Cognitive impairment and psychopathology in out-of-hospital cardiac arrest survivors in Denmark: The REVIVAL cohort study protocol by Jacob Eifer Moller, Christian Hassager, Selina Kikkenborg Berg, Ola Ekholm, Trine Bernholdt Rasmussen, Mette Kirstine Wagner, Sophia Armand, Patrick MacDonald Fisher, Gitte Moos Knudsen, Dea Siggaard Stenbæk

“…At 3-month follow-up, the primary study outcomes for 200 survivors include the Danish Affective Verbal Learning Test-26 (VAMT-26), Delis-Kaplan Executive Function System tests (trail making, colour-word interference, word and design fluency), Rey’s Complex Figure and Letter-number sequencing subtest of Wechsler Adult Intelligence Scale-IV, HADS and IES-R. …”
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Trends, outcomes and knowledge gaps in mobile apps for reproductive endocrinology and infertility: a scoping review protocol by Alba Regina de Abreu Lima, Emerson Roberto dos Santos, Aline Russomano de Gouvêa, Natália Almeida de Arnaldo Silva Rodriguez Castro, João Daniel de Souza Menezes, Matheus Querino da Silva, Helena Landin Gonçalves Cristóvão, Cíntia Canato Martins, Jéssica Gisleine de Oliveira, Patrícia da Silva Fucuta, Alexandre Lins Werneck, Gerardo Maria de Araújo Filho, Heloisa Cristina Caldas, Vânia Maria Sabadoto Brienze, Júlio César André, Antônio Hélio Oliani

“…Introduction Infertility is a complex condition that affects millions worldwide, with significant physical, emotional and social implications. …”
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Response of YPM x Ross 708 male broilers to diets containing varying inclusions of phytase, calcium butyrate, and bacitracin methylene disalicylate during the grower and finisher p... by Joseph P. Gulizia, Zubair Khalid, Maria T. Terra-Long, Jose I. Vargas, Jose R. Hernandez, Wilmer J. Pacheco, James T. Krehling, Kenneth S. Macklin, William A. Dozier, III, Klint W. McCafferty, Ruediger Hauck

“…Overall, broiler intestinal health and physiology were influenced by CB and BMD depending on phytase concentration, demonstrating the complex interactions between these feed additives.…”
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Impaired Fibrinolysis in Angiographically Documented Coronary Artery Disease by Adriano Basques Fernandes, Luciana Moreira Lima, Marinez Oliveira Sousa, Vicente de Paulo Coelho Toledo, Rashid Saeed Kazmi, Bashir Abdulgader Lwaleed, Maria das Graças Carvalho

“…It acts by blocking the formation of a ternary complex of plasminogen, fibrin, and tissue plasminogen activator (t-PA). …”
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Higher education students' perceptions of ChatGPT: A global study of early reactions. by Dejan Ravšelj, Damijana Keržič, Nina Tomaževič, Lan Umek, Nejc Brezovar, Noorminshah A Iahad, Ali Abdulla Abdulla, Anait Akopyan, Magdalena Waleska Aldana Segura, Jehan AlHumaid, Mohamed Farouk Allam, Maria Alló, Raphael Papa Kweku Andoh, Octavian Andronic, Yarhands Dissou Arthur, Fatih Aydın, Amira Badran, Roxana Balbontín-Alvarado, Helmi Ben Saad, Andrea Bencsik, Isaac Benning, Adrian Besimi, Denilson da Silva Bezerra, Chiara Buizza, Roberto Burro, Anthony Bwalya, Cristina Cachero, Patricia Castillo-Briceno, Harold Castro, Ching Sing Chai, Constadina Charalambous, Thomas K F Chiu, Otilia Clipa, Ruggero Colombari, Luis José H Corral Escobedo, Elísio Costa, Radu George Crețulescu, Marta Crispino, Nicola Cucari, Fergus Dalton, Meva Demir Kaya, Ivo Dumić-Čule, Diena Dwidienawati, Ryan Ebardo, Daniel Lawer Egbenya, MoezAlIslam Ezzat Faris, Miroslav Fečko, Paulo Ferrinho, Adrian Florea, Chun Yuen Fong, Zoë Francis, Alberto Ghilardi, Belinka González-Fernández, Daniela Hau, Md Shamim Hossain, Theo Hug, Fany Inasius, Maryam Jaffar Ismail, Hatidža Jahić, Morrison Omokiniovo Jessa, Marika Kapanadze, Sujita Kumar Kar, Elham Talib Kateeb, Feridun Kaya, Hanaa Ouda Khadri, Masao Kikuchi, Vitaliy Mykolayovych Kobets, Katerina Metodieva Kostova, Evita Krasmane, Jesus Lau, Wai Him Crystal Law, Florin Lazăr, Lejla Lazović-Pita, Vivian Wing Yan Lee, Jingtai Li, Diego Vinicio López-Aguilar, Adrian Luca, Ruth Garcia Luciano, Juan D Machin-Mastromatteo, Marwa Madi, Alexandre Lourenço Manguele, Rubén Francisco Manrique, Thumah Mapulanga, Frederic Marimon, Galia Ilieva Marinova, Marta Mas-Machuca, Oliva Mejía-Rodríguez, Maria Meletiou-Mavrotheris, Silvia Mariela Méndez-Prado, José Manuel Meza-Cano, Evija Mirķe, Alpana Mishra, Ondrej Mital, Cristina Mollica, Daniel Ionel Morariu, Natalia Mospan, Angel Mukuka, Silvana Guadalupe Navarro Jiménez, Irena Nikaj, Maria Mihaylova Nisheva, Efi Nisiforou, Joseph Njiku, Singhanat Nomnian, Lulzime Nuredini-Mehmedi, Ernest Nyamekye, Alka Obadić, Abdelmohsen Hamed Okela, Dorit Olenik-Shemesh, Izabela Ostoj, Kevin Javier Peralta-Rizzo, Almir Peštek, Amila Pilav-Velić, Dilma Rosanda Miranda Pires, Eyal Rabin, Daniela Raccanello, Agustine Ramie, Md Mamun Ur Rashid, Robert A P Reuter, Valentina Reyes, Ana Sofia Rodrigues, Paul Rodway, Silvia Ručinská, Shorena Sadzaglishvili, Ashraf Atta M S Salem, Gordana Savić, Astrid Schepman, Samia Mokhtar Shahpo, Abdelmajid Snouber, Emma Soler, Bengi Sonyel, Eliza Stefanova, Anna Stone, Artur Strzelecki, Tetsuji Tanaka, Carolina Tapia Cortes, Andrea Teira-Fachado, Henri Tilga, Jelena Titko, Maryna Tolmach, Dedi Turmudi, Laura Varela-Candamio, Ioanna Vekiri, Giada Vicentini, Erisher Woyo, Özlem Yorulmaz, Said A S Yunus, Ana-Maria Zamfir, Munyaradzi Zhou, Aleksander Aristovnik

“…They found it useful for simplifying complex information and summarizing content, but less reliable for providing information and supporting classroom learning, though some considered its information clearer than that from peers and teachers. …”
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Based on bioinformatics, SESN2 negatively regulates ferroptosis induced by ischemia reperfusion via the System Xc−/GPX4 pathway by Jiejie Hu, Lijun Qin, Guoqiang Zhu, Jingjing Ren, Hongxia Wang, Jing Jin, Haixue Zheng, Dan Li, Zhaoming Ge

“…Protein–protein interaction (PPI) analysis combined with molecular complex detection (MCODE) identified six hub genes, namely, Ddit3, Atf3, Sesn2, Trib3, Ppp1r15a, and Gadd45a. …”
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Draft genome sequence of a co-harbouring blaNDM-5 and mcr-1.1 Escherichia coli phylogroup A isolate associated with patient colonisation in Ireland by Anna Tumeo, Francesca McDonagh, Aneta Kovarova, Kate Ryan, Christina Clarke, Georgios Miliotis

“…Results: E. coli E230738 genome was identified to belong to phylogroup-A/ST10 complex and to harbour 63 ARGs, 17 of which acquired. …”
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Management of CAR-T cell therapy in patients with multiple myeloma: a systematic review and expert consensus in Australia by P. Joy Ho, Hang Quach, M. Hasib Sidiqi, M. Hasib Sidiqi, Cindy H. Lee, Jason Butler, Andrew Spencer, Kenneth Micklethwaite, Kenneth Micklethwaite, Kenneth Micklethwaite, Kenneth Micklethwaite, Jingya Li, Elissa Cusson, Robert Bagnall, Simon J. Harrison

“…BackgroundRegulatory bodies have recently approved chimeric antigen receptor (CAR)-T cell therapies for patients with multiple myeloma (MM), but the treatment process involves complex decision making. To support the introduction of these therapies, we aimed to establish consensus expert opinion on best practices of all aspects of the management of patients with MM undergoing CAR-T cell therapy in Australia.MethodsWe conducted a modified RAND/UCLA two-round Delphi panel informed by a systematic literature review (SLR). …”
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C60 fullerene improves the recovery of biomechanical parameters of muscle soleus contraction in rats after chronic alcoholization by Д. М. Ноздренко, В. Нан, Т. Ю. Матвієнко, К. І. Богуцька, Т. Я. Шевчук, В. П. Берест, Ю. І. Прилуцький

“…Background: Recovery of biomechanical parameters of contraction of muscles damaged by alcoholic myopathy is a rather complex and long-term process. Therefore, the search for effective therapeutic means for its acceleration is an extremely urgent task in biomedicine. …”
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Multidimensional analysis and enhancement strategies for ecological environment quality at the county level under dual carbon goals: a case study of Shaanxi Province, China by Jianfeng Li, Jianfeng Li, Jianfeng Li, Yongxin Hu, Yongxin Hu, Jian Li, Liangyan Yang, Liangyan Yang, Jie Yan

“…However, most studies on ecological environment quality (EEQ) focus on urban areas, with limited attention to county-level analyses, particularly regarding the complex interactions between climate, topography, and human activities. …”
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Artificial intelligence conversational agents in mental health: Patients see potential, but prefer humans in the loop by Hyein S. Lee, Hyein S. Lee, Colton Wright, Julia Ferranto, Jessica Buttimer, Clare E. Palmer, Andrew Welchman, Kathleen M. Mazor, Kimberly A. Fisher, David Smelson, Laurel O’Connor, Laurel O’Connor, Nisha Fahey, Nisha Fahey, Apurv Soni, Apurv Soni, Apurv Soni

“…About half endorsed negative opinions, citing AI’s lack of empathy, technical limitations in addressing complex mental health situations, and data privacy concerns. …”
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Association between body composition indices and vascular health: a systematic review and meta-analysis by Mohammad Nikoohemmat, Amirhossein Ramezani Ahmadi, Ali Valizadeh, Seyed Mohammadmisagh Moteshakereh, Reza Yari-Boroujeni, Zahra Seifi, Majid Valizadeh, Behnaz Abiri

“…Conclusion This meta-analysis highlights the complex relationship between body composition and vascular health. …”
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Navigating Patient Satisfaction: A Qualitative Insight into Healthcare Delivery during the COVID-19 Pandemic by Shazina Saeed, Manmohan Singhal, Mohd Shannawaz, Mandeep Kumar Arora

“…Participants expressed a range of emotions, from frustration to gratitude, highlighting the complexities of navigating healthcare during an unprecedented time. …”
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Clinical significance of HER2 in urothelial carcinoma and analysis of its correlation with glycolytic metabolic characteristics by Andong Guo, Andong Guo, Chenrui Wu, Jishuang Cao, Kejia Zhu, Kejia Zhu, Sentai Ding, Sentai Ding

“…The association of HER2 positivity with advanced tumor stages and high LDH levels underscores its complex involvement in disease progression. This study highlights the need to explore HER2’s biological mechanisms further and pursue combined therapeutic strategies.…”
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HINT1 suppression protects against age-related cardiac dysfunction by enhancing mitochondrial biogenesis by Michio Sato, Tsuyoshi Kadomatsu, Jun Morinaga, Yuya Kinoshita, Daisuke Torigoe, Haruki Horiguchi, Sumio Ohtsuki, Shuji Yamamura, Ryoko Kusaba, Takanori Yamaguchi, Goro Yoshioka, Kimi Araki, Tomohiko Wakayama, Keishi Miyata, Koichi Node, Yuichi Oike

“…We also showed that activity of the BAF chromatin remodeling complex is repressed by HINT1, whose expression in heart increases with age, leading to decreased transcription of Tfam, which promotes mitochondrial biogenesis. …”
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Deciphering the role of metal ion transport-related genes in T2D pathogenesis and immune cell infiltration via scRNA-seq and machine learning by Zuhui Pu, Zuhui Pu, Tony Bowei Wang, Ying Lu, Ying Lu, Zijing Wu, Zijing Wu, Yuxian Chen, Ziqi Luo, Xinyu Wang, Lisha Mou, Lisha Mou

“…IntroductionType 2 diabetes (T2D) is a complex metabolic disorder with significant global health implications. …”
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Deep learning captures the effect of epistasis in multifactorial diseases by Vladislav Perelygin, Alexey Kamelin, Alexey Kamelin, Nikita Syzrantsev, Layal Shaheen, Layal Shaheen, Anna Kim, Nikolay Plotnikov, Anna Ilinskaya, Valery Ilinsky, Alexander Rakitko, Alexander Rakitko, Maria Poptsova

“…Routinely, the weights of individual SNPs are estimated by the linear regression model that assumes independent and linear contribution of each SNP to the phenotype. However, for complex multifactorial diseases such as Alzheimer’s disease, diabetes, cardiovascular disease, cancer, and others, association between individual SNPs and disease could be non-linear due to epistatic interactions. …”
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“Holding on to Hope”: follow up qualitative findings of a tobacco treatment intervention for people experiencing mental health conditions by Tessa-May Zirnsak, Kristen McCarter, Melissa L. McKinlay, Ashleigh Guillaumier, Nadine Cocks, Catherine Brasier, Laura Hayes, Amanda L. Baker, Donita E. Baird, Billie Bonevski, Ron Borland, Ron Borland, David Castle, Erin Forbes, Peter J. Kelly, Catherine Segan, Catherine Segan, Rohan Sweeney, Alyna Turner, Alyna Turner, Jill M. Williams, Lisa Brophy, Lisa Brophy

“…Quitting tobacco can be harder for people experiencing SMI due to higher levels of nicotine dependence, more severe withdrawal, and many other complex factors. The Quitlink study was a randomized controlled trial combining a tailored 8-week Quitline intervention delivered by dedicated Quitline counsellors plus combination nicotine replacement therapy for people who experience SMI. …”
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Improving the Detection, Assessment, Management and Prevention of Delirium in Hospices (the DAMPen-D study): protocol for a co-design and feasibility study of a flexible and scalab... by Najma Siddiqi, Chao Huang, Maureen Twiddy, Miriam Johnson, Margaret Ogden, Kathryn Sartain, Imogen Featherstone, Jason Boland, Mark Pearson, Catriona Jackson, Gillian Jackson

“…Introduction Delirium is a complex condition in which altered mental state and cognition causes severe distress and poor clinical outcomes for patients and families, anxiety and stress for the health professionals and support staff providing care, and higher care costs. …”
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Bioelectric stimulation outperforms brain derived neurotrophic factor in promoting neuronal maturation by María del Pilar Diego-Santiago, María Ujué González, Esther María Zamora Sánchez, Nuria Cortes-Carrillo, Carlos Dotti, Francesc Xavier Guix, Sahba Mobini

“…Increased accumulated charge facilitates the development of complex neuronal morphologies and axonal ramification, outperforming exogenous neurotrophic factors. …”
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