Network pharmacology and experimental verification to investigate the mechanism of isoliquiritigenin for the treatment of Alzheimer’s disease by Waimao Gao, Guang Yang, Xinjuan Liu, Kaifan Hu, Jie Pan, Xingyu Wang, Yan Zhao, Ying Xu

“…The protein-protein interaction (PPI) network was constructed and clusters were obtained using the Molecular Complex Detection (MCODE) and the Cytohubba plugins. …”
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Neuropsychological features of patients of reproductive age diagnosed with breast cancer at the stage of surgical treatment using xenon-oxygen therapy by D. A. Rozenko, A. I. Shikhlyarova, L. N. Vaschenko, N. N. Popova, Yu. Yu. Arapova, A. Yu. Ardzha, A. A. Korobov

“…The early postoperative period in patients with newly diagnosed breast cancer is characterized by the formation of a depressive symptom complex. The use of a course of xenon-oxygen therapy contributes to the normalization of the subjective feeling of physical and psychological health, increasing vital and social activity. …”
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Management of Irritable Bowel Syndrome: Novel Approaches to the Pharmacology of Gut Motility by Carmelo Scarpignato, Iva Pelosini

“…Unfortunately, no single drug has proven to be effective in treating IBS symptom complex. In addition, the use of some medications has often been associated with unpleasant side effects. …”
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Spatiotemporal variations of surface and groundwater interactions under climate and land use land cover change scenarios by Kotapati Narayana Loukika, Venkata Reddy Keesara, Eswar Sai Buri, Venkataramana Sridhar

“…The behaviour of water between the surface and subsurface is a dynamic and intricate process, involving a complex interplay between surface water and groundwater. …”
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TAB2 deficiency induces dilated cardiomyopathy by promoting mitochondrial calcium overload in human iPSC-derived cardiomyocytes by Wenrui Sun, Jianchao Zhang, Shuang Li, Wanrong Fu, Yangyang Liu, Mengduan Liu, Jianzeng Dong, Xiaoyan Zhao, Xiaowei Li

“…Abstract Background TGF-β-activated kinase 1 binding protein 2 (TAB2) is an intermediary protein that links Tumor necrosis factor receptor 1 (TNFR1) and other receptor signals to the TGF-β-activated kinase 1 (TAK1) signaling complex. TAB2 frameshift mutations have been linked to dilated cardiomyopathy (DCM), while the exact mechanism needs further investigation. …”
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Combined real-time fMRI and real time fNIRS brain computer interface (BCI): Training of volitional wrist extension after stroke, a case series pilot study. by Avi K Matarasso, Jake D Rieke, Keith White, M Minhal Yusufali, Janis J Daly

“…Measures were: Arm Motor Assessment Tool, functional domain (AMAT-F; 13 complex functional tasks), Fugl-Meyer arm coordination scale (FM); active wrist extension range of motion (ROM); volume of activation (fMRI); and fNIRS HbO concentration. …”
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The expansion and loss of specific olfactory genes in relatives of parasitic lice, the stored-product psocids (Psocodea: Liposcelididae) by Jun Sun, Jian Wu, Sheng-Yuan Sun, Zhi-Dong Chen, Guy Smagghe, Jin-Jun Wang, Dan-Dan Wei

“…This increase may be due to the inability of parasitic lice to survive without a host, whereas booklice have a wide range of feeding habits and live in complex and variable environments. Furthermore, we observed that the IR gene family in L. tricolor has undergone a certain degree of amplification, which may facilitate its adaptation to diverse environmental conditions. …”
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Describing viewpoints on human‐nature relationships to unveil socio‐environmental conflicts and support community‐based projects by Beatriz Demasi, Nina Garcia de Almeida Prado, Flávia Pereira Lima, Charbel N. El‐Hani, Renata Pardini

“…Two viewpoints associated with community members revealed contrasting standpoints about nature resulting from complex transformations—from resource‐dependent to tourism‐dependent—in the community. …”
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Wind–Wave Misalignment in Irish Waters and Its Impact on Floating Offshore Wind Turbines by Thomas Shanahan, Breiffni Fitzgerald

“…This work emphasizes improved design and testing protocols for FOWTs in complex marine environments and highlights the suitability of ERA5 for climate analysis in Ireland.…”
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Development of Stylistics and Rhetoric in Lithuania by Irena Smetonienė, Marius Smetona

“… Every concept has its own history and its own prehistory, without which it is impossible to understand both complex and simple phenomena of life, and this article provides a brief overview of the development of rhetoric and stylistics from antiquity to the present day. …”
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Practical application of a nutraceutical in age-related macular degeneration by T.G. Kamenskikh, Kolbenev I.O, Veselova E.V, Batischeva Yu.S.

“…<br> <b>Conclusions</b>: Retinorm, as a balanced source of substances necessary for the retina, can be recommended for the use in the complex therapy of patients with a «dry» form of AMD.…”
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Shock reaction model for impact energy release behavior of Al/PTFE reactive material by Bao-yue Guo, Ke-rong Ren, Xia-yin Ma, Gan Li, Cai-min Huang, Zhi-bin Li, Rong Chen

“…The reaction mechanism of these materials is complex, and it is difficult to directly monitor the chemical reaction process. …”
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Modelling pre-Hispanic settlement patterns in Alto de Toche, Colombia by César Augusto Velandia, Daniel Ramírez, Jhony Carvajal, David Bejarano

“…The Toche region in Colombia contains an outstanding anthropised ecosystems presence (8000 BP), characterised by complex inherited cultural patterns, according to the evidences on the eastern margin of the Andes Central Cordillera. …”
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Rapid Detection of Hybrid Maize Parental Lines Using Stacking Ensemble Machine Learning by M. Aqil, M. Azrai, M. J. Mejaya, N. A. Subekti, F. Tabri, N. N. Andayani, Rahma Wati, S. Panikkai, S. Suwardi, Z. Bunyamin, E. Roy, M. Muslimin, M. Yasin, E. Prakasa

“…Hybrid maize seed production is a relatively complex task due to the coexistence of three distinct types of maize plants in the field: female, male, and contaminant/off-type plants. …”
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Molecular Dynamics Simulation of CO₂-ECBM Under Different Moisture Contents by Xiaoyu Cheng, Xuanping Gong, Cheng Cheng, Quangui Li, Ziqiang Li

“…The interactions among water molecules, coal beds, and gases during the process of coal bed methane mining are highly complex. The water and methane (CH₄)/carbon dioxide (CO₂) molecules compete for adsorption and undergo a series of reactions that affect gas diffusion. …”
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Targeting necroptosis in MCF-7 breast cancer cells: In Silico insights into 8,12-dimethoxysanguinarine from Eomecon Chionantha through molecular docking, dynamics, DFT, and MEP stu... by Maram B Alhawarri, Mohammad G Al-Thiabat, Amit Dubey, Aisha Tufail, Katreen Banisalman, Ghazi A Al Jabal, Eman Alkasasbeh, Esra'a Ibrahim Al-Trad, Bilal Harieth Alrimawi

“…In addition, the individual residue contribution analysis highlighted key interactions, with ARG149 showing a significant contribution (-176.24 kcal/mol) in the MLKL-SG-A complex. DFT and MEP studies corroborated these findings, revealing that the electronic structure of SG-A is conducive to stable binding interactions, characterized by a narrow band gap (~0.16 units) and distinct electrostatic potential favourable for necroptosis induction. …”
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Impact of functional re-education and environmental adaptation in cancer patients with respiratory pathology: Study protocol. by Eduardo Jose Fernandez-Rodriguez, Maria Isabel Rihuete-Galve, Alberto Garcia-Martin, Celia Sanchez-Gomez, Fausto Jose Barbero-Iglesias, Roberto Mendez-Sanchez, Ana Silvia Puente-Gonzalez, Susana Saez-Gutierrez, Emilio Fonseca-Sanchez, Juan Jesus Cruz-Hernandez

“…<h4>Methods</h4>A two-arm, randomized, parallel, controlled clinical trial will be conducted by the University of Salamanca, Spain, in collaboration with the Medical Oncology Service of the University Health Care Complex of Salamanca. The trial aims to recruit 80 oncology patients who exhibit symptoms of dyspnoea during hospital admission. …”
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Defining and measuring long COVID fatigue: a scoping review by Deborah Edwards, Jennifer Davies, Christine Bundy, Rachael Pattinson, Bethan Thomas, Carys Dale, Benjamin Jenkins, Helena Lande

“…It is clear from other conditions that the definition and measurement of fatigue can be complex; however, it is not clear how fatigue is defined and measured in long COVID. …”
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Advancing dental biofilm models: the integral role of pH in predicting S. mutans colonization by Jay S. Sangha, Valentina Gogulancea, Thomas P. Curtis, Nicholas S. Jakubovics, Paul Barrett, Aline Metris, Irina D. Ofiţeru

“…ABSTRACT Mathematical models can provide insights into complex interactions and dynamics within microbial communities to complement and extend experimental laboratory approaches. …”
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The Efficacy of Conversational AI in Rectifying the Theory-of-Mind and Autonomy Biases: Comparative Analysis by Marcin Rządeczka, Anna Sterna, Julia Stolińska, Paulina Kaczyńska, Marcin Moskalewicz

“…Notably, general-purpose bots showed more consistent accuracy and adaptability in recognizing and addressing bias-related cues across different contexts, suggesting a broader flexibility in handling complex cognitive patterns. In addition, in affect recognition tasks, general-purpose chatbots not only excelled but also demonstrated quicker adaptation to subtle emotional nuances, outperforming therapeutic bots in 67% (4/6) of the tested biases. …”
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