Identification of potent TMPRSS4 inhibitors through structural modeling and molecular dynamics simulations by Ismail Hdoufane, Mehdi Oubahmane, Youssef Habibi, Christelle Delaite, Mohammed M. Alanazi, Driss Cherqaoui

“…Moreover, through a systematic analysis, MD simulations and MM-GBSA binding free energy calculations revealed that the best candidates Ergotamine, S55746, NPC478048, Lifirafenib, and NPC77101 are highly stable drug candidates in complex with TMPRSS4, displaying low RMSD and RMSF values with strong binding stability. …”
Get full text

Autonomous Emergency Gliding Landing Guidance and Control of Tilt-Wing Electric Vertical Take-Off and Landing for Urban Air Mobility Missions Using Control Barrier Functions by Liqun Ma, Yangchen Ding, Jianzhong Yang

“…The innovative combination of CBFs and global optimization techniques sets a new precedent for resilient aircraft control in complex urban scenarios, paving the way for the safe integration of eVTOLs into everyday urban life.…”
Get full text

Device Modeling Based on Cost-Sensitive Densely Connected Deep Neural Networks by Xiaoying Tang, Zhiqiang Li, Lang Zeng, Hongwei Zhou, Xiaoxu Cheng, Zhenjie Yao

“…Therefore, this work proposes a machine learning-based device modeling algorithm to capture the complex nonlinear relationship between parameters and electrical characteristics of gate-all-around (GAA) nanowire field-effect transistors (NWFETs) from technology computer-aided design (TCAD) simulation results. …”
Get full text

A Comparison of Dysautonomias Comorbid with Cyclic Vomiting Syndrome and with Migraine by Gisela Chelimsky, Shruti Madan, Amer Alshekhlee, Elizabeth Heller, Kevin McNeeley, Thomas Chelimsky

“…Cross-sectional study of patients utilizing the ODYSA instrument, evaluating the probability of 12 functional/autonomic diagnoses, CVS, migraine, orthostatic intolerance (OI), reflex syncope, interstitial cystitis, Raynaud's syndrome, complex regional pain syndrome (CRPS), irritable bowel syndrome, functional dyspepsia, functional abdominal pain, fibromyalgia, and chronic fatigue syndrome. …”
Get full text

ULSOSEAL Technique: A Unique Technique to Achieve Hemostasis Using ExoSeal in High-Risk Patients after Common Femoral Artery Puncture by Yohsuke Honda, Shinsuke Mori, Tomoya Fukagawa, Toshihiko Kishida, Takahide Nakano, Shigemitsu Shirai, Masafumi Mizusawa, Kenji Makino, Masakazu Tsutsumi, Norihiro Kobayashi, Masahiro Yamawaki, Yoshiaki Ito

“…ExoSeal is a novel, completely extravascular hemostatic device that can treat punctures of the common femoral artery; however, it is not preferable for use in cases that require hemostasis of complex puncture sites. From November 2019 to August 2020, the ULSOSEAL technique was performed in 35 patients with implanted stents (6 patients, 17%), severe calcification (32 patients, 91%), and plaque (7 patients, 20%) around the puncture site; the presence of these conditions is usually undesirable when using ExoSeal. …”
Get full text

Health-Related Quality of Life in Gilles de la Tourette Syndrome: A Decade of Research by Andrea Eugenio Cavanna, Kate David, Valentina Bandera, Cristiano Termine, Umberto Balottin, Anette Schrag, Caroline Selai

“…Analysis of the first decade of studies specifically addressing HR-QOL in GTS suggests that co-morbid conditions are key factors in determining HR-QOL in young patients, whilst the picture is more complex in adults with GTS. These findings offer some general directions for both current clinical practice and future research.…”
Get full text

Nanopore sequencing of protozoa: Decoding biological information on a string of biochemical molecules into human-readable signals by Branden Hunter, Timothy Cromwell, Hyunjin Shim

“…The long reads from nanopore sequencing offer the advantage of obtaining contiguous information, which is particularly beneficial for decoding complex or repetitive regions in a genome. In this study, we investigated the efficacy of nanopore sequencing in decoding biological information from distinctive genomes in metagenomic samples, which pose significant challenges for traditional short-read sequencing technologies. …”
Get full text

The association between the oral microbiome and hypertension: a systematic review by Sadeq Ali Al-Maweri, Abeer A. Al-Mashraqi, Gamilah Al-Qadhi, Nezar Al-Hebshi, Raidan Ba-Hattab

“…Still, a few taxa were repeatedly found enriched in hypertension including Aggregatibacter, Kingella, Lautropia, and Leptotrachia besides the red complex periodontal pathogens. When considering only studies that controlled for false discovery rates and confounders, Atopobium, Prevotella, and Veillonella were identified as consistently associated with hypertension.Conclusion There are significant differences in the oral microbiome between hypertensive and normotensive subjects. …”
Get full text

Proinflammatory Effects of Diesel Exhaust Nanoparticles on Scleroderma Skin Cells by A. Mastrofrancesco, M. Alfè, E. Rosato, V. Gargiulo, C. Beatrice, G. Di Blasio, B. Zhang, D. S. Su, M. Picardo, S. Fiorito

“…Autoimmune diseases are complex disorders of unknown etiology thought to result from interactions between genetic and environmental factors. …”
Get full text

Land Subsidence in the Yangtze River Delta, China Explored Using InSAR Technique From 2019 to 2021 by Hongbo Jiang, Guangcai Feng, Yuexin Wang, Zhiqiang Xiong, Hesheng Chen, Ning Li, Zeng Lin

“…Despite the potential of interferometric synthetic aperture radar (InSAR) for monitoring LS, its application across vast delta regions may be hindered by complex data processing, high computational demands, and the need for standardized results. …”
Get full text

Data Fusion Applied to the Leader-Based Bat Algorithm to Improve the Localization of Mobile Robots by Wolmar Araujo-Neto, Leonardo Rocha Olivi, Daniel Khede Dourado Villa, Mário Sarcinelli-Filho

“…The increasing demand for autonomous mobile robots in complex environments calls for efficient path-planning algorithms. …”
Get full text

A lethal disease of the European bison – posthitis is conditionally determined by its genomics by Sazia Kunvar, Sylwia Czarnomska, Cino Pertoldi, Astrid V. Stronen, Iwona Ruczyńska, Małgorzata Tokarska

“…The conditional nature of posthitis and ‘false negative’ sampling represent major difficulties in investigating this disease, and we recommend a complex genomic and environmental factors association assay that could eventually explain the puzzling etiology of posthitis and help mitigate this threat to the European bison.…”
Get full text

Analytic Hierarchy Process (AHP) for a Landfill Site Selection in Chachapoyas and Huancas (NW Peru): Modeling in a GIS-RS Environment by Jhonsy O. Silva López, Rolando Salas López, Nilton B. Rojas Briceño, Darwin Gómez Fernández, Renzo E. Terrones Murga, Daniel Iliquín Trigoso, Elgar Barboza Castillo, Manuel Oliva Cruz, Miguel Ángel Barrena Gurbillón

“…The evaluation of suitable landfill sites is a complex process and requires various legislative, technical, social, and environmental criteria. …”
Get full text

A Fatigue Driving Detection Algorithm Based on Facial Motion Information Entropy by Feng You, Yunbo Gong, Haiqing Tu, Jianzhong Liang, Haiwei Wang

“…First, we introduce an improved YOLOv3-tiny convolutional neural network to capture the facial regions under complex driving conditions, eliminating the inaccuracy and affections caused by artificial feature extraction. …”
Get full text

Effect of Liquid Marble 3D Culture System on In Vitro Maturation and Embryo Development of Prepubertal Goat Oocytes by Andrea Podda, Linda Dujíčková, Federica Ariu, Giovanni Giuseppe Leoni, Dolors Izquierdo, Maria-Teresa Paramio, Luisa Bogliolo

“…The aim of this study was to evaluate the effect of liquid marble (LM) microbioreactors as a 3D culture system on IVM and the subsequent embryo development of prepubertal goat oocytes. The cumulus–oocyte complexes (COCs) recovered from prepubertal goat ovaries underwent IVM in drops under oil (the 2D system and the control group) and in the 3D LM system (the LM group). …”
Get full text

Improved integral cryptanalysis of SPNbox in digital rights management systems by Jun Liu, Dachao Wang, Yupu Hu, Jie Chen, Baocang Wang

“…On this basis, we propose new competitive 3‐round key recovery attacks with lower complexities. Particularly, the improved attack on 3‐round SPNbox‐32 only requires 232 chosen plaintexts, whereas the current best attack necessitates 262 chosen plaintexts. …”
Get full text

scSMD: a deep learning method for accurate clustering of single cells based on auto-encoder by Xiaoxu Cui, Renkai Wu, Yinghao Liu, Peizhan Chen, Qing Chang, Pengchen Liang, Changyu He

“…By integrating innovative computational techniques, the SMD model provides a powerful framework for unraveling cellular complexities, enhancing our understanding of biological processes, and elucidating disease mechanisms. …”
Get full text

Sakit Kepala pada Variasi Anatomi Hidung dan Sinus Paranasal by Tika Hakikah, Dolly Irfandy, Bestari Jaka Budiman

“…These variations can cause narrowing of the osteomeatal complex. Computed tomography was the primary modality for evaluating anatomical variations of the nasal and paranasal sinuses in diagnosis and management. …”
Get full text

Machine Learning Techniques to Analyze the Influence of Silica on the Physico-Chemical Properties of Aerogels by Hamdi Chaouk, Emil Obeid, Jalal Halwani, Jack Arayro, Rabih Mezher, Omar Mouhtady, Eddie Gazo-Hanna, Semaan Amine, Khaled Younes

“…Overall, this study highlights the effectiveness of machine learning techniques like PCA in optimizing and understanding the complex inter-relationships among the physico-chemical properties of silica aerogels.…”
Get full text

Neurobiological Mechanisms Underlying Psychological Dysfunction After Brain Injuries by Prashin Unadkat, Tania Rebeiz, Erum Ajmal, Vincent De Souza, Angela Xia, Julia Jinu, Keren Powell, Chunyan Li

“…The review highlights promising therapeutic avenues for addressing injury-associated psychological dysfunction, emphasizing Nrf2, neuropeptides, and nonpharmacological therapies as multi-mechanistic interventions capable of modulating upstream mediators to address the complex interplay of factors underlying psychological dysfunction in brain injury. …”
Get full text