melanoma by Tanase Timis, Sanda Buruiana, Delia Dima, Madalina Nistor, Ximena Maria Muresan, Diana Cenariu, Adrian-Bogdan Tigu, Ciprian Tomuleasa

“…In 2020, cutaneous melanoma constituted approximately 1.3% of all cancer deaths that occurred within the European Union, thereby highlighting the necessity for effective prevention, timely diagnosis, and sustainable treatment measures, especially as a growing number of cases occur among younger patients. …”
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Transmission of synthetic seed bacterial communities to radish seedlings: impact on microbiota assembly and plant phenotype by Simonin, Marie, Préveaux, Anne, Marais, Coralie, Garin, Tiffany, Arnault, Gontran, Sarniguet, Alain, Barret, Matthieu

“…Still, the identity and phenotypic effects of these taxa that constitute a primary inoculum of plant microbiota is mostly unknown. …”
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Mapping neuro-disabilities and their dimensions among under 5 years of age children in the southern agricultural corridor of Tanzania: a preliminary baseline survey by Peter M. Chilipweli, Namanya Basinda, Paul Alikado Sabuni, Fredy Hyera, Upendojackline Liana, Titus Robert Leeyio, Elias C. Nyanza, Awerasia Vera Ngowi

“…The children’s median age was 24 months, with the majority aged between 13 and 48 months. Boys constituted a slight majority (59.4%). The majority of mothers were married (72.4%), had primary education (56.6%), and were engaged in non-farming occupations (56.3%). …”
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