Attitudes of German General Practitioners Toward eHealth Apps for Dementia Risk Reduction: Qualitative Interview Study by Adrian Schultz, Melanie Luppa, Markus Bleckwenn, Steffi G Riedel-Heller, Andrea Zuelke

“… BackgroundeHealth interventions constitute a promising approach to disease prevention, particularly because of their ability to facilitate lifestyle changes. …”
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Probabilistic estimation of rheological properties in subduction zones using sequences of earthquakes and aseismic slip by Tobias Köhne, Rishav Mallick, Mark Simons

“…Here, we find that the ability to fit surface observations using functional or mechanical models assuming frictional behavior does not constitute sufficient evidence to actually infer frictional behavior at depth, as the surface expressions are virtually indistinguishable from deformation generated from models with depth-variable power-law viscous behavior. …”
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Assessment of factors predicting the nutritional status of geriatric people in Tabuk, Saudi Arabia by Samar Lafi Aljohani

“…The age of almost half of them (49.2%) ranged between 60 and 69 years, and males constituted 56.4% of them. Overall, 17.3% of the participants were malnourished, whereas 41.4% were at risk of malnutrition. …”
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Immoral misdemeanor incompatible with the continuation of work as a ground for termination of the employment contract at the initiative of the owner or authorized body by V. V. Sychova

“…The Constitution of Ukraine enshrines and guarantees the right to work as an opportunity to earn a living by work that a person freely chooses or agrees to. …”
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Structure- and machine learning-guided engineering demonstrate that a non-canonical disulfide in an anti-PD-1 rabbit antibody does not impede antibody developability by Wei-Ching Liang, Hongkang Xi, Dawei Sun, Luigi D’Ascenzo, Jonathan Zarzar, Nicole Stephens, Ryan Cook, Yinyin Li, Zhengmao Ye, Marissa Matsumoto, Jian Payandeh, Matthieu Masureel, Yan Wu

“…Our case study thus indicates that, while the non-canonical inter-CDR disulfide bond found in rabbit antibodies does not necessarily constitute an obstacle to therapeutic antibody development, combining structure- and ML-guided approaches can provide a fast and efficient way to improve antibody properties and remove potential liabilities.…”
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Advances in Cell and Immune Therapies for Melanoma by Tanase Timis, Sanda Buruiana, Delia Dima, Madalina Nistor, Ximena Maria Muresan, Diana Cenariu, Adrian-Bogdan Tigu, Ciprian Tomuleasa

“…In 2020, cutaneous melanoma constituted approximately 1.3% of all cancer deaths that occurred within the European Union, thereby highlighting the necessity for effective prevention, timely diagnosis, and sustainable treatment measures, especially as a growing number of cases occur among younger patients. …”
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Transmission of synthetic seed bacterial communities to radish seedlings: impact on microbiota assembly and plant phenotype by Simonin, Marie, Préveaux, Anne, Marais, Coralie, Garin, Tiffany, Arnault, Gontran, Sarniguet, Alain, Barret, Matthieu

“…Still, the identity and phenotypic effects of these taxa that constitute a primary inoculum of plant microbiota is mostly unknown. …”
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Metagenomic insights into the development of microbial communities of straw and leaf composts by Anastasiia K. Kimeklis, Anastasiia K. Kimeklis, Grigory V. Gladkov, Olga V. Orlova, Tatiana O. Lisina, Alexey M. Afonin, Alexey M. Afonin, Tatiana S. Aksenova, Arina A. Kichko, Alla L. Lapidus, Evgeny V. Abakumov, Evgeny V. Abakumov, Evgeny E. Andronov

“…We identified nine metagenome-assembled genomes (MAGs) as the most promising prokaryotic decomposers due to their abnormally high quantity of PULs for their genome sizes, which were confirmed by 16S rRNA gene amplicon sequencing to constitute the bulk of the community at all stages of substrate degradation. …”
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Green biosynthetic silver nanoparticles from Ageratum conyzoides as multifunctional hemostatic agents: Combining hemostasis, antibacterial, and anti-inflammatory properties for eff... by Yang Li, Yinfeng Tan, Huange Zhao, Shiting Chen, Azadeh Nilghaz, Rong Cao, Songlin Zhou

“…Herein, we demonstrate that medicinal plant-derived silver nanoparticles (AgNPs) exhibit the potential to constitute a promising multifunctional hemostatic reagent library. …”
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Standardization and validation of a novel reverse transcriptase polymerase chain reaction method for detecting virulent strains of the infectious bursal disease virus by Vladimir Longa-Bobadilla, Phillip Ormeño-Vásquez, Manuel Criollo-Orozco, Luis Tataje-Lavanda, Katherine Huamán-Gutierrez, Ángela Montalván, Mirko Zimic, Manolo Fernández-Sanchez, Manolo Fernández-Díaz

“…Conclusion: Our novel RT-PCR procedure has been demonstrated to be helpful in selectively amplifying the consensus sequence of the VP5 gene, indicating that this novel RT-PCR procedure constitutes an important and useful tool to execute initial discrimination of field-retrieved samples containing and not containing virulent strains of this virus before deciding to execute a blindly and more costly sequencing procedure of all the samples together.…”
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Frequency and factors associated with loss to follow-up in newly diagnosed rheumatoid arthritis patient: a single-centre study by Sumariyono Sumariyono, Rudy Hidayat, Faisal Parlindungan, Suryo Anggoro Kusumo Wibowo, Anna Ariane, Johanda Damanik, Abirianty Priandani Araminta, Ryzkianty Annis Nurdin

“…Introduction Lost to follow-up (LTFU) rheumatoid arthritis (RA) patients constitute a population that potentially experiences worsening of their disease. …”
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Distribution of Tunisian beet wild relatives (Beta sp.) according to morphological characteristics and eco-geographical origin by Kaouther Ben Mahmoud, Najla Mezghani, Youssef Ouakrim, Neila Mezghani, Noura Jemai, Ahmed Jemmali

“…Arcang. and Beta macrocarpa Guss. are crop wild relative taxa belonging to the primary gene pool. They constitute a crucial gene reserve for enhancing cultivated Beta species (B. vulgaris subsp. vulgaris L.). …”
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Hybrid peptides inspired by the RWQWRWQWR sequence inhibit cervical cancer cells growth in vitro by Natalia Ardila-Chantré, Claudia Marcela Parra-Giraldo, Yerly Vargas-Casanova, Andrea Carolina Barragán-Cardenas, Ricardo Fierro-Medina, Zuly Jenny Rivera-Monroy, Jhon Erick Rivera-Monroy, Javier Eduardo García-Castañeda

“…The combination of the RWQWRWQWR sequence with short anticancer peptides and cell-penetrating peptides allowed the creation of hybrid peptides with improved cytotoxic potency against cervical cancer. Hybrid peptides constitute a novel, viable, and useful strategy for the design and identification of peptide drugs with anticancer activity.…”
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Efficacy and Tolerance of Vascular Electrical Stimulation Therapy in the Management of Vaso-Occlusive Crises in Patients with Sickle Cell Disease: A Phase II Single-Centre Randomiz... by Renée-Paule Botti, Sie Saïda Bokoum, Etienne L’Hermite, Dohoma Alexis Silue, Boidy Kouakou, Sarah Anastasie Bognini, Serge Arnaud Agoua, Edgar Mandeng Ma Linwa, Roméo Ayemou, Kouassi Gustave Koffi

“…The study arms were divided as follows: our control group (group 0) constituted of 10 patients followed with conventional therapy (Analgesics + Hydration + NSAIDs), while 20 patients were divided equally into two interventional arms—10 patients followed with VEST + Analgesics + Hydration (group 1) and the other 10 patients followed with VEST + Analgesics + Hydration + NSAIDs (group 2). …”
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Evaluation of a strategy for tumor-initiating stem cell eradication in primary human glioblastoma cultures as a model by E. V. Dolgova, A. S. Proskurina, E. A. Potter, T. V. Tyrinova, O. S. Taranov, Ya. R. Efremov, K. E. Orishchenko, S. V. Mishinov, V. V. Stupak, A. A. Ostanin, E. R. Chernykh, S. S. Bogachev

“…On day 15, this indicator constituted 1/7.45 for mitomycin C and 1/10.28 for mitomycin C + DNA with reference to the control. …”
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Land-use and land-cover changes and emerging non-tuberculous and tuberculous infectious diseases in humans and animals: a mixed-methods review of research findings from global and... by Jean-François Guégan, Carlos A Vargas Campos, Christine Chevillon, Ahmadou Sylla, Magdalene Dogbe, Kayla M Fast, Jennifer Pechal, Alex Rakestraw, Matthew E Scott, Michael W Sandel, Heather Jordan, M Eric Benbow

“…Research on Mycobacterium bovis, and to a larger extent on M. ulcerans, constitutes convincing illustrations of the importance of acknowledging shifts in spatio-temporal scales, from local to global and inter-annual to decadal ones, when evaluating responses of mycobacteria to LULC changes. …”
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DepRescribing inapprOpriate Proton Pump InhibiTors (DROPIT): study protocol of a cluster-randomised controlled trial in Swiss primary care by Stefan Neuner-Jehle, Katharina Tabea Jungo, Sven Streit, Sven Trelle, Nicolas Rodondi, Carole Elodie Aubert, Kristie Rebecca Weir, Enriqueta Vallejo-Yagüe, Samantha Chan, Marie Roumet, Pascal Juillerat, Sofia Carolina Zambrano Ramos, Jennifer Inauen, Angela Edith Schulthess-Lisibach, Renata Vidonscky Lüthold, Clémentine Tombez, Martina Zangger, Flurina Jenal, Yvonne Mattmann, Christof Bieri, Michaela Barbier

“…Participants treated by the same GP constitute a cluster. Clusters are randomised 1:1 to either the intervention group or the control group.Interventions The intervention components consist of deprescribing tools including educational material, decision aids for both participants and GPs, and additional trainings for GPs only. …”
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The bacterial microbiome of symbiotic and menthol-bleached polyps of long-term aquarium-reared Galaxea fascicularis by Puntin, Giulia, Wong, Jane C. Y., Röthig, Till, Baker, David M., Sweet, Michael, Ziegler, Maren

“…They exist as metaorganisms (holobionts), constituted by the association between the (coral) animal host, its obligate endosymbiotic algae (Symbiodiniaceae), and other microorganisms comprising bacteria, viruses, archaea, fungi and other protists. …”
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Path analysis of factors influencing length of stay and hospitalisation expenses for oral cancer patients in tertiary hospitals in southeastern China: a cross-sectional study by Jing Wang, Chen Chen, Xiaoying Hu, Yi Fan, Yaping Wang, Yu Qiu, Qiujiao Yang, Mingming Xu, Yanfeng Weng, Yanni Li, Lisong Lin, Fa Chen, Baochang He, Fengqiong Liu

“…Treatment and surgery fees constituted the largest proportion of total expenses (28.59%), followed by inspection and laboratory test fees (20.63%), comprehensive medical service fees (19.27%), drug fees (18.09%) and medical consumables fees (11.69%). …”
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The expression profile of genes associated with behavior, stress, and adult neurogenesis along the hippocampal dorsoventral axis in tame and aggressive foxes by Yu. V. Alexandrovich, E. V. Antonov, S. G. Shikhevich, A. V. Kharlamova, L. V. Meister, Y. V. Makovka, D. V. Shepeleva, R. G. Gulevich, Yu. E. Herbeck

“…It is presumed that these genes constitute an important part of the mechanism reducing stress induced by contacts with humans and contribute to linking stress regulation with adult neurogenesis in tame foxes and domesticated animals in general.…”
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