Design and synthesis of amino-substituted N-arylpiperidinyl-based inhibitors of the (immuno)proteasome by Gobec Martina, Obreza Aleš, Jukič Marko, Baumgartner Ana, Mihelčič Nja, Potočnik Špela, Virant Julija, Mlinarič Irena, Stanislav Raščan, Sosič Gobec Izidor

“…The constitutive proteasome and the immunoproteasome represent validated targets for pharmacological intervention in the context of various diseases, such as cancer, inflammation, and autoimmune diseases. …”
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The Zn- or Cu-Thionein Character of a Metallothionein Determines Its Metal Load When Synthesized in Physiological (Metal-Unsupplemented) Conditions by Mercè Capdevila, Òscar Palacios, Sílvia Atrian

“…Therefore, intrinsically different roles can be hypothesized for the constitutively-produced MT peptides in the absence of any metal overload, depending on their Zn- or Cu-thionein character.…”
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Host-Parasite Relationship in Cystic Echinococcosis: An Evolving Story by Alessandra Siracusano, Federica Delunardo, Antonella Teggi, Elena Ortona

“…The larval stage of Echinococcus granulosus causes cystic echinococcosis, a neglected infectious disease that constitutes a major public health problem in developing countries. …”
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Human Milk Oligosaccharides: The Journey Ahead by Chandan Ray, Joshi A. Kerketta, Subhash Rao, Snehal Patel, Shantanu Dutt, Kamal Arora, Femitha Pournami, Phani Bhushan

“…Human milk oligosaccharides (HMOs) are unconjugated glycans that constitute an important component of the protection conferred by breast milk on the neonate. …”
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The Laplace Virtual Fields Method for the direct extraction of viscoelastic properties of materials by Marcot, Quentin, Fourest, Thomas, Langrand, Bertrand, Pierron, Fabrice

“…The Laplace transform enables the use of theory of elasticity in the Laplace domain. The constitutive equations are expressed in the plane stress framework with the 2D plane stress stiffness coefficients. …”
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Myocardial Damage in SARS-CoV-2 Infection by Elizabeth Sellén Sanchén, Joaquín Sellén Crombet, Lisandra Sellén Fundora

“…Patients with a history of arterial hypertension, coronary heart disease and cardiomyopathy constitute a very high risk population of complications from the coronavirus. …”
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Design of Tunable Equalizers Using Multilayered Half Mode Substrate Integrated Waveguide Structures Added Absorbing Pillars by Shuxing Wang, Yongfei Wang, Dewei Zhang, Yi Zhang, Dongfang Zhou

“…Resonant cavities distributing in the upper substrate and the bottom substrate, with the middle substrate layer which works as the transmission line together, constitute a multilayer structure. The design method and theoretical analysis are summarized first. …”
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Writing and reading in Montessori preschools in the digital age – A valid teaching approach? by Per Gynther, Eva-Maria Tebano Ahlquist

“…Such studies could constitute an important contribution to the discussion about when and how writing by hand should be introduced within, as well as outside the Montessori community. …”
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Current Status of the Immunomodulation and Immunomediated Therapeutic Strategies for Multiple Sclerosis by Shyi-Jou Chen, Yen-Ling Wang, Hueng-Chuen Fan, Wen-Tsung Lo, Chih-Chien Wang, Huey-Kang Sytwu

“…This paper highlights the growing evidence that Th17 cells play the core role in the complex adaptive immunity of EAE/MS and discusses the roles of the associated immune cells and cytokines. These constitute the modern immunological basis for the development of novel clinical and preclinical immunomodulatory therapies for MS discussed in this paper.…”
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Regulation of Annexin I in Rheumatoid Synovial Cells by Glucocorticoids and Interleukin-1 by Eric F. Morand, Pam Hall, Paul Hutchinson, Yuan H. Yang

“…The glucocorticoid (GC)-induced antiinflammatory molecule annexin I is expressed in leukocytes and has antiinflammatory effects in animal models of arthritis, but the expression of annexin I in rheumatoid arthritis (RA) fibroblast-like synoviocytes (FLS) is unknown. We report the constitutive and dexamethasone (DEX)-inducible expression of annexin I in RA FLS. …”
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The Nicotinic Acetylcholine Receptor as a Target for Antidepressant Drug Development by Noah S. Philip, Linda L. Carpenter, Audrey R. Tyrka, Lawrence H. Price

“…Although clinical data remain limited, preliminary results in this area constitute a compelling argument for further evaluation of the nAChR as a target for future antidepressant drug development.…”
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Free Vibration of Embedded Porous Plate Using Third-Order Shear Deformation and Poroelasticity Theories by Ali Ghorbanpour Arani, Zahra Khoddami Maraghi, Mehdi Khani, Iman Alinaghian

“…To obtain the Biot formulation of the constitutive equations for a porous material, linear poroelasticity theory is used. …”
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Synthesis and Characteristics of 1,2,4,5-Tetrazines for Using as High Energy Density Materials (HEDMs) by Sebastian Górecki, Agnieszka Kudelko

“…Nitrogen-rich heterocycles constitute a family of high energy density materials (HEDMs) that have been developing intensively in recent years. …”
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Raindrop size distribution variability associated with size‐dependent advection in convective precipitation systems by Megumi Okazaki, Kosei Yamaguchi, Tomoro Yanase, Eiichi Nakakita

“…According to the results, the raindrops constituting the maximum, local minimum, and local maximum followed different advection processes. …”
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Mapping design-driven processes for the regeneration of small fortified towns in inland areas by Massimo Brignoni, Giorgio Dall’Osso, Silvia Gasparotto, Riccardo Varini

“… The contribution aims to focus on and deal with a methodology of mapping, typifying and cataloguing selected design interventions based on the impacts that the various design disciplines are or have been able to induce at different scales of action in the contexts of small fortified towns, constituting the primary settlement cores of the so-called inland areas. …”
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Highly robust co‐estimation of state of charge and state of health using recursive total least squares and unscented Kalman filter for lithium‐ion battery by Xiaohui Li, Weidong Liu, Bin Liang, Qian Li, Yue Zhao, Jian Hu

“…Abstract State of charge (SOC) and state of health (SOH) constitute pivotal factors in the efficient and secure management of lithium‐ion batteries, particularly within the context of electric vehicles. …”
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A frictionless contact problem for viscoelastic materials by Mikäel Barboteu, Weimin Han, Mircea Sofonea

“…The body is assumed to have a viscoelastic behavior that we model with the Kelvin-Voigt constitutive law. The contact is frictionless and is modeled with the well-known Signorini condition in a form with a zero gap function. …”
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Unlocking the potential of hydrogen deuterium exchange via an iterative continuous-flow deuteration process by Kevin Tatoueix, Marco Lepron, Cédric Barboux, Marie-Christine Scherrmann, Grégory Pieters, Sophie Feuillastre

“…Abstract Labelled compounds bearing hydrogen isotopes are keystones in diverse areas constituting a multi-billion dollar global market including drugs, diagnostics, biology, toxicology and smart materials. …”
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Niemann-Pick Disease: An Underdiagnosed Lysosomal Storage Disorder by Inusha Panigrahi, Manoj Dhanorkar, Renu Suthar, Chanchal Kumar, Mullai Baalaaji, Babu Ram Thapa, Jasvinder Kalra

“…Lysosomal storage disorders (LSDs) collectively constitute a significant public health burden in developing countries. …”
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Collapse Pressure Analysis of Transversely Isotropic Thick-Walled Cylinder Using Lebesgue Strain Measure and Transition Theory by A. K. Aggarwal, Richa Sharma, Sanjeev Sharma

“…The concept of transition theory based on Lebesgue strain measure has been used to simplify the constitutive equations. Results have been analyzed theoretically and discussed numerically. …”
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