Current Status of the Immunomodulation and Immunomediated Therapeutic Strategies for Multiple Sclerosis by Shyi-Jou Chen, Yen-Ling Wang, Hueng-Chuen Fan, Wen-Tsung Lo, Chih-Chien Wang, Huey-Kang Sytwu

“…This paper highlights the growing evidence that Th17 cells play the core role in the complex adaptive immunity of EAE/MS and discusses the roles of the associated immune cells and cytokines. These constitute the modern immunological basis for the development of novel clinical and preclinical immunomodulatory therapies for MS discussed in this paper.…”
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Regulation of Annexin I in Rheumatoid Synovial Cells by Glucocorticoids and Interleukin-1 by Eric F. Morand, Pam Hall, Paul Hutchinson, Yuan H. Yang

“…The glucocorticoid (GC)-induced antiinflammatory molecule annexin I is expressed in leukocytes and has antiinflammatory effects in animal models of arthritis, but the expression of annexin I in rheumatoid arthritis (RA) fibroblast-like synoviocytes (FLS) is unknown. We report the constitutive and dexamethasone (DEX)-inducible expression of annexin I in RA FLS. …”
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The Nicotinic Acetylcholine Receptor as a Target for Antidepressant Drug Development by Noah S. Philip, Linda L. Carpenter, Audrey R. Tyrka, Lawrence H. Price

“…Although clinical data remain limited, preliminary results in this area constitute a compelling argument for further evaluation of the nAChR as a target for future antidepressant drug development.…”
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Free Vibration of Embedded Porous Plate Using Third-Order Shear Deformation and Poroelasticity Theories by Ali Ghorbanpour Arani, Zahra Khoddami Maraghi, Mehdi Khani, Iman Alinaghian

“…To obtain the Biot formulation of the constitutive equations for a porous material, linear poroelasticity theory is used. …”
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Numerical simulation of early-age shrinkage effects on RC member deflections and cracking development by P. Bernardi, R. Cerioni, E. Michelini, A. Sirico

“…To this aim, an existing non-linear constitutive relation for cracked reinforced concrete elements is extended herein to include early-age concrete shrinkage. …”
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In silico (Eco)toxicology and molecular docking of halogenated and oxygenated rotenoid derivatives by Damião Sampaio de Sousa, Anthony Barbosa Belarmino, Victor Moreira de Oliveira, Francisco Rogênio da Silva Mendes, Emmanuel Silva Marinho, Gabrielle Silva Marinho

“… The rotenoids are compounds widely disseminated in the agro-industrial and chemical-pharmacological sectors due to their structural constitution and versatility in biological activities, however, these present toxic activity for fish. …”
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Synthesis and Characteristics of 1,2,4,5-Tetrazines for Using as High Energy Density Materials (HEDMs) by Sebastian Górecki, Agnieszka Kudelko

“…Nitrogen-rich heterocycles constitute a family of high energy density materials (HEDMs) that have been developing intensively in recent years. …”
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Raindrop size distribution variability associated with size‐dependent advection in convective precipitation systems by Megumi Okazaki, Kosei Yamaguchi, Tomoro Yanase, Eiichi Nakakita

“…According to the results, the raindrops constituting the maximum, local minimum, and local maximum followed different advection processes. …”
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THE OPTIMIZATION STRATEGY OF DEFENSE DIPLOMACY IN THE STRATEGIC DIALOGUE FORUM: INDONESIA'S PARTICIPATION IN THE SHANGRI-LA DIALOGUE by Jonni Mahroza, Anak Agung Banyu Perwita, Frega Ferdinand Wenas Inkiriwang

“…The findings show that the formulation of Indonesia's national interest in defense diplomacy refer to the Preamble to the 1945 Constitution, the application of free and active foreign policy, and the vision of the President. …”
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Mapping design-driven processes for the regeneration of small fortified towns in inland areas by Massimo Brignoni, Giorgio Dall’Osso, Silvia Gasparotto, Riccardo Varini

“… The contribution aims to focus on and deal with a methodology of mapping, typifying and cataloguing selected design interventions based on the impacts that the various design disciplines are or have been able to induce at different scales of action in the contexts of small fortified towns, constituting the primary settlement cores of the so-called inland areas. …”
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Highly robust co‐estimation of state of charge and state of health using recursive total least squares and unscented Kalman filter for lithium‐ion battery by Xiaohui Li, Weidong Liu, Bin Liang, Qian Li, Yue Zhao, Jian Hu

“…Abstract State of charge (SOC) and state of health (SOH) constitute pivotal factors in the efficient and secure management of lithium‐ion batteries, particularly within the context of electric vehicles. …”
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Situating the Jungle-village in Leonard Woolf’s The Village in the Jungle (1913) by Vihanga Perera

“…This paper addresses a gap in literary research in the scholarship on Leonard Woolf’s The Village in the Jungle: a lack of demonstrated understanding on the part of major critics as to what constitutes a village-jungle in the early-20th-century Ceylonese context and, as a result, misunderstanding of the novel’s main characters and events. …”
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Política de familia en América del Sur: un análisis comparado by Leidi Viviana Moreno-Parra, Carmen Verde-Diego, Rubén González-Rodríguez

“…A review of the literature and an analysis of the constitutions, social policies, plans, programs, projects, and national services related to the family have been carried out through institutional websites. …”
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A frictionless contact problem for viscoelastic materials by Mikäel Barboteu, Weimin Han, Mircea Sofonea

“…The body is assumed to have a viscoelastic behavior that we model with the Kelvin-Voigt constitutive law. The contact is frictionless and is modeled with the well-known Signorini condition in a form with a zero gap function. …”
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Unlocking the potential of hydrogen deuterium exchange via an iterative continuous-flow deuteration process by Kevin Tatoueix, Marco Lepron, Cédric Barboux, Marie-Christine Scherrmann, Grégory Pieters, Sophie Feuillastre

“…Abstract Labelled compounds bearing hydrogen isotopes are keystones in diverse areas constituting a multi-billion dollar global market including drugs, diagnostics, biology, toxicology and smart materials. …”
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Niemann-Pick Disease: An Underdiagnosed Lysosomal Storage Disorder by Inusha Panigrahi, Manoj Dhanorkar, Renu Suthar, Chanchal Kumar, Mullai Baalaaji, Babu Ram Thapa, Jasvinder Kalra

“…Lysosomal storage disorders (LSDs) collectively constitute a significant public health burden in developing countries. …”
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Spatial point pattern analysis of urban retail stores: the case of twelve large- and medium-sized Greek cities by Michail-Christos TSOUTSOS, Yorgos N. PHOTIS

“…The results reveal that the retail stores’ distribution has a clustered and random spatial pattern at least in one city, where the high population density and the increase in rental prices of premises for professional activities constitute the factors that form these spatial patterns respectively. …”
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Capacitance and Conductance Compensation Methods for Efficient Computing‐In‐Memory Designs by Yubiao Luo, Fei Qiao, Zhong Sun

“…It enables efficient CIM designs by intentionally letting the sum of capacitances or conductances of two or more rows or columns in the memory array equal, thus resulting in a concise mathematical formula regarding the memory cell data and the input data, which constitute computing primitives. Here, the capacitance and conductance compensation methods are reviewed that have been used for CIM designs based on static random‐access memory (SRAM) in combination with capacitors and nonvolatile resistive memory, respectively, and uncover the underlying principles and their application to CIM. …”
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STUDY ON THE STATIC TORSION STIFFNESS OF RUBBER SPRING BY EXPERIMENT AND SIMULATION (MT) by DUAN Yu, TAO YouRui, PEI JiaXing, ZHANG Yu

“…Firstly, the Mooney-Rivlin model was used to fit the rubber constitutive parameters, and the finite element model of rubber spring was established. …”
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Considerations on improving the level of reliability and capacity of the energy system by Cristina Ionici, Nicoleta Mihuț

“…They are, in fact, some huge "green" batteries that constitute an electrical energy storage solution, at the level of 2020 they represented 95% of global storage.…”
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