Hemorrhagic Shock Induces a Rapid Transcriptomic Shift of the Immune Balance in Leukocytes after Experimental Multiple Injury by Lisa Debler, Annette Palmer, Sonja Braumüller, Bettina Klohs, Tom Eirik Mollnes, Karlheinz Holzmann, Markus Huber-Lang, Rebecca Halbgebauer

“…After additional HS in PT mice, the gene expression of pathways related to the innate immunity, such as IL-6 production, neutrophil chemotaxis, cell adhesion, and toll-like receptor signaling was upregulated, whereas pathways of the adaptive immune system, such as B- and T-cell activation as well as the MHC class II protein complex, were downregulated. These results demonstrate that an additional HS plays an important role in the immune dysregulation early after PT by shifting the balance to increased innate and reduced adaptive immune responses.…”
Get full text

Neuroophthalmic Manifestations of Intracranial Tumours in Children by Megha Kotecha, Sarang Gotecha, Ashish Chugh, Prashant Punia

“…Diagnosis of pediatric intracranial tumours is complex and requires a multidisciplinary approach for prompt management. …”
Get full text

Event-Related Potentials Elicited by Face and Face Pareidolia in Parkinson’s Disease by Gulsum Akdeniz, Gonul Vural, Sadiye Gumusyayla, Hesna Bektas, Orhan Deniz

“…Pareidolia is a type of complex visual illusion that permits the interpretation of a vague stimulus as something known to the observer. …”
Get full text

Mixture Ratio Design Optimization of Coal Gangue-Based Geopolymer Concrete Based on Modified Gravitational Search Algorithm by Daming Zhang, Fangjin Sun, Tiantian Liu, Zhonghao Xu

“…Coal gangue geopolymer concrete contains many mineral admixtures and alkaline activators; the concrete mixture ratio design has always been a complex problem. The framework of the mix design optimization by the proposed method is established in this work. …”
Get full text

A Machine Learning Approach for Environmental Assessment on Air Quality and Mitigation Strategy by Chetan Shetty, S. Seema, B. J. Sowmya, Rajesh Nandalike, S. Supreeth, Dayananda P., Rohith S., Vishwanath Y., Rajeev Ranjan, Venugopal Goud

“…Predicting air pollution is a complex task due to various challenges associated with the dynamic and multifaceted nature of the atmosphere such as meteorological variability, local emissions and sources, data quality and availability, and emerging pollutants. …”
Get full text

Education programmes on performance-based assessment for allied health and nursing clinical educators: A scoping review protocol [version 2; peer review: 1 approved, 2 approved wit... by Lucy Alpine, Emer Barrett, David Mockler, Anne O'Connor, Julie Broderick

“…Background Performance-based assessment (PBA) is a complex process undertaken in the workplace by healthcare practitioners known as clinical educators, who assist universities in determining health professional students’ readiness for independent practice. …”
Get full text

Enhanced Sweet Sorghum Growth and Soil Quality in Coastal Saline–Alkali Soils Through Organic Acid-Containing Bio-Based Materials and Microbial Synergy by Wei Xue, Shengjie Yang, Xiaoyu Liu, Man Qian, Huiyan Wang, He Yang, Xinbao Liu, Yixin Shen, Jianlong Li, Zhengguo Sun

“…Coastal mudflats are characterized by high salinity and alkalinity, along with low mineral nutrient availability, making it challenging to achieve high biomass or effective yields when directly cultivating food or fodder crops. Exogenous complex saline soil amendments can enhance forage production, but their effects on soil salinity reduction and nutrient activation remain unclear. …”
Get full text

Reducing postoperative blood product usage and costs in cardiothoracic surgery: the implementation of a multispecialty perioperative care model incorporating a haemostasis checklis... by Krishnaswamy Sundararajan, Peter Hibbert, Christopher Daniel Smith, Adrian De Luca

“…This quality initiative was successful in overcoming traditional silos of care and describes how quality improvement methodology utilising a multispecialty and multidisciplinary approach can be applied to solve complex issues in the perioperative period. Here, we demonstrate a reproducible and sustainable model for reducing blood product use in the cardiothoracic perioperative population.…”
Get full text

Potential Involvement of IL-17F in Asthma by Kyoko Ota, Mio Kawaguchi, Satoshi Matsukura, Masatsugu Kurokawa, Fumio Kokubu, Junichi Fujita, Yuko Morishima, Shau-Ku Huang, Yukio Ishii, Hiroaki Satoh, Nobuyuki Hizawa

“…The receptor for IL-17F is the heterodimeric complex of IL-17RA and IL-17RC, and IL-17F activates many signaling pathways. …”
Get full text

Large Language Models for UAVs: Current State and Pathways to the Future by Shumaila Javaid, Hamza Fahim, Bin He, Nasir Saeed

“…Unmanned Aerial Vehicles (UAVs) have emerged as a transformative technology across diverse sectors, offering adaptable solutions to complex challenges in both military and civilian domains. …”
Get full text

Transapical Approach for Mitral Valve Repair during Insertion of a Left Ventricular Assist Device by Mark J. Russo, Aurelie Merlo, Elizabeth M. Johnson, Shahab Akhter, Sean McCarney, Jennifer Steiman, Allen Anderson, Valluvan Jeevanandam

“…The surgical procedure is less complex and has a shorter CPB time and LOS, and all of the patients demonstrated significant improvement in postoperative MR and moderate improvement in PAP.…”
Get full text

Understanding Burnout among Surgical residents: a mixed method study by Fariba Khanipoor, Zhila Fereidouni, Sahar Neshat Far, Leila Bazrafkan, Mohammad Nabizadeh

“…Abstract Burnout is a complex condition that can strangely affect individuals in healthcare professions, such as surgeons and surgical residents. …”
Get full text

High-Performance Multi-Object Tracking for Autonomous Driving in Urban Scenarios With Heterogeneous Embedded Boards by Alessio Medaglini, Biagio Peccerillo, Sandro Bartolini

“…It is made possible by a plethora of modern technologies, such as AI, low-power hardware, and complex computing. Common stages of Autonomous Driving systems are the identification of objects in the scene (Object Detection), and the ability to predict the evolution of the tracked objects’ states – usually, positions and velocities (Multi-Object Tracking). …”
Get full text

An interval Type-2 fuzzy Fractional-Order PD-PI controller for frequency stabilization of islanded microgrids optimized with CO algorithm by Siavash Shirali, Saeed Zolfaghari Moghaddam, Mortaza Aliasghary

“…To overcome these limitations, the cheetah optimizer (CO) is employed, for its superior global search capability, ability to avoid local optima, and simplicity, as it does not rely on complex mathematical formulations. Different scenarios are considered in which the effect of the proposed controller on network frequency changes has been compared with two other controllers, i.e., interval type-2 fuzzy fractional-order tilt integral derivative (IT2FFOTID) and interval type-2 fuzzy fractional-order proportional integral derivative (IT2FFOPID) using several optimization methods. …”
Get full text

Individuals of older adults hospitalized with social isolation by Jercy Subyen Iglesias Toriza, Elaine Teresa Gutiérrez Pérez, Linet Pérez Jurajuria, Galia Yagnalis Delgado Pagán, Yara Díaz Ibáñez

“…Introduction: social isolation is a complex and multidimensional phenomenon that affects people's lives, promotes inequality and affects dignity and personal and social identity. …”
Get full text

Perch Hydrolysates from Upcycling of Perch Side Streams Accelerate Wound Healing by Enhancing Fibroblasts to Secrete Procollagen I, Fibronectin, and Hyaluronan by Jia-Feng Chang, Chih-Yu Hsieh, Ling-Ni Chen, Mao-Hsiang Lee, Yi-Han Ting, Chi-Yu Yang, Chih-Cheng Lin

“…In this study, perch hydrolysates were produced from perch side steams using a designed commercial complex enzyme via a proprietary pressure extraction technique. …”
Get full text

Comparative Biochemical and Histopathological Studies on the Efficacy of Metformin and Virgin Olive Oil against Streptozotocin-Induced Diabetes in Sprague-Dawley Rats by Khadijah Saeed Balamash, Huda Mohammed Alkreathy, Elham Hamed Al Gahdali, Sawsan Omer Khoja, Aftab Ahmad

“…Treatment of diabetic patients with antioxidant, such as extra virgin olive oil (EVOO), may be beneficial in numerous debilitating complexities. This study was aimed at assessing the protective role of virgin olive oil in reducing hyperglycemia in streptozotocin- (STZ-) induced diabetic rats. …”
Get full text

The Kidney Transplant Evaluation Process in the Elderly: Reasons for Being Turned down and Opportunities to Improve Cost-Effectiveness in a Single Center by Beatrice P. Concepcion, Rachel C. Forbes, Aihua Bian, Heidi M. Schaefer

“…The kidney transplant evaluation process for older candidates is complex due to the presence of multiple comorbid conditions. …”
Get full text

Responses of an <i>In Vitro</i> Coculture Alveolar Model for the Prediction of Respiratory Sensitizers (ALIsens^®) Following Exposure to Skin Sensitizers and Non-Sensitiz... by Sabina Burla, Aline Chary, Tommaso Serchi, Sébastien Cambier, Kristie Sullivan, Elizabeth Baker, Nikaeta Sadekar, Arno C. Gutleb

“…The results demonstrate that ALIsens^® is a promising <i>in vitro</i> complex model that could successfully discriminate respiratory sensitizers from skin sensitizers and non-sensitizers. …”
Get full text

Fractionation of Buckwheat Seed Phenolics and Analysis of Their Antioxidant Activity by Karamać Magdalena, Biskup Izabela, Kulczyk Anna

“…The antioxidant activity was tested as ABTS⋅+ and DPPH⋅ scavenging activity and capability to reduce the Fe(III)/2,4,6-Tris(2-pyridyl)-s-triazine complex to the ferrous form. Results were expressed as Trolox equivalent antioxidant capacity (TEAC), IC50 and ferric reducing antioxidant power (FRAP) values, respectively. …”
Get full text