Multidimensional features of sporadic Creutzfeldt-Jakob disease in the elderly: a case report and systematic review by Jiangfeng Liao, Jiangfeng Liao, Wenming Hu, Wenming Hu, Shiheng Chen, Chunyu Huang, Chunyu Huang, Senwei Dong, Senwei Dong, Wanjin Chen, Wanjin Chen, Xiaochun Chen, Longfei Chen, Longfei Chen

“…Restricted hyperintensities were reported in 60.0% cases on DWI, periodic sharp wave complexes in 73.3% cases on electroencephalogram, and cerebral hypoperfusion/hypometabolism in 26.7% cases on molecular imaging. …”
Get full text

Harnessing new mHealth technologies to Strengthen the Management of Multidrug-Resistant Tuberculosis in Vietnam (V-SMART trial): a protocol for a randomised controlled trial by Ben J Marais, Joel Negin, James Johnston, Virginia Wiseman, Greg J Fox, Thu Anh Nguyen, Binh Hoa Nguyen, Viet Nhung Nguyen, Justin Beardsley, Guy Barrington Marks, Kavindhran Velen, Tho Dang, Hoang Anh Nguyen, Dinh Hoa Vu, Thu Thuong Do, Cuong Pham Duc, Huu Lan Nguyen, Huu Thuong Pham, Warwick Britton

“…Introduction Multidrug-resistant tuberculosis (MDR-TB) remains a major public health problem globally. Long, complex treatment regimens coupled with frequent adverse events have resulted in poor treatment adherence and patient outcomes. …”
Get full text

Opening a career door!: The role of ChatGPT adoption in digital entrepreneurial opportunity recognition and exploitation by Cong Doanh Duong, Thi Thanh Hoa Phan, Bich Ngoc Nguyen, Thanh Van Pham, Ngoc Diep Do, Anh Trong Vu

“…The findings of the study unravel the complex dynamics within the extended SOR model, showcasing positive relationships between ChatGPT adoption in entrepreneurship and digital entrepreneurial identity aspiration, digital entrepreneurial opportunity exploration, and exploitation. …”
Get full text

Exploring the utility of different bulking agents for speeding up the composting process of household kitchen waste by Sania Mussa, Muhammad Farhan, Shoaib Ahmad, Khadija Zahra, Amina Kanwal, Qaiser Farid Khan, Muhammad Afzaal, Abdul Wahid, Pallab K. Sarker, Mohamed A. El-Sheikh, Shafaqat Ali

“…Abstract Household kitchen waste (HKW) is produced in large quantity and its management is difficult due to high moisture content and complex organic matter. Aerobic composting of HKW is an easy, efficient, cost-effective and eco-friendly method. …”
Get full text

Aspirin modulates generation of procoagulant phospholipids in cardiovascular disease, by regulating LPCAT3 by Majd B. Protty, Victoria J. Tyrrell, Ali A. Hajeyah, Bethan Morgan, Daniela Costa, Yong Li, Anirban Choudhury, Rito Mitra, David Bosanquet, Alex Reed, Iuliia K. Denisenko, Katsuyuki Nagata, Hideo Shindou, Benjamin F. Cravatt, Alastair W. Poole, Takao Shimizu, Zaheer Yousef, Peter W. Collins, Valerie B. O’Donnell

“…P2Y12 inhibition or aspirin had little impact on eoxPL in leukocytes. Complex aspirin-dependent gender and seasonal effects on platelet eoxPL generation were seen in healthy subjects. …”
Get full text

Phylogeography and biological characterization of H12N2 virus isolated from whooper swan in Central China by Pengfei Ren, Zhen Gao, Xing Li, Jiao Tang, Pei Li, Zhonglin Huang, Jinchi Guo, Pengfei Cui, Lin Jin, Junping Li, Libin Liang

“…Phylogenetic analysis revealed that the H12N2 isolate belongs to the Eurasian lineage, with its HA gene likely originating from a duck-derived H12N5 virus and its NA gene potentially derived from an H9N2 virus, indicating that it is a complex reassorted virus. Animal experiments in domestic ducks and chickens demonstrated that the virus replicates at low levels in the respiratory tract of poultry and exhibits moderate horizontal transmission in ducks. …”
Get full text

Globular-shaped Aβ oligomers have diverse mechanisms for promoting Aβ aggregations with the facilitation of fibril elongation by Hiroto Nakano, Sadao Hikishima, Makoto Mori, Jota Minamikawa, Daiki Muramatsu, Yasuhiro Sakashita, Tokuhei Ikeda, Moeko Noguchi-Shinohara, David B. Teplow, Kenjiro Ono

“…We also showed that the molecular interaction of gAβO was altered by the presence and amount of MF seeds in the reaction buffers, indicating that complex interactions would exist among different Aβ species. …”
Get full text

Exploring the capacity of microorganism treatment for fermentation and glycosidic aroma bioconversion from rose oil distillation wastewater by Mohammad Karami, Mohsen Bagheri, Alireza Abbasi-Baharanchi, Kamahladin Haghbeen, Abdolrahim Nouri, Ali Asghar Karkhane, Mansour Ghorbanpour, Mohsen Farhadpour

“…It poses major ecological difficulties when disposed of in surface water and public drainage systems, due to the high concentration of complex degradable chemical compounds, such as polyphenols. …”
Get full text

The relationship between college students’ Suicidal ideation and rejection sensitivity: a network analysis by Yang He, Tianqi Yang, Chunyan He, Yuanbei Zhang, Huilin Yang, Shen Huang, Jianjun Liu, Xihong Li, Tao Xu, Shengjun Wu

“…In the rejection sensitivity community, R17 “No confidence” exhibited the highest positive BEI value (0.26), whereas R13 “Sense of collectivity” had the highest negative BEI value (-0.08). Conclusions Complex correlation pathways exist between rejection sensitivity and suicidal ideation. …”
Get full text

Comparison of Left Ventricular Function after His Bundle Pacing vs Left Bundle Branch Area Pacing Implantation by Kurniawan Prakoso, Kevin Wibawa, Giky Karwiky, Mohammad Rizki Akbar, Januar Wibawa Martha, Mohammad Iqbal

“…Conclusion: HBP resulted in narrower QRS complex. However, both HBP and LBBAP showed a trend of LV function improvement in patients with LV dysfunction. …”
Get full text

Evaluating an implementation programme for medication review with follow-up in community pharmacy using a hybrid effectiveness study design: translating evidence into practice by Fernando Martínez-Martínez, Shalom I Benrimoj, Victoria Garcia-Cardenas, Raquel Varas-Doval, Miguel A Gastelurrutia, Maria Jose Zarzuelo, Beatriz Perez-Escamilla

“…MRF service outcomes were similar to the cluster RCT study; however, the magnitude of the outcomes was delayed.Conclusions The implementation of pharmacy services is a complex multifactorial process, conditioned by numerous implementation factors. …”
Get full text

Surgical treatment of fourth branchial apparatus anomalies: a case series study by Wan-Xin Li, Yanbo Dong, Aobo Zhang, Jun Tian, Cheng Lu, Jean Pierre Jeannon, Liangfa Liu

“…Abstract Background Fourth branchial apparatus anomalies, are rare clinical entities, and present as complex cysts, sinuses and fistulae in the neck that can be difficult to manage. …”
Get full text

Towards an ontology of mental health: Protocol for developing an ontology to structure and integrate evidence regarding anxiety, depression and psychosis [version 2; peer review: 1... by Jennifer Potts, Micaela Santilli, Claire Friedrich, Jaycee Kennett, Janna Hastings, Susan Michie, Paulina M. Schenk

“…Conclusion and discussion The Mental Health Ontology supports the formal representation of complex upper-level entities within mental health and their relationships. …”
Get full text

The Association of Depression and Anxiety Disorders With Gastrointestinal Symptoms Among Nurses by Behnam Masihipour, Fariborz Mansour-Ghanaei, Saman Maroufizadeh, Soheil Hassanipour, Mehrnaz Asgharnezhad, Adele Isanazar, Kourosh Mojtahedi, Farahnaz Joukar

“…Background: The significant overlap of psychological disorders in both functional and organic gastrointestinal (GI) diseases highlights the complex and interconnected relationship between the brain and the gut.  …”
Get full text

Positive impacts of typical desert photovoltaic scenarios in China on the growth and physiology of sand-adapted plants by Ruibing Meng, Ruibing Meng, Ruibing Meng, Zhongju Meng, Zhongju Meng, Zhongju Meng, Xiaomeng Ren, Jiale Cai, Jiale Cai, Jiale Cai, Xufang Tong, Xufang Tong, Xufang Tong

“…Desert regions are characterized by complex terrain, frequent wind–sand activities, and extreme environmental conditions making vegetation recovery after disturbances difficult. …”
Get full text

Chemical Composition and Antimicrobial Activity of Subcritical CO2 Extract of Lepidium latifolium L. (Brassicaceae) by Balzhan B. Azimkhanova, Gulbaram O. Ustenova, Kamalidin O. Sharipov, Kayrolla D. Rakhimov, Galiya M. Sayakova, Ardak B. Jumagaziyeva, Elena V. Flisyuk, Nadezhda G. Gemejiyeva

“…The technology of carbon dioxide extraction has undoubted advantages over traditional methods of extraction: it has a controlled selectivity in relation to groups of biologically active substances, allows deep extraction, and maximizes the release of rich complexes of compounds contained in plants. In this study, firstly, the CO2 extract was obtained under subcritical conditions from the aerial part of L. latifolium L., and the composition was determined. …”
Get full text

Targeting of the HER2/HER3 signaling axis overcomes ligand‐mediated resistance to trastuzumab in HER2‐positive breast cancer by Satomi Watanabe, Kimio Yonesaka, Junko Tanizaki, Yoshikane Nonagase, Naoki Takegawa, Koji Haratani, Hisato Kawakami, Hidetoshi Hayashi, Masayuki Takeda, Junji Tsurutani, Kazuhiko Nakagawa

“…The anti‐HER2 antibody pertuzumab and anti‐HER3 antibody patritumab both target this heregulin–HER3‐HER2 complex in different ways. This study examined the anticancer efficacy of dual HER2 and HER3 blockade in trastuzumab‐resistant HER2‐positive breast cancer. …”
Get full text

Segmented evolution and exploration targets of the Cambrian platform margin in the Manxi area, Tarim Basin by Zongquan Hu, Fan Feng, Chengming Fang, Zicheng Cao, Tieyi Wang, Kangkang Guo, Yang Li, Shi Wang

“…In this segment, the Shayilike Formation transgressive deposits and the high-energy mound-shoal complexes along the platform margin of the Wusonggeer Formation constitute the optimal reservoir - cap rock assemblage, establishing this segment as the most promising target for hydrocarbon exploration in the platform margin.…”
Get full text

The effect of electroslag remelting on the cleanliness of CrNiMoWMnV ultrahigh-strength steels by Ali M., Porter D., Kömi J., Heikkinen E.P., Eissa M., El Faramawy H., Mattar T.

“…The NMIs were classified into four major classes: oxides, sulphides, nitrides, and complex multiphase inclusions. ESR brings about large changes in the area percentages, number densities, maximum equivalent circle diameters, and the chemical composition of the various NMIs. …”
Get full text

Quantifying the potential value of entomological data collection for programmatic decision-making on malaria control in sub-Saharan African settings by Nora Schmit, Hillary M. Topazian, Matteo Pianella, Giovanni D. Charles, Peter Winskill, Penelope A. Hancock, Ellie Sherrard-Smith, Katharina Hauck, Thomas S. Churcher, Azra C. Ghani

“…Abstract Background The availability of many tools for malaria control leads to complex decisions regarding the most cost-effective intervention package based on local epidemiology. …”
Get full text