Asymptomatic Hyperuricemia and the Kidney: Lessons from the URRAH Study by Cecilia Barnini, Elisa Russo, Giovanna Leoncini, Maria Carla Ghinatti, Lucia Macciò, Michela Piaggio, Francesca Viazzi, Roberto Pontremoli

“…The interplay between hyperuricemia and CKD is complex; while in vitro studies and animal models support a role for uric acid mediating glomerular and tubule-interstitial damage, and HSUA has been shown to predict the onset and progression of CKD, the expectations of renal protection by the use of urate lowering treatment (ULT) are inconsistent. …”
Get full text

Integration of ordered porous materials for targeted three-component gas separation by Xue Jiang, Yu Wang, Hui Wang, Lu Cheng, Jian-Wei Cao, Jin-Bo Wang, Rong Yang, Dong-Hui Zhang, Run-Ye Zhang, Xiu-Bo Yang, Su-Hang Wang, Qiu-Yu Zhang, Kai-Jie Chen

“…We introduced a pore integration strategy of modularizing ordered pore structures with specific functions for on-demand assembly to deal with complex multi-component separation systems, which are unattainable by each individual pore. …”
Get full text

A healthy lifestyle of student youth in the context of a dangerous social and environmental environment in Ukraine by Vlada Bilohur, Oleksandr Morhunov, Kseniia Yarymbash, Iryna Skrypchenko, Ratko Pavlovıc

“…The purpose of our research was to study the factors of a healthy lifestyle of student youth in the context of a dangerous social and ecological environment in Ukraine. 28 first-year students took part in the research. The work used a complex of general scientific theoretical methods: the method of analyzing scientific literature, synthesis, systematization, generalization, the method of surveying applicants (online in the Google Forms application), testing the profile of a healthy lifestyle, methods of mathematical statistics. …”
Get full text

A ribosome-associating chaperone mediates GTP-driven vectorial folding of nascent eEF1A by Ibrahim M. Sabbarini, Dvir Reif, Kibum Park, Alexander J. McQuown, Anjali R. Nelliat, Charlotte Trejtnar, Volker Dötsch, Eugene I. Shakhnovich, Andrew W. Murray, Vladimir Denic

“…Proteomics and biochemical reconstitution reveal that Ypl225w functions as a co-translational chaperone by forming dual interactions with the eEF1A G domain nascent chain and the UBA domain of ribosome-bound nascent polypeptide-associated complex (NAC). Lastly, we show that Ypl225w primes eEF1A nascent chains for binding to GTP as part of a folding mechanism tightly coupled to chaperone recycling. …”
Get full text

A paper-based HPV E7 oncoprotein assay for cervical precancer detection at the point of care by Chelsey A. Smith, Sai Paul, Karen E. Haney, Sonia G. Parra, Meaghan Bond, Leticia López, Mauricio Maza, Juan Felix, Preetha Ramalingam, Pablo Escobar, Philip E. Castle, Kathleen M. Schmeler, Rebecca R. Richards-Kortum

“…Specifically, HPV mRNA and oncoprotein tests that have high specificity for cervical precancer and cancer require complex sample preparation protocols and expensive instrumentation. …”
Get full text

Molecular Dynamics Simulation on the Mechanism of Shale Oil Displacement by Carbon Dioxide in Inorganic Nanopores by Chengshan Li, Hongbo Xue, Liping Rao, Fang Yuan, Zhongyi Xu, Tongtong He, Chengwei Ji, Zhengbin Wu, Jiacheng Yan

“…Shale oil reservoirs feature a considerable number of nanopores and complex minerals, and the impact of nano-pore confinement and pore types frequently poses challenges to the efficient development of shale oil. …”
Get full text

Methylenetetrahydrofolate reductase gene polymorphisms, lipid profiles, and basic renal functional markers as risk for myocardial infarction: A case-control study and haplotype ana... by Perović Svetlana, Vujović Slavica, Kapur-Pojskić Lejla, Garai Nemanja, Šćepanović Anđelka

“…Myocardial infarction (MI) is a serious cardiovascular disease and the primary cause of mortality, with a complex etiopathology. Identifying the genetic basis of myocardial infarction (MI) is essential for developing personalized medical treatments. …”
Get full text

Unveiling the antiglioblastoma potential of harmicens, harmine and ferrocene hybrids by Poje Goran, Šakić Davor, Marinović Marina, You Jiangyang, Tarpley Michael, Williams Kevin P., Golub Nikolina, Dernovšek Jaka, Tomašič Tihomir, Bešić Erim, Rajić Zrinka

“…Therefore, the antiproliferative activity of harmicens might be a combination of complex molecular interactions.…”
Get full text

Comprehensive single-cell pan-cancer atlas unveils IFI30+ macrophages as key modulators of intra-tumoral immune dynamics by Lihe Jiang, Lihe Jiang, Lihe Jiang, Peili Wang, Peili Wang, Yixuan Hou, Jingying Chen, Hua Li, Hua Li

“…Identifying robust genetic regulators in this context is imperative.MethodsThis study elucidates IFI30's role in enhancing Major Histocompatibility Complex II (MHC-II) restriction antigen processing. …”
Get full text

Increasing the concentration of plasma molecules improves the biological activity of platelet-rich plasma for tissue regeneration by Mikel Sánchez, Jon Mercader Ruiz, Daniel Marijuán Pinel, Pello Sánchez, Nicolás Fiz, Jorge Guadilla, Juan Azofra, Maider Beitia, Diego Delgado

“…However, it is crucial to go beyond simple platelet concentration and examine the complex molecular composition both inside and outside platelets. …”
Get full text

PARP inhibition-associated heterochromatin confers increased DNA replication stress and vulnerability to ATR inhibition in SMARCA4-deficient cells by Kimiyoshi Yano, Megumi Kato, Syoju Endo, Taichi Igarashi, Ryoga Wada, Takashi Kohno, Astrid Zimmermann, Heike Dahmen, Frank T. Zenke, Bunsyo Shiotani

“…Here, we screened for DNA damage response inhibitors that enhance ATRi-induced cytotoxicity using SWI/SNF complex-deficient cells and identified a potent synergy between ATRi and poly(ADP-ribose) polymerase inhibitor (PARPi), particularly in SMARCA4-deficient cells. …”
Get full text

A novel ambiguity resolution model of BeiDou navigation satellite system/inertial navigation system tightly coupled for kinematic-to-kinematic precise relative positioning by Ling Wu, Yongrong Sun, Xiyu Fu, Qinghua Zeng

“…However, the relative positioning performance is degraded greatly with low fixation rate of ambiguity with low-cost receivers. Especially, in the complex dynamic environment, ambiguity resolution effect is influenced by the satellite signal blocked, multipath outlier, and abnormal state prediction. …”
Get full text

Investigation of Floating Offshore Wind Farm Layout Optimization Considering Mooring Line Constraints by Haiying Sun, Mingdan Li, Tianhui Fan, Chenzhi Cai

“…Floating offshore wind turbines (FOWTs) have become a promising solution for harnessing wind energy in deeper seas. However, the complex interplay between FOWT layout, mooring line patterns, and wake effects significantly influences the overall performance of a floating offshore wind farm (FOWF). …”
Get full text

From investigation to detection: Criminal Investigation Organs of Perm province during years of revolution and civil war in Russia by V. I. Teterin

“…Despite the high actuality of the subject connected with the necessity of building a civil society in our country the modern historiography does not cover а complex study of the soviet system of criminal investigation formation in certain regions. …”
Get full text

Aroma profile of two commercial truffle species from Yunnan and Sichuan, China: inter- and intraspecific variability and shared key compounds by Bin Lu, Jesús Perez-Moreno, Fengming Zhang, Andrea C. Rinaldi, Fuqiang Yu

“…Furthermore, truffles of different provenance had distinct proportions of volatile constituents, suggesting that, besides genetic factors, edaphic and microclimatic conditions influence the synthesis of VOCs in a complex manner.…”
Get full text

HDSA-Net: Haze Density and Semantic Awareness Network for Hyperspectral Image Dehazing by Qianru Liu, Tiecheng Song, Anyong Qin, Yin Liu, Feng Yang, Chenqiang Gao

“…Hyperspectral image (HSI) dehazing is a challenging task due to the complex imaging conditions. Existing deep learning-based dehazing methods neither fully consider the physical characteristics of HSIs, nor take advantage of high-level semantic information to improve the dehazing performance. …”
Get full text

Sliding Mode Backstepping Control of Excavator Bucket Trajectory Synovial in Particle Swarm Optimization Algorithm and Neural Network Disturbance Observer by Xiangfei Tao, Kailei Liu, Jing Yang, Yu Chen, Jiayuan Chen, Haoran Zhu

“…As a consequence of the problem of position tracking control spawned from external disturbance and other factors in the self-mining servo system of excavators, a strategy of sliding mode backstepping control based on the particle swarm optimization algorithm and neural network disturbance observer (PSO-NNDO-SMBC) was recommended accordingly. Meanwhile, the complex disturbance was estimated online and compensated for by the system control input by the universal approximation property of the neural network disturbance observer (NNDO). …”
Get full text

Using Quantitative Trait Locus Mapping and Genomic Resources to Improve Breeding Precision in Peaches: Current Insights and Future Prospects by Umar Hayat, Cao Ke, Lirong Wang, Gengrui Zhu, Weichao Fang, Xinwei Wang, Changwen Chen, Yong Li, Jinlong Wu

“…This study examines the complex genetic structure that underlies the morphology of peach fruits, paying special attention to the interaction between genome editing, genomic selection, and marker-assisted selection. …”
Get full text

A phylogenetic epidemiology approach to predicting the establishment of multi-host plant pests by Shannon Colleen Lynch, Edeli Reyes-Gonzalez, Emily L. Bossard, Karen S. Alarcon, Natalie L. R. Love, Allan D. Hollander, Beatriz E. Nobua-Behrmann, Gregory S. Gilbert

“…We model a beetle-pathogen symbiotic complex on trees, introduced from Southeast Asia to California. …”
Get full text

Correction of cellular and humoral links immunity in piglets under the weaning condition by Nataliia Ohorodnyk, Vitalii Tkachuk, Nataliia Motko, Andriy Boyko, Serhii Pavkovych

“…Accordingly, this study aimed to investigate the effect of a complex liposomal preparation on the cellular and humoral components of the piglet immune system after weaning. …”
Get full text