Analysis of the Impact of Using a Gamified App for Spanish Spelling Practice in Primary Education by Esteban Vázquez-Cano, Javier Fombona, María Belén Morales-Cevallos, Eloy López-Meneses

“…The Binomial Effect Size Display highlighted notable improvements in specific spelling categories, such as complex letter combinations and accent rules. Discussion centered on the benefits of integrating gamification and ubiquitous learning tools in education, emphasizing the app’s adaptability and immediate feedback, which encouraged independent learning and sustained motivation. …”
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Coordination of preventive, emergency and restorative trading strategies under uncertain sequential extreme weather events by Xuemei Dai, Jing Zhou, Xu Zhang, Kaifeng Zhang, Wei Feng

“…Effective coordination of preventive, emergency, and restorative strategies can mitigate losses during these events, but designing optimal trading strategies for joint LE and LF markets remains complex. This paper introduces a novel trading method to address this challenge. …”
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Exploring Cervical Adenocarcinoma: Epidemiological Insights, Diagnostic and Therapeutic Challenges, and Pathogenetic Mechanisms by Shuhui Li, Congrong Liu, Liang Weng

“…CA, in particular, presents a formidable challenge in clinical management due to its low early detection rate, pronounced aggressiveness, high recurrence rate, and mortality, compounded by the complexities associated with late‐stage treatment. There is limited understanding of the similarities and differences in the pathogenesis mechanisms between CA and SCC, such as tumor heterogeneity and the tumor immune microenvironment (TME). …”
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A localized tracing technique to explore intra-amygdala functional and structural correlates of individual variability in behavioral response by Allie Lipshutz, Allie Lipshutz, Victoria Saltz, Victoria Saltz, Victoria Saltz, Kristin R. Anderson, Kristin R. Anderson, Alessia Manganaro, Alessia Manganaro, Dani Dumitriu, Dani Dumitriu, Dani Dumitriu

“…Specifically, we combine a retrograde transsynaptic rabies tracing system with cFos colocalization immediately after an acute stressor to elucidate local structural and stress-activated connectivity within the amygdala complex in female and male mice.Results and discussionWe show how specific structural and functional connections can predict individual variability along a spectrum of social approach/avoidance following acute social defeat stress. …”
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A Comprehensive Approach to Intrusion Detection in IoT Environments Using Hybrid Feature Selection and Multi-Stage Classification Techniques by G. Logeswari, J. Deepika Roselind, K. Tamilarasi, V. Nivethitha

“…The rapid expansion of Internet of Things (IoT) devices has led to an increasingly complex threat landscape, challenging traditional Intrusion Detection Systems (IDS) to effectively handle the vast and diverse data generated by IoT networks. …”
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Gut Microbiome and Inflammation: A Study of Diabetic Inflammasome-Knockout Mice by Roma Pahwa, Miriam Balderas, Ishwarlal Jialal, Xinpu Chen, Ruth Ann Luna, Sridevi Devaraj

“…Diabetes is a proinflammatory state, evidenced by increased pattern recognition receptors and the inflammasome (NOD-like receptor family pyrin domain (NLRP)) complex. Recent reports have elucidated the role of the gut microbiome in diabetes, but there is limited data on the gut microbiome in NLRP-KO mice and its effect on diabetes-induced inflammation. …”
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The role of CLDN11 in promotion of granulosa cell proliferation in polycystic ovary syndrome via activation of the PI3K-AKT signalling pathway by Min Wang, Tong Chen, Jiani Zheng, Caomeihui Shen, Guitian He, Jingshun Zhang, Boqi Zhang, Lianwen Zheng

“…Abstract Polycystic ovary syndrome (PCOS) is a complex gynecological endocrinological condition that significantly impacts women’s fertility during their reproductive lifespan. …”
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Building digital platform ecosystems: A synthetization of fundamental design topics from a literature review by Thomas Goertler, Marcel Papert, Isabel Fischer, Malou Schmidt

“…In practical terms, our findings provide valuable guidance to practitioners to help them make informed design and resource allocation decisions in the context of complex transformation projects. The identified themes synthesize the activities necessary to develop a platform's ecosystem and can be viewed as a basic design framework. …”
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Exenatide Is an Effective Antihyperglycaemic Agent in a Mouse Model of Wolfram Syndrome 1 by Tuuli Sedman, Kertu Rünkorg, Maarja Krass, Hendrik Luuk, Mario Plaas, Eero Vasar, Vallo Volke

“…Wolfram syndrome 1 is a very rare monogenic disease resulting in a complex of disorders including diabetes mellitus. …”
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Development of a rapid detection technology system for noxious plants based on a novel isothermal amplification technique by Ting Zhang, Ting Zhang, Han Xu, Mengdi Liu, Wei Zhang

“…We targeted the seeds, leaves, and grain impurities of four major noxious weeds: Amaranthus palmeri, the A.tuberculatus complex, Rhaponticum repens, and Euphrosyne xanthiifolia, we designed and screened primers and probes suitable for this isothermal amplification method, determined their limit of detection, optimized the genomic DNA extraction methods, and verified the method. …”
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ARV1 p.Gln62Ter, a novel mutation linked to developmental and epileptic encephalopathy-38 by Mostafa Neissi, Ayoob Radhi Al-Zaalan, Misagh Mohammadi-Asl, Mojdeh Roghani, Javad Mohammadi-Asl, Kamele Jorfi

“…The use of whole exome sequencing revealed a rare and likely pathogenic ARV1 gene mutation, emphasizing the significance of this genetic screening method in unraveling the complexities of developmental and epileptic encephalopathies.…”
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In Silico Study of Alkaloids: Neferine and Berbamine Potentially Inhibit the SARS-CoV-2 RNA-Dependent RNA Polymerase by Rishab Marahatha, Asmita Shrestha, Kabita Sharma, Bishnu P. Regmi, Khaga Raj Sharma, Pramod Poudel, Ram Chandra Basnyat, Niranjan Parajuli

“…Further, molecular dynamics simulation of 90 ns revealed the conformational stability of the neferine-RdRP complex.…”
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Integrating socio-economic support into drug-resistant TB care to optimise treatment outcomes by J. Limo, C. Pahe, I. Kathure, L. Ndungu, A. Mahihu, C. Mwashumbe, E. Mueni, H. Momanyi

“…This low TSR occurs amidst a complex range of treatment challenges, including psychosocial factors. …”
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A review of characteristic lengths in the coupled criterion framework and advanced fracture models by Molnár, Gergely, Doitrand, Aurélien, Estevez, Rafael,  Gravouil, Anthony

“…These enhancements could better capture the complex behaviors at smaller scales.The paper concludes by advocating for a combined approach that integrates various fracture models, which could provide a more comprehensive understanding of crack initiation and propagation across different scales. …”
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Clinical and microbiological characterization of patients with pneumonia associated with mechanical ventilation, Cienfuegos 2015-2017 by Roberto Carlos Barletta Farías, Leonardo Javier Pérez Ponce, Jorge Emilio Barletta del Castillo, Marcos Antonio González Guirola, Rolando Laín Sánchez Castellanos, Misael Pujol Pérez

“…<p><strong>Foundation</strong>: Pneumonia associated with mechanical ventilation is associated with high morbidity and mortality, and its integral management is complex.<br /><strong>Objective</strong>: to describe the clinical and microbiological characteristics in patients with pneumonia associated with mechanical ventilation.…”
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Erythrocyte Shape Abnormalities, Membrane Oxidative Damage, and β-Actin Alterations: An Unrecognized Triad in Classical Autism by Lucia Ciccoli, Claudio De Felice, Eugenio Paccagnini, Silvia Leoncini, Alessandra Pecorelli, Cinzia Signorini, Giuseppe Belmonte, Roberto Guerranti, Alessio Cortelazzo, Mariangela Gentile, Gloria Zollo, Thierry Durand, Giuseppe Valacchi, Marcello Rossi, Joussef Hayek

“…Autism spectrum disorders (ASDs) are a complex group of neurodevelopment disorders steadily rising in frequency and treatment refractory, where the search for biological markers is of paramount importance. …”
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Liver macrophage-derived exosomal miRNA-342-3p promotes liver fibrosis by inhibiting HPCAL1 in stellate cells by Wenshuai Li, Lirong Chen, Qi Zhou, Tiansheng Huang, Wanwei Zheng, Feifei Luo, Zhong Guang Luo, Jun Zhang, Jie Liu

“…Abstract Background The progression of liver fibrosis involves complex interactions between hepatic stellate cells (HSCs) and multiple immune cells in the liver, including macrophages. …”
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Enhanced YOLOv10 Framework Featuring DPAM and DALSM for Real-Time Underwater Object Detection by Suthir Sriram, Aburvan P., Arun Kaarthic T. P., Nivethitha Vijayaraj, Thangavel Murugan

“…Recently, spotting underwater objects has been increasingly difficult due to the complexities of marine environments and varied visibility conditions. …”
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Associations of Physical Activity and Sedentary Behaviors with Dietary Behaviors among US High School Students by Richard Lowry, Shannon Michael, Zewditu Demissie, Laura Kann, Deborah A. Galuska

“…However, the associations of PA and sedentary behaviors with dietary behaviors are complex and not well understood. Purpose. To describe the associations of PA and sedentary behaviors with dietary behaviors among a representative sample of US high school students. …”
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Evaluation of Yeast Alcohol Acetyltransferases for Ethyl Acetate Production in Clostridium ljungdahlii by Santiago T. Boto, Kareem Gerges, Bettina Bardl, Miriam A. Rosenbaum

“…However, we also show that this opens the door to more complex esterification reactions of higher added value biomolecules.…”
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