Using computer modeling to find new LRRK2 inhibitors for parkinson’s disease by María C. García, Sebastián A. Cuesta, José R. Mora, Jose L. Paz, Yovani Marrero-Ponce, Frank Alexis, Edgar A. Márquez

“…Abstract Parkinson’s disease (PD) is a complex neurodegenerative disorder that affects multiple neurotransmitters, and its exact cause is still unknown. …”
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Study of Regulatory and Institutional Framework for the Relocation of the National Capital in Indonesia by Arif Hidayat, Laga Sugiarto, Dewi Sulistianingsih, Bintang Rafli Ananta, Muhammad Abid A Syakur

“…Previous studies have often been opinion-based and lacked scientific rigor, especially in addressing the complexities of policy implementation. This research aims to fill this gap by providing a detailed analysis of the policy from regulatory and institutional perspectives. …”
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Drivers in the conservation of urban green space depletion: A case study of Wa Municipality, Ghana by Sabastian Batasuma, Wei Cao, Nathan Awelama Atigah, Emefa Acorlor Garnet, Joshua Kojo Bonzo, Justice Gyimah

“…This study focuses on the Wa Municipality, examining the interplay between urbanization, regulatory policies, and human behavior in influencing green space loss.The innovation of this research lies in its integrated approach, combining qualitative insights with regression analysis to uncover complex dynamics affecting urban green spaces. Using statistical analysis and qualitative insights combined, the study revealed that while regulatory policies play a positive role in the preservation of green spaces (with a regression coefficient of Rp = 1.07, p < 0.01), both urbanization (Ur = -0.14, p < 0.05) and human behavior (Hb = -0.34, p < 0.05) significantly contribute to their decline.These findings highlight the critical need for robust legal frameworks and active community engagement to mitigate the negative effects of environmental degradation. …”
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Frequency of Different Types of Diagnostic Errors in Patients with Central Nervous System Infections: A Cross-Sectional Observational Study by HamidReza Naderi, Fereshte Sheybani, Omid Khosravi, Mehdi Jabbari Nooghabi

“…Although diagnosis and management of CNS infection in some patients are straightforward, clinical decision making in facing patients with complex scenarios often requires clinical reasoning instead of relying only on intuitive diagnosis. …”
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In Silico Study of Coumarins: Wedelolactone as a Potential Inhibitor of the Spike Protein of the SARS-CoV-2 Variants by Saurav Katuwal, Siddha Raj Upadhyaya, Rishab Marahatha, Asmita Shrestha, Bishnu P. Regmi, Karan Khadayat, Saroj Basnet, Ram Chandra Basnyat, Niranjan Parajuli

“…Furthermore, coarse-grained molecular dynamics (MD) simulation studies of spike protein-wedelolactone complexes validated the stable binding of wedelolactone in the respective binding pockets. …”
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Delineation of the Genetic Architecture and Clinical Polymorphism of 3q29 Duplication Syndrome: A Review of the Literature and a Report of Two Novel Patients With Single‐Gene BDH1... by A. A. Kashevarova, M. E. Lopatkina, O. Yu. Vasilyeva, D. A. Fedotov, A. D. Lobanov, E. A. Fonova, I. Z. Zhalsanova, A. A. Zarubin, O. A. Salyukova, E. O. Belyaeva, V. V. Petrova, E. G. Ravzhaeva, A. A. Agafonova, A. D. Cheremnykh, N. B. Torkhova, S. L. Vovk, I. N. Lebedev

“…Conclusion Chromosome 3q29 duplication syndrome is characterized by a complex genetic architecture and clinical polymorphism.…”
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How spinal GABAergic circuits modulate cerebral processing of postsurgical pain by Bruno Pradier, Daniel Segelcke, Nathalie Just, Mirjam Augustin, Nina Nagelmann, Cornelius Faber, Esther Pogatzki-Zahn

“…These findings underscore the complex and interconnected nature of brain networks in post-surgical pain processing, and provide insights into potential spinal targets for pharmacological intervention to alleviate post-surgical pain and prevent it's chronification.…”
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On the computation of the Basal Envelope Surface of Talwegs using the Analytic Element Method by Le Moine, Nicolas

“…The BEST is thus the real part of a complex analytic (holomorphic) function which can be modeled using analytic slit elements, with very low computational requirements and without the need for kriging, as it is often seen in the literature. …”
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Lived experiences of life with newly diagnosed advanced cancer – a qualitative interview study by Johanna Swenne, Ricko Damberg Nissen, Torben Frøstrup Hansen, Lars Henrik Jensen, Jens Søndergaard, Mette Stie

“…Conclusion The experiences of patients living with incurable cancer reveal a complex interplay of psychological, emotional, and existential responses. …”
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Association of age at menopause with type 2 diabetes mellitus in postmenopausal women: a systematic review and meta-analysis by Faezeh Zakerinasab, Taif Haiham Al Saraireh, Amirhesam Amirbeik, Rasoul Hossein Zadeh, Fariba Arbab Mojeni, Qumars Behfar

“…In conclusion, this present meta-analysis emphasizes the importance of the complex relationship between earlier menopausal age and risk of T2DM development.…”
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Association between Visceral Fat and Bone Mineral Density in Both Male and Female Patients with Adult Growth Hormone Deficiency by Linman Li, Li Zhong, Xiaoya Zheng, Wenyi You, Yunting Wang, Jihui Yu, Xun Wu, Wei Ren, Gangyi Yang

“…The interactions between various body composition and bone are known to be complex in nature. However, very few studies have examined this crosstalk in AGHD. …”
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Legionella pneumophila response to shifts in biofilm structure mediated by hydrodynamics by Ana Rosa Silva, C. William Keevil, Ana Pereira

“…This study investigates the complex relationship between hydrodynamics (80 RPM and stagnation), biofilm mesoscale structure and Legionella pneumophila colonization, by addressing three key questions: (1) How do low flow vs stagnation conditions affect biofilm response to L. pneumophila colonization?…”
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Rethinking Obesity Counseling: Having the French Fry Discussion by Jonathan Bonnet, Aaron George, Pippa Evans, Mina Silberberg, Diana Dolinsky

“…Childhood obesity is a complex problem that warrants early intervention. …”
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Development of Postural Control in Healthy Children: A Functional Approach by Christine Assaiante, Sophie Mallau, Sébastien Viel, Marianne Jover, Christina Schmitz

“…Head stabilization during posturokinetic activities, particularly locomotion, constitutes a complex motor skill requiring a long time to develop during childhood. …”
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Evaluating the synergy: anxiety prevalence and alcohol consumption patterns in high-income countries using Granger causality analysis by Binguni Senarathne, Dinithi Palliyaguru, Anne Oshini, Janudi Gamage, Ruwan Jayathilaka, Lochana Rajamanthri, Colinie Wickramarachchi

“…This research paper explores the complex relationship between the prevalence of anxiety and the consumption patterns of wine, beer, and spirits across fifty-two high-income countries with a continental analysis. …”
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A Universal MDO Framework Based on the Adaptive Discipline Surrogate Model by Hua Su, Chun-lin Gong, Liang-xian Gu

“…Results show that the number of discipline evaluations in the framework is half or less of the original MDO solution method and is very useful and suitable for the complex high-fidelity MDO problem.…”
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Chemical, Mineralogical, and Refractory Characterization of Kaolin in the Regions of Huayacocotla-Alumbres, Mexico by L. M. Romero-Guerrero, R. Moreno-Tovar, A. Arenas-Flores, Y. Marmolejo Santillán, F. Pérez-Moreno

“…The SEM technique was useful in the determination of the morphology of kaolinite and impurities of Na, Mg, K, and Fe of the complex clay illite-andalusite-dickite group. Thermogravimetric analysis was useful to discover the decomposition temperature and reveal the significant difference between 400 and 800°C, which showcases the greatest mass loss due to dehydration and carbonates decomposition. …”
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Digital twin-centered hybrid data-driven multi-stage deep learning framework for enhanced nuclear reactor power prediction by James Daniell, Kazuma Kobayashi, Ayodeji Alajo, Syed Bahauddin Alam

“…Traditional physics-based models, while valuable, can be computationally intensive and may not fully capture the complexities of real-world reactor behavior. This paper introduces a novel hybrid digital twin-focused multi-stage deep learning framework that addresses these limitations, offering a faster and more robust solution for predicting the final steady-state power of reactor transients. …”
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A novel electrical rock typing approach to improve estimating formation resistivity factor in carbonate rocks by Milad Mohammadi, Mohammad Emami Niri, Abbas Bahroudi, Aboozar Soleymanzadeh, Shahin Kord

“…Abstract Estimating petrophysical properties in carbonate rocks is challenging due to their complex pore structure, which leads to scattered data when analyzing the relationship between formation resistivity factor (F) and porosity. …”
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Thymus Hyperplasia and Thymoma Type B in Patients with Myasthenia Gravis: Two case reports and Literature Review by Selman Dumani, Altin Kuqo, Ermal Likaj, Saimir Kuci, Majlinda Ikonomi, Laureta Dibra, Alessia Mehmeti, Ejona Celiku, Altin Veshti

“… Introduction: The thymus gland plays a pivotal role in immune system regulation, but conditions such as thymic hyperplasia (TH) and thymoma pose distinct clinical challenges due to their rarity and complex presentation in surgical practice. Both conditions can mimic similar symptoms, particularly in patients with Myasthenia Gravis (MG), where surgery serves as both a diagnostic and therapeutic intervention. …”
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