Molecular Mechanisms of Alzheimer’s Disease Induced by Amyloid-β and Tau Phosphorylation Along with RhoA Activity: Perspective of RhoA/Rho-Associated Protein Kinase Inhibitors for... by Eun Hee Ahn, Jae-Bong Park

“…The typical function of Rho GTPases involves regulating actin filament formation. Neurons, with their complex processes and synapse connections, rely on cytoskeletal dynamics for structural support. …”
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Reaction of the Liver upon Long-Term Treatment of Fluoxetine and Atorvastatin Compared with Alcohol in a Mouse Model by Zhiliang Chen, Tony C. H. Chow, Shicong Wang, Gigi C. T. Leung, Sharon L. Y. Wu, David T. Yew

“…Comparisons of animals treated with the three drugs were carried out: serum aspartate transaminase (AST), alanine transaminase (ALT), and albumin were measured; liver tumor necrosis factor alpha (TNF alpha) and transforming growth factor beta (TGF beta-1) levels were evaluated; proliferative cells were detected via immunohistochemistry (IHC) targeting on proliferating cell nuclear antigen (PCNA) and minichromosome maintenance complex component 2 (MCM2); for apoptosis, IHC targeting on activated caspase-3 and terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) were employed; and histopathology was also documented in all groups. …”
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Study on the temperature prediction model of residual coal in goaf based on ACO-KELM by ZHAI Xiaowei, WANG Chen, HAO Le, LI Xintian, HOU Qinyuan, MA Teng

“…Existing studies on the temperature prediction of residual coal in goafs have mainly focused on the relationship between temperature and gas concentration, with limited attention given to the complex nonlinear relationships between the residual coal temperature in the goaf, the distance from the working face, and the air leakage velocity. …”
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Analysis of financial performance budget absorption in production forest areas in Karawang regency by Didit Supriyadi, Yosep Yudianto, Mayadita Kapriyanti, Kukuh Wahyu Nugroho

“…Thus, these findings provide in-depth insight into the complex relationship between these factors and highlight the central role of budget absorption in achieving optimal financial performance in the Karawang Regency production forest area.…”
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Developmental inequity and the impact of pesticide exposure on gut and brain health in developing nations – a Brazilian perspective by Jessica Gama, Bianca Cruz Neves, Antonio Pereira

“…The gastrointestinal tract, home to a complex microbiome, plays an essential role in immune regulation and neurological functions. …”
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The Use of Yoga in the Treatment of PCOS by Agnieszka Przesor Przezor, Natalia Medźwiedzka

“… Polycystic ovary syndrome (PCOS) is a complex and common endocrine disorder, and  affects women of reproductive age. …”
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Physical and Biological Characterizations of Injectable Thermosensitive Poly(N-Isopropylacrylamide)-Collagen I Hydrogels Intended for Meniscus Repair by Chunhai Ke, Xuanyuan Lu, Jiahua Ni, Ruicong Li, Qi Chen, Zhaoxiang Peng

“…Rheological characterizations showed that, under room temperature, the complex viscosity, the storage modulus, and the loss modulus, respectively, increased from 0.71±0.35 Pa•s to 110.95±23.22 Pa•s, from 3.28±2.02 Pa to 658.06±128.07 Pa, and from 3.30±1.01 Pa to 308.78±56.67 Pa, as the collagen I content in the hydrogel increased from 0% to 1%. …”
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Opposite roles of serotonin and neuropeptide FMRFamide in the regulation of epigenetic processes involved in the longterm memory formation by L. N. Grinkevich, O. V. Vorobiova

“…We found that the incubation of the CNS with serotonin induces methylation of histone H3 at both activating (Н3K4me3) and inhibitory (Н3K9me2) sites, while incubation with FMRFamide has an opposite effect reducing methylation of histone H3 in the subesophageal complex of ganglia, important for defensive behaviour. …”
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Flexible Model Predictive Control for Bounded Gait Generation in Humanoid Robots by Tianbo Yang, Yuchuang Tong, Zhengtao Zhang

“…With advancements in bipedal locomotion for humanoid robots, a critical challenge lies in generating gaits that are bounded to ensure stable operation in complex environments. Traditional Model Predictive Control (MPC) methods based on Linear Inverted Pendulum (LIP) or Cart–Table (C-T) methods are straightforward and linear but inadequate for robots with flexible joints and linkages. …”
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A Comprehensive Propagation Prediction Model Comprising Microfacet Based Scattering and Probability Based Coverage Optimization Algorithm by A. S. M. Zahid Kausar, Ahmed Wasif Reza, Lau Chun Wo, Harikrishnan Ramiah

“…Both of the space and time complexities of the proposed algorithm surpass the existing algorithms. …”
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Inheritance of ornamental traits in bird cherry families with the cultivar ‘Nezhnost’ in their pedigree by A. V. Lokteva, V. S. Simagin

“…Our data indicate a manifold composition of the gene complexes controlling the manifestation of both the pink flower trait and spring red leaves.Conclusion. …”
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Why do patients with ‘primary care sensitive’ problems access ambulance services? A systematic mapping review of the literature by Ali R G Shaw, Sarah Purdy, Matthew J Booker

“…Objective Emergency ambulance use for problems that could be managed in primary care continues to rise owing to complex reasons that are poorly understood. The objective of this systematic review is to draw together published evidence across a variety of study methodologies and settings to gain a better understanding of why patients seek help from ambulance services for these problems.Design Systematic searches were undertaken across the MEDLINE, EMBASE, PsychINFO, CINAHL, Health Management Information Consortium and Health Management Information Service publication databases. …”
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Locally Delivered Umbilical Cord Mesenchymal Stromal Cells Reduce Chronic Inflammation in Long-Term Nonhealing Wounds: A Randomized Study by Yulia Suzdaltseva, Sergey Zhidkih, Sergey L. Kiselev, Victor Stupin

“…Inflammation is part of a complex biological response to injury that mediates a rapid mobilization of cells and triggers the restoration of tissue homeostasis. …”
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Challenges and prospects for developing genetic resistance in common wheat against stem rust in Western Siberia by V. N. Kelbin, E. S. Skolotneva, E. A. Salina

“…Current studies on bread wheat resistance to stem rust have two main subjects: complex analysis for resistance of bread wheat germplasm using molecular markers, field screening and laboratory tests against samples of different fungal populations, and searching for sources and donors of new genes and gene loci, including cultivated and wild relatives of wheat. …”
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TRIM25: A Global Player of Cell Death Pathways and Promising Target of Tumor-Sensitizing Therapies by Wolfgang Eberhardt, Usman Nasrullah, Josef Pfeilschifter

“…A better understanding of the complex repertoire of cell death modulatory effects by TRIM25 is an essential prerequisite for validating TRIM25 as a potential target for future anticancer therapy to surmount the high failure rate of currently used chemotherapies.…”
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The 2019 Social Protests in Latin America: Global Context and Ecuadorian Case-Study by A. N. Pyatakov

“…The author stresses that although socio-economic explanations of the global protest phenomenon that focus on such issues as the growth of inequality and social polarization, are correct, they are insufficient for a comprehensive understanding of the new and complex phenomenon. As an alternative, the author suggests using the concept of ‘social singularity’. …”
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Reading and Calculation Neural Systems and Their Weighted Adaptive Use for Programming Skills by Joao Castelhano, Isabel C. Duarte, Joao Duraes, Henrique Madeira, Miguel Castelo-Branco

“…By unraveling the neural correlates of program understanding and bug detection, this work provides a framework to understand error monitoring in this novel complex faculty.…”
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Understanding the use of co-design methods for research involving older adults living with HIV: A scoping review protocol. by Paige Brown, Hardeep Singh, Esther Su, Luxey Sirisegaram, Sarah E P Munce, Andrew D Eaton, Alice Zhabokritsky, Stuart McKinlay, Kristina M Kokorelias

“…Co-design methodologies, aligning with patient-centered care, have potential for informing interventions addressing the complex needs of older adults with HIV. Despite challenges, co-design has shown promise in empowering older individuals to actively participate in shaping their care experiences. …”
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Russia and the West: Clash of energy interests through the lens of realist and liberal approaches by Yu. V. Borovsky

“…Substantial disagreements arose on all major issues of the agenda, from the views on the prospects for the Russian fuel and energy complex development and participation of foreign capital in it, to the implementation of concrete gas transportation projects and to assessments of opportunities for legal and institutional regulation of energy relations in Europe and the world. …”
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Russian University Cities: Expectations vs. Reality by I. D. Turgel, K. D. Bugrov, A. D. Oykher

“…The article concludes that, due to the specifics of its genesis and evolution, the phenomenon of a university city in Russia receives a new significance, reflecting the diversity of relationships between a large city and a complex, hierarchical system of universities operating in the socio-economic space of a common territory.…”
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