Identification of natural compound inhibitors for substrate-binding site of MTHFD2 enzyme: Insights from structure-based drug design and biomolecular simulations by Nisarg Rana, Priyanka Solanki, Rukmankesh Mehra, Anu Manhas

“…A computational structure-based drug design approach was employed to identify inhibitors targeting the active site of the MTHFD2 enzyme. …”
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Adverse birth outcome and associated factors among mothers with antepartum hemorrhage in public hospitals Tigray, northern Ethiopia, 2020 by Tomas Amare Abraha, Gebremedhin Kinfe Gebremariam, Berhane Teklay Asfaha, Tensay Kahsay Weldegebreal, Desta Hailu Aregawi

“…Logistic regression was computed and variables which have a P-value less than 0.2 on bivariable analysis were taken to multivariable analysis. …”
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Screening and validation of tsRNAs associated with lung adenocarcinoma by LU Chunli, SHAN Yifan, XIE Weijia

“…Methods‍　The differential expression of tsRNAs between lung adenocarcinoma tissues and normal tissues was analyzed based on the database of the Computational Medicine Center. The effects of tsRNAs expression levels on the prognosis of lung adenocarcinoma patients were analyzed based on the Cancer Genome Atlas （TCGA） database （TCGA-LUAD）. …”
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Epithelial stem cells from human small bronchi offer a potential for therapy of idiopathic pulmonary fibrosisResearch in context by Zeyu Liu, Qi Zheng, Zhoubin Li, Moli Huang, Cheng Zhong, Ruize Yu, Rong Jiang, Haotian Dai, Jingyuan Zhang, Xiaohua Gu, Yongle Xu, Chunwei Li, Shan Shan, Feng Xu, Yue Hong, Tao Ren

“…Post-transplantation assessments included lung function, exercise capacity and high resolution computed tomography (HRCT) scans were analyzed to quantify the clinical benefits conferred by the BCs transplantation. …”
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Prognostic and clinicopathological role of soluble programmed cell death ligand-1 in patients with diffuse large B-cell lymphoma: a meta-analysis by Hongbin Lu, Lulu Luo, Jie Mi, Min Sun, Huaping Wang, Zheng Wang, Wenwen Ding

“…The value of sPD-L1 in predicting the overall survival (OS) and progression-free survival (PFS) of patients with DLBCL was analyzed by computing the combined hazard ratios (HRs) and 95% confidence intervals (CIs). …”
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Application of deep learning model based on unenhanced chest CT for opportunistic screening of osteoporosis: a multicenter retrospective cohort study by Chengbin Huang, Dengying Wu, Bingzhang Wang, Chenxuan Hong, Jiasen Hu, Zijian Yan, Jianpeng Chen, Yaping Jin, Yingze Zhang

“…This study aimed to establish and validate a convolutional neural network (CNN) model based on unenhanced chest computed tomography (CT) images of the vertebral body and skeletal muscle for opportunistic screening in patients with osteoporosis. …”
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The role of paternal support in breastfeeding outcomes: a meta-analytic review by Si-si Zhou, Jia Lu, An Qin, Yang Wang, Wei Gao, Hong Li, Lin Rao

“…The choice between fixed or random effects models was determined by the outcomes of the heterogeneity test, and relative risks (RR) along with 95% confidence intervals (CI) were computed. Results A comprehensive search yielded 3065 studies, of which eight were included in the meta-analysis. …”
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Assessing water and energy fluxes in a regional hydrosystem: case study of the Seine basin by Kilic, Deniz, Rivière, Agnès, Gallois, Nicolas, Ducharne, Agnès, Wang, Shuaitao, Peylin, Philippe, Flipo, Nicolas

“…Simulated ORCHIDEE surface water and energy fluxes feed fast surface runoff and slow recharge respectively and then is used as CaWaQS forcings to compute river discharges, hydraulic heads and temperature dynamics through space and time, within each of the hydrosystem compartments. …”
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Co-creation and application of a framework for the de-prioritization of urban communities during insecticide-treated bed net mass campaigns for malaria prevention and control in Kw... by Ifeoma D. Ozodiegwu, Laurette Mhlanga, Eniola A. Bamgboye, Adeniyi F. Fagbamigbe, Cyril Ademu, Chukwu Okoronkwo, Joshua O. Akinyemi, Akintayo O. Ogunwale, IkeOluwapo O. Ajayi, Beatriz Galatas

“…During the framework’s operationalization, malaria risk scores were computed at the ward level using four key variables, including malaria case data and environmental factors, and subsequently mapped. …”
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Mortality trends of traumatic brain injuries in the adult population of the United States: a CDC WONDER analysis from 1999 to 2020 by Muhammad Hamza Dawood, Yusra Fazli, Sejal Lund, Shurjeel Uddin Qazi, Rija Tahir, Areehah Zafar Masood, Aiman Azam Qureshi, Saleha Safdar, Heraa Zaheer, Muhammad TayyabMuzaffar Chaychi

“…Age-adjusted mortality rates (AAMRs) per 100,000 individuals and annual percent change (APC) were computed and stratified based on year, gender, race/ethnicity, and geographic region. …”
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Is Lateral Ligament Complex Repair Necessary in All Unstable Elbow Injuries with Coronoid Fractures? A Comparative Study: A Case Series by Nishaanth Ragavan, Rex Chandrabose

“…Magnetic resonance imaging (MRI) with computed tomography (CT) evaluation was done in all cases to assess the osseous and ligamentous status to select the appropriate surgical approach and method of fixation. …”
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Identification of PET/CT radiomic signature for classification of locally recurrent rectal cancer: A network-based feature selection approach by Sara Dalmonte, Maria Adriana Cocozza, Dajana Cuicchi, Daniel Remondini, Lorenzo Faggioni, Paolo Castellucci, Andrea Farolfi, Emilia Fortunati, Alberta Cappelli, Riccardo Biondi, Arrigo Cattabriga, Gilberto Poggioli, Stefano Fanti, Gastone Castellani, Francesca Coppola, Nico Curti

“…This work aimed to develop a machine learning model for predicting LRRC using radiomic features extracted from 18F-FDG Positron Emission Tomography/Computed Tomography (PET/CT). Methods: CT and PET images of PET/CT examinations were retrospectively collected from 44 patients, with 29 cases of recurrence (66 %) and 15 cases with no local recurrence (34 %). …”
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Impairment of myocardial perfusion correlates with heart failure severity in patients with non‐compaction cardiomyopathy by Andraz Cerar, Martina Jaklic, Sabina Frljak, Gregor Poglajen, Gregor Zemljic, Barbara Guzic Salobir, Maja Dolenc Novak, Monika Stalc, Rok Zbacnik, Mirta Kozelj

“…At the same time, serum levels of N‐terminal pro‐B‐type natriuretic peptide (NT‐proBNP) have been measured, and myocardial single‐photon emission computed tomography at rest and on stress was used to define significant myocardial ischemia defined as summed difference score ≥ 2. …”
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Global trends and research frontiers on machine learning in sustainable animal production in times of climate change: Bibliometric analysis aimed at insights and orientations for t... by Robson Mateus Freitas Silveira, Concepta Mcmanus, Iran José Oliveira da Siva

“…The main insights generated in the bibliometric analysis were (i) sustainable animal production changed from unidisciplinary science to multidisciplinary science linked to agricultural, environmental and engineering sciences, mainly to genetics and computing; (ii) the concept of sustainable animal production emerged from animal welfare and climate change concepts found in UN's 2030 Agenda; (iii) omics sciences, greenhouse gases, energy efficiency and animal welfare are the main keywords for bibliometric analyses in future studies related to sustainable animal production in the coming centuries; (iii) prediction and classification analyses, i.e., supervised machine learning models used as main tools in animal production; (iv) residual feed intake applied to measure sustainable feed efficiency in animal farming in the past and nowadays; and (v) The United States, China, Brazil and Australia are the main countries publishing studies on sustainability in animal production, but only China has been gaining prominence in publications in this field, in recent years, and it will turn this country into an emerging leader in future publications on this topic. …”
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Irreducible representation of surface distributions and Piola transformation of external loads sustainable by third gradient continua by dell’Isola, Francesco, Fedele, Roberto

“…The presented results allow for the formulation of well-posed boundary condition problems for third gradient continua in the Lagrangian description, and are relevant in computational mechanics. In view of the obtained Piola transformation formulas, the concept of dead loads needs to be modified. …”
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Psychosocial well-being index and sick leave in the workplace: a structural equation modeling of Wittyfit data by Rémi Colin-Chevalier, Bruno Pereira, Samuel Dewavrin, Thomas Cornet, Julien Steven Baker, Frédéric Dutheil

“…Structural equation modeling facilitated computation of workers’ psychosocial well-being index (AIC: 123,016.2, BIC: 123,231.2, RMSEA: 0.03). …”
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Proper timing or ERCP and cholecystectomy on acute cholecystitis: a systematic review and meta-analysis by Giuliana Fulco Gonçalvez, Louise Lopes Barros, Sofia Emereciano Gurgel, Kleyton Santos de Medeiros, Irami Araújo Filho

“…Data synthesis used R-4.1.0 Project for Statistical Computing for Windows, with meta-analysis via fixed-effects model and I2 for heterogeneity. …”
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Digital Twin Technology in Resolving Polycystic Ovary Syndrome and Improving Metabolic Health: A Comprehensive Case Study by Paramesh Shamanna, MD, Anuj Maheshwari, MD, Ashok Keshavamurthy, MD, Sanjay Bhat, DM, Abhijit Kulkarni, DM, Shivakumar R, MD, Kumar K, MD, Mukulesh Gupta, MD, Mohamed Thajudeen, MD, Ranjita Kulkarni, MD, Shashikiran Patil, MD, Shashank Joshi, DM

“…Ultrasound showed reduced ovarian volume and improved fatty liver infiltration, while computed tomography scan revealed significant reductions in epicardial (21.8%), pericardial (69.9%), and visceral fat (44.4%). …”
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Antithrombotic therapy for a case report of acute myocardial infarction after laparoscopic radical cystectomy by Zilong Wang, Zilong Wang, Zilong Wang, Zilong Wang, Huisheng Yuan, Junhao Chu, Shishuai Duan, Zhihui Zhang, Changze Song, Muwen Wang

“…This study aims to contribute clinical insights for clinicians to manage high-risk patients with acute myocardial infarction post-major surgery.Methods and resultsThe 64-year-old male patient was admitted for multiple high-grade urothelial carcinomas of the bladder. The preoperative computed tomography angiography revealed intra-luminal stenosis of the coronary arteries. …”
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Sequence-based GWAS in 180,000 German Holstein cattle reveals new candidate variants for milk production traits by Ana-Marija Križanac, Christian Reimer, Johannes Heise, Zengting Liu, Jennie E. Pryce, Jörn Bennewitz, Georg Thaller, Clemens Falker-Gieske, Jens Tetens

“…These can also come with both computational and time burdens, as presented in our study. …”
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