Toxic effects and mechanisms of nanoplastics and sulfonamide antibiotics on Scenedesmus obliquus by Jianyuan Yang, Zhen Yang, Jing Wang, Yanpeng Liang, Honghu Zeng, Litang Qin, Xiaohong Song, Lingyun Mo

“…The prevalence of nanoplastics (NPs) and sulfonamide antibiotics (SAs) in the aquatic environment is potentially harmful to the environment, and these pollutants are often present in the environment in the form of composite ones, thereby introducing more complex effects and hazards to the environment. Therefore, it is crucial to investigate the toxic effects of the individual target pollutants and their mixtures. …”
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Cancer stem cells and tumor-associated macrophages as mates in tumor progression: mechanisms of crosstalk and advanced bioinformatic tools to dissect their phenotypes and interacti... by Francesco Verona, Sebastiano Di Bella, Roberto Schirano, Camilla Manfredi, Francesca Angeloro, Giulia Bozzari, Matilde Todaro, Matilde Todaro, Giuseppe Giannini, Giuseppe Giannini, Giorgio Stassi, Veronica Veschi

“…Here, we aim to elucidate the most recent insights on CSCs biology and their complex interactions with TME immune cells, specifically TAMs, tracing an exhaustive scenario from the primary tumor to metastasis formation.…”
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PINK1 modulates Prdx2 to reduce lipotoxicity‐induced apoptosis and attenuate cardiac dysfunction in heart failure mice with a preserved ejection fraction by Hao Zhang, Tianyu Xu, Xiyuan Mei, Qiming Zhao, Qiling Yang, Xianghui Zeng, Zhuang Ma, Haobin Zhou, Qingchun Zeng, Dingli Xu, Hao Ren

“…Abstract Introduction Heart failure with preserved ejection fraction (HFpEF) is a complex condition characterized by metabolic dysfunction and myocardial lipotoxicity. …”
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Clinical, pathological, and genotypic analysis of infectious bronchitis virus in broiler chickens in the Abu Dhabi Emirate, United Arab Emirates by Hassan Zackaria Ali Ishag, Abdelnasir Mohammed Adam Terab, Ebrahim Mohamad Abdalsalam Osman, El Tigani Ahmed El Tigani-Asil, El Tigani Ahmed El Tigani-Asil, Mohammed Saleh Albreiki, Oum Keltoum Bensalah, Asma Abdi Mohamed Shah, Abdelmalik Ibrahim Khalafalla

“…Two strains (9.1%) classified within GI-23 lineage have a < 99% identity to the 4/91 and Mass serotypes vaccine strains and are considered as filed strains.ConclusionCo-circulation of three IBV lineages (GI-13, GI-1, and GI-23) in the Abu Dhabi broiler flocks showing IB symptoms were detected. This complex scenario of different IBV lineages circulation may account for the persistent outbreaks despite vaccination efforts. …”
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Targeting aldose reductase using natural African compounds as promising agents for managing diabetic complications by Miriam E. L. Gakpey, Shadrack A. Aidoo, Toheeb A. Jumah, George Hanson, Siyabonga Msipa, Florence N. Mbaoji, Omonijo Bukola, Palesa C. Tjale, Mamadou Sangare, Hedia Tebourbi, Olaitan I. Awe

“…Molecular dynamics simulations and MM-PBSA analysis confirmed that the compounds bound to AR exhibited high stability and less conformational change to the AR-inhibitor complex.ConclusionThis study highlighted the potential inhibitory activity of 5 compounds that belong to the African region: (+)-Pipoxide, Zinc000095485961, Naamidine A, (−)-Pipoxide, and 1,6-di-o-p-hydroxybenzoyl-beta-d-glucopyranoside. …”
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Carbohydrate ligand engagement with CD11b enhances differentiation of tumor-associated myeloid cells for immunotherapy of solid cancers by Mei Zhang, Veronique Roche, Victor Sandoval, Claire Wolford, Zachary Senders, Julian Anthony Kim, Susan Pereira Ribeiro, Alex Yicheng Huang, Rafick-Pierre Sekaly, Joshua Lyons

“…Importantly, we observed that the BG34-200-CD11b engagement triggered endocytosis of the binding complexes in TAIMs, which induced intracellular F-actin cytoskeletal rearrangement, effective phagocytosis, and intrinsic ICAM-1 (intercellular adhesion molecule I) clustering. …”
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Astaxanthin mitigates doxorubicin-induced cardiotoxicity via inhibiting ferroptosis and autophagy: a study based on bioinformatic analysis and in vivo/vitro experiments by Bowen Yin, Jingyi Ren, Xuanyi Liu, Yadong Zhang, Jinshi Zuo, Rui Wen, Huanting Pei, Miaomiao Lu, Siqi Zhu, Zhenao Zhang, Ziyi Wang, Yanyi Zhai, Yuxia Ma

“…Current reports indicate that doxorubicin-induced cardiotoxicity (DIC) is a complex phenomenon involving various modes of cell death. …”
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Telenursing on primary family caregivers and children with disabilities: a scoping review by Kaori Nishigaki, Noyuri Yamaji, Noyuri Yamaji, Naho Adachi, Tomoko Kamei, Kyoko Kobayashi, Shota Kakazu, Yuki Yonekura

“…Five studies focused on children with medical complexities, and two focused on children with neurodevelopmental disabilities, including developmental delays. …”
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Mfsd2a suppresses colorectal cancer progression and liver metastasis via the S100A14/STAT3 axis by Linfeng Sun, Xiangdong Li, Yuhao Xiao, Wenjie Yu, Xuyang Chen, Ziyi Wang, Nan Xia, Xuejiao Chen, Minhao Chen, Haoliang Zhu, Jie Li, Jie Wei, Sheng Han, Liyong Pu

“…The pathogenesis of CRLM involves complex molecular mechanisms and the hepatic immune microenvironment, but current clinical prevention and treatment are significantly limited. …”
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Identification of strengths and weaknesses of the healthcare system for persons living with rare diseases in Catalonia (Spain), and recommendations to improve its comprehensive att... by José Hernández-Rodríguez, Fernando Martínez-Valle, Xènia Acebes, Carmen Alerany, Jordi Antón, Gonzalo Calvo, Marian Corral, Jordi Cruz, M. Antònia Mangues-Bafalluy, José Mateo, Josefa Rivera, Albert Salazar, Roser Francisco, Cristina Mallol, Rita Reig-Viader, Ariadna Tigri-Santiña, Assumpta Ricart, Francesc Palau

“…Abstract Background Rare diseases (RDs) are a heterogeneous group of complex and low-prevalence conditions in which the time to establish a definitive diagnosis is often too long. …”
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Identification of serotype O3b and high-risk clone ST37 of Klebsiella pneumoniae revealed by comparative genomic analysis by Sivaraman Gopalan Krishnan, Sudha Sajeev, Visnuvinayagam Sivam, Raja Swaminathan T., Rakshit Ojha, Bibek Ranjan Shome, Mark Holmes, Thanigaivel Sundaram, Ramesh M. D., Saranya Vinayagam, Suseela Meesala, Tabarak Malik, Tabarak Malik, Pavan Kumar Dara

“…Moreover, K. pneumoniae has several species complexes (KpSC) and is very difficult to differentiate using routine microbiological methods. …”
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Refining Established Practices for Research Question Definition to Foster Interdisciplinary Research Skills in a Digital Age: Consensus Study With Nominal Group Technique by Jana Sedlakova, Mina Stanikić, Felix Gille, Jürgen Bernard, Andrea B Horn, Markus Wolf, Christina Haag, Joel Floris, Gabriela Morgenshtern, Gerold Schneider, Aleksandra Zumbrunn Wojczyńska, Corine Mouton Dorey, Dominik Alois Ettlin, Daniel Gero, Thomas Friemel, Ziyuan Lu, Kimon Papadopoulos, Sonja Schläpfer, Ning Wang, Viktor von Wyl

“… BackgroundThe increased use of digital data in health research demands interdisciplinary collaborations to address its methodological complexities and challenges. This often entails merging the linear deductive approach of health research with the explorative iterative approach of data science. …”
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Soil chemical factors contributing to differences in bacterial communities among tea field soils and their relationships with tea quality by Shuning Zhang, Shuning Zhang, Naoki Yanagisawa, Mio Asahina, Hiroto Yamashita, Hiroto Yamashita, Hiroto Yamashita, Takashi Ikka, Takashi Ikka, Takashi Ikka, Takashi Ikka

“…We conducted pot cultivation of tea plant ‘Yabukita’ to investigate how soil chemical factors affect bacterial communities and their influences on the nutrient status and quality of tea plants, and finally explored the complex relationships between soil bacterial features and tea quality.Results and discussionThe results showed that soil bacterial α-diversity was higher level in soils D and E, with distinct β-diversity patterns separating higher pH soils (D and E) from lower pH soils (A, B, and C). …”
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HIV-1 transcription start sites usage and its impact on unspliced RNA functions in people living with HIV by Saiful Islam, Frank Maldarelli, Olga A. Nikolaitchik, Zetao Cheng, Robert Gorelick, Maria A. Nikolaitchik, Vinay K. Pathak, Wei-Shau Hu

“…Our study illustrates the complex regulation of HIV-1 unspliced RNA in people living with HIV and provides valuable insights into how HIV-1 unspliced RNAs serve their functions in vivo.IMPORTANCEHIV-1 virions must contain unspliced RNA and its translation products to maintain infectivity. …”
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Diversity and Functional Insights into Endophytic Fungi in Halophytes from West Ordos Desert Ecosystems by Xingzhe Wang, Yan Zhang, Jingpeng Li, Yiteng Ding, Xiaodan Ma, Peng Zhang, Haijing Liu, Jie Wei, Yuying Bao

“…Co-occurrence network analysis showed significant differences in fungal networks across halophyte types, with the most complex network observed in excreting halophytes, characterized by the highest number of nodes and connections, indicating tighter fungal symbiotic relationships. …”
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Seasonal Mathematical Model of Salmonellosis Transmission and the Role of Contaminated Environments and Food Products by Mohammed H. Alharbi, Fawaz K. Alalhareth, Mahmoud A. Ibrahim

“…Salmonellosis continues to be a global public health priority in which humans, livestock, and the contaminated environment interact with food to create complex interactions. Here, a new non-autonomous model is proposed to capture seasonal dynamics of Salmonella typhimurium transmission with key compartments that include humans, cattle, and bacteria in environmental and food sources. …”
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Effect of Planting Systems on the Physicochemical Properties and Bioactivities of Strawberry Polysaccharides by Qiuqiu Zhang, Renshuai Huang, Guangjing Chen, Fen Guo, Yan Hu

“…Additionally, GP-SP exerted superior α-glucosidase inhibition (IC₅₀ = 2.4583 mg/mL), in line with kinetic and fluorescence quenching analyses showing a higher enzyme–substrate complex binding affinity (<i>Kis</i> = 1.6682 mg/mL; <i>Ka</i> = 5.1352 × 10⁵ M⁻¹). …”
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Technical Report on the New Ultrasound Lateral Mid-Shaft Approach to the Sciatic Nerve: A Never-Ending Story by Giuseppe Sepolvere, Mario Tedesco, Mario Cibelli, Dario Cirillo, Angelo Sparaco, Giuseppe Gagliardi, Giuseppina Costagliola, Loredana Cristiano, Valeria Rita Scialdone, Maria Rosaria Pasquariello, Fabrizio Di Zazzo, Luigi Merola, Mirco Della Valle, Daniela Arminio, Leonardo Maria Bottazzo, Marco Folliero, Giorgio Ranieri, Domenico Pietro Santonastaso, Antonio Coviello

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