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21961
Interleukin-12 Inhibits Tumor Growth and Metastasis Promoted by Tumor-Associated Mesenchymal Stem Cells in Triple-Negative Breast Cancer
Published 2024-09-01“…These genesshowed increased expression in TA-MSCs, TNBC cells, and tumor tissues.Conclusion: The findings of the present study revealed a complex interplay between TA-MSCs and TNBC cells thataffects tumor growth and metastasis. …”
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21962
Association between the attentional network efficiency and change of direction speed ability in young male Indian footballers
Published 2025-01-01“…The attentional networks is the basis of the fundamental cognitive abilities controlling complex behavior. The present study aimed to investigate the association between CODS ability and the efficiency of alerting, orienting, and executive components of the attentional networks, and decision-making in footballers.MethodsSeventy-eight male footballers (age: 15.4 ± 0.87 years, BMI: 19.4 ± 1.98 kg/m2) during pre-season completed a battery of field tests comprising Illinois agility test (IAT), 30 m sprint, standing broad jump, and Yo-Yo test. …”
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21963
Professionalisation and governance in sports organisations: towards an integrated understanding
Published 2025-01-01“…Sports practitioners aware of the complex relationship between professionalisation and governance concepts may manage future organisational change processes more successfully. …”
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21964
Advancements and opportunities to improve bottom–up estimates of global wetland methane emissions
Published 2025-01-01“…Major tropical and arctic wetland complexes are regional hotspots of CH _4 emissions. …”
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21965
Unravelling the prognostic and operative role of intratumoural microbiota in non‐small cell lung cancer: Insights from 16S rRNA and RNA sequencing
Published 2025-01-01“…Abstract Background Complex interrelationships between the microbiota and cancer have been identified by several studies. …”
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21966
Reticulocyte hemoglobin content: a new frontier in iron deficiency diagnostics for major surgical patients
Published 2025-01-01“…Treatment of ID is straightforward, however implementing a comprehensive anemia management strategy within clinical routines is complex. Recently, reticulocyte hemoglobin content (Ret-He) has been evaluated as an early marker for ID diagnosis. …”
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21967
The additional impact of metabolic syndrome on left ventricular deformation and myocardial energetic efficiency impairment in ischemia with nonobstructive coronary arteries patient...
Published 2025-01-01“…Metabolic syndrome (MetS) is a complex of multiple cardiac metabolic risk factors, significantly increasing the risk of major adverse cardiovascular events in INOCA patients. …”
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21968
Atherosclerotic Risk Factors in Children with Celiac Disease
Published 2020-01-01“…Celiac disease (CD) is a complex autoimmune disorder occurring in genetically susceptible individuals. …”
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21969
The Explo’Santé mixed methods protocol: an interventional research school health promotion project in France
Published 2025-01-01“…Methods Explo’Santé is an observational study based on a mixed methods research design, which aims to evaluate the effects of a health promotion programme, to elicit its implementation process and identify contextual factors. This 3-year, complex programme targets primary school pupils aged 8 to 10. …”
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21970
LLT1 overexpression renders allogeneic-NK resistance and facilitates the generation of enhanced universal CAR-T cells
Published 2025-01-01“…Results Genetic editing of CD38 universal CAR-T cells, including CD38, T cell receptor alpha constant (TRAC), beta-2-microglobulin (B2M), and class II major histocompatibility complex transactivator (CIITA) knockdowns, was successfully achieved. …”
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21971
Effect of Medication Management at Home via Pharmacist-Led Home Televisits: Protocol for a Cluster Randomized Controlled Trial
Published 2025-02-01“…In addition, older adults often use over-the-counter medications and supplements, further complicating their medication regimens. Complex medication regimens are potentially harmful to older adults. …”
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21972
Exploring the relationships between self-efficacy, self-care, and glycaemic control in primary care diabetes management
Published 2024-12-01“…Objectives: Our study aimed to identify the complex interplay between self-efficacy, self-care practice, and glycaemic control among people with type 2 diabetes mellitus (PWDs) to inform the design of more targeted and effective behavioural interventions in primary care. …”
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21973
Evaluating the Impacts of Procedural and Patient-Specific Factors on the Outcomes of Transcatheter Aortic Valve Implantation (TAVI)
Published 2025-01-01“…Logistic regression analysis underscored the incremental risks posed by procedural complexities and comorbidities. <i>Conclusions</i>: Procedural factors such as fluoroscopy duration and contrast volume, along with patient-specific attributes including age, left ventricular function, and valve calcification patterns, critically influence TAVI outcomes. …”
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21974
PGC-1α Promotes mitochondrial biosynthesis and energy metabolism of goose fatty liver
Published 2025-01-01“…Furthermore, we observed a significant increase in the mitochondrial DNA (mtDNA) copy number, the activity of mitochondrial respiratory chain complex Ⅳ (MRCC Ⅳ), succinate dehydrogenase (SDH), malate dehydrogenase (MDH), and the NAD+/NADH ratio in fatty liver. …”
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21975
Bidirectional effect modifications of temperature and PM2.5 on myocardial infarction morbidity and mortality in Beijing, China from 2007 to 2021
Published 2025-01-01“…Background: Ambient temperatures and PM2.5 can trigger myocardial infarction (MI), while little is known about the complex interplay between these two factors on MI, especially morbidity. …”
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21976
Knockout of the inhibitory receptor TIGIT enhances the antitumor response of ex vivo expanded NK cells and prevents fratricide with therapeutic Fc-active TIGIT antibodies
Published 2023-12-01“…TIGIT KO NK cells upregulated mTOR complex 1 (mTORC1) signaling and had better metabolic fitness with an increased basal glycolytic rate when co-cultured with cancer cells compared with WT NK cells. …”
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21977
Molecular mechanisms impact on fluoroquinolone resistance among E.coli from enteric carriage monitoring before prostate biopsy and earliest description of qnrB81
Published 2024-11-01“…Worrying incidence of FQs-R E. coli isolates in the rectal flora of our local population showed the potential to cause post-infection. FQ resistance is a complex interplay between mutations in the QRDRs and PMQR determinants that impact MICs. …”
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21978
Liver transcriptome analysis reveals PSC-attributed gene set associated with fibrosis progression
Published 2025-03-01“…Herein, we identify a PSC-specific gene set of biliary fibrosis progression attributing to a uniquely complex milieu of different cell types, including innate and adaptive immune cells while neutrophils and macrophages showed an earlier involvement in fibrosis initiation in PSC in contrast to PBC and metabolic dysfunction-associated steatotic liver disease. …”
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21979
Sex and outcomes of patients with microsatellite instability-high and BRAF V600E mutated metastatic colorectal cancer receiving immune checkpoint inhibitors
Published 2025-02-01“…Exploratory transcriptomic analyses suggest that tumors of males with BRAF mutated MSI-H metastatic CRC are characterized by an enrichment of androgen receptor signature and an immune-depleted microenvironment, with a reduction in memory B cells, activated natural killer cells, and activated myeloid dendritic cells.Conclusions Overall, our findings suggest a complex interplay between sex and BRAF mutational status that may modulate the activity of ICIs in patients with MSI-H mCRC and pave the way to novel tailored strategies.…”
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21980
Anterior Controllable Antedisplacement and Fusion (ACAF) for Cervical Stenosis Patients With Hyperextension Injury: A Retrospective Study
Published 2025-02-01“…Associated pathologies were herniated nucleus pulposus (HNP) in five patients, OPLL in three cases, and HNP‐osteophyte complexes (HNP‐OC) in six patients. At the final follow‐up, 13 patients were improved to E. …”
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