Systematic analysis of the pharmacogenomics landscape towards clinical implementation of precision therapeutics in Greece by George P. Patrinos, Kariofyllis Karamperis, Margarita-Ioanna Koufaki, Maria Skokou, Zoe Kordou, Eirini Sparaki, Margarita Skaraki, Christina Mitropoulou

“…Clinical implementation of PGx is a complex undertaking involving a multidisciplinary approach that includes, among others, a thorough understanding of a country’s preparedness to adopt this modern discipline and a detailed knowledge of PGx biomarkers allelic spectrum at a population level. …”
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Optimal Asynchronous Guaranteed Cost Control of Uncertain Markov Jump Systems With Actuator Saturation and Nonideal Transition Probabilities by Jiazheng Liu, Yang Yang, Yaru Song

“…Moreover, since it is complex to obtain accurate transition probabilities for the Markov chain of the original system and the hidden Markov model in the observation process, unknown and uncertain transition probabilities are simultaneously considered in both mode transitions and mode observation processes, and a separation strategy is implemented to handle the nonideal probabilities in each process independently. …”
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Beneficial Effects of Capybara Oil Supplementation on Steatosis and Liver Apoptosis in Obese Mice by Luciana Lontro Alves, Priscila Gomes Pereira, Bianca Torres Ciambarella, Miguel Porto Campos, Kíssila Rabelo, Ana Lúcia Rosa Nascimento, Raíssa Leal de Carvalho dos Santos Cunha, Cherley Borba Vieira Andrade, Alan Cesar Nunes Moraes, Andressa Bernardi, Fernanda Verdini Guimarães, Jemima Fuentes Ribeiro da Silva, Jorge José de Carvalho

“…Obesity is a complex chronic disease characterized by excess body fat (adipose) that is harmful to health and has been a major global health problem. …”
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High-Order Engineering Fastest Controller and Its Application in Thermal Power Units by Shangyao Shi, Jun Li, Yijia Huo, Ruiqi Li, Pengyun Chen

“…In the domain of industrial process control, the ubiquitous proportional–integral–derivative (PID) control paradigm, while foundational, is deemed insufficient amidst evolving complexities. In alignment with China’s strategic “dual-carbon” targets, extant thermal power installations are mandated to facilitate profound peak load navigation and expedited frequency modulation services. …”
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Towards a Bipolar World. Book Review of ‘The Second World War and the Transformation of International Relations: From Multipolarity to a Bipolar World’ edited by L.S. Belousov and... by V. I. Batyuk

“…In particular, the book provides a detailed picture of the complex interactions within the strategic triangle — the Soviet Union, the United States, and Great Britain — both during the war and in the years after the war. …”
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Influence of Process Parameters on Content Uniformity of a Low Dose Active Pharmaceutical Ingredient in a Tablet Formulation According to GMP by Muselík Jan, Franc Aleš, Doležel Petr, Goněc Roman, Krondlová Anna, Lukášová Ivana

“…Processes are regulated by complex directives, forcing the producers to validate, using sophisticated methods, the content uniformity of intermediates as well as final products. …”
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Prevalence and Temporal Distribution of Extrasystoles in Septic ICU Patients: The Feasibility of Predicting Fluid Responsiveness Using Extrasystoles by Johannes Enevoldsen, Cristhian Potes, Minnan Xu-Wilson, Simon T. Vistisen

“…Twenty-four-hour ECG recordings from a convenience sample of 50 patients diagnosed with sepsis were extracted from the MIMIC-II waveform database, and ECGs were visually examined for correct QRS complex detection. Custom-made algorithms identified potential extrasystoles based on RR intervals. …”
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Enhancing drug discovery and patient care through advanced analytics with the power of NLP and machine learning in pharmaceutical data interpretation by Nagalakshmi R, Surbhi Bhatia Khan, Ananthoju Vijay kumar, Mahesh T R, Mohammad Alojail, Saurabh Raj Sangwan, Mo Saraee

“…Key technological integrations include BERT embeddings, which provide nuanced contextual understanding of complex medical texts, and cosine similarity measures coupled with TF-IDF vectorization to significantly enhance the precision and reliability of text-based medical recommendations. …”
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Spatial Dynamics of Specialized and Sophisticated Small and Medium-Sized Enterprises on New High-Quality Productive Forces from an Evolutionary Economic Geography Perspective by Huibo Zhong, Mingwei Chu, Yuhang Xia, Keyu Zhai, Xing Gao

“…Additionally, the geographically weighted regression (GWR) model was employed to investigate the complex and spatially varied relationships between key characteristics of specialized and sophisticated SMEs and NHPFs. …”
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Effect of Alkaloids from Nelumbinis Plumula against Insulin Resistance of High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease in Mice by Yong Xie, Yi Zhang, Zebin Guo, Hongliang Zeng, Baodong Zheng

“…The present results supported the view that the pathogenesis of NAFLD was complex with inflammation, together with increasing serum glucose and IR. …”
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Capsule network approach for monkeypox (CAPSMON) detection and subclassification in medical imaging system by M. Nuthal Srinivasan, Mohamed Yacin Sikkandar, Maryam Alhashim, M. Chinnadurai

“…Addressing the shortcomings of traditional Machine Learning and Deep Learning models, our ESACN model utilizes the dynamic routing and spatial hierarchy capabilities of CapsNets to differentiate complex patterns such as those seen in monkeypox, chickenpox, measles, and normal skin presentations. …”
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Fusion Features-Based Entity Recognition Method for Safety Knowledge of Non-Coal Open-Pit Mine by Ziji Ma, Rui Zhao, Jianhua Huang, Shicheng Liu, Feilong Wang, Zhikang Shuai

“…However, as a key step in the construction of knowledge graph, it is a major challenge to recognize and extract entities from the complex field of safety production in non-coal open-pit mines. …”
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Natural product virtual-interact-phenotypic target characterization: A novel approach demonstrated with Salvia miltiorrhiza extract by Rui Xu, Hengyuan Yu, Yichen Wang, Boyu Li, Yong Chen, Xuesong Liu, Tengfei Xu

“…Natural products (NPs) have historically been a fundamental source for drug discovery. Yet the complex nature of NPs presents substantial challenges in pinpointing bioactive constituents, and corresponding targets. …”
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Multi-bandwidth reconstruction for photoacoustic tomography using cascade U-net by Zezheng Qin, Lingyu Ma, Zhigang Lei, Yiming Ma, Weiwei Fu, Mingjian Sun

“…Preliminary results from simulations and in vivo experiments illustrate the system’s robust multi-bandwidth imaging capabilities, achieving an excellent PSNR of 34.78 dB and a structural similarity index measure (SSIM) of 0.94 in the high-frequency reconstruction of complex mouse abdominal structures. This innovative PACT system is notable for its capability to seamlessly acquire multi-bandwidth full-view PAIs, thereby advancing the application of PAI technology in the biomedical domain.…”
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Can social adversity and mental, physical and oral multimorbidity form a syndemic? A concept and protocol paper by Easter Joury, Easter Joury, Eliana Nakhleh, Ed Beveridge, Derek Tracy, Derek Tracy, Derek Tracy, Derek Tracy, Ellie Heidari, Ellie Heidari, David Shiers, David Shiers, David Shiers, Silke Vereeken, Emily Peckham, Simon Gilbody, Simon Gilbody, Jayati Das-Munshi, Farida Fortune, Farida Fortune, Vishal R. Aggarwal, Masuma Mishu, Masuma Mishu, Joseph Firth, Joseph Firth, Kamaldeep Bhui, Kamaldeep Bhui, Kamaldeep Bhui, Kamaldeep Bhui

“…Structural equation modelling (SEM) will be utilised to conceptualise syndemic factors and model complex relationships between directly observed and indirectly observed (latent) variables (syndemic constructs).Discussionthe syndemic conceptualisation provides a valuable framework to understand health and illness, and hence to better design and deliver effective and cost-effective preventative and curative integrated (syndemic) care to improve patient and population health. …”
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Mechanical properties and energy absorption of CoCrNi functionally graded TPMS cellular structures by Zhaoyi Wang, Junxian Zhou, Yunzhuo Lu, Dongming Li, Deyu Yue, Xu Zhang, Bingzhi Chen

“…CoCrNi medium-entropy alloy (MEA), combining both high strength and ductility, which can significantly enhance the energy absorption efficiency and resistance to failure deformation of complex energy-absorbing structures. In this study, CoCrNi uniform and functionally gradient structures based on Gyroid and Diamond topologies were designed and manufactured via selective laser melting (SLM) technique. …”
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Drug response is related to NR3C1 and FAAH polymorphism in Chinese pediatric epilepsy patients by Hongli Wang, Chu Li, Qian Li, Ning Li, Huiling Qin

“…Abstract Background Childhood epilepsy is a common neurological syndrome with complex etiology and recurrent seizures. It seriously affects the growth and development of child patients. …”
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Shallow-water mussels (Mytilus galloprovincialis) adapt to deep-sea environment through transcriptomic and metagenomic insights by Luyang Sun, Xiaolu Liu, Li Zhou, Hao Wang, Chao Lian, Zhaoshan Zhong, Minxiao Wang, Hao Chen, Chaolun Li

“…This study examined transcriptomic and microbiome changes in shallow-water mussels Mytilus galloprovincialis exposed to deep-sea conditions at the Site-F cold seep in the South China Sea. Results reveal complex gene expression adjustments in stress response, immune defense, homeostasis, and energy metabolism pathways during adaptation. …”
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Therapeutic Angiogenesis Using Basic Fibroblast Growth Factor in Combination with a Collagen Matrix in Chronic Hindlimb Ischemia by Jianyin Zhou, Yilin Zhao, Jinling Wang, Sheng Zhang, Zhengjin Liu, Maochuan Zhen, Yun Liu, Pingguo Liu, Zhenyu Yin, Xiaomin Wang

“…Although therapeutic angiogenesis by angiogenic cytokines is a feasible strategy to improve regional blood flow in ischemic regions, the optimal delivery mode needs to be established. Here we designed a complex of collagen matrix (CM) and basic fibroblast growth factor (bFGF) and evaluated its proangiogenic effect in ischemic hindlimbs. …”
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Droplet-based high-throughput 3D genome structure mapping of single cells with simultaneous transcriptomics by Honggui Wu, Maoxu Wang, Yinghui Zheng, X. Sunney Xie

“…Abstract Single-cell three-dimensional (3D) genome techniques have advanced our understanding of cell-type-specific chromatin structures in complex tissues, yet current methodologies are limited in cell throughput. …”
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