Hydroxysafflor Yellow A Inhibits LPS-Induced NLRP3 Inflammasome Activation via Binding to Xanthine Oxidase in Mouse RAW264.7 Macrophages by Xiaolong Xu, Yuhong Guo, Jingxia Zhao, Ning Wang, Junying Ding, Qingquan Liu

“…Computation docking illustrated that, in this HSYA-XO complex, HSYA was surrounded by Leu 648, Leu 712, His 875, Leu 873, Ser 876, Glu 879, Phe 649, and Asn 650 with a binding energy of −5.77 kcal/M and formed hydrogen bonds with the hydroxyl groups of HSYA at Glu 879, Asn 650, and His 875. …”
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Benchmarking the identification of a single degraded protein to explore optimal search strategies for ancient proteins by Rodriguez Palomo, Ismael, Nair, Bharath, Chiang, Yun, Dekker, Joannes, Dartigues, Benjamin, Mackie, Meaghan, Evans, Miranda, Macleod, Ruairidh, Olsen, Jesper V., Collins, Matthew J.

“…Palaeoproteomics is a rapidly evolving discipline, and practitioners are constantly developing novel strategies for the analyses and interpretations of complex, degraded protein mixtures. The community has also established standards of good practice to interrogate our data. …”
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Characterization of relaparotomies performed at the Dr. Gustavo Aldereguía Lima General University Hospital (2015-2017) by Jorge Ernesto Gonzalez García, Mayquel Monzón Rodriguez, Lidia Torres Ajá, Dianelys Molina Macías

“…<p><strong>Background</strong>: Relaparotomies are associated with a considerable percentage of morbidity and mortality in patients who require intensive care; and around this procedure it is complex to decide when and how to do it, so that it is effective in every way. …”
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Tunning valence state of cobalt centers in Cu/Co-CoO1-x for significantly boosting water-gas shift reaction by Xing-Chi Li, Jun-Hao Wang, Tao-Tao Huang, Yang Hu, Xin Li, De-Jiu Wang, Wei-Wei Wang, Kai Xu, Chun-Jiang Jia, Hao Dong, Guangshe Li, Chen Li, Ya-Wen Zhang

“…Abstract Dual active sites with synergistic valence state regulation under oxidizing and reducing conditions are essential for catalytic reactions with step-wise mechanisms to modulate the complex adsorption sites of reactant molecules on the surfaces of heterogeneous catalysts with maximized catalytic performances, but it has been rarely explored. …”
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Effects of Li2O on Structure and Viscosity of CaO-Al2O3-Based Mold Fluxes by Lifeng Chen, Kun Liu, Peng Han, Bin Yang, Lianghua Feng

“…Viscosity test shows that CaO/Al2O3 = 0.88–2 continuously increased, when the cosolvent content Li2O = 1%–4%, CaO-Al2O3-based mold flux viscosity decreased, the degree of network structure polymerization decreased, and the complex structure depolymerized. Increasing the water content in the cosolvent is beneficial to reduce the viscosity of the crystallizer.…”
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Effect of non-contact induction heating on HA coatings and bone cement, an ex vivo study [version 2; peer review: 2 approved, 1 approved with reservations] by Robert Kamphof, Dr. Bart G.C.W. Pijls, Dr. Rob G.H.H. Nelissen, Jeroen Mesman-Vergeer, Dr. Giuseppe Cama

“…These protective mechanisms make treatment of prosthetic joint infection increasingly complex. Non-contact induction heating is an upcoming technology that uses heat to eradicate bacteria that are present on the surface of metallic implants. …”
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The Association of the Phylogenetic Typing of the Klebsiella pneumoniae Isolates with Antibiotic Resistance by Shabnam Baghbanijavid, Hossein Samadi Kafil, Safar Farajniya, Seyed Reza Moaddab, Hasan Hosainzadegan, Fatemeh Yeganeh Sefidan, Mojtaba Varshouchi, Hamed Ebrahimzadeh Leylabadlo, Reza Ghotaslou

“…Klebsiella pneumoniae complex (KPC) accounts for approximately one-third of all Gram-negative infections. …”
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SGLT2i and GLP-1RA in Cardiometabolic and Renal Diseases: From Glycemic Control to Adipose Tissue Inflammation and Senescence by Luis D'Marco, Valery Morillo, José Luis Gorriz, María K. Suarez, Manuel Nava, Ángel Ortega, Heliana Parra, Nelson Villasmil, Joselyn Rojas-Quintero, Valmore Bermúdez

“…The neuroendocrine and immunometabolism mechanisms underlying adipose tissue inflammation in individuals with diabetes and cardiometabolic and renal diseases are complex and not fully understood. Summary. This review intends to expose the probable molecular mechanisms and compile evidence of the synergistic or additive anti-inflammatory effects of SGLT2i and GLP-1RA and their potential impact on the management of patients with obesity and cardiorenal compromise.…”
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Ambient wing cistern: History, anatomy, imaging and approaches: An overview by Mohamed R. Emara, Alkawthar M. Abdulsada, Abdulaziz S. Alayyaf, Hussein A. Baban, Hala A. Al-Hchaimi, Mustafa Ismail, Samer S. Hoz

“…Bengt Liliequist (1923–2008). Due to its complex tridimensional anatomy, it has been a subject of confusion in neuroanatomy. …”
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Hydrodynamics and Aquatic Vegetation Drive Spatial Patterns of Environmental DNA in Ponds by Sandra R. Mayne, Jeffrey A. Manning, Stephen M. Henderson, Meghan B. Parsley, Katherine M. Strickler, Jeffrey R. Nielson, Caren S. Goldberg

“…These spatial and temporal dynamics indicate that eDNA transport processes in ponds are highly complex. Sampling away from aquatic vegetation, in the surface mixed layer, and upwind of potential sources, in addition to sampling at many locations within a pond and considering temporal patterns, may improve detection of rare pond species. …”
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Myocardial infarction without obstructive coronary artery disease (MINOCA) by Klever Geovanny Cárdenas Chacha, Yeseb Janira Vera Torres, Antonella Fanny Montenegro Villavicencio, Amilkar Suárez, Shirley Abigail López Baños

“…Its diagnosis is based on coronary angiography, which initiates an etiological search process that is often complex, but with prognostic and therapeutic importance. …”
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The Effects of Vitamin D on Gentamicin-Induced Acute Kidney Injury in Experimental Rat Model by Ender Hur, Alev Garip, Asuman Camyar, Sibel Ilgun, Melih Ozisik, Sena Tuna, Murat Olukman, Zehra Narli Ozdemir, Eser Yildirim Sozmen, Sait Sen, Fehmi Akcicek, Soner Duman

“…Acute kidney injury (AKI) pathogenesis is complex. Findings of gentamicin nephrotoxicity are seen in 30% of the AKI patients. …”
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The role of delays in innate and adaptive immunity to intracellular bacterial infection by Simeone Marino, Edoardo Beretta, Denise E. Kirschner

“…The immune response in humans is complex and multi-fold. Initially an innate response attempts to clear any invasion by microbes. …”
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Nuclear Factor-Kappa B Activity Regulates Brain Expression of P-Glycoprotein in the Kainic Acid-Induced Seizure Rats by Nian Yu, Qing Di, Hao Liu, Yong Hu, Ying Jiang, Yu-kui Yan, Yan-fang Zhang, Ying-dong Zhang

“…Furthermore, PDTC pre-treatment significantly decreased P-gp expression along with NF-κB activation in the hippocampus CA3 area and amygdala complex of rats compared with the EP group, implying that NF-κB activation involved in the seizure susceptibility and seizure induced brain P-gp over-expression. …”
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Analyzing customer churn behavior using datamining approach: hybrid support vector machine and logistic regression in retail chain by Mohammad Barzegar, Aliakbar Hasani

“…Customer churn is one of the challenges of business management in today's complex competitive environment. For this purpose, the organization must have an efficient system to detect and analyze the factors influencing customer churn. …”
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Federated Digital Twins: A Scheduling Approach Based on Temporal Graph Neural Network and Deep Reinforcement Learning by Young-Jin Kim, Hanjin Kim, Beomsu Ha, Won-Tae Kim

“…The concept of digital twin (DT), which has supported the optimization of physical system across various industries, now extends into federated digital twin (fDT) to manage complex, interconnected systems. Recent research and standardization efforts in DT have expanded their focus from optimizing individual physical twins to coordinating DT functionalities to optimize the services provided by set of physical twins. …”
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Synergistic Approach of High-Precision 3D Printing and Low Cell Adhesion for Enhanced Self-Assembled Spheroid Formation by Chunxiang Lu, Aoxiang Jin, Chuang Gao, Hao Qiao, Huazhen Liu, Yi Zhang, Wenbin Sun, Shih-Mo Yang, Yuanyuan Liu

“…However, current spheroid manufacturing techniques face challenges such as complex workflows, the need for specialized personnel, and poor batch reproducibility. …”
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Analyzing Drought Propagation and Its Influential Factors in the Upper Nan Watershed, Thailand by Muhammad Chrisna Satriagasa, Piyapong Tongdeenok, Naruemol Kaewjampa

“…This dual focus provides a comprehensive analysis of drought dynamics, enhancing the understanding of drought propagation and its complexities. The integration of global and local influences provides insights applicable across diverse water resource management contexts. …”
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Enhanced Morbidity of Pectoralis Major Myocutaneous Flap Used for Salvage after Previously Failed Oncological Treatment and Unsuccessful Reconstructive Head and Neck Surgery by Christiana Maria Ribeiro Salles Vanni, Leandro Luongo de Matos, Mário Paulo Faro Junior, Jossi Ledo Kanda, Cláudio Roberto Cernea, Lenine Garcia Brandão, Fábio Roberto Pinto

“…The reconstruction of complex cervicofacial defects arising from surgical treatment for cancer is a real challenge for head and neck surgeons, especially in salvage reconstruction surgery and/or failed previous reconstruction. …”
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Effects of Thermal and Stress Cycles on the Mechanical Properties and Acoustic Emission Characteristics of Rocks by Xianwei Meng, Xinran Zhang, Mingbo Chi, Kun Du

“…These findings contribute to understanding the complex interactions between pretreatment methods and rock behavior in engineering applications.…”
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