Genetic investigations of autosomal recessive inherited ichthyosis impressed by fetal ultrasound: Exome sequencing and haplotype linkage analysis by Ting-Yu Chang, Zhu Wei Lim, Yi-Tzu Chu, Wan-Ju Wu, Mei-Hui Lee, Shun-Ping Chang, Dong-Jay Lee, Wen-Hsiang Lin, Ming Ho, Jin-Chung Shih, Gwo-Chin Ma, Ming Chen

“…Objective: Ichthyosis are complex skin diseases, characterized by hyperkeratosis with various degrees of thickening, desquamation, and erythema. …”
Get full text

A disintegrin and metallopeptidase domain (ADAM) 12, ADAM 17 mRNA and ADAM10 protein hold potential as biomarkers for detection of early gastric cancer by Sooyeon Oh, Sang-Soo Lee, Hoeyoung Jin, Seo-Hyeon Choi, Choong-Keun Cha, Jooho Lee, KyuBum Kwack, Sang Gyun Kim, Sang-Woon Choi

“…As a proof-of-concept pilot study, the expression of ADAM8, ADAM9, ADAM10, ADAM12, ADAM17, and major histocompatibility complex (MHC) class I chain-related sequence A (MICA), a ligand for NKG2D, in gastric cancer was investigated in silico using The Cancer Genome Atlas (TCGA) database. …”
Get full text

Disease-Related Knowledge, Stress, and Quality of Life of Parental Caregivers of Children with Cleft Lip and Palate in a Selected Hospital in Ho Chi Minh City, Vietnam by Phung Le Thi Kim, Leonora Collantes, Phuong Lam Hoai, An Phan Huynh, Nghia Le Trung, Tu Nguyen Thanh, Anh Nguyen Viet, Kieu Nguyen Thi Thanh, Truc Pham Thanh Luu, Phi Duong Nguyen

“…Parental caregivers, particularly mothers, face considerable challenges in managing complex treatment pathways and addressing their children's multifaceted needs. …”
Get full text

High-Performance Photocatalytic Multifunctional Material Based on Bi₄Ti₃O₁₂-Supported Ag and Ti₃C₂T_x for Organic D... by Kexi Zhang, Bingdong Yan, Xiaohong Wang, Yang Cao, Wanjun Hao, Jinchun Tu

“…With the rapid development of modern science and technology and the diversification of social needs, traditional single-performance materials struggle to meet the complex and changeable application scenarios. To address the multifaceted requirements of biomedical applications, such as disease diagnosis and treatment, scientists are dedicated to developing new multifunctional biomaterials with multiple activities. …”
Get full text

Identification and validation of immune and diagnostic biomarkers for interstitial cystitis/painful bladder syndrome by integrating bioinformatics and machine-learning by Tao Zhou, Can Zhu, Wei Zhang, Qiongfang Wu, Mingqiang Deng, Zhiwei Jiang, Longfei Peng, Hao Geng, Zhouting Tuo, Zhouting Tuo, Ci Zou

“…Moreover, PLAC8 overexpression was found to promote the proliferation of urothelial cells without affecting their migratory ability by inhibiting the Akt/mTOR/PI3K signaling pathway.ConclusionsOur study identifies potential diagnostic candidate genes and reveals the complex immune landscape associated with IC/BPS. Among them, PLAC8 is a promising diagnostic biomarker that modulates the immune response in patients with IC/BPS, which provides new insights into the future diagnosis of IC/BPS.…”
Get full text

The Conceptual Domain of Hunting and Its Negative Representation in Love: A Cognitive-Cultural Analysis by Raheleh Gandomkar, Masoomeh Hashemi

“…These representations are complex, but from a cognitive perspective, their significance lies in how they draw upon the source domain of hunting, shaping the thinking and reasoning about love and seduction in the texts under study. …”
Get full text

A systematic review and meta-analysis of influencing factors of postoperative wound healing in patients with anal fistula (肛瘘患者术后伤口愈合影响因素系统评价与Meta分析)... by CHEN Qi (陈祺), LIU Zhiping (刘志平), BAI Jianying (白建英), LIU Bo (刘博), FENG Jiangxu (冯江雪)

“…Conclusion Age(≥60 years old), alcohol consumption, diabetes, anal fistula duration > 6 months, complex anal fistula, constipation, poor stool quality, postoperative wound infection, and poor wound drainage were the influencing factors of postoperative wound healing in patients with anal fistula. …”
Get full text

Deviant Behaviors of Students in Educational System: A Meta-synthesis Model-Building Theory by Mehdi Mohammaadi, Farzane Deimehkar Haghighi

“…Introduction Deviant behavior among adolescents is a complex phenomenon shaped by a variety of individual, familial, peer, and societal influences. …”
Get full text

Epigenetic Inhibitors Differentially Impact TGF-β1 Signaling Cascades in COPD Airway Smooth Muscle Cells by Karosham Diren Reddy, Dikaia Xenaki, Ian M. Adcock, Brian G. G. Oliver, Razia Zakarya

“…However, a deeper understanding of the complex mechanisms associated with DNA methylation, histone post-translational changes and RNA methylation in the context of regulatory pathways remains to be elucidated. …”
Get full text

Identification of heat tolerant lentil genotypes through stress tolerance indices by Rohit Sarkar, Gyan Prakash Mishra, Premakumar, Ankita Singh, Jenia Roy, Kumbarahally Murthigowda Shivaprasad, Shashidhar B. Reddappa, Sudhir Kumar, Ruchi Bansal, Uttarayan Dasgupta, Soma Gupta, Susheel Kumar Sarkar, Sanjeev Gupta, Shiv Kumar, Harsh K. Dikshit, Prachi Sripathrao Yadav, Muraleedhar S. Aski

Get full text

Role of plasminogen/plasmin system components and matrix metalloproteases in retinal artery occlusion following cardiac surgery by L.V. Natrus, N.Ia. Kovalchuk, I.S. Tanasiichuk, Iu.O. Panchenko

“…Enzyme-linked immunosorbent assay kits were used to determine plasma plasminogen activator inhibitor (PAI)-1, plasmin-α2-antiplasmin complex (PAP), and tissue inhibitor of MMP-3 (TIMP-3) levels. …”
Get full text

Evaluating the dual impact of microbial activity and aged refuse layers on landfill leachate clogging: An experimental and LCA perspective by Zhaobin Li, Waifan Tang, Shulun Mak, Siukei Lam, Qingwen Li

“…Background: Leachate-induced clogging in landfill drainage systems significantly impairs operational efficiency while posing substantial environmental risks. The complex interactions among leachate components (e.g., organic matter, heavy metals, and inorganic salts), microbial communities, and inorganic precipitates lead to clogging that reduces hydraulic conductivity. …”
Get full text

What is the relationship between exposure to environmental pollutants and severe mental disorders? A systematic review on shared biological pathways by Pierluigi Catapano, Mario Luciano, Salvatore Cipolla, Daniela D'Amico, Alessandra Cirino, Maria Chiara Della Corte, Gaia Sampogna, Andrea Fiorillo

“…The biological mechanisms by which environmental pollution and climate change influence the onset and exacerbation of severe mental disorders are complex and include gene expression, inflammation, oxidative stress, and anatomical brain changes. …”
Get full text

The role of ultrasound combined with water bath in the establishment of animal models of rat urethral stricture by Xiaojian Ye, Xianjing Lin, Yehui Chen, Rongquan Xu, Jiawei Zhou

“…Urethral stricture presents a complex challenge in urology, often requiring invasive treatment modalities. …”
Get full text

Association between some environmental risk factors and attention-deficit hyperactivity disorder among children in Egypt: a case-control study by Riham Abdelhamid Hussein, Rania Hussein Refai, Aleya Hanafy El-zoka, Hanan Galal Azouz, Mohamed Fakhry Hussein

“…Abstract Background Attention-Deficit Hyperactivity Disorder (ADHD) is a complex disease that negatively impacts the social and academic/occupational activities of children and is more common in boys than in girls. …”
Get full text

Experimental Investigations of Offshore Sand Production Monitoring Based on the Analysis of Vibration in Response to Weak Shocks by Yichen Li, Gang Liu, Zongwen Jia, Min Qin, Gang Wang, Yinan Hu, Jialin He, Kai Wang

“…The dynamic time-frequency response, field test results, and actual laboratory results are consistent, verifying the effectiveness of the method proposed in this paper and further providing a theory for improving the effectiveness of the sand production monitoring method under complex multiphase flow conditions. This study also provides technical guidance for the industrial application of sand production monitoring devices in offshore oil wells.…”
Get full text

Housing Price Forecasting Using AI (LSTM) by Hossein Ziyadi, Erfan Salavati, Mohammad Mahdi Lotfi Heravi

“…This dynamic gets more complex when a variety of quantitative and qualitative data from diverse types and from several markets are added to the model. …”
Get full text

Challenges of Engineering Skillsets Essential for Driving Circularity of Smart Cities by Benjamin Neale, Sakdirat Kaewunruen, Dan Li, Ayfer Donmez Cavdar, Rand Askar, Tatjana Tambovceva, Diana Bajare

“…This information will benefit the industry by informing businesses and councils about the key skillsets and capabilities to look out for when employing people to implement any aspect of circular practices in a smart city setting, with an emphasis on enhancing efficiency, achieving deliverables, and thinking systemically to address complex challenges they may face during the implementation. …”
Get full text

Defects at the Posttranscriptional Level Account for the Low TCRζ Chain Expression Detected in Gastric Cancer Independently of Caspase-3 Activity by Ana Aguinaga-Barrilero, Patricia Castro-Sánchez, Ignacio Juárez, Alberto Gutiérrez-Calvo, Noelia Rodríguez-Pérez, Adela Lopez, Remedios Gómez, José M. Martin-Villa

“…Other chains pertaining to the TCR-CD3 complex (CD3ε) showed no significant differences (MFI values). …”
Get full text

An Improved Bio-Inspired Material Generation Algorithm for Engineering Optimization Problems Including PV Source Penetration in Distribution Systems by Mona Gafar, Shahenda Sarhan, Ahmed R. Ginidi, Abdullah M. Shaheen

“…The adaptable and non-linear adjustments of QILP’s quadratic function allow the algorithm to traverse complex landscapes more effectively. This innovative IMGO, along with the original MGO, is developed to support applications across three phases, showcasing its versatility and enhanced optimization capabilities. …”
Get full text