A structure-based designed small molecule depletes hRpn13Pru and a select group of KEN box proteins by Xiuxiu Lu, Monika Chandravanshi, Venkata R. Sabbasani, Snehal Gaikwad, V. Keith Hughitt, Nana Gyabaah-Kessie, Bradley T. Scroggins, Sudipto Das, Wazo Myint, Michelle E. Clapp, Charles D. Schwieters, Marzena A. Dyba, Derek L. Bolhuis, Janusz W. Koscielniak, Thorkell Andresson, Michael J. Emanuele, Nicholas G. Brown, Hiroshi Matsuo, Raj Chari, Deborah E. Citrin, Beverly A. Mock, Rolf E. Swenson, Kylie J. Walters

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Piloting an automated query and scoring system to facilitate APDS patient identification from health systems by Amy M. FitzPatrick, Aaron T. Chin, Sharon Nirenberg, Charlotte Cunningham-Rundles, Keith Sacco, Jesse Perlmutter, Joseph F. Dasso, Athanasios Tsalatsanis, Jay Maru, Jessica Creech, Jolan E. Walter, Nicholas Hartog, Neema Izadi, Mandy Palmucci, Manish J. Butte, Klaus Loewy, Anurag Relan, Nicholas L. Rider

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Exploring the ability of plasma pTau217, pTau181 and beta-amyloid in mirroring cerebrospinal fluid biomarker profile of Mild Cognitive Impairment by the fully automated Lumipulse®... by Marcella Catania, Claudia Battipaglia, Alberto Perego, Erika Salvi, Emanuela Maderna, Federico Angelo Cazzaniga, Paolo M. Rossini, Camillo Marra, Nicola Vanacore, Alberto Redolfi, Daniela Perani, Patrizia Spadin, Maria Cotelli, Stefano Cappa, Naike Caraglia, Pietro Tiraboschi, Fabrizio Tagliavini, Giuseppe Di Fede

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Insufficient Evidence to Recommend Shu Mian Capsule in Managing Depression With or Without Comorbid Insomnia: A Systematic Review With Meta-Analysis and Trial Sequential Analysis by Zhao FY, Xu P, Kennedy GA, Jin X, Wang YM, Zhang WJ, Yue LP, Ho YS, Fu QQ, Conduit R

“…Fei-Yi Zhao,1– 3,* Peijie Xu,4,* Gerard A Kennedy,2,* Xiaochao Jin,5,6 Yan-Mei Wang,3 Wen-Jing Zhang,3 Li-Ping Yue,1 Yuen-Shan Ho,7 Qiang-Qiang Fu,8 Russell Conduit2 1Department of Nursing, School of International Medical Technology, Shanghai Sanda University, Shanghai, 201209, People’s Republic of China; 2School of Health and Biomedical Sciences, RMIT University, Bundoora, Melbourne, VIC, 3083, Australia; 3Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 200071, People’s Republic of China; 4School of Computing Technologies, RMIT University, Melbourne, VIC, 3000, Australia; 5Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai, People’s Republic of China; 6Shanghai Jiaotong University School of Nursing, Shanghai, People’s Republic of China; 7School of Nursing, Faculty of Health and Social Sciences, The Hong Kong Polytechnic University, Hong Kong SAR, People’s Republic of China; 8Yangpu Hospital, School of Medicine, Tongji University, Shanghai, 200090, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yuen-Shan Ho, School of Nursing, Faculty of Health and Social Sciences, The Hong Kong Polytechnic University, Hong Kong SAR, People’s Republic of China, Tel +852 2766-6410, Fax +852 2364-9663, Email janice.ys.ho@polyu.edu.hk Qiang-Qiang Fu, Yangpu Hospital, School of Medicine, Tongji University, Shanghai, 200090, People’s Republic of China, Tel + 86 021-6569 0520, Fax + 86 021-6569 6249, Email qiangqiang.fu@tongji.edu.cnAim: This systematic review with trial sequential analysis (TSA) aims to evaluate the efficacy and safety of Shu Mian Capsule (SMC), a commercial Chinese polyherbal preparation, for managing depression with or without comorbid insomnia.Methods: Controlled clinical trials assessing SMC against waitlist control, placebo or active controls, or as an adjunct treatment were searched across seven databases. …”
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Comparative analysis of morphologival parameters in isolated and fused L5 spondylolysis patients on the basis of CT features by Rui Ma, Xiaoxia Huang, Luyao Li, Ye Kai, Jun Liu, Gao Leilei, Xiangning Sun, Yong Teng

“…Patients with a pars interarticularis separation distance ≥ 2 mm were classified into the isolated group (Group A, 66 patients), while those with a separation distance < 1 mm were classified into the fused group (Group B, 51 patients).Additionally, 117 patients without spondylolysis but experiencing lower back pain were included as the control group (group C). Multislice spiral computed tomography (MSCT) was used to measure the morphological parameters of the L5 vertebra in all three groups, including the sagittal pedicle height (SPH), transverse pedicle width (TPW), transverse pedicle vertical length (TPVL), pedicle screw trajectory length (PSTL), pedicle angle of attack (PAA), frontal vertebral body height (FVH), posterior vertebral body height (PVH), sagittal midline intervertebral space height (SMISH), horizontal vertebral body angle (HVA), and vertical vertebral body angle (VVA). …”
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Soil moisture controls over carbon sequestration and greenhouse gas emissions: a review by Yuefeng Hao, Jiafu Mao, Charles M. Bachmann, Forrest M. Hoffman, Gerbrand Koren, Haishan Chen, Hanqin Tian, Jiangong Liu, Jing Tao, Jinyun Tang, Lingcheng Li, Laibao Liu, Martha Apple, Mingjie Shi, Mingzhou Jin, Qing Zhu, Steve Kannenberg, Xiaoying Shi, Xi Zhang, Yaoping Wang, Yilin Fang, Yongjiu Dai

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Extensive Inactive Neurocysticercosis: A Case Report in Mbeya, Southern Highlands of Tanzania by Makasi CE, Ngowi BJ, Stelzle D, Kilale AM, Mahande MJ, Welte TM, Winkler AS, Mmbaga BT

“…Taenia solium serology was done by LDBIO Cysticercosis IgG Western Blot test, which tested positive for antibodies, but the apDia Cysticercosis Antigen (Ag) ELISA antigen test was negative. His computed tomography (CT) scan of the brain showed approximately 138 calcified neurocysticercosis typical lesions, 108 being located in the parenchyma, 15 in the extra parenchyma, and 15 in the subarachnoid space, consistent with a diagnosis of extensive calcified NCC. …”
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Amyloidogenic immunoglobulin light chains disturb contractile function and calcium transients in a human cardiac spheroid model of light chain (AL) amyloidosis by Mélanie Bézard, Jean-Sébastien Vartanian-Grimaldi, Julien Henri, Denisa Calin, Amira Zaroui, Mounira Kharoubi, Thibaud Damy, Onnik Agbulut, Ekaterini Kordeli

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Single-qubit anisotropy induced by micromagnet in Si-MOS quantum dot by Ning Chu, Xin Zhang, Rong-Long Ma, Zhen-Zhen Kong, Wei-Zhu Liao, Sheng-Kai Zhu, Chu Wang, Ao-Ran Li, Gui-Lei Wang, Gang Cao, Hai-Ou Li, Guo-Ping Guo

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Impacts of irrigation expansion on moist-heat stress based on IRRMIP results by Yi Yao, Agnès Ducharne, Benjamin I. Cook, Steven J. De Hertog, Kjetil Schanke Aas, Pedro F. Arboleda-Obando, Jonathan Buzan, Jeanne Colin, Maya Costantini, Bertrand Decharme, David M. Lawrence, Peter Lawrence, L. Ruby Leung, Min-Hui Lo, Narayanappa Devaraju, William R. Wieder, Ren-Jie Wu, Tian Zhou, Jonas Jägermeyr, Sonali McDermid, Yadu Pokhrel, Maxwell Elling, Naota Hanasaki, Paul Muñoz, Larissa S. Nazarenko, Kedar Otta, Yusuke Satoh, Tokuta Yokohata, Lei Jin, Xuhui Wang, Vimal Mishra, Subimal Ghosh, Wim Thiery

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Spatial and temporal heterogeneity of soil respiration in a bare-soil Mediterranean olive grove by S. Aranda-Barranco, S. Aranda-Barranco, P. Serrano-Ortiz, P. Serrano-Ortiz, A. S. Kowalski, A. S. Kowalski, E. P. Sánchez-Cañete, E. P. Sánchez-Cañete

“…The results indicate that <span class="inline-formula"><i>R</i>_{s  Under-Tree}</span> was 3 times higher than <span class="inline-formula"><i>R</i>_s Alley</span> in the annual computations. Higher <span class="inline-formula"><i>R</i>_s</span> was found on the southern face, and an exponential decay of <span class="inline-formula"><i>R</i>_s</span> was observed until the alley's center was reached. …”
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Figuring Out Gas and Galaxies In Enzo (FOGGIE). VIII. Complex and Stochastic Metallicity Gradients at z > 2 by Ayan Acharyya, Molly S. Peeples, Jason Tumlinson, Brian W. O’Shea, Cassandra Lochhaas, Anna C. Wright, Raymond C. Simons, Ramona Augustin, Britton D. Smith, Eugene Hyeonmin Lee

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Network and systems biology approaches help investigate gene regulatory interactions between Salmonella disease and host in chickens: Model‐based in silico evidence combined with g... by Reza Tohidi, Hoda Javaheri Bargourooshi, Arash Javanmard

“…To start, we used free computational tools and online bioinformatics resources, including predicting gene function using a multiple association network integration algorithm (geneMania), the Kyoto Encyclopedia of Genes and Genomes, the Annotation, Visualization and Integrated Discovery (DAVID) database and the stimulator of interferon genes. …”
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Physics-Informed Neural Networks for Modal Wave Field Predictions in 3D Room Acoustics by Stefan Schoder

“…Different methods like hyperparameter optimization, adaptive refinement, Fourier feature engineering, and locally adaptive activation functions with slope recovery are tested to tailor the PINN’s accuracy to an experimentally validated finite element analysis reference solution computed with openCFS. The hyperparameter study and optimization are conducted regarding the network depth and width, the learning rate, the used activation functions, and the deep learning backends (PyTorch 2.5.1, TensorFlow 2.18.0 1, TensorFlow 2.18.0 2, JAX 0.4.39). …”
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Harnessing genomic and bioinformatic data to broaden understanding of leukaemia across continents by Gumelar Gugun, Ulfa Mia Maria, Amukti Danang Prasetyaning, Irham Lalu Muhammad, Yuliani Sapto, Adikusuma Wirawan, Khairi Sabiah, Darmawi Darmawi, Chong Rockie, Ates Ilker, Singh Dilpreet, Chavan Aditya Ashok

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An Arctic sea ice concentration data record on a 6.25&thinsp;km polar stereographic grid from 3 years of Landsat-8 imagery by H.-S. Jung, S.-M. Lee, S.-M. Lee, J.-H. Kim, K. Lee

“…The classified data were projected onto a 6.25 km polar stereographic grid, and SIC for each grid cell was obtained by counting ice-classified pixels within the grid. SIC was only computed for grid cells where more than 99 % of their area was covered with Landsat-8 pixels to limit the uncertainty in SIC arising from grids that are not fully concentrated with Landsat-8 pixels. …”
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Hooks, Lines, and Sinkers: How Active Galactic Nucleus Feedback and Cosmic-Ray Transport Shape the Far-infrared–Radio Correlation of Galaxies by Sam B. Ponnada, Rachel K. Cochrane, Philip F. Hopkins, Iryna S. Butsky, Sarah Wellons, N. Nicole Sanchez, Cameron Hummels, Yue Samuel Lu, Dušan Kereš, Christopher C. Hayward

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Characterizing local forest structural complexity based on multi-platform and -sensor derived indicators by Patrick Kacic, Ursula Gessner, Christopher R. Hakkenberg, Stefanie Holzwarth, Jörg Müller, Kerstin Pierick, Dominik Seidel, Frank Thonfeld, Michele Torresani, Claudia Kuenzer

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Effectiveness of the Modified WHO Labour Care Guide to Detect Prolonged and Obstructed Labour Among Women Admitted at Eight Publicly Funded, Midwife-Led Community Health Facilities... by Mugyenyi GR, Tumuhimbise W, Atukunda EC, Tibaijuka L, Ngonzi J, Kayondo M, Kanyesigye M, Musimenta A, Yarine FT, Byamugisha JK

“…Godfrey R Mugyenyi,1,2 Wilson Tumuhimbise,3 Esther C Atukunda,2,4 Leevan Tibaijuka,1 Joseph Ngonzi,1 Musa Kayondo,1 Micheal Kanyesigye,2 Angella Musimenta,3 Fajardo T Yarine,1 Josaphat K Byamugisha5 1Obstetrics and Gynaecology Department, Mbarara University of Science and Technology, Mbarara, Uganda; 2Support Mom’s Project, Mbarara University of Science and Technology, Mbarara, Uganda; 3Computing and Informatics Department, Mbarara University of Science and Technology, Mbarara, Uganda; 4Pharmacy department, Mbarara University of Science and Technology, Mbarara, Uganda; 5Obstetrics and Gynaecology department, Makerere University College of Health Sciences, Kampala, UgandaCorrespondence: Godfrey R Mugyenyi, Email gmugyenyi@must.ac.ugBackground: Obstructed labour, a sequel of prolonged labour, remains a significant contributor to maternal and perinatal deaths in low resource settings.Objective: We evaluated the modified WHO labour care guide (LCG) in detecting prolonged/obstructed labour compared to the traditional partograph at publicly funded maternity centers in Southwestern Uganda.Methods: LCG was deployed to monitor labour by trained health care providers in 2023. …”
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Spatial Characterization of Woody Species Diversity in Tropical Savannas Using GEDI and Optical Data by Franciel Eduardo Rex, Carlos Alberto Silva, Eben North Broadbent, Ana Paula Dalla Corte, Rodrigo Leite, Andrew Hudak, Caio Hamamura, Hooman Latifi, Jingfeng Xiao, Jeff W. Atkins, Cibele Amaral, Ernandes Macedo da Cunha Neto, Adrian Cardil, Angelica M. Almeyda Zambrano, Veraldo Liesenberg, Jingjing Liang, Danilo Roberti Alves De Almeida, Carine Klauberg

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