NMDA Reduces Tau Phosphorylation in Rat Hippocampal Slices by Targeting NR2A Receptors, GSK3β, and PKC Activities by Audrée De Montigny, Ismaël Elhiri, Julie Allyson, Michel Cyr, Guy Massicotte

“…The molecular mechanisms that regulate Tau phosphorylation are complex and currently incompletely understood. In the present study, pharmacological inhibitors were deployed to investigate potential processes by which the N-methyl-D-aspartate (NMDA) subtype of glutamate receptors modulates Tau phosphorylation in rat hippocampal slices. …”
Get full text

Integrated microfluidics-based construction of anti-BTN2A2 gel droplet cell preparations for non-invasive tumor-infiltrating lymphocyte therapy by Yishen Tian, Jingxuan Li, Na Yang, Yang Zhao, Jiancao Zuo, Hang Xiong, Yiwen Pan, Li Xiao, Min Su, Feng Han, Zhixu He, Rong Hu

“…Specifically, the cell preparation exerted its anti-tumor effects through multiple mechanisms: Firstly, the surface BTN2A2 antibodies effectively inhibited the proliferation of Tregs and MDSCs within the tumor microenvironment; Secondly, leveraging the T cell antigen receptors (TCRs) present in the blood T cells, which were similar to those of tumor-infiltrating lymphocytes, significantly enhanced their targeting and cytotoxic capabilities; Furthermore, the CMP component within the droplets effectively promoted the infiltration of T cells into tumor tissues. In the complex immunosuppressive microenvironment, the synergistic action of these components markedly enhanced the clearance efficacy of the immune system. …”
Get full text

Mechanical response of deep circular shaft supported by steel frame and sprayed concrete in loess-paleosol sequence: A case study by Jiawei Kang, Guohua Deng, Shengjun Shao, Liqin Wang

“…Generally, the actual lateral pressure exerted on underground structures is relatively small and its distribution is complex. A deep circular shaft, 53.5 m deep and 9.6 m in diameter, was constructed in the loess-paleosol sequence in China, supported by a steel frame and sprayed concrete. …”
Get full text

Targeting lipid metabolism of macrophages: A new strategy for tumor therapy by Nan Shao, Hui Qiu, Jing Liu, Daimin Xiao, Juanjuan Zhao, Chao Chen, Jiajia Wan, Mengmeng Guo, Guiyou Liang, Xu Zhao, Lin Xu

“…In particular, we emphasize that there is complex lipid metabolism connections between TAMs and distinct tumors, which influences TAM to bias from M1 to M2 phenotype in tumor progression, and ultimately promotes tumor occurrence and development. …”
Get full text

Getting more by asking for less: Linking species interactions to species co-distributions in metacommunities by Barbier, Matthieu, Bunin, Guy, Leibold, Mathew A.

“…At its core, the problem is that distributional patterns reflect the 'realized niche', the net result of a complex interplay of processes involving dispersal, environmental, and interaction effects. …”
Get full text

Scientific basis for design low-speed synchronous permanent magnet generators for wind power plants by A. A. Tatevosyan

“…In this paper, the scientific basis for designing wind power plants (WPP) with low-speed synchronous generators on permanent magnets (SGPM) is understood as a system of scientific knowledge that forms the theoretical basis for the practice of designing a complex object, such as WPP consisting of interconnected equipment and structures designed to convert wind energy into electrical energy. …”
Get full text

Inhibitory Effect on the Tyrosinase Activity and Low Cytotoxicity of Monounsaturated Long-Chain Chelating Fatty Ester by ANTONIO SERGIO C. CARVALHO, TATIANA N. PEDROSA, HERONILDES A. DANTAS FILHO, RAQUEL C. MONTENEGRO, EMERSON S. LIMA, MARNE C. DE VASCONCELLOS, ALBERDAN S. SANTOS

“…The IC50 and IC90 values for tyrosinase inhibitory activity for chelating fatty ester and their complexes are values > 400 µM. Finally, the assay with the series showed no hemolytic activity (EC50> 250 μg mL-1), and not cytotoxic to B16F10, ACP-02, and human dermal fibroblast cells at 100 µM and showed no hemolytic potential at the concentration of IC50 250 µM.…”
Get full text

Discovery of conserved peptide-MHC epitopes for directly alloreactive CD8+ T cells by Alexandra E. Hill, Eric T. Son, Moumita Paul-Heng, Chuanmin Wang, Shivanjali Ratnaseelan, Martina Denkova, Pouya Faridi, Asolina Braun, Anthony W. Purcell, Nicole A. Mifsud, Alexandra F. Sharland

“…Mass Spectrometry allied with in-vivo generation of activated alloreactive T cell populations and tetramer screening facilitates the identification of endogenous peptides that are directly recognised in complex with allogeneic Major Histocompatibility class I (MHC I) molecules by alloreactive CD8+ T cells. …”
Get full text

Computational design, expression, and characterization of a Plasmodium falciparum multi-epitope, multi-stage vaccine candidate (PfCTMAG) by Joan A. Chick, Nadege N. Abongdia, Robert A. Shey, Tobias O. Apinjoh

“…Current malaria vaccines are limited in efficacy, duration of protection, and safety, due to the high antigenic diversity and complex life cycle of the Plasmodium parasite. This study sought to design and assess a more effective multi-stage, multi-epitope vaccine candidate for the control of malaria. …”
Get full text

Effects of straw amendment on the bioavailability of selenite in soil and its mechanisms by Mingxing Qi, Dan Wang, Hui Zhai, Fei Zhou, Hao Wu, Wanchen Zhao, Rongxin Ren, Jingyi Shi, Dongli Liang

“…Consequently, HA–Se was more likely to form in krasnozems enriched with HA. 2D-COS evidenced that HA mineralization promoted Se bioavailability in krasnozems with high-Se treatment. After selenite complexed with saturated and unsaturated aliphatic carboxyl groups (CO) of DOM, it formed Hy–Se and FA–Se in Lou soil, which could be directly absorbed by wheat roots. …”
Get full text

End-to-end neural automatic speech recognition system for low resource languages by Sami Dhahbi, Nasir Saleem, Sami Bourouis, Mouhebeddine Berrima, Elena Verdú

“…The rising popularity of end-to-end (E2E) automatic speech recognition (ASR) systems can be attributed to their ability to learn complex speech patterns directly from raw data, eliminating the need for intricate feature extraction pipelines and handcrafted language models. …”
Get full text

How mechanochemistry affects the composition and properties of disordered fluorite BaSnF4? by Mercadier, Briséïs, Legein, Christophe, Duttine, Mathieu, Body, Monique, Gutierrez, Ana Gabriela Porras, Leclerc, Sandrine, Lebedev, Oleg,  Masquelier, Christian, Dambournet, Damien

“…Overall, this work demonstrates that the interplay between the microstructure, composition and the transport properties of fluoride ion conductors is indeed complex, with many factors at play, including size, strain, defects or composition.…”
Get full text

Four Decades of <i>Bacillus</i> Biofertilizers: Advances and Future Prospects in Agriculture by Xinmai Wu, Yan Liu, Baolei Jia, Lili Tao, Han Li, Jingbang Wang, Ziqi Yuan, Xiaobao Sun, Yanlai Yao

“…Key research hotspots have evolved from basic applications to complex interactions involving synthetic microbial communities and advanced multi-omics techniques. …”
Get full text

Biodegradation of CAHs and BTEX in groundwater at a multi-polluted pesticide site undergoing natural attenuation: Insights from identifying key bioindicators using machine learning... by Feiyang Xia, Tingting Fan, Mengjie Wang, Lu Yang, Da Ding, Jing Wei, Yan Zhou, Dengdeng Jiang, Shaopo Deng

“…However, the interpretation of the diverse microbial communities in relation to complex pollutants is still challenging, and there is limited research in multi-polluted groundwater. …”
Get full text

On Modeling Agent Behavior Change Through Multi-Typed Information Diffusion in Online Social Networks by Masaaki Miyashita, Norihiko Shinomiya, Daisuke Kasamatsu, Genya Ishigaki

“…However, existing models addressing misinformation diffusion often lack the capacity to represent the complex behavioral phenomena driven by multiple information types and do not fully capture the subjective decision-making processes of individuals influenced by information. …”
Get full text

Strengthening teamwork and respect (STAR) in maternity units: developing a health system intervention in South Africa by Tanya Doherty, Ruwayda Petrus, Sandra Land, Christiane Horwood, Veronique Filippi, Lyn Haskins, Cleo Phewa, Sphindile Mapumulo, Silondile Luthuli, Vaughn M. John

“…Disrespect and abuse in maternity services in South Africa has been described over several decades and are rooted in the country’s complex socio-political landscape and unequal health system which places strain on public sector health professionals. …”
Get full text

Dataset for comparative analysis of precision metagenomics and traditional methods in urinary tract infection diagnosticsNCBI by Rob E. Carpenter, Sadia Almas, Vaibhav K. Tamrakar, Rahul Sharma

“…By offering insights into both polymicrobial infections and rare pathogens, this dataset supports the advancement of diagnostic strategies for complex and chronic UTIs.…”
Get full text

Optimization of Fused Deposition Modeling Parameters for Mechanical Properties of Polylactic Acid Parts Based on Kriging and Cuckoo Search by Yuan Yang, Yiyang Wang, Bowen Xue, Changxu Wang, Bo Yang

“…As an emerging rapid manufacturing technology, 3D printing has been widely applied in numerous fields such as aerospace, shipbuilding, and wind power, by virtue of its advantage in efficiently fabricating components with complex structures and integrated functions. In response to the problems of poor mechanical properties and difficulty in selecting process parameters for fused deposition modeling (FDM), this paper analyzed the principle of FDM and proposed a parameter optimization method based on a Kriging and Cuckoo Search (CS) algorithm aimed at improving the mechanical properties of 3D printed polylactic acid (PLA) parts. …”
Get full text

Testing of diagnostic test-systems for detection of antibodies to foot-and-mouth disease virus structural proteins with enzyme-linked immunosorbent assay for their serotype specifi... by N. N. Lugovskaya, E. A. Silanteva, T. V. Okovytaya, A. A. Kharitonova, Y. M. Gochmuradov, E. A. Razgulyaeva, O. O. Budina, E. A. Yasneva

“…Inconclusive test results require confirmation with other serological tests. Complex tests for FMDV using different diagnostic methods such as ELISA with standard and reference test-systems and/or virus neutralization test in cell culture are to be considered as the best option.…”
Get full text

A guide for the generation of repositories of clinical samples for research on Chagas disease. by Nieves Martínez-Peinado, Juan Carlos Gabaldón-Figueira, Roberto Rodrigues Ferreira, María Carmen Thomas, Manuel Carlos López, Tania Cremonini Araújo-Jorge, Belkisyolé Alarcón de Noya, Soledad Berón, Janine Ramsey, Irene Losada Galván, Alejandro Gabriel Schijman, Adriana González Martínez, Andrés Mariano Ruiz, Gimena Rojas, Roberto Magalhães Saraiva, Oscar Noya-González, Andrea Gómez, Rosa A Maldonado, Jimmy Pinto, Faustino Torrico, Ivan Scandale, Fernán Agüero, María-Jesús Pinazo, Joaquim Gascón, Alejandro Marcel Hasslocher-Moreno, Julio Alonso-Padilla, NHEPACHA Network (New Tools for the Diagnosis and Evaluation of Chagas Disease)

“…Currently, 2 anti-parasitic drugs are available to treat the disease (nifurtimox and benznidazole), but diagnostic methods require of a relatively complex infrastructure and trained personnel, limiting its widespread use in endemic areas, and the access of patients to treatment. …”
Get full text