A Zinc Polyphenolic Compound Increases Maize Resistance Against Infection by <i>Bipolaris maydis</i> by Luis Felipe Lata-Tenesaca, Marcos José Barbosa Oliveira, Aline Vieira Barros, Leandro Castro Silva, João Américo Wordell Filho, Fabrício Ávila Rodrigues

“…The goal of this study was to investigate the potential of Semia^® (zinc (20%) complexed with a plant-derived pool of polyphenols (10%)) to hamper the infection of maize leaves by <i>B. maydis</i> by analyzing their photosynthetic performance and carbohydrate and antioxidative metabolism, as well as the expression of defense-related genes. …”
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Impacts of drought on respiratory mortality in the upper midwest United States: a population subgroup assessment by Yeongjin Gwon, Yuanyuan Ji, Jesse D Berman, Azar M Abadi, Ronald D Leeper, Jared Rennie, Jesse E Bell

“…Drought is a complex climate phenomenon that varies regionally and temporally across the globe. …”
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Piloting creative engagement strategies to explore themes of parenthood with fathers by Iryna Culpin, Iryna Culpin, Catherine Lamont-Robinson, Mark Billington, Matthew James, James Prewett, Gareth Ward, Mireia Bes Garcia, Giovanni Biglino, Giovanni Biglino

“…The richness and diversity of these unique responses suggest that arts-based methodology can facilitate public engagement with men and lead to deep reflections on complex and socially constructed phenomena such as fathering and parenthood.…”
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Do coping strategies mediate the effects of childhood adversities and traumata on clinical high-risk of psychosis, depression, and social phobia? A cross-sectional study on patient... by Zhixiong Chang, Naweed Osman, Carolin Martha Doll, Theresa Katharina Lichtenstein, Marlene Rosen, Eva Meisenzahl, Hanna Kadel, Joseph Kambeitz, Kai Vogeley, Frauke Schultze-Lutter

“…Conclusions Our findings underscore the complex interplay of the CAT domains and their relevant mediators with mental health outcomes that likely reflect underlying sex-specific psychological, social, cultural and neurobiological mechanisms. …”
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Gcn2 rescues reprogramming in the absence of Hog1/p38 signaling in C. neoformans during thermal stress by David Goich, Amanda L. M. Bloom, Sean R. Duffy, Maritza N. Ventura, John C. Panepinto

“…More broadly, this study highlights complex interplay between core conserved signal transduction pathways and the utility of molecular assays to better understand how these pathways are connected.IMPORTANCECryptococcus neoformans is an opportunistic pathogen of humans that causes deadly cryptococcal meningitis, which is is responsible for an estimated 19% of AIDS-related mortality. …”
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NCAPD3 promotes diffuse large B-cell lymphoma progression through modulating SIRT1 expression in an H3K9 monomethylation-dependent manner by Tiange Lu, Juan Yang, Yiqing Cai, Mengfei Ding, Zhuoya Yu, Xiaosheng Fang, Xiangxiang Zhou, Xin Wang

“…Introduction: Condensin, a family of structural maintenance of chromosome complexes, has been shown to regulate chromosome compaction and segregation during mitosis. …”
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TCR-engaging scaffolds selectively expand antigen-specific T-cells with a favorable phenotype for adoptive cell therapy by Marco Donia, Özcan Met, Julie Westerlin Kjeldsen, Sine Reker Hadrup, Inge Marie Svane, Arianna Draghi, Anders Handrup Kverneland, Christina Heeke, Siri Amanda Tvingsholm, Marcus Svensson Frej, Vibeke Mindahl Rafa, Ulla Kring Hansen, Maria Ormhøj, Alexander Tyron, Agnete W P Jensen, Mohammad Kadivar, Amalie Kai Bentzen, Kamilla K Munk, Gitte N Aasbjerg, Jeppe S H Ternander, Tripti Tamhane, Christian Schmess, Samuel A. Funt, Søren Nyboe Jakobsen

“…Here, in this study, we present a novel technology for ex vivo expansion of antigen-specific T-cells; artificial antigen-presenting scaffolds (Ag-scaffolds) consisting of a dextran-polysaccharide backbone, decorated with combinations of peptide-Major Histocompatibility Complex (pMHC), cytokines and co-stimulatory molecules, enabling coordinated stimulation of antigen-specific T-cells.Methods The capacity of Ag-scaffolds to expand antigen-specific T-cells was explored in ex vivo cultures with peripheral blood mononuclear cells from healthy donors and patients with metastatic melanoma. …”
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The evolving landscape of COVID-19: factors associated with in-hospital COVID-19 related mortality during the 2023–2024 phase of JN.1 subvariant dominance by Drieda Zaçe, Albiana Çekrezi, Christopher Jones, Ludovica Ferrari, Giuseppe De Simone, Elisabetta Teti, Vincenzo Malagnino, Marco Iannetta, Loredana Sarmati, Anna Maria Geretti

“…Abstract Background COVID-19 remains a complex health challenge. We analysed the characteristics and outcomes of COVID-19-related hospitalisations during JN.1 variant dominance. …”
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Col1A1 as a new decoder of clinical features and immune microenvironment in ovarian cancer by Xiao Xiao, Fangyi Long, Shaolan Yu, Wengjuan Wu, Dayan Nie, Xiaoyan Ren, Wen Li, Xujuan Wang, Ling Yu, Pinghan Wang, Gang Wang

“…BackgroundsCollagen type I alpha 1 chain (COL1A1) is a key protein encoding fibrillar collagen, playing a crucial role in the tumor microenvironment (TME) due to its complex functions and close association with tumor invasiveness. …”
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Exploration of alcohol dehydrogenase EutG from Bacillus tropicus as an eco-friendly approach for the degradation of polycyclic aromatic compounds by Muhammad Naveed, Fatima Iqbal, Tariq Aziz, Ayesha Saleem, Tayyab Javed, Mahrukh Afzal, Muhammad Waseem, Metab Alharbi, Thamer H. Albekairi

“…The lowest energy of − 10.3 was obtained with Indeno[1,2,3-cd] pyrene and the best docked complex was visulaized through discover studio to analyze its binding residues. …”
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Translation of PET radiotracers for cancer imaging: recommendations from the National Cancer Imaging Translational Accelerator (NCITA) consensus meeting by Martina A. McAteer, Daniel R. McGowan, Gary J. R. Cook, Hing Y. Leung, Tony Ng, James P. B. O’Connor, Luigi Aloj, Anna Barnes, Phil J. Blower, Kevin M. Brindle, John Braun, Craig Buckley, Daniel Darian, Paul Evans, Vicky Goh, David Grainger, Carol Green, Matt G. Hall, Thomas A. Harding, Catherine D. G. Hines, Simon J. Hollingsworth, Penny L. Hubbard Cristinacce, Rowland O. Illing, Martin Lee, Baptiste Leurent, Sue Mallett, Radhouene Neji, Natalia Norori, Nora Pashayan, Neel Patel, Kieran Prior, Thomas Reiner, Adam Retter, Alasdair Taylor, Jasper van der Aart, Joseph Woollcott, Wai-Lup Wong, Jan van der Meulen, Shonit Punwani, Geoff S. Higgins

“…Abstract Background The clinical translation of positron emission tomography (PET) radiotracers for cancer management presents complex challenges. We have developed consensus-based recommendations for preclinical and clinical assessment of novel and established radiotracers, applied to image different cancer types, to improve the standardisation of translational methodologies and accelerate clinical implementation. …”
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Long-Term Results of Medical and Surgical Methods for Elimination of the Internal Anal Sphincter Spasm in Chronic Anal Fissure (NCT03855046) by S. I. Achkasov, R. Yu. Khryukin, E. E. Zharkov, A. A. Ponomarenko, O. Yu. Fomenko, N. I. Klopkov, Z. Z. Kamaeva, E. Yu. Lebedeva, K. I. Sagidova

“…Long-term results of complex treatment were studied in 126 patients (54 (43 %) men and 72 (57 %) women), the median follow-up was 12.3 (12.2; 15.7) months. …”
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A rare deleterious missense mutation in the AXIN2 gene in Chinese women with polycystic ovary syndrome by Ying Zhang, Yu Chen, Fa-Ying Liu, Jing-Wen Fu, Xian-Xian Liu, Jun Tan, Ou-Ping Huang, Yang Zou

“…The causative factors of PCOS are complex, and genetic structure remains a long-standing medical challenge in genetics. …”
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“A torch, a rope, a belly laugh”: engaging with the multiple voices of support groups for people living with rare dementia by Paul M. Camic, Emma Harding, Sam Rossi-Harries, Oliver S. Hayes, Mary Pat Sullivan, Lawrence Wilson, Nikki Zimmermann, Roberta McKee-Jackson, Joshua Stott, Nick C. Fox, Catherine J. Mummery, Jonathan D. Rohrer, Jason D. Warren, Rimona S. Weil, Sebastian James Crutch

“…The poems portray the complex, dynamic and relational aspects of how support groups provide a necessary form of connection for this population. …”
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Utilizing multidisciplinary mobile outreach clinics to provide comprehensive diabetic foot care to patients experiencing homelessness by Kris M. Boelitz, MD, Jaeyoung Lee, BS, Michael D. Pepin, BS, Yiming Zhang, MS, Mallory Gibbons, MSN, NP, Frances J. Lagana, DPM, Shahida Balaparya, EdD, MBA, RVT, Lindsey Carr, Jessin Varghese, BS, NP, Caitlin Sorensen, MD, Jessica P. Simons, MD, MPH, Douglas Jones, MS, MD, Andres Schanzer, MD, Tammy T. Nguyen, MD, PhD

“…The MMC focused on providing diabetic foot ulcer care and screening because it is a complex medical problem that disproportionately impacts unhoused individuals and requires multidisciplinary care. …”
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Gastrointestinal complications of hepatic glycogen storage disease: a national survey questionnaire study in China by Xiaoyan Zhang, Zexiong Su, Jiaxing Wu, Hanshi Zeng, Xun Jiang, Ying Wang, Huiqing Shen, Xiaoli Xie, Yuan Xiao, Qing Tang, Xiaoping Luo, Xuemei Zhong, Huan Chen, Jiaoli Lan, Yongxin Chen, Xiaolu Zeng, Huiqiong Zhang, Zhiling Li, Yuxin Zhang, Min Yang

“…Abstract Background Hepatic glycogen storage diseases (GSD) are inborn errors of metabolism with abnormal storage or utilization of glycogen, a complex disease with significant genetic heterogeneity and similar clinical manifestations. …”
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Gene expression changes in blastocyst hatching affect embryo implantation success in mice by Liyou An, Liang Zhang, Yulin Wu, Yadi Teng, Zihan Liu, Meixiang Ma, Miaolong Li, Xinrong Peng, Chenxi Liu

“…Based on the hatching outcome, we identified three transcription patterns in developing blastocysts, with complex changes in the transcriptional regulation network of failed hatched blastocysts vs. successfully hatched blastocysts. …”
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Evolution characteristics of overburden structure in inclined fully mechanized caving under residual coal pillars of the upper layer by LIU Yong, WANG Hongwei, WU Xuesong, TIAN Chengpeng, GUAN Rongfu, NIE Yunxiao, FAN Zhiwei, CAO Peipei

“…In the stratified fully mechanized caving of ultra-thick coal seams, the inclined layout of upper and lower caving faces leads to lower fully mechanized caving face intermittently crossing residual coal pillars of the upper layer. This results in complex overburden breakage and mine pressure behavior, posing challenges to surrounding rock control and hindering safe coal production. …”
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Spatial and Temporal Variations in 94-GHz Radar Backscatter From a Springtime Snowpack by William D. Harcourt, Duncan A. Robertson, David G. Macfarlane, Brice R. Rea, Mike R. James, Mark Diggins, Blair Fyffe

“…The high sensitivity of 94-GHz radar backscatter to changes in snow surface conditions demonstrates the capabilities of millimeter-wave radar for daily monitoring of snow cover characteristics across complex topography with a spatial resolution of approximately a few meters.…”
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Genome-wide identification of the Sec14 gene family and the response to salt and drought stress in soybean (Glycine max) by Jinyu Zhang, Liying Zou, Li Wang, Dongchao Zhang, Ao Shen, Yongqi Lei, Maoni Chao, Xinjuan Xu, Zhiwei Xue, Zhongwen Huang

“…Abstract Background The Sec14 domain is an ancient lipid-binding domain that evolved from yeast Sec14p and performs complex lipid-mediated regulatory functions in subcellular organelles and intracellular traffic. …”
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