Oral medications for the treatment of postural orthostatic tachycardia syndrome; a systematic review of studies before and during the COVID-19 pandemic by Benjamin C. Pierson, Kyle Apilado, Kyle Apilado, M. Alaric Franzos, M. Alaric Franzos, Rhonda Allard, James D. Mancuso, David Tribble, David Tribble, David Saunders, Tracey Perez Koehlmoos, Tracey Perez Koehlmoos

“…BackgroundPostural Orthostatic Tachycardia Syndrome (POTS) is a complex form of dysautonomia that presents with abnormal autonomic reflexes upon standing, leading to symptoms such as lightheadedness, tachycardia, fatigue, and cognitive impairment. …”
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CD200R1 immune checkpoint blockade by the first-in-human anti-CD200R1 antibody 23ME-00610: molecular mechanism and engineering of a surrogate antibody by Cristina Melero, S. Jimmy Budiardjo, Anahita Daruwalla, Lance Larrabee, Oleg Ganichkin, Alexander J. Heiler, Jill Fenaux, Ben Chung, Germaine Fuh, Yao-Ming Huang

“…Herein, we dissect the molecular mechanism of 23ME–00610 blockade of hCD200R1 by solving the crystal structure of 23ME–00610 Fab in complex with hCD200R1 and performing mutational studies, which show 23ME–00610 blocks the interaction between hCD200 and hCD200R1 through steric hindrance. …”
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Antibiotic Resistance and Molecular Epidemiological Characteristics of Streptococcus agalactiae Isolated from Pregnant Women in Guangzhou, South China by Zhaomin Cheng, Pinghua Qu, Peifeng Ke, Xiaohan Yang, Qiang Zhou, Kai Lan, Min He, Nannan Cao, Sheng Qin, Xianzhang Huang

“…All the strains were divided into 18 STs that were assigned to nine clonal complexes. Most of the major STs were distributed into specific serotypes, including ST19/serotype III, ST17/serotype III, ST485/serotype Ia, ST862/serotype III, and ST651/serotype III. …”
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Socioeconomic factors and sex effects of postpartum maternal depression on offspring internalizing symptoms: a systematic review and meta-analysis by Yang Geng, Wenlan Liu, Zhiying Yu, Hui Zhang, Yun Li, Weihua Zhao

“…Therefore, the significant sex effects of postpartum maternal depression are more likely due to complex interactions between maternal depression and the intrauterine and postpartum environments that shape offspring sex-difference trajectories, with consequences occurring for later internalizing symptoms in adolescence. …”
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Increased methane production associated with community shifts towards Methanocella in paddy soils with the presence of nanoplastics by Zhibin He, Yarong Hou, Ying Li, Qicheng Bei, Xin Li, Yong-Guan Zhu, Werner Liesack, Matthias C. Rillig, Jingjing Peng

“…Genes associated with the degradation of complex carbohydrates and aromatic carbon were significantly enriched. …”
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Political economy analysis of health financing reforms in times of crisis: findings from three case studies in south-east Asia by Sophie Witter, Maria Paola Bertone, Sushil Baral, Ghanshyam Gautam, Saugat K. C. Pratap, Aungsumalee Pholpark, Nurmala Selly Saputri, Arif Budi Darmawan, Nina Toyamah, Rizki Fillaili, Valeria de Oliveira Cruz, Susan Sparkes

“…However, successful health financing reforms involve complex interactions among a range of stakeholders, as well as with context factors, including shocks and crises of different nature. …”
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Evaluation of gestational nonpersistent pesticide exposure with newborn size and gestational length in rural Ghana using a novel time-varying extension of multiple informant models by Wylie BJ, Kaali S, Duttweiler L, Ae-Ngibise KA, Mujtaba M, Tawiah C, Gibson E, Calafat AM, Ospina M, Jack DJ, Agyei O, Lee AG, Roberts DJ, Boamah-Kaali EA, Factor-Litvak P, Modest AM, Hauser R, Coull BA, Asante KP

“…Extending multiple informant models to account for the complex data structure allowed us to discern effects in opposing directions by distinct pesticide classes. …”
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Inequalities in utilization of maternal health services in Ethiopia: evidence from the PMA Ethiopia longitudinal survey by Asebe Hagos, Misganaw Guadie Tiruneh, Melak Jejaw, Kaleb Assegid Demissie, Lemlem Daniel Baffa, Demiss Mulatu Geberu, Getachew Teshale, Tesfahun Zemene Tafere

“…The difference (D) in maternal health service utilization between advantaged and disadvantaged population groups exceeded 20 percentage points in all four dimensions of inequality for the three maternal health indicators. Similarly, the complex summary measures of inequality (PAR and PAF) also showed high levels of inequality in the utilization of ANC four, SBA, and PNC across all four dimensions of inequality. …”
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Determination of Sequential Well Placements Using a Multi-Modal Convolutional Neural Network Integrated with Evolutionary Optimization by Seoyoon Kwon, Minsoo Ji, Min Kim, Juliana Y. Leung, Baehyun Min

“…In geoenergy science and engineering, well placement optimization is the process of determining optimal well locations and configurations to maximize economic value while considering geological, engineering, economic, and environmental constraints. This complex multi-million-dollar problem involves optimizing multiple parameters using computationally intensive reservoir simulations, often employing advanced algorithms such as optimization algorithms and machine/deep learning techniques to find near-optimal solutions efficiently while accounting for uncertainties and risks. …”
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Identification of major trauma using the simplified abbreviated injury scale to estimate the injury severity score: a diagnostic accuracy and validation study by David Eidenbenz, Tobias Gauss, Tobias Zingg, Vincent Darioli, Cécile Vallot, Pierre-Nicolas Carron, Pierre Bouzat, François-Xavier Ageron

“…However, AIS coding is complex and requires specifically trained staff. A simple yet reliable scoring system is needed. …”
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Abdominal synthetic CT generation for MR-only radiotherapy using structure-conserving loss and transformer-based cycle-GAN by Chanwoong Lee, Chanwoong Lee, Young Hun Yoon, Young Hun Yoon, Young Hun Yoon, Jiwon Sung, Jun Won Kim, Yeona Cho, Jihun Kim, Jaehee Chun, Jin Sung Kim, Jin Sung Kim, Jin Sung Kim

“…This study showed the improvement of sCT using transformer and structure preserving loss even with the complex anatomy of the abdomen.…”
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Altered medial temporal lobe subregion volumes in systemic lupus erythematosus patients with neuropsychiatric symptoms by Z. Makdad Najeeb, P. C. Sundgren, A. Jönsen, K. Zervides, J. Lätt, T. Salomonsson, J. Nystedt, P. Nilsson, A. Bengtsson, G. Kuchcinski, L. E. M. Wisse

“…Partial correlation analyses showed a significant positive correlation between left Brodmann Area 35 volume and complex attention scores in SLE patients. No significant associations between MTL subregion volumes and depression scores were demonstrated. …”
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Characterisation of <i>Staphylococcus aureus</i> Strains and Their Prophages That Carry Horse-Specific Leukocidin Genes <i>lukP/Q</i> by Stefan Monecke, Sindy Burgold-Voigt, Andrea T. Feßler, Martina Krapf, Igor Loncaric, Elisabeth M. Liebler-Tenorio, Sascha D. Braun, Celia Diezel, Elke Müller, Martin Reinicke, Annett Reissig, Adriana Cabal Rosel, Werner Ruppitsch, Helmut Hotzel, Dennis Hanke, Christiane Cuny, Wolfgang Witte, Stefan Schwarz, Ralf Ehricht

“…We examined the genomes, including the <i>lukP/Q</i> prophages, of <i>S. aureus</i> strains belonging to clonal complexes CC1, CC350, CC816, and CC8115. In addition to sequencing, phages were characterised by mitomycin C induction and transmission electron microscopy (TEM). …”
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Exploring the role of inflammatory biomarkers in trigeminal neuralgia by Shenglong Lai, Haiyang Li, Yazhou Xing, Du Wu, Lin Wang, Qinghua Liang

“…Background: Trigeminal neuralgia (TN) is a severe facial pain disorder with complex etiology. Inflammation has been suggested as a contributing factor to TN pathogenesis. …”
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The impact of long-term exposure to NO2, O3, and their oxidative potential on adolescents’ mental health, and the protective role of school-based greenness by Jiajia Dang, Yaqi Wang, Ning Ma, Shan Cai, Jianhui Guo, Yunfei Liu, Haoyu Zhou, Xinyao Lian, Di Shi, Ziyue Chen, Yihang Zhang, Jiaxin Li, Tianyu Huang, Guangrong Zhu, Jing Li, Jun Ma, Yi Song

“…These results highlight the complex relationship between NO2, O3, OX, and mental health, with particular emphasis on the underexplored role of OX. …”
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Genetic Polymorphisms in RNF138, ABCA1 and ESRRG-GPATCH2 Genes and their Role in Insulin Resistance Risk among Normal BMI Individuals in Indian Population: A Case-control Study by Sabitha Thummala, Sarah Fathima, Nithya Kruthi, Junaid Ahmed Khan Ghori, Katherine Saikia, Vivek Belde, Balamurali Andiyakkal Rajendran, Rahul Ranganathan

“…Conclusion: This study underscores the importance of genetic factors in the risk of developing IR among Indians with a normal BMI, suggesting a complex interplay of genetics beyond traditional risk factors. …”
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SPA14 liposomes combining saponin with fully synthetic TLR4 agonist provide adjuvanticity to hCMV vaccine candidate by Ernesto Luna, Sophie Ruiz, Marie Garinot, Cyril Chavagnac, Pankaj Agrawal, John Escobar, Laurent Revet, Marie-Jeanne Asensio, Fabienne Piras, Francis G. Fang, Donald R. Drake, Bachra Rokbi, Daniel Larocque, Jean Haensler

“…When tested as an adjuvant in vivo with human cytomegalovirus glycoprotein B (gB) and pentamer complex (PC) as test antigens, SPA14 was generally well tolerated and as active as AS01B for the induction of long-lasting CMV-neutralizing antibodies in mice and non-human primates (NHPs). …”
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The association of serum total bile acids and deep venous thrombosis by Bolin Li, Xinxin Feng, Xinping Kang, Yi Zhao, Miaomiao Cao, Bao Xu, Hui Liu, Shuyi Deng, Yue Wu, Tao Zheng

“…These findings have significant implications for understanding the complex interplay between bile acid metabolism and deep venous thrombosis, and warrant further investigation.…”
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MUC5B modulation of early oral biofilm glucose metabolism by Carolina Robertsson, Carolina Robertsson, Julia Davies, Gunnel Svensäter, Anders Bay Nord, Niclas Norrström, Claes Wickström

“…IntroductionSalivary mucin MUC5B has been suggested to support eubiosis in early oral biofilms by regulating the attachment of commensals, while downregulating dysbiotic activities related to dental caries development, such as microbial carbohydrate transport and metabolism.MethodsTo investigate how the metabolism of glucose, a potential driver for dental caries, in early mono- and dual-species biofilms of oral Actinomyces naeslundii and Streptococcus gordonii clinical isolates was affected by the presence of the complex salivary mucin MUC5B, this study employed nuclear magnetic resonance (NMR)-based metabolomics with the interpretation of network integration.Results and discussionMUC5B reduced early attachment in the presence of glucose compared with uncoated surfaces but maintained even species distribution. …”
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Progress in phase field research of dead lithium in lithium batteries by Jing LIU, Huiyi CHEN, Huiyu LIU, Shu LI

“…This study focuses on analyzing these mechanisms and influencing factors from the perspective of the phase field, which is a powerful computational method to simulate microstructure evolution, providing insights into the complex dynamics of lithium deposition and the conditions and influencing factors for the formation of lithium dendrites and dead Lithium. …”
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