Heterozygous mutation in BRCA2 induces accelerated age-dependent decline in sperm quality with male subfertility in rats by Yashiro Motooka, Hideaki Tanaka, Yuki Maeda, Misako Katabuchi, Tomoji Mashimo, Shinya Toyokuni

“…Abstract Tumor suppressor BRCA2 executes homologous recombination to repair DNA double-strand breaks in collaboration with RAD51, involving exon 11 and 27. Exon 11 constitutes a region where pathogenic variants (PVs) accumulate, and mutations in this region are known to contribute to carcinogenesis. …”
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Investigation of Clinical Characteristics and Etiological Factors in Children with Molar Incisor Hypomineralization by Maria Rita Giuca, Maria Cappè, Elisabetta Carli, Lisa Lardani, Marco Pasini

“…Methods. 120 children, selected from the university dental clinic, were included: 60 children (25 boys and 35 girls; average age: 9.8 ± 1.8 years) with MIH formed the test group and 60 children (27 boys and 33 girls; average age: 10.1 ± 2 years) without MIH constituted the control group. Distribution and severity of MIH defects were evaluated, and a questionnaire was used to investigate the etiological variables; chi-square, univariate, and multivariate statistical tests were performed (significance level set at p<0.05). …”
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Growth Rate and Yield of Two Tomato Varieties (Lycopersicon esculentum Mill) under Green Manure and NPK Fertilizer Rate Samaru Northern Guinea Savanna by A. S. Isah, E. B. Amans, E. C. Odion, A. A. Yusuf

“…The variety and fertilizer constituted the main plot while green manure was allocated in subplot. …”
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Congenital malformations in children of diabetic mothers in the province of Cienfuegos. 2016-2019 by Fanny Arbolay Sanabria, Lázaro Roberto Herrera Fragoso, Maylé Santos Solí, Gladys Bárbara Barberis Pérez, Walkiria Díaz Senra, María Soledad Vilches León

“…Major congenital malformations constituted the largest percentage and the most affected system was the cardiovascular system. …”
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Effectiveness of Criminal Offense Law Regarding Illegal Levies: Reforming Social Organizations within the Indonesian Legal Framework by Muhammad Ishar Helmi, Pujiyono Pujiyono, Khamami Zada, Mara Sutan Rambe, Mualimin Mochammad Sahid

“…Actions taken by these organizations, such as coercing traders for illegal levies or soliciting donations, constitute criminal offenses under Article 368, paragraph (1) of the Criminal Code and are further underscored in Article 59, paragraph (2) of the law on Mass Organizations. …”
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Dynamics of phase separation from holography by Maximilian Attems, Yago Bea, Jorge Casalderrey-Solana, David Mateos, Miguel Zilhão

“…We show that all four stages are well described by the constitutive relations of second-order hydrodynamics that include all second-order gradients that are purely spatial in the local rest frame. …”
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Brincidofovir Use after Foscarnet Crystal Nephropathy in a Kidney Transplant Recipient with Multiresistant Cytomegalovirus Infection by Romain Vial, Christine Zandotti, Sophie Alain, Alexandre Decourt, Noémie Jourde-Chiche, Raj Purgus, Charleric Bornet, Laurent Daniel, Valérie Moal, Tristan Legris

“…Cytomegalovirus (CMV) antiviral drug resistance constitutes an increasing challenge in transplantation. …”
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Acute Soft Head Syndrome as the Initial Presentation of Sickle Cell Disease in an Adolescent in Rural Western Uganda: Case Report by Abukar Ali Ahmed, Dalton Kambale Munyambalu, Awil Abdulkadir Abdi, Elias Joseph Xwatsal, Hanan Asad Hassan, Ibrahim Ahmed Nur, Abdikani Ali Hassan, Venance Emmanuel Mswelo

“…In such settings, the pre-existing poor socio-economic background coupled with atypical presentation constitute a major impediment for timely diagnosis.…”
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Mechanical properties and energy absorption of CoCrNi functionally graded TPMS cellular structures by Zhaoyi Wang, Junxian Zhou, Yunzhuo Lu, Dongming Li, Deyu Yue, Xu Zhang, Bingzhi Chen

“…Additionally, based on experimental validation, the Johnson-Cook constitutive model for SLM-ed CoCrNi was successfully developed and applied to finite element analysis (FEA) predictions. …”
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Persistent functional and taxonomic groups dominate an 8,000-year sedimentary sequence from Lake Cadagno, Switzerland by Paula Rodriguez, Jasmine S. Berg, Longhui Deng, Longhui Deng, Hendrik Vogel, Michal Okoniewski, Mark A. Lever, Mark A. Lever, Cara Magnabosco

“…Most of our knowledge of deep sedimentary life comes from marine environments; however, despite their relatively small volume, lacustrine sediments constitute one of the largest global carbon sinks and their deep sediments are largely unexplored. …”
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Design Improvements and Best Practices in Small-Scale Biodigesters for Sustainable Biogas Production: A Case Study in the Chillon Valley, Perú by Yoisdel Castillo Alvarez, Reinier Jiménez Borges, Carlos Diego Patiño Vidal, Fanny Mabel Carhuancho Leon, José Santos Pinares Buendia, Jose Alberto Samaniego Nolasco

“…Agribusiness ranks second as the sector with the highest greenhouse gas emissions linked to methane, constituting a crucial challenge for global sustainability. …”
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Modulation of Acid Sphingomyelinase in Melanoma Reprogrammes the Tumour Immune Microenvironment by Emma Assi, Davide Cervia, Laura Bizzozero, Annalisa Capobianco, Sarah Pambianco, Federica Morisi, Clara De Palma, Claudia Moscheni, Paolo Pellegrino, Emilio Clementi, Cristiana Perrotta

“…Since acid sphingomyelinase (A-SMase) downregulation in melanoma was shown to determine a malignant phenotype, we aimed here to elucidate the role of A-SMase in the regulation of tumour immunogenic microenvironment using in vivo melanoma models in which A-SMase was either downregulated or maintained at constitutively high levels. We found high levels of inflammatory factors in low A-SMase expressing tumours, which also displayed an immunosuppressive/protumoural microenvironment: high levels of myeloid-derived suppressor cells (MDSCs) and regulatory T lymphocytes (Tregs), as well as low levels of dendritic cells (DCs). …”
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Synthesis and Physicochemical Characterization of Anion Exchanger Based on Green Modified Bottle Gourd Shell by Dragana Z. Marković-Nikolić, Aleksandar Lj. Bojić, Saša R. Savić, Sanja M. Petrović, Dragan J. Cvetković, Milorad D. Cakić, Goran S. Nikolić

“…The structural changes of MLV precursors during green modification and the success of synthesis and biosorbent performances before and after the removal of anions from contaminated solutions have been registered and clarified by physicochemical methods, which include elemental analysis, chemical constitution, morphological characterization, and FTIR spectroscopy. …”
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Numerical Simulation of Corroded Reinforced Concrete Beam Strengthened by a Steel Plate with Different Strengthening Schemes by Huang Tang, Jianxin Peng, Linfa Xiao, Xinhua Liu, Jianren Zhang

“…The FE models use the coupled damaged-plasticity constitutive law for concrete in tension and compression and consider the bond-slip between the corroded tensile steel bar and concrete. …”
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The nature of self-medication in Uganda: a systematic review and meta-analysis by Danladi Makeri, Priscilla Peter Dilli, Theophilus Pius, Naheem Adekilekun Tijani, Abdullateef Afolabi Opeyemi, Kadai Alhaji Lawan, Shango Patience Emmanuel Jakheng, Reagan Muhwezi, Ambrose Shabohurira, Ibe Michael Usman, Ezera Agwu

“…Conclusion At least 1 in 2 Ugandans self-medicate and antibiotics constitute the dominant self-medicated drugs compounding the situation in an era of antimicrobial resistance. …”
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Comprehensive investigation into the effects of oxygen concentration on pyrite oxidation processes and key ion migration patterns in black rock layers by Zihang Liu, Zhangjun Dai, Fei Yu, Kaiwen Tong, Jianhua Guo, Kang Huang, Shanglin Qin, Shanxiong Chen

“…Although this initial phase only accounts for 8 % of the entire oxidation process, it constitutes 77 % of the overall reaction. After this peak, the rate gradually decreases and stabilizes. …”
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Anorectal conditions associated with human papillomavirus. Cienfuegos, 2020-2021 by Yuselis María Sánchez Reyes, Jorge Luis Estepa Pérez, José Antonio Feliú Rosa, Jorge Luis Estepa Ramos, Lianet González Gutiérrez

“…<p><strong>Foundation:</strong> the human papillomavirus is a double-stranded DNA virus that infects the squamous epithelium in healthy individuals to produce warts and condylomas; it constitutes a health problem that affects globally.<br /><strong>Objective:</strong> to identify the prevalence of anorectal conditions associated with human papillomavirus.…”
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A variant W chromosome in Centromochlus heckelii (Siluriformes, Auchenipteridae) and the role of repeated DNA in its heteromorphism by Chrystian Aparecido Grillo Haerter, Patrik Ferreira Viana, Fábio Hiroshi Takagui, Sandro Tonello, Vladimir Pavan Margarido, Daniel Rodrigues Blanco, Josiane Baccarin Traldi, Roberto Laridondo Lui, Eliana Feldberg

“…In this population, the W chromosome is subtelocentric, whereas the only previous study on C. heckelii reported a metacentric W chromosome. Constitutive heterochromatin (CH) and accumulation of microsatellite motifs have significantly contributed to this W chromosome enlargement. …”
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Study on the Mechanical Properties of Red Clay under Drying-Wetting Cycles by Yanli Qi, MingZhou Bai, Hao Zhou, Hai Shi, Pengxiang Li, Bohu He

“…With an increase in the number of dry and wet cycles, the attenuation gradually decreased. The constitutive model of the deviatoric stress and strain curve of red clay under dry and wet cycles was a plastic-hardening type. …”
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Towards a better understanding of biofoams: Multi-technique characterization of various tannin-furanic foams to assist in material selection for product design by Thomas Sepperer, Giulia Saccomano, Diana E. Bedolla, Raphael J.F. Berger, Primoz Šket, Elena Longo, Gregor A. Zickler, Saeed Borhani, Diego Dreossi, Lisa Vaccari, Maurizio E. Musso, Francesco D’Amico

“…Aiming to sustainable manufacturing options, materials that are discarded from the industry and to which a second life may be given are highly desirable. Condensed tannins constitute the starting point to create tannin-furanic foams, a rigid biobased material that could be a sustainable alternative to those derived from fossil fuel-based chemicals. …”
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