Crosstalk between non-coding RNAs and programmed cell death in colorectal cancer: implications for targeted therapy by Seyed Reza Taha, Mehdi Karimi, Bahar Mahdavi, Milad Yousefi Tehrani, Ali Bemani, Shahriar Kabirian, Javad Mohammadi, Sina Jabbari, Meysam Hushmand, Alireza Mokhtar, Mohammad Hossein Pourhanifeh

“…Its progression is influenced by complex interactions involving genetic, epigenetic, and environmental factors. …”
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Management of rare and undiagnosed diseases: insights from researchers and healthcare professionals in Türkiye by Sinem Durmus, Emrah Yucesan, Sinem Aktug, Begum Utz, Ahmet Okay Caglayan, Ahmet Okay Caglayan, Pinar Gencpinar, Cagatay Günay, Yavuz Oktay, Ravza Nur Yildirim, Ayca Yigit, Ugur Ozbek

“…IntroductionDiagnosis, treatment and management of rare diseases (RD) pose unique challenges due to their complex nature, significantly impacting the daily experiences of researchers and healthcare professionals working in this field. …”
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Floor Failure Characteristics in Deep Island Longwall Panel: Theoretical Analysis and Field Verification by Pengpeng Wang, Yixin Zhao, Qingshan Ren, Yaodong Jiang, Cun Zhang, Yirui Gao

“…The research results could provide a certain reference for floor failure and water inrush mechanisms under complex geological conditions in deep mining.…”
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How do age and sex influence pain threshold and tolerance among Santal tribal people living in West Bengal, India? by Arpita Santra, Subrata Kumar Roy, Monali Goswami, Diptendu Chatterjee

“…The perception of pain, encompassing pain threshold and tolerance levels, is a complex phenomenon influenced by biological, psychological, and sociocultural factors. …”
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Case Study: Analyzing CFTR Mutations and SNPs in Pulmonary Fibrosis Patients with Unclear Symptoms by Sahar Yousaf, null Sumaira, Iqbal Bano, Atia Rehman, Samra Kousar, Muhammad Usman Ghani, Mariam Shahid

“…Further research is needed to understand these complexities and improve diagnostic and treatment approaches.…”
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High‐Efficiency Flexible GaAs/InGaAs Dual‐Junction Solar Cells Fabricated by Metallic Nanoparticle‐Based Wafer Bonding by Yeongho Kim, Suho Park, Thuy Thi Nguyen, Jiyeon Jeon, Byong Sun Chun, Sang Jun Lee

“…Conventional fabrication techniques for multijunction cells, such as metamorphic epitaxy, direct wafer bonding, and adhesive wafer bonding, are still expensive and produce low yields owing to the use of complex process steps and sophisticated equipment. …”
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Improvement in Impaired Social Cognition but Not Seizures by Everolimus in a Child with Tuberous Sclerosis-Associated Autism through Increased Serum Antioxidant Proteins and Oxidan... by Kunio Yui, George Imataka, Hitomi Sasaki, Yohei Kawasaki, Tohru Okanshi, Ryoichi Shiroki, Shigemi Yoshihara

“…We investigated the effect of the mammalian target of rapamycin (mTOR) inhibitor everolimus on tuberous sclerosis complex- (TSC-) associated autistic symptoms and focal seizures with impaired awareness in a female child with TSC. …”
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Volume Changes and Mechanical Properties of Expansive Mudstone below Canals under Wet-Dry/Wet-Dry-Freeze-Thaw Cycles by Rui Zhu, Ying-hao Huang, Zhu Song, Feng Zhou

“…The complex environment in northern China is the main reason for degradation of expansive mudstone below the canals, which resulted in instability and damage of canal slopes. …”
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A Way to Improve Luminescent Efficiency of Bis-Chalcone Derivatives by Meng Guan Tay, Mee Hing Tiong, Ying Ying Chia, Suzie Hui Chin Kuan, Zhi-Qiang Liu

“…This work provides another way to improve the emission efficiency of chalcone related compounds apart from using the complexation method which has been reported before.…”
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Beneficial Roles of 1-MCP on Regulation of Photosynthetic Electron Transport and Energy Dissipation in Chrysanthemum Under Heat Stress by Runtian Miao, Xiaoman Liu, Yilin Zhao, Yanli Zhao, Han Dong, Gan Huang, Yonghua Li

“…Specifically, 1-MCP treatment significantly increases the fraction of active oxygen-evolving complex (OEC) centers and reduces relative variable fluorescence intensity at the J step (V_J) as well as the efficiency of electron transfer at the PSI acceptor side (δ_Ro). …”
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Characterization of sexual and reproductive behaviour in female high school students by Perla Caridad López Hernández, Eneida Bravo Polanco, Carmen Benítez Cabrera, Lisbet Cepero Äguila

“…The success they integrate their sexuality with, depends on a complex set of factors. <strong><br />Objective:</strong> To characterize sexual and reproductive behaviour of female high school students. …”
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Business Process Modeling Patterns for Blockchain Application Development by Fouzia Alzhrani, Kawther Saeedi, Liping Zhao

“…Our contribution provides a standardized framework for modeling blockchain application requirements, enabling software developers to better understand the complex needs of blockchain applications and design more effective solutions.…”
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Dam-breach process simulation and risk assessment of outburst flood induced by the Tangjiashan landslide-dammed lake by Junxue Ma, Chong Xu, Jian Chen

“…The region is characterized by complex river channels and steep terrain, which significantly influenced flood dynamics. …”
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Flexible modular dwelling for rural environments; specific case: Cebadas – Ecuador [version 2; peer review: 2 approved] by Karina Elizabeth Cajamarca Dacto, Maikol Josueé González Espinosa, Dany Marcelo Tasan Cruz, Erick Fabricio Nieto Páez, Jean Carlos Montero Riofrio

“…Conclusions The flexible modular dwelling project for rural environments addresses complex housing needs, highlighting the flexibility and adaptability of an expandable module. …”
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A New Spectrophotometric Method for Hydrogen Sulphide Through Electrolytically Generated Mn(III) With O-Tolidine by M. S. Suresha, Mansour S. Abdul Galil, Mahadevaiah, M. A. Sathish, M. S. Yogendra Kumar, G. Nagendrappa

“…The stoichiometry between Mn(III) and o-tolidine and stability constant of the complex were determined by Job's continuous method, the corresponding values were found to be 2:1 and 1.42X105 Lmol-1. …”
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Progressive Intramuscular Haematoma in a 12-Year-Old Boy: A Case of Acquired Haemophilia A by Manori Gamage, Sadeepa Weerasinghe, Mohamed Nasoor, A. M. P. W. Karunarathne, Sashi Praba Abeyrathne

“…He was managed with FEIBA and recombinant FVII activated complexes and prednisolone 1 m/kg/day regime to control bleeding. …”
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Chromosomal Changes in relation to Clinical Outcome in Larynx and Pharynx Squamous Cell Carcinoma by Mario Hermsen, Marta Alonso Guervós, Gerrit Meijer, Paul van Diest, Carlos Suárez Nieto, Cesar Alvarez Marcos, Andrés Sampedro

“…Invasive head and neck squamous carcinomas are among the cytogenetically most complex tumors. Perhaps for this reason, there is little consensus on the prognostic value of specific chromosomal aberrations. …”
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Employees’ attitudes and work-related stress in the digital workplace: an empirical investigation by Maddalena Cavicchioli, Fabio Demaria, Francesca Nannetti, Anna Chiara Scapolan, Tommaso Fabbri

“…This study examines the complex relationship between digitalization and work-related stress, with a particular emphasis on the impact of both digital activities (i.e., number of actions and virtual meetings) and employees’ attitudes (i.e., job satisfaction, person-organization fit, engagement, and work-life interface) on stress levels.MethodsDrawing on data from Microsoft 365 activity records and an online survey of employees in an Italian AI firm, this study applies Factor Analysis and Generalized Additive Models to analyze the above-mentioned interactions in a highly digitalized context.ResultsFindings indicate that the time–space intensification and extension of the working experience has a significant impact in terms of increasing work-related stress when exceeding certain number of off-hours digital actions and virtual meetings. …”
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Remote Minimally Invasive Surgery – Haptic Feedback and Selective Automation in Medical Robotics by Christoph Staub, Keita Ono, Hermann Mayer, Alois Knoll, Heinz Ulbrich, Robert Bauernschmitt

“…The automation of recurrent tasks and force feedback are complex problems in medical robotics. We present a novel approach that extends human-machine skill-transfer by a scaffolding framework. …”
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Adaptive Immune Response to Model Antigens Is Impaired in Murine Leukocyte-Adhesion Deficiency-1 Revealing Elevated Activation Thresholds In Vivo by Thorsten Peters, Wilhelm Bloch, Oliver Pabst, Claudia Wickenhauser, Claudia Uthoff-Hachenberg, Susanne V. Schmidt, Georg Varga, Stephan Grabbe, Daniel Kess, Tsvetelina Oreshkova, Anca Sindrilaru, Klaus Addicks, Reinhold Förster, Werner Müller, Karin Scharffetter-Kochanek

“…Although extensive in vitro work has established an essential function of β2 integrins in adhesive and signaling properties for cells of the innate and adaptive immune system, their respective participation in an altered adaptive immunity in LAD1 patients are complex and only partly understood in vivo. Therefore, we investigated adaptive immune responses towards different T-dependent antigens in a murine LAD1 model of β2 integrin-deficiency (CD18−/−). …”
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