Actively protective combinatorial analysis: A scalable novel method for detecting variants that contribute to reduced disease prevalence in high-risk individuals by J Sardell, S Das, K Taylor, C Stubberfield, A Malinowski, M Strivens, S Gardner

“…We show how this can be used to identify mechanisms in the background of normal cellular biology that work to slow or stop progression of complex, chronic diseases.Actively protective combinatorial analysis identifies combinations of features that contribute to reducing risk of disease in individuals who remain healthy even though their genomic profile suggests that they have high risk of developing disease. …”
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Data-Driven Technologies for Energy Optimization in Smart Buildings: A Scoping Review by Joy Dalmacio Billanes, Zheng Grace Ma, Bo Nørregaard Jørgensen

“…Despite the benefits, challenges such as high initial costs, technical complexities, security risks, and user acceptance hinder their widespread adoption. …”
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Correlation Analysis Between Multi-Drug Resistance Phenotype and Virulence Factor Expression of Clinical <i>Pseudomonas aeruginosa</i> by Wenli Xu, Runcheng Zhou, Jingwei Pan, Zhuangcong Liu, Xuyu Huang, Yueqiao Lin, Nan Li, Kecan Chen, Wenbo Sun, Yi Deng, Anping Yang, Xin Chen

“…The correlation between multidrug-resistant PA and virulence factor expression is complex. PA, which were good at producing pyocyain and forming biofilm, were highly resistant to cephalosporins, beta-lactams and carbepenems; hence, such drugs are not proper for anti-infective treatment in clinics.…”
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Failure mechanics mechanisms and permeability stage evolution of limestone considering wave velocity and failure surface characteristics by Genshui Wu, Weijian Yu, Bao Pan, Chuangfeng Fang, Hanxiao Guo, Chao Zhang

“…The confining pressure affects the internal pore and crack structure of the rock, generating complex seepage network channels and causing changes in permeability properties. …”
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Prevalence and predictors of NTM in presumed/confirmed drug-resistant TB by E.T. Abbew, R. Laryea, F. Sorvor, Y.A. Poku, N. Lorent, D. Obiri-Yeboah, L. Lynen, L. Rigouts

“…The MPT64 assay was performed on positive cultures to distinguish between Mycobacterium tuberculosis complex MTBc and NTM. NTM isolates were re-cultured for species identification using GenoType® Mycobacterium CM/AS line-probe assay, polymerase chain reaction, and Sanger sequencing targeting 16S rRNA and rpoB genes. …”
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Effect of Polymer Network Architecture on Adsorption Kinetics at Liquid–Liquid Interfaces: A Comparison Between Poly(NIPAM-co-AA) Copolymer Microgels and Interpenetrating Network M... by Galina A. Komarova, Elena Yu. Kozhunova, Rustam A. Gumerov, Igor I. Potemkin, Irina R. Nasimova

“…Specifically, the use of stimuli-responsive particles can introduce new properties and broaden the application range of such complex systems. Recently, we demonstrated that emulsions stabilized by microgels composed of interpenetrating networks (IPNs) of poly-N-isopropylacrylamide (PNIPAM) and polyacrylic acid (PAA) exhibit higher colloidal stability upon heating compared to PNIPAM homopolymer and other relevant PNIPAM-based copolymer counterparts. …”
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Consultation diagnoses and procedures billed among recent graduates practicing general otolaryngology – head & neck surgery in Ontario, Canada by Antoine Eskander, Paolo Campisi, Ian J. Witterick, David D. Pothier

“…Practitioners with a narrow range of procedure codes or a high rate of complex procedure codes, were deemed subspecialists and therefore excluded. …”
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Together throughout the year: seasonal patterns of bacterial and eukaryotic microbial communities in a macrotidal estuary by Vincent Hervé, Jérôme Morelle, Josie Lambourdière, Pascal Jean Lopez, Pascal Claquin

“…Abstract Background Estuaries are complex ecosystems linking river and marine environments, where microorganisms play a key role in maintaining ecosystem functions. …”
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Mental Health Services for Serious Mental Illness: Scoping Review of Randomised Controlled Trials by Pablo Roson Rodriguez, Xiao Chen, Marcelo Arancibia, Eva Madrid, Farhad Shokraneh, Clive E. Adams, Juan Víctor Ariel Franco

“…Trials classification was difficult due to the poor report of the characteristics of these complex interventions. This database can be used to plan and prioritise systematic reviews according to the needs of stakeholders. …”
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Fetoplacental Discrepancy with Normal Karyotype in Amniotic Fluid and Two Different Cell Lines in Placenta by Veronica Ortega, Christina Mendiola, Eric Williamson, Kenneth Higby, Gopalrao V. N. Velagaleti

“…However, we could not confirm the possibility that CPM contributed to the IUFD in our case given the complex medical history of the mother.…”
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Pinglu Canal Construction and Its Impact on Wildlife Habitat Connectivity: A Multi-Species Network Analysis and Ecological Restoration Strategy by Yuan Cao, Kai Su, Yongfa You, Xuebing Jiang, Chuang Li, Junjie Chen

“…This study uses the MaxEnt model to identify habitats for 11 wildlife species within the study area, categorized into terrestrial mammals, amphibians and reptiles, forest birds, and water birds, thereby constructing a multi-species habitat connectivity network (MHCN). Through complex network analysis, we assess habitat connectivity before and after the canal’s construction, as well as after implementing habitat optimization strategies. …”
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Genomic signatures of habitat isolation and paleo-climate unveil the “island-like” pattern in the glasshouse plant Rheum nobile by Hum Kala Rana, Santosh Kumar Rana, Hang Sun, Dong Luo

“…Ensemble Species Distribution Modelling suggested multiple refugia during or even before the Last Glacial Maximum, indicating a complex historical distribution. The “island-like” genetic patterns of Rheum nobile results from fragmented habitats and prolonged isolation during the Quaternary glaciation. …”
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piR-26441 inhibits mitochondrial oxidative phosphorylation and tumorigenesis in ovarian cancer through m6A modification by interacting with YTHDC1 by Jing Yuan, Bu-Min Xie, Yu-Meng Ji, Hai-Juan Bao, Jie-Lin Wang, Jia-Chen Cheng, Xiang-Chun Huang, Yang Zhao, Shuo Chen

“…The resultant TSFM loss reduced mitochondrial complex I activity and mitochondrial OXPHOS, leading to mitochondrial dysfunction in OC cells, increased reactive oxygen species levels, and thus, DNA damage and apoptosis in OC cells, thereby inhibiting OC progression. …”
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Prevalence and morphology of middle mesial canals in mandibular first molars and their relationship with anatomical aspects of the mesial root: a CBCT analysis by Dandan Wang, Ru Wang, Hongyan Xu, Qianqian Zhang, Yali Guo

“…Conclusions The morphology of MMCs is complex, and most of them exhibit confluent canals. …”
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Multi-omic and machine learning analysis of mitochondrial RNA modification genes in lung adenocarcinoma for prognostic and therapeutic implications by Xiao Zhang, Jiatao Liu, Yaolin Cao, Wei Wang, Haoran Lin, Yue Yu

“…Lung cancer remains the leading cause of cancer-related deaths, driven by complex pathogenesis and poor prognosis. Recognizing the pivotal role of mitochondrial RNA modifications (MRM) in cancer progression, this study aims to provide a comprehensive analysis of MRM-related genes and their clinical relevance in lung adenocarcinoma (LUAD). …”
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Modeling quinoa growth under saline and water-limiting conditions using SWAP-WOFOST by Diana C. Estrella Delgado, Tom De Swaef, Jan Vanderborght, Eric Laloy, Gerda Cnops, Maarten De Boever, Abdelaziz Hirich, Ayoub El Mouttaqi, Sarah Garré

“…Quinoa (Chenopodium quinoa Willd.) is a “salt-loving” plant, known for its tolerance to drought and salinity using complex stress responses. However, available models of quinoa growth are limited, particularly under salinity stress. …”
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Prediction of Adhesively Bonded Polyurethane-to-Steel Double Butt Joint Failure Using Uncertainty Analysis by Xiaofu Li, Chuanpeng Ji, Zhi Zhang, Shiwei Zhang, Hongqin Liu, Shulin Wang

“…However, damage in the mode of adhesive failure and cohesive failure, as well as the adherend failure, could still occur, and it has been realized that the reliability of the adhesively bonded joint depends on numerous complex and even nonlinearly interacting factors. …”
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Epidemiological and molecular characteristics of extraintestinal pathogenic escherichia coli isolated from diseased cattle and sheep in Xinjiang, China from 2015 to 2019 by Xiaoxiao Gu, Qin Wu, Yingjin Chai, Xin Huang, Xia Zhou, Mengli Han, Tongzhong Wu, Xingxing Zhang, Fagang Zhong

“…Escherichia coli infection is common and tends to be complex in Xinjiang, a major region of cattle and sheep breeding in China. …”
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The perspectives of metabolomics studies of potato plants by R. K. Puzanskiy, V. V. Yemelyanov, T. A. Gavrilenko, M. F. Shishova

“…The sum of metabolites, which is produced as a result of metabolic network activity, is defined as metabolome. Complex studies of metabolic diversity with the use of modern state-of-the-art chromatography approaches and highly precise detection of individual compounds revealed specificity of metabolic spectra from subcellular to organism levels and its amazing plasticity under the influence of a variety of internal and external stimuli. …”
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Experimental Study of Volumetric Fracturing Properties for Shale under Different Stress States by Hongjian Wang, Jin Li, Fei Zhao, Jinyu Dong, Yanzong Cui, Wanlin Gong

“…Additionally, when the lateral in situ stress difference coefficient is smaller, the rock specimen has an evident trend to form more complex cracks. When the shale rock was subjected to lateral disturbance loads, the critical failure strength was approximately 10 MPa less than that in the state of constant loading, indicating that the specimen with disturbance loads is more likely to be fractured. …”
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