In silico analysis of the effect of HCV genotype-specific polymorphisms in Core, NS3, NS5A, and NS5B proteins on T-cell epitope processing and presentation by Samina Baig, Samina Baig, Assel Berikkara, Ramsha Khalid, Syed A. Subhan, Tanveer Abbas, Syed Hani Abidi

“…In silico results reveal that epitopes from genotype 6b (NS3), 6d/r (NS5B), 6o and 6 k (NS5A) exhibit higher immunogenicity than other genotypes, forming more energetically stable complexes with host receptors. These epitopes, compared to those from the same positions but different genotypes, showed binding energies of −144.24 kcal/mol, −85.30 kcal/mol, and − 43 kcal/mol, respectively. …”
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AiGPro: a multi-tasks model for profiling of GPCRs for agonist and antagonist by Rahul Brahma, Sunghyun Moon, Jae-Min Shin, Kwang-Hwi Cho

“…Leveraging multi-scale context aggregation and bidirectional multi-head cross-attention mechanisms, our approach demonstrates that ensemble models may not be necessary for predicting complex GPCR states and small molecule interactions. …”
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Comprehensive overview of genotype distribution and prevalence of human papillomavirus in cervical lesions by Yang Liu, Chengquan Zhao, Tiannan Wang, Yuhong Ye, Terrel Jones, Xianxu Zeng

“…The distribution of HR-HPV in severe squamous lesions is complex, involving many HR-HPV genotypes in addition to HPV16, while the distribution of HR-HPV genotypes in endocervical glandular lesions is mainly limited in HPV18 and HPV16.Large datasets from China have identified the three most common HR-HPV genotypes in this population as stratified by diagnostic category: HPV52, HPV16, HPV58 in histologically negative cases and cervical intraepithelial neoplasia 1 (CIN1); HPV16, HPV52, HPV58 in CIN2/3; HPV16, HPV58, HPV52 or HPV18 in squamous cell carcinoma (SCC); HPV16, HPV18 and HPV52 in endocervical adenocarcinoma in situ (AIS), invasive adenocarcinoma, as well as mixed squamous and glandular lesions. …”
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Risk barriers and sustainability in payment for ecosystem service implementation in smallholder forestry by A. Ibrahim, S. Withaningsih, R. Kinseng, Parikesit ., D. Muhamad

“…The importance of reliable data is emphasized by technical hurdles like accurate measurement of ecosystem services and monitoring complexities, necessitating innovative solutions and robust methodologies. …”
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Faktor Risiko Asma Pada Murid Sekolah Dasar Usia 6-7 Tahun di Kota Padang by Afdal ., Finny Fitry Yani, Darfioes Basir, Rizanda Machmoed

“…The occurrence of asthma is considered as a complex interaction between genetic factors and environmental factors. …”
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Trends, challenges and solutions of digital information security in Central and Eastern Europe by Serhii Lubenets, Igor Harchenko, Tetiana Shediakova

“…The problems and directions of ensuring effective international digital information security in Central and Eastern Europe (CEE) are considered, which are based on the analysis of the current state, key trends and challenges of information security in this region, using current reporting materials of international companies specializing in information security issues and development of appropriate complex tools for its provision. The subject of research in the article is the issue of ensuring international digital information security in the CEE. …”
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Klasifikasi Aktivitas Manusia Menggunakan Algoritme Computed Input Weight Extreme Learning Machine dengan Reduksi Dimensi Principal Component Analysis by M. Sofyan Irwanto, Fitra A. Bachtiar, Novanto Yudistira

“…Sensor-based technique can also be performed using smartphones, but smartphone has disadvantages in performing complex alghorithmic computation. Moreover, feature extraction of the data from the signal captured by the sensor has high dimensions. …”
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THE ROLE OF N. I. VAVILOV AND VIR’S SCIENTISTS IN DESERT RECLAMATION by N. I. Dzyubenko, A. A. Kochegina

“…Vavilov’s plans to solve the complex problems of desert and semi-desert reclamation in the areas of the USSR; afforestation, melioration and climatic studies; problems of southern industrial crops; formation of sustainable forage crop cultivation for livestock, and establishment of oases. …”
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Prevalence and associated factors of multidimensional poverty among rural households in East Gojjam zone, Northern Ethiopia: a community-based cross-sectional study by Amare Wubishet Ayele, Yeshiwas Ewinetu, Asefa Delesho, Yirsie Alemayehu, Hayimro Edemealem

“…Abstract Backgrounds Poverty is a complex and multifaceted global public health issue, particularly prevalent in Ethiopia, including the East Gojjam Zone. …”
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Les paysages mémoriels de la Grande Guerre (1914-1918) : un changement de paradigme dans la recherche sur le tourisme de mémoire by Myriam Jansen-Verbeke, Wanda George

“…Seule une étude comparative et équilibrée du point de vue géographique permet de mieux appréhender la relation complexe des nations et des peuples du 21e siècle avec le patrimoine de mémoire, tangible et intangible, du siècle précédent. …”
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COMPETENZE CHIAVE PER IL CURRICOLO VERTICALE: L’OPINIONE DEGLI INSEGNANTI E I MATERIALI DIDATTICI by Matteo La Grassa, Monica Barni

“…However, it also emerges that a ‘vertical’ approach is very complex to implement for logistical and organisational reasons and due to the lack of specific training that can foster constructive dialogue between groups of teachers with different competences and disciplinary objectives. …”
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Peningkatan Akurasi Metode Weighted Fuzzy Time Series Forecasting Menggunakan Algoritma Evolusi Differensial dan Fuzzy C-Means by Agus Fachrur Rozy, Solimun Solimun, Ni Wayan Surya Wardhani

“…The DE algorithm works by seeking the best solution in a complex parameter space through iterations and performance evaluations, thereby significantly enhancing the performance of the forecasting model. …”
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A first study on sperm sexing in water buffalo through magnetic nanoparticles by Syed Murtaza Hassan Andrabi, Muhammad Hammad Fayyaz, Muhammad Shafiq Haider, Ghulam Muhammad Ali

“…Consequently, in the sexed groups, the Y-bearing sperm-MNP complexes remained attached to the tube’s inner wall due to the magnetic force. …”
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PRACTICAL TRAINING OF OFFICERS OF THE STATE FIRE SERVICE THROUGH GAME-BASED LEARNING by V. V. Bulgakov, A. A. Lazarev, E. P. Konovalenko, T. A. Mochalova

“…However, in a technologically developed society, there is a contradiction between the increased requirements to young officers’ competencies and the impossibility to achieve a proper complex of graduates’ characteristics by providing education through only standard traditional techniques, which continue to be prevalent in higher education and ensure optimisation of professional activity in general.The aim of the present publication was to present the developed methodology of game-based learning for training of cadets of educational organisations of higher education of the EMERCOM of Russia. …”
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Blockchain-Based Value-Added Tax System: A Systematic Review by Vahideh Ghanooni Shishavan, Shaban Elahi, Sadegh Dorri Nogoorani, Ali Yazdian Varjani

“…Encryption alone cannot guarantee the privacy of electronic invoices, and while zero-knowledge proofs seem to be a suitable solution, they come with considerable complexities. ConclusionAccording to the inherent characteristics of the blockchain, it can be concluded that a blockchain is a suitable option for the VAT system and the right architecture is a permissioned private blockchain. …”
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Ketamine Infusion as an Adjunct to Opioid Analgesia in Pediatric Patients with High-Risk Neuroblastoma Undergoing Treatment with Dinutuximab: Adverse Effects and Safety in a Non-IC... by Streby KA, Tobias JD, McPhaden E, Downie S, Stanek J, Roth C, Patel PO

“…No other significant statistical differences in adverse effects were observed in patients’ receiving opioids versus opioids plus ketamine.Conclusion: Findings suggest ketamine is safe in a non-ICU setting for treatment of complex pain during anti-GD2 immunotherapy. Additional prospective studies are needed to quantify the effect of reducing opioid side effects by including ketamine in pain management plans.Keywords: anti-GD2 immunotherapy, dinutuximab, neuropathic pain, pediatric analgesia, ketamine, high-risk neuroblastoma, opioid…”
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Effect of General Anesthesia Combined with Transversus Abdominis Plane Block on Postoperative Sleep Disorders in Elderly Patients Undergoing Gastrointestinal Tumor Surgery: A Prosp... by Pu J, Guo C, Xiao Y, Cao Y, Liu Z, Jin Y, Hu Y

“…The group GA received the sedation-aspiration complex general anesthesia regimen, while the group GT underwent bilateral transversus abdominis plane blocks (TAPB) after the same induction of anesthesia. …”
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Empagliflozin-based quadruple oral therapy for type 2 diabetes: a prospective cohort study by Fatemeh Moosaie, Shiva Abedinzadeh, Soghra Rabizadeh, Kimia Daneshvar, Mohammadamin Noorafrooz, Fatemeh Alsadat Mojtahedi, Niloofar Deravi, Seyede Marzie Fatemi Abhari, Akam Ramezani, Alipasha Meysamie, Marzieh Hajibabaei, Sahar Karimpour Reyhan, Mahsa Abbaszadeh, Manouchehr Nakhjavani, Alireza Esteghamati

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Combined characterization of pore structurein deep medium-rank coal using mercury intrusion and liquid nitrogen adsorption methods and its pore fractal characteristics by Qi LI, Yong WU, Lei QIAO

“…The fractal dimensions based on the Menger sponge model ranged from 2.6 to 3.0, indicating irregular pore shapes, complex pore structures, and generally rough pore surfaces. (2) The effective pore size tested using liquid nitrogen adsorption method ranged from 3 to 177 nm with significant differences in total pore volume and specific surface area among the mining areas. …”
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The prolonged health sequelae “of the COVID-19 pandemic” in sub-Saharan Africa: a systematic review and meta-analysis by Melsew Setegn Alie, Getayeneh Antehunegn Tesema, Getayeneh Antehunegn Tesema, Gossa Fetene Abebe, Desalegn Girma

“…The emergence of new symptoms or the persistence of existing ones after a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) diagnosis has given rise to a complex clinical issue known as “long COVID-19” (LC). …”
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