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β-Caryophyllene and Statins in Bone Fracture Healing – A Narrative Review
Published 2025-01-01“…Hilik Marom,1,* Mansoor A Khan,1,* Nissim Darvish,2,* Paul Tornetta III,3,* Amal Khoury,4,* Yoram A Weil,5,* Nathan WM Skelley,6,* Daniel C Allison,7,* Sahar Meiron,2,* Tami Ehrmann Barr1,* 1R&D, OrthoTreat Ltd, Tel Aviv-Jaffa, Israel; 2Corporate Office, OrthoTreat Ltd, Tel Aviv-Jaffa, Israel; 3Department of Orthopaedic Surgery and Orthopaedic Trauma, Chobanian and Avedisian School of Medicine, Boston Medical Center, Boston, MA, USA; 4Division of Orthopaedic Surgery, Orthopaedic, and Reconstructive Trauma Surgery, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel; 5Department of Orthopaedics, Hadassah Hebrew University Hospital, Jerusalem, Israel; 6Department of Orthopaedics, Sanford Health, Sioux Falls, SD, USA; 7Department of Orthopaedic Oncology, Cedars-Sinai Medical Center, Los Angeles, CA, USA*These authors contributed equally to this workCorrespondence: Tami Ehrmann Barr, Email drbarr@orthotreat.ioAbstract: Bone fractures are a leading cause of morbidity and healthcare expenditure globally. The complex healing process involves inflammation, cartilage formation, mineralization, and bone remodeling. …”
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29243
Call for Papers: Intergenerational Justice Prize 2020
Published 2020-02-01“…Undoubtedly, intergenerational transfers of wealth by inheritance and gifts (and related issues of inheritance and gift tax) are a complex issue that has been the subject of many political and philosophical discussions. …”
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29244
COVID-19 is a risk factor for retinal vein occlusion in younger patients?
Published 2022-02-01“…Management of younger patients with RVO required a complex diagnostic approach to assess systemic risk factors and obligatory evaluation of baseline retinal ischemia using fluorescein angiography (FA) or optical coherence tomography angiography (OCTA). …”
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29245
Typology and Visual Analysis of Seyed Ali Akbar Golestaneh's Shikasta Script Writings
Published 2024-04-01“…Regarding simple-letter composition, the features of complex writing, the system of composition and arrangement of elongations (Mads), the tendency to alliance of circular and curved forms in both horizontal and stepped ways, and the composition of micro-elements (including repetition of similar and aligned movements, tangency, intrusion, and merging of letters with each other) in Golestaneh's works can be expressed.…”
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29246
Computational network analysis of two popular skin cancers provides insights into the molecular mechanisms and reveals common therapeutic targets
Published 2025-01-01“…Gene regulatory network analysis revealed complex interactions between genes, miRNAs, and transcription factors, with TP53, BCL2, and EGFR playing central roles. …”
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29247
Identification and Analysis of Potential Immune-Related Biomarkers in Endometriosis
Published 2023-01-01“…The pathophysiology of endometriosis is complex and depends on a variety of biological processes and pathways. …”
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29248
Co-administration of Hibiscus sabdariffa linn and Daflon-500® mitigates weight loss, hyperglycemia, hematological and oxidative changes in male rats with type-2 diabetes
Published 2025-02-01“…Background: Diabetes mellitus is a complex metabolic disorder associated with persistent hyperglycemia and metabolic imbalance. …”
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29249
Law of Ukraine “on administrative procedure”: new terminology and legal value of the law
Published 2024-12-01“…The methodology includes a complex analysis of the issues, theoretical elaboration of the current legal material on the raised issue and formation of relevant conclusions and recommendations. …”
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29250
Migration of Health Workers and Its Impacts on the Nigerian Health Care Sector: Protocol for a Scoping Review
Published 2025-01-01“…Understanding the factors driving migration, its effects on health care delivery, and potential policy interventions is critical for addressing this complex issue. ObjectiveThis study aims to comprehensively examine the factors encouraging the emigration of Nigerian health workers, map out the effects of health worker migration on the Nigerian health system, document the loss of investment in health training and education resulting from migration, identify relevant policy initiatives addressing migration, determine the effects of Nigerian health worker migration on destination countries, and identify the benefits and demerits to Nigeria of health worker migration. …”
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29251
Analysis of argument structure constructions in the large language model BERT
Published 2025-01-01“…Our study underscores the complex, layered processing of linguistic constructions in BERT, revealing both similarities and differences compared to recurrent models like LSTMs. …”
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Combating COVID-19 and its co-infection by Aspergillus tamarii SP73-EGY using in vitro and in silico Studies
Published 2025-01-01“…Molecular dynamics simulations were employed to examine the structural stability and flexibility of these complexes. This confirmed the high binding affinities of Kojic acid and 4(4-Methylbenzylidene)cyclohexane-1,3-dione, thereby proving their potential as novel anti-SARS-CoV-2.…”
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29253
Valuation method for sub-indicators of rock burst risk based on mining depth and tectonic stress
Published 2024-12-01“…The mechanical properties of deep rocks differ from those of the shallow layers due to the complex environment. Rock burst disasters are often induced under the disturbance of coal mining. …”
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29254
Utilization and Predictors of Maternal Health Care Services among Women of Reproductive Age in Hawassa University Health and Demographic Surveillance System Site, South Ethiopia: A...
Published 2020-01-01“…However, major predictors that influence the utilization of the existing maternal health care services are complex and differ from place to place. Therefore, assessing these predictors assists health planners to prioritize promotion strategies and is a fundamental step for intervention. …”
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Physicians’, pharmacists’, and nurses’ education of patients about antibiotic use and antimicrobial resistance in primary care settings: a qualitative systematic literature review...
Published 2025-01-01“…The use of delayed prescriptions emerged as a strategy for improved AMR stewardship and to meet patients’ expectations for antibiotic treatment, though it raised concerns about undermining professional responsibility and authority in ensuring appropriate antibiotic use.ConclusionHealthcare professionals’ role in educating patients about antibiotic use and AMR in primary care settings was complex, with different challenges faced by nurses, pharmacists and primary care physicians. …”
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29257
Outcomes of Open Reduction and Modified McLaughlin’s Procedure in Neglected Posterior Shoulder Dislocation
Published 2023-07-01“…The management of neglected posterior GHJ dislocation is complex, ranging from conservative measures to surgical intervention. …”
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Decision support systems for waste-to-energy technologies: A systematic literature review of methods and future directions for sustainable implementation in Ghana
Published 2025-02-01“…These tools have demonstrated their effectiveness in handling the complex, multi-faceted nature of WtE technology selection and implementation, addressing issues ranging from site selection to technology ranking based on multiple criteria. …”
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29259
The Effective Compound Combination of Bufei Yishen Formula III Improves the Mitochondrial Dysfunction via Inhibiting JNK/Sab Pathway in COPD Mice
Published 2025-01-01“…Furthermore, ECC-BYF III ameliorated mitochondrial dysfunction by restoring the mitochondrial membrane potential, increasing mitochondrial complex I activity, and decreasing tumor necrosis factor-α (TNF-α) level and protein expressions of SH3BP5 (Sab), Phospho-JNK (P-JNK), and cleaved CASP3.Conclusion: The results suggest that the potential therapeutic benefit of ECC-BYF III against mitochondrial dysfunction in COPD is due to the inhibition of the JNK/Sab pathway, which will help to further understand the potential mechanisms of ECC-BYF III in the treatment of COPD. …”
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