Global sensitivity analysis and uncertainty quantification for a mathematical model of dry anaerobic digestion in plug-flow reactors by Daniele Bernardo Panaro, Andrea Trucchia, Vincenzo Luongo, Maria Rosaria Mattei, Luigi Frunzo

“…Sensitivity analysis and uncertainty quantification constitute essential tools in the field of biological systems modeling. …”
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Harnessing the potential of chloroplast-derived expression elements for enhanced production of cellulases in Escherichia coli by Ayesha Siddiqui, Muhammad Mudassar Iqbal, Asad Ali, Iqra Fatima, Hazrat Ali, Aamir Shehzad, Sameer H. Qari, Ghulam Raza, Muhammad Aamer Mehmood, Peter J. Nixon, Niaz Ahmad

“…In this study, two cellulases (β-glucosidase and endoglucanase) were heterologously expressed in Escherichia coli under a chloroplast-derived constitutive promoter and expression-enhancing terminator. …”
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Coronary angiographic assessment of streptokinase efficacy in young patients with ST-elevation myocardial infarction by Chetan Solanki, Kuwer Devi Singh, Sunil Kumar Tripathi, Manoj Indurkar, Rakesh Kumar Tikadar

“…Results: The majority of patients (66%) were 31–40 years old, with males constituting 88% of the population. Single vessel disease was predominant (84%) among the study population. …”
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Analysis of syphilis epidemiological characteristics among the resident population in Ruian City, 2014‒2023 by HONG Wansheng, CHEN Jiangmin, ZHOU Limin, HU Yunlei, CHEN Chunnan, CHEN Liangchai, LI Jun, HUANG Jieru, ZHOU Zumu

“…In terms of occupation, the highest proportion was found among housekeepers and the unemployed, constituting 42.70% the total cases. Dermatology departments reported the most cases in medical institutions, accounting for 33.38% of the total cases. …”
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G Protein-Coupled Receptor 17 Inhibits Glucagon-like Peptide-1 Secretion via a Gi/o-Dependent Mechanism in Enteroendocrine Cells by Jason M. Conley, Alexander Jochim, Carmella Evans-Molina, Val J. Watts, Hongxia Ren

“…Here, we expressed the human GPR17 long isoform (hGPR17L) in GLUTag cells, a murine EEC line, and we used the GPR17 synthetic agonist MDL29,951 together with pharmacological probes and genetic approaches to quantitatively assess the contribution of GPR17 signaling to GLP-1 secretion. Constitutive hGPR17L activity inhibited GLP-1 secretion, and MDL29,951 treatment further inhibited this secretion, which was attenuated by treatment with the GPR17 antagonist HAMI3379. …”
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Flow Unit Model of Channel Sand Body and Its Effect on Remnant Oil Distribution: A Case Study of PI Formation in the Eastern Transition Zone of Daqing Oilfield by Yue Zhang, You-liang Ji, Hui-jian Wen, Shi-zhong Ma, Dong-lai Bai, Bin-chi Zhang, Ben-kang Xing

“…We found that the strong-current limiting flow unit in the point bar is the enrichment area of free-state microscopic remnant oil and that the medium-current limiting and weak-current limiting flow units also have relatively high free microscopic remnant oil. These constitute the remaining oil enrichment areas in the study area.…”
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Systematic literature review on Calcium Pyrophosphate Deposition (CPPD) nomenclature: condition elements and clinical states— A Gout, Hyperuricaemia and Crystal-Associated Disease... by Georgios Filippou, Antonella Adinolfi, Emilio Filippucci, Nicola Dalbeth, Robert Terkeltaub, Tristan Pascart, Edoardo Cipolletta, Silvia Sirotti, Charlotte Jauffret, Sara Tedeschi, Daniele Cirillo, Luca Ingrao, Alessandro Lucia

“…This systematic literature review constituted its first step and aimed to provide a state-of-the-art analysis of the medical literature of the last 20 years.Methods A systematic literature search was undertaken in the PubMed, Cochrane and Embase databases between 2000 and 2022, restricted to studies on humans and in the English language. …”
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Investigation on True Stress-Strain Curves of Flat and Corner Regions of Cold-Formed Section Using 3D Digital Image Correlation Method by Bo Xu, Junwu Xia, Renwei Ma, Jian Wang, Xiaomiao Chen, Hongfei Chang, Lihai Zhang

“…The load-displacement curves from numerical simulations fit very well with those of coupon tests, which validate the reliability of the optic measurement and the dependability of the simplified constitutive models.…”
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The sulfur-related metabolic status of Aspergillus fumigatus during infection reveals cytosolic serine hydroxymethyltransferase as a promising antifungal target by Reem Alharthi, Monica Sueiro-Olivares, Isabelle Storer, Hajer Bin Shuraym, Jennifer Scott, Reem Al-Shidhani, Rachael Fortune-Grant, Elaine Bignell, Lydia Tabernero, Michael Bromley, Can Zhao, Jorge Amich

“…We identified a set of 15 genes that were consistently expressed at higher levels in vivo than in vitro, suggesting that they may be particularly relevant for intrapulmonary growth and thus constitute promising drug targets. Indeed, the role of 5 of the 15 genes has previously been empirically validated, supporting the likelihood that the remaining candidates are relevant. …”
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Blended digital health intervention for adolescents at high risk with digital media use disorders: protocol for a randomised controlled trial within the Res@t-Consortium by Oliver Labrenz, Oliver Labrenz, Lucie Waedel, Lucie Waedel, Michael Kölch, Michael Kölch, Susanne Lezius, Christina Wacker, Antonia Fröhlich, Antonia Fröhlich, Kerstin Paschke, Rainer Thomasius, Olaf Reis, Olaf Reis

“…Secondary outcomes include EEG measurements and changes in standardised psychopathological variables.DiscussionShould the Res@t app prove efficacious when compared to a waitlist control group, it would constitute an evidence-based intervention for the treatment of DMUD in children and adolescents. …”
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A Newborn with Genital Ambiguity, 45,X/46,XY Mosaicism, a Jumping Chromosome Y, and Congenital Adrenal Hyperplasia by Lei Zhang, Linda D. Cooley, Sonal R. Chandratre, Atif Ahmed, Jill D. Jacobson

“…This is the first case of coexisting CAH and 45,X/46,XY mosaicism reported in the English literature and the third case of a constitutional chromosome Y “jumping translocation.” Our report documents the medical and genetic complexity of children such as this one with ambiguous genitalia and discusses the need for a multidisciplinary team approach.…”
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Introducing the Condor Array Telescope. V. Deep Broad- and Narrowband Imaging Observations of the M81 Group by Kenneth M. Lanzetta, Stefan Gromoll, Michael M. Shara, David Valls-Gabaud, Frederick M. Walter, John K. Webb

“…Here we describe the acquisition and processing of these observations, which together constitute unique very deep imaging observations of a large portion of the M81 Group through a complement of broad- and narrowband filters. …”
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Riverine microplastic discharge along the southern Black Sea coast of Türkiye by Yahya Terzi, Rafet Çağrı Öztürk, Ahmet Raif Eryaşar, İlhan Yandi, Ahmet Şahin, Fatih Yılmaz, Kenan Gedik, Sedat Gündoğdu

“…MP sizes ranged predominantly between 200–1000 μ m, and fibers constituted the majority of shapes (64.1%), followed by fragments (28.3%). …”
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B and NK Cells Closely Correlate with the Condition of Patients with Acute Pancreatitis by Xin Wei, Weifeng Yao, Huiping Li, Jingjing Qian, Yaosheng Xie, Zhuo Zhang, Hong Lu, Liang Shi, Xiangyang Lin

“…Materials and Methods. 131 acute pancreatitis (AP) patients and 11 chronic pancreatitis (CP) patients constituted the patients’ group; 20 healthy individuals were enrolled as healthy controls (HC). …”
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Child Injury in Israel: Emergency Room Visits to a Children's Medical Center by Michal Hemmo-Lotem, Claudia Jinich-Aronowitz, Liri Endy-Findling, Michal Molcho, Michal Klein, Yehezkel Waisman, Yehuda L. Danon, Joav Merrick

“…Despite this low rate of non-Jewish patients, however, they constituted 20% of later hospitalizations. The main injuries recorded were bruises and wounds from blunt objects, falls, motor vehicle–related accidents, and sport injuries. …”
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A compressive damage model for a rock considering the microcrack mechanical behavior by Cui LIU, Zhong LI, Feiya XU, Mo ZHANG, Xiaowei CAO, Heng LEI

“…This study provides new insight into the establishment of the rock damage constitutive model under compression.…”
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Deficiency of Dietary Fiber in Slc5a8-Null Mice Promotes Bacterial Dysbiosis and Alters Colonic Epithelial Transcriptome towards Proinflammatory Milieu by Sathish Sivaprakasam, Pramodh K. Ganapathy, Mohd Omar Faruk Sikder, Moamen Elmassry, Sabarish Ramachandran, Kameswara Rao Kottapalli, Vadivel Ganapathy

“…Various factors alter the gut microbiota which lead to dysbiosis; in particular, diet and dietary fibers constitute important determinants. Dietary fiber protects against IBD; bacteria ferment these dietary fibers in colon and generate short-chain fatty acids (SCFAs), which mediate the anti-inflammatory actions of dietary fibers. …”
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Primary Fallopian Tube Carcinoma: Results of a Single-Institutional Retrospective Analysis of 17 Patients with Evaluation of Staging and Prognostic Factors by Neserine Tounsi, Hanen Bouazize, Ikram Margheli, Nadia Boujelbene, Hechiche Monia, Maher Slimane, Khaled Rahel

“… OBJECTIVE: Primary carcinoma of the fallopian tubes is one of the less common gynecological cancers. It constitutes (0.14-0.18%) of gynecological malignancies. …”
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Eight-element flexible MIMO antenna based on characteristics mode theory with enhanced channel capacity for sub 6 GHz 5G communications by Deepthi Mariam John, Shweta Vincent, Sameena Pathan, Kunjan D Shinde, B S Supreetha, Tanweer Ali

“…The single-element antenna constitutes a co-planar waveguide (CPW) fed transformed circular monopole antenna designed using the theory of characteristic modes (CMA) to cover the specific band. …”
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Molecular assessment of splicing variants in a cohort of patients with inborn errors of immunity: methodological approach and interpretation remarks by Laura Miguel Berenguel, Carla Gianelli, Carla Gianelli, Carla Gianelli, Elisabet Matas Pérez, Teresa del Rosal, Ana Méndez Echevarría, Ángel Robles Marhuenda, Marta Feito Rodríguez, Maria Teresa Caballero Molina, Maria Teresa Caballero Molina, Lorena Magallares García, Brenda Sánchez Garrido, Samantha Hita Díaz, Luis Allende Martínez, Luis Allende Martínez, Pilar Nozal Aranda, Pilar Nozal Aranda, Pilar Nozal Aranda, Carmen Cámara Hijón, Carmen Cámara Hijón, Carmen Cámara Hijón, Eduardo López Granados, Eduardo López Granados, Eduardo López Granados, Rebeca Rodríguez Pena, Rebeca Rodríguez Pena, Rebeca Rodríguez Pena, María Bravo García-Morato, María Bravo García-Morato, María Bravo García-Morato

“…Reverse transcription-polymerase chain reaction (RT-PCR) is the molecular assay employed for pathogenicity validation.ResultsWe detected 23 patients of 20 pedigrees with splicing variants in IEI genes, which constitutes the 12.3% of our cohort. In total, 21 splicing variants were analyzed, 10 of which had previously been reported in the literature and 11 novel ones. …”
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