Using Gap Visualization to Navigate Multivariate Metabarcode Data, Select Primer Pairs, and Enhance Reference Data Quality by Xin‐Yi Chua, Louise Ord, Stephen J. Bent, David Lovell, Annette McGrath

“…Since reference data sets are large and complex, we provide a simple and intuitive method to navigate subsets of reference sequence data containing conflicting or ambiguous relationships between genomic information and taxonomic classification. …”
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Lipid Oxidation at the Crossroads: Oxidative Stress and Neurodegeneration Explored in <i>Caenorhabditis elegans</i> by Julia Tortajada-Pérez, Andrea del Valle Carranza, Cristina Trujillo-del Río, Mar Collado-Pérez, José María Millán, Gema García-García, Rafael Pascual Vázquez-Manrique

“…The findings from <i>Caenorhabditis elegans</i> studies offer valuable insights into these complex processes and highlight potential avenues for developing targeted therapies to mitigate neurodegenerative disease progression.…”
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An HLA-Transgenic Mouse Model of Type 1 Diabetes That Incorporates the Reduced but Not Abolished Thymic Insulin Expression Seen in Patients by Jeffrey Babad, Riyasat Ali, Jennifer Schloss, Teresa P. DiLorenzo

“…Multiple genetic loci contribute to disease susceptibility in humans, with the most responsible locus being the major histocompatibility complex (MHC). Certain MHC alleles are predisposing, including the common HLA-A∗02:01. …”
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Damage and Failure Evolution Mechanism for Coal Pillar Dams Affected by Water Immersion in Underground Reservoirs by Fangtian Wang, Ningning Liang, Gang Li

“…However, coal pillar dams must operate in complex environments that combine dynamic-static superimposed stress fields and water immersion; moreover, coal pillar dams subjected to both stress and seepage are more susceptible to damage and even collapse. …”
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Unlocking precision medicine: clinical applications of integrating health records, genetics, and immunology through artificial intelligence by Yi-Ming Chen, Tzu-Hung Hsiao, Ching-Heng Lin, Yang C. Fann

“…AI-enabled immunology data analysis, including dimensionality reduction, cell population identification, and sample classification, provides unprecedented insights into complex immune responses. The review highlights real-world examples of AI-driven precision medicine platforms and clinical decision support tools in rheumatology. …”
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An Electronic Slime-Based Epidermal Electrode Using Carbon Nanocomposites for Biosignal Sensing by Yu Feng, Hui Sun, Meng Chen, Cong Wu, Jiankun Li, Zhi Li, Kremena Makasheva, Na Liu, Guanglie Zhang, Wen Jung Li

“…Recent advancements in functional nanomaterials have propelled the development of these electrodes; however, their fabrication often involves complex processes and expensive raw materials. While significant progress has been made in enhancing the biocompatibility of electrodes through the use of human-friendly materials, improvements in flexibility and conductivity are still needed to ensure optimal skin conformability and compliance. …”
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Radiotherapy for Melanoma: More than DNA Damage by Susanne J. Rogers, Emsad Puric, Brigitte Eberle, Niloy R. Datta, Stephan B. Bodis

“…Given the immune priming effect of radiotherapy, there is a strong but complex biological rationale and an increasing body of evidence for synergy in combination with immune checkpoint inhibitors, which are now first-line therapy in patients with recurrent or metastatic melanoma. …”
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Inter- and intra-varietal clonal differences influence the aroma compound profiles of wines analyzed by GC–MS and GC-IMS by Huawei Chen, Shijian Bai, Bowei Yang, Ruihua Ren, Zizhu Tang, Zhenwen Zhang, Qingqing Zeng

“…Our results revealed that white wine CH VCR6 and red wine CS VCR11 possessed the most complex aromas. These findings address the research gap concerning the genetic determinants of wine aroma, highlighting the significance of grape variety and clone selection in developing wines with desirable sensory attributes.…”
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Radial Basis Function Coupling with Metaheuristic Algorithms for Estimating the Compressive Strength and Slump of High-Performance Concrete by Amir Reza Taghavi Khangah, Erfan Khajavi, Hasti Azizi, Amir Reza Alizade Novin

“…The results highlight hybrid machine learning models as the potential to solve complex challenges in civil engineering and provide new approaches toward sustainable and efficient infrastructure development.…”
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TiO2 Photocatalyst Nanoparticle Separation: Flocculation in Different Matrices and Use of Powdered Activated Carbon as a Precoat in Low-Cost Fabric Filtration by Carlos F. Liriano-Jorge, Ugur Sohmen, Altan Özkan, Holger Gulyas, Ralf Otterpohl

“…Results showed that the impact of these substances on TiO2 nanoparticle flocculation is rather complex and strongly affected by pH. When humic acid was present, TiO2 particles did not show efficient flocculation in the neutral and slightly basic pH range. …”
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A Comprehensive Review on Limitations of Autonomous Driving and Its Impact on Accidents and Collisions by Amit Chougule, Vinay Chamola, Aishwarya Sam, Fei Richard Yu, Biplab Sikdar

“…Additionally, the paper delves into the ethical and regulatory dimensions associated with autonomous driving, accentuating the legal complexities that arise from accidents involving self-driving vehicles. …”
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Harnessing natural polymers and nanoparticles: Synergistic scaffold design for improved wound healing by Anitha S, Nandini Robin Nadar, Srividya Shivakumar, Sharma S C, Siddharth P, Surekha Varalakshmi V, Rajesh Lenka, Rajadurai S

“…Wound care involves many strategies from simple local dressing to complex debridement techniques such as bioactive dressings and skin grafting. …”
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Engineering tomato disease resistance by manipulating susceptibility genes by Duoduo Wang, Palash Mandal, Md Sazan Rahman, Lirong Yang

“…However, the utilization of the full potential of this technique is challenging due to the complex plant-pathogen interactions and current technological limitations. …”
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A deep learning method for differentiating safflower germplasm using optimal leaf structure features by Hoang Thien Van, Phuong Thuy Khuat, Trang Van, Thai Thanh Tuan, Yong Suk Chung

“…The OLSF, calculated as the average response of a multidirectional Gabor filter bank and optimized with the structural similarity index measure (SSIM), enhances complex leaf features, such as veins, texture, and frequency variations, to enhance the classification performance of deep learning models. …”
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Computational Role of Autocatalytic Chemical Reaction in the Dynamics of a Ternary Hybrid Nanofluid Past a Rotating Stretching Surface by Shreedevi Madiwal, N. B. Naduvinamani, J. K. Madhukesh, Umair Khan, Anuar Ishak, Raman Kumar, Md Irfanul Haque Siddiqui

“…An essential aspect of understanding complex systems is studying the interplay between fluid movement, heat transport, and chemical processes. …”
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Neuropilin 1 Mediates Keratinocyte Growth Factor Signaling in Adipose-Derived Stem Cells: Potential Involvement in Adipogenesis by Simona Ceccarelli, Cristina Nodale, Enrica Vescarelli, Paola Pontecorvi, Valeria Manganelli, Giovanni Casella, Maria Giuseppina Onesti, Maurizio Sorice, Ferdinando Romano, Antonio Angeloni, Cinzia Marchese

“…Adipogenesis is regulated by a complex network of molecules, including fibroblast growth factors. …”
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Label-free proteomic analysis of Duchenne and Becker muscular dystrophy showed decreased sarcomere proteins and increased ubiquitination-related proteins by Juliana Cristina Tobar da Silva, Mariângela Rangel Alves Nogueira, Yara Martins da Silva, Fábio César Sousa Nogueira, Nathalie Henriques Silva Canedo, Katia Carneiro, Denise de Abreu Pereira

“…These conditions often result from structural defects in the Dystrophin–Glycoprotein Complex (DGC), as seen in Duchenne Muscular Dystrophy (DMD) and Becker Muscular Dystrophy (BMD). …”
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Functional Stability of Plasminogen Activator Inhibitor-1 by Songul Yasar Yildiz, Pinar Kuru, Ebru Toksoy Oner, Mehmet Agirbasli

“…Thus, relying solely on plasma concentrations of PAI-1 without assessing its function may be misleading in interpreting the role of PAI-1 in many complex diseases. Environmental conditions, interaction with other proteins, mutations, and glycosylation are the main factors that have a significant impact on the stability of the PAI-1 structure. …”
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Sustained slow-release TGF-β3 in a three-dimensional-printed titanium microporous scaffold composite system promotes ligament-to-bone healing by Liwei Zhu, Yuzhe Liu, Yifu Sun, Zhenjia Che, Youbin Li, Tengyue Liu, Xudong Li, Chengzhe Yang, Lanfeng Huang

“…Micro-CT results demonstrated that the complex promotes the osseointegration of titanium scaffolds in bone defects. …”
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Emended snake optimizer to solve multiobjective hybrid energy generation scheduling by Kaur Avneet, Dhillon J.S., Singh Manmohan

“…The snake optimization algorithm (SOA) often gets stuck in the local minima while solving complex engineering optimization problems, resulting in sluggish convergence behavior. …”
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