Targeting SLC4A4: A Novel Approach in Colorectal Cancer Drug Repurposing by Krunal Pawar, Pramodkumar P. Gupta, Pooran Singh Solanki, Ravi Ranjan Kumar Niraj, Shanker L. Kothari

“…Background: Colorectal cancer (CRC) is a complex and increasingly prevalent malignancy with significant challenges in its treatment and prognosis. …”
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Extreme precipitation associated with atmospheric rivers over West Antarctic ice shelves: insights from kilometre-scale regional climate modelling by E. Gilbert, D. Pishniak, J. A. Torres, A. Orr, M. Maclennan, M. Maclennan, N. Wever, K. Verro, K. Verro

“…The RCM simulations suggest that rainfall during these events can fall directly as supercooled drizzle but also that rainfall is concentrated around steep terrain due to the interaction of ARs with complex orography. We also show that while the amount of MetUM-simulated snowfall was comparatively resolution-insensitive, the amount of rainfall simulated was not, with rainfall amounts over Thwaites Ice Shelf 4–16 times higher in 1 km simulations compared to 12 km simulations. …”
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Will the increase of medical equipment affect medical expenditure? Empirical evidence from a quasi-experiment in China by Qiwei Deng, Zhongliang Zhou, Chi Shen, Dan Cao, Dantong Zhao, Yaxin Zhao, Jianmin Gao

“…Results The increase in the number of large-scale medical equipment by 1 — regardless of the initial configuration — resulted in the increase of the average cost per outpatient visit and the average cost per inpatient visit by 10.6% (p < 0.05) and 8.0% (p < 0.05), respectively. Our complex difference in differences model illustrates that the increase in the number of large-scale medical equipment by 1 — regardless of the initial configuration—results in an increase in the average diagnostic cost per outpatient visit and the average diagnostic cost per inpatient visit by 27. 3% (p < 0.01) and 25. 5% (p < 0.01), respectively. …”
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Vascular Contractility Relies on Integrity of Progranulin Pathway: Insights Into Mitochondrial Function by Shubhnita Singh, Ariane Bruder, Rafael M. Costa, Juliano V. Alves, Sivakama Bharathi, Eric S. Goetzman, Thiago Bruder‐Nascimento

“…Background The complex interplay between vascular contractility and mitochondrial function is central to cardiovascular disease. …”
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Study on scour simulation and boundary condition conversion technology for a shallow foundation bridge by Gangping Fan, Huanzhe Li, Tianzhuo Wang, Jian Che, Xing Li, Chunyang Dou, Tong Wu

“…This method addresses the current limitations in simulating complex scouring forms in bridge flood damage research, providing reliable technical support for subsequent studies on the damage behavior of shallow foundation bridges under flood scouring conditions.…”
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Evaluation of Antimicrobial and Wound Healing Effects of Gold Nanoparticles Containing Abelmoschus esculentus (L.) Aqueous Extract by Shahla Korani, Khodabakhsh Rashidi, Mona Hamelian, Ali R. Jalalvand, Ahmad Tajehmiri, Mitra Korani, Thozhukat Sathyapalan, Amirhossein Sahebkar

“…Background. Wound healing is a complex process of replacing devitalized cellular structures and tissues with healthy cells and tissue. …”
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Blue elixir of youth and wellness: The multicomponent-multitarget paradigm of Curcuma caesia Roxb by Sabrina Burattini, Federico Gianfanti, Francesco Onesimo, Sabrina Donati Zeppa, Barbara Canonico, Mariele Montanari, Giovanna Panza, Daniele Lopez, Giosuè Annibalini, Fabiana Fanelli, Roberta Saltarelli, Michele Mari, Michele Retini, Riham Osman, Aghna Mariam, Matteo Micucci, Giovanni Caprioli, Agnese Santanatoglia, Deborah Agostini, Michela Battistelli

“…Aging is a complex biological process influenced by genetic, environmental, and lifestyle factors, including diet and exercise. …”
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Comparative miRNAome combined with transcriptome and degradome analysis reveals a novel miRNA-mRNA regulatory network associated with starch metabolism affecting pre-harvest sprout... by Longqing Sun, Ting Zhao, Dandan Qin, Jing Dong, Daorong Zhang, Xifeng Ren

“…Conclusion Our findings revealed the complex impact of the miRNA-mediated mechanism for forming intrinsic and inherent differences, which resulting in significant difference on PHS performance between white wheat varieties.…”
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Multi-scale fracture characterization method for transitional shale reservoir based on post-stack multi-attribute ant-tracking fusion and pre-stack wide-azimuth gathers AVAZ analys... by Hongjie Peng, Jingtao Zhao, Zhen Qiu, Qin Zhang, Wen Liu, Weiliang Kong, Wanli Gao, Tongjie Sheng, Wenyu Li, Yugang Yang

“…The characteristics of transitional shale reservoirs, including complex lithological combinations, frequent changes in lithology, low resolution and variable frequency of seismic data, as well as the presence of strong reflection shielding in coal seams, significantly influence fracture prediction. …”
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Does environmental public policy act as a slowdown for urban expansion? A 2012-2023 analysis with Landsat images by Jorge Alberto Escandón-Calderón, Columba Jazmín López-Gutiérrez, Demian Vázquez-Muñoz, Marco Antonio Gálvez-Lomelín, Marcela Rosas-Chavoya

“…The budget increase focused on environmental conservation activities and rural development of the CZ appears to have affected the dynamics of urban expansion in the peri-urban area of one of the most complex cities in the world.…”
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A Novel CGM Metric-Gradient and Combining Mean Sensor Glucose Enable to Improve the Prediction of Nocturnal Hypoglycemic Events in Patients with Diabetes by Jingzhen Li, Xiaojing Ma, Igbe Tobore, Yuhang Liu, Abhishek Kandwal, Lei Wang, Jingyi Lu, Wei Lu, Yuqian Bao, Jian Zhou, Zedong Nie

“…Additionally, the results indicated that the specificity and sensitivity based on the proposed method were better than the conventional metrics of low blood glucose index (LBGI), coefficient of variation (CV), mean absolute glucose (MAG), lability index (LI), etc., and the complex metrics of MSG+LBGI, MSG+CV, MSG+MAG, and MSG+LI, etc. …”
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It tastes sweeter when melted: Exploring the impact of food temperature on tongue temperature and perceived sweetness/vanilla by Hannah McNeill, Rebecca Ford, Ian Fisk, Margaret Thibodeau, Gloria Liu, Marion Doyennette, Qian Yang

“…The relationship between perceived sweetness intensity and temperature of food is complex. Previous research on the effect of temperature on sweetness perception primarily focused on single solutions. …”
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Effect of infill pattern on mechanical properties of 3D printed PLA-Zn composites for drone frame structures: A topology optimization integrated application study by P. Arunkumar, D. Balaji, N. Radhika, L. Rajeshkumar, Sanjay Mavinkere Rangappa, Suchart Siengchin

“…The capability of additive manufacturing (AM) to handle complex geometries with ease has opened many avenues in topological optimization and lightweight structural design. …”
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An ecological connectivity dataset for Black Sea obtained from sea currentsZenodo by Nikolaos Nagkoulis, Christos Adam, Ioannis Mamoutos, Stelios Katsanevakis, Antonios D. Mazaris

“…Sea currents are essential for exploring marine structural connectivity, but transforming sea current data into spatial connectivity matrices involves complex and resource-intensive processing steps to ensure accuracy and usability. …”
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Boosting singlet oxygen generation for salinity wastewater treatment through co-activation of oxygen and peroxymonosulfate in photoelectrochemical process by Qianqian Yang, Zhiyuan Feng, Yanbo Zhou, Hongying Zhao, Guohua Zhao

“…The COD removal for coal wastewater and complex industrial wastewater in real scenarios is found to reach a value of 90%-96% in 3 h. …”
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Biotin's protective effects against nicotine withdrawal-induced anxiety and depression: Mechanistic insights into serotonin, inflammation, BDNF, and oxidative stress in male rats by Dawood Hossaini, Mohammad Jalal Nazari, Khan Baba Ghazanfar, Mohammad Edris Amiri, Mohammad Tariq Anwary, Mohammad Jawad Jawad, Murtaza Haidary

“…Discussion: This study suggests that biotin may have significant therapeutic potential for alleviating the side effects associated with nicotine withdrawal, particularly anxiety and depression. Given the complex neurobiological mechanisms underlying withdrawal symptoms, biotin's ability to modulate critical signaling pathways such as serotonin metabolism, neuroinflammation, and oxidative stress could provide a multifaceted treatment approach.…”
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Towards a new spatial representation of bone remodeling by Jason M. Graham, Bruce P. Ayati, Prem S. Ramakrishnan, James A. Martin

“…By including in this formalism further details, such as more complex cytokine interactions and accurate parameter values, it is possible to obtain simulations of phenomena related to bone remodeling with spatial behavior much as in vitro and in vivo. …”
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The Innovative Design of Deep In Situ Pressure Retained Coring Based on Magnetic Field Trigger Controller by Guikang Liu, Mingzhong Gao, Zhiwen Yang, Ling Chen, Maoquan Fu, Heping Xie

“…The results show that a complex magnetization combination can weaken the nonlinear negative correlation between the magnetic force and distance. …”
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Thermal radiation and thermo-diffusion in Casson-ferrofluid over a magnetized porous surface: RSM analysis by S. Manjunatha, J. Santhosh Kumar, Khalil Ur Rehman, Wasfi Shatanawi, S.V.K. Varma

“…Some important contributions include discussing response surface methods and studying the complex connections between Casson fluid, porosity, and the stretching ratio parameter.…”
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Retrospective analysis of spring barley cultivars developed by Omsk breeders (1936–2021) by P. N. Nikolaev, O. A. Yusova, N. I. Aniskov, O. N. Kovaleva, I. V. Safonova

“…Of these, 19 cultivars were obtained by pair hybridization; 4 cultivars by the complex stepwise hybridization technique; 4 cultivars through individual selection using the population approach. …”
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