A pilot study examining Toronto-area family physician perspectives on thyroid neoplasm evaluation by Arjun Kundra, David P. Goldstein, Kimberly Wintemute, Sangeet Ghai, Richard W. Tsang, Karuna Gupta, Donatus R. Mutasingwa, Jeff Weissberger, Ella Huszti, Patrick Brown, Huan Jiang, Anna M. Sawka

“…Conclusion There are likely multiple complex factors leading to potential overdiagnosis of TC in primary care, including some physicians’ knowledge gaps about appropriate indications for TN investigations as well as patients’ requests and expectations.…”
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Supplementation with Standardized Green/Black or White Tea Extracts Attenuates Hypertension and Ischemia-Reperfusion-Induced Myocardial Damage in Mice Infused with Angiotensin II by Mario de la Fuente-Muñoz, Marta Román-Carmena, Sara Amor, María C. Iglesias-de la Cruz, Patricia Martorell, Sonia Guilera-Bermell, Reme García Bou, Antonio M. Inarejos-García, Ángel L. García-Villalón, Miriam Granado

“…The aim of this study was to assess the possible beneficial effects of two tea extracts, one of white tea (ADM^® White Tea; WTE) and another one composed of a mixture of black tea and green tea (ADM^® Tea Complex; CTE), on the cardiovascular alterations induced by angiotensin II (AngII) infusion in mice. …”
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Identification of common and specific fibrosis-related genes in three common chronic kidney diseases by Zhangning Fu, Xiaodong Geng, Chao Liu, Wanjun Shen, Zheyi Dong, Guannan Sun, Guangyan Cai, Xiangmei Chen, Quan Hong

“…Background Kidney fibrosis is the common final pathway of virtually all advanced forms of chronic kidney disease (CKD) including diabetic nephropathy (DN), IgA nephropathy (IgAN) and membranous nephropathy (MN), with complex mechanism. Comparative gene expression analysis among these types of CKD may shed light on its pathogenesis. …”
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Pelvic Drop Changes due to Proximal Muscle Strengthening Depend on Foot-Ankle Varus Alignment by Aline de Castro Cruz, Sérgio Teixeira Fonseca, Vanessa Lara Araújo, Diego da Silva Carvalho, Leonardo Drumond Barsante, Valéria Andrade Pinto, Thales Rezende Souza

“…However, the varus alignment of the foot-ankle complex (FAC) may influence the effects of muscle strengthening, due to the relationship of FAC alignment with pelvic and hip kinematics. …”
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Non-communicable diseases and their associations with outpatient services utilisation: insight from a population-based survey in Malaysia by Jabrullah Ab Hamid, Awatef Amer Nordin, Suhana Jawahir, Adilius Manual, Iqbal Ab Rahim, Sarah Nurain Mohd Noh, Nur Elina Ab Mutalib, Nurul Salwana Abu Bakar

“…Characteristics of respondents and those having multimorbidity were described using complex sample descriptive statistics. We used multivariable logistic regression to determine the associated factors of having multimorbidity and the association between the number of non-communicable diseases and outpatient services utilisation.Results Overall, 11 347 respondents were included in the analysis. …”
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The regulatory role of cystatin C in autophagy and neurodegeneration by T. A. Korolenko, A. B. Shintyapina, A. B. Pupyshev, A. A. Akopyan, G. S. Russkikh, M. A. Dikovskaya, V. A. Vavilin, E. L Zavjalov, M. A. Tikhonova, T. G. Amstislavskaya

“…Autophagy is a dynamic cellular process involved in the turnover of proteins, protein complexes, and organelles through lysosomal degradation. …”
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Towards implementing new payment models for the reimbursement of high-cost, curative therapies in Europe: insights from semi-structured interviews by Thomas Desmet, Thomas Desmet, Sissel Michelsen, Sissel Michelsen, Elena Van den Brande, Walter Van Dyck, Steven Simoens, Isabelle Huys

“…BackgroundNew ways of reimbursement for high-cost, one-shot curative therapies such as advanced therapy medicinal products (ATMPs) are a growing area of interest to stakeholders in market access such as industry representatives, legislative and accounting experts, physicians, hospital managers, hospital pharmacists, patient representatives, policymakers, and sickness funds. Due to the complex nature of ATMPs, new payment models and reimbursement modalities are proposed yet not widely applied across Europe.ObjectivesThis study aimed to elicit opinions on and insights into the governance aspect of implementing outcome-based spread payments (OBSP) in Belgium for the reimbursement of innovative therapies. …”
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Investigating intra‐tumoural heterogeneity and microenvironment diversity in primary cardiac angiosarcoma through single‐cell RNA sequencing by Jingyuan Huo, Zhen Wang, Wenting Zhao, Miao Chen, Haoyang Li, Fengpu He, Xiao Tian, Yaqi Ma, Firyuza Husanova, Liang Ma, Yiming Ni, Hongda Ding, Weidong Li, Hongfei Xu

“…Conclusion This study elucidates the complex cellular landscape and immune microenvironment of PCAS, highlighting potential molecular targets for the development of novel therapies. …”
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Russian Science Foundation grant No. 20-14-00140 supported this study. The authors are thankful to the multi-access Center “Bioinformatics” for the use of computational resources a... by O. V. Vishnevsky, I. V. Chadaeva, E. B. Sharypova, B. M. Khandaev, K. A. Zolotareva, A. V. Kazachek, P. M. Ponomarenko, N. L. Podkolodny, D. A. Rasskazov, E. V. Zemlyanskaya, A. G. Bogomolov, O. A. Podkolodnaya, L. K. Savinkova, M. P. Ponomarenko

“…Our previous studies presented our publicly available Web service Plant_SNP_TATA_Z­tester, which makes it possible to estimate the equilibrium dissociation constant (KD) of TBP complexes with plant proximal promoters (as output data) using 90 bp of their DNA sequences (as input data). …”
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Recombinant Anti-PF4 Antibodies Derived from Patients with Vaccine-Induced Immune Thrombocytopenia and Thrombosis (VITT) Facilitate Research and Laboratory Diagnosis of VITT by Luisa Müller, Venkata A. S. Dabbiru, Lucy Rutten, Rinke Bos, Roland Zahn, Stefan Handtke, Thomas Thiele, Marta Palicio, Olga Esteban, Marta Broto, Tom Paul Gordon, Andreas Greinacher, Jing Jing Wang, Linda Schönborn

“…Results: rAbs bound to PF4 alone, but not to PF4/polyanion complexes in rapid chemiluminescence assays. Chemiluminescence assays and both anti-PF4 IgG and anti-PF4 IgG/heparin ELISA showed concentration-dependent PF4 binding of all six rAbs, however, with different reactivities among them. …”
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Surgical resection, radiotherapy and percutaneous thermal ablation for treatment of stage 1 non-small cell lung cancer: protocol for a systematic review and network meta-analysis by Arun Chockalingam, Menelaos Konstantinidis, Brandon Koo, John Timothy Moon, Andrew Tran, Sahar Nourouzpour, Emily Lawson, Kathleen Fox, Peiman Habibollahi, Bruno Odisio, Mohammed Loya, Ali Bassir, Nariman Nezami

“…However, as patients are becoming medically more complex presenting with advanced disease, minimally invasive image-guided percutaneous ablations are gaining popularity. …”
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Exploring the impact and mechanisms of behavioral activation on sleep disorders in colorectal cancer: a randomized controlled trial by Anlong Li, Runze Huang, Han Ge, Dajie Liu, Shaochun Liu, Yingxue Jia, Jiaying Chai, Xinyi Zheng, Lijun Liu, Chen Gan, Jian Xu, Ling Cheng, Mingjun Zhang, Huaidong Cheng

“…Cognitive behavioral therapy for insomnia (CBT-I) is considered the first-line treatment but is often complex, costly, and requires highly trained therapists. …”
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Earth–lunar thermal effect on the temperature stability of TianQin telescope and the suppression methods by Wenbo Chang, Yuxiang Wang, Wenhai Tan, Guanhua Wu, Houyuan Chen, Wei Li, Zizheng Li, Fan Zhu, Zhu Li, Xuefeng Zhang, Shanqing Yang

“…TianQin is a geocentric space-based gravitational wave detection mission, it will confront a more complex and variable orbital thermal environment compared to heliocentric orbit missions like LISA. …”
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Identification of Adulterated Deer Blood Crystals in Traditional Chinese Medicine Based on MALDI-TOF MS Peptide Fingerprints Technique by Shen-xing WANG, Ling CAO, Qing HUANG, Cong-yu MA, Jian-bin PAN, Hao-dong ZHAO, Hai-wei SHI, Bin DI, Hong-yuan CHEN

“…The proposed method has the advantages of high specificity, rapidity, and convenience, which enables sensitive and specific detection of target characteristic peptides in complex matrix samples, and also can provide a highly accurate analytical approach for the identification of adulteration of deer blood crystals and blood crystal-based traditional Chinese medicine products.…”
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Modulatory effects of selenium nanoparticles on gut microbiota and metabolites of juvenile Nile tilapia (Oreochromis niloticus) by microbiome-metabolomic analysis by Jing Ni, Lirong Ren, Ying Liang, Ying Ma, Hejian Xiong

“…This study evaluated the in vitro effects of our previous synthesized SeNPs, coated with abalone visceral polysaccharide-protein complexes (PSP-SeNPs), on the proliferation of probiotics and common aquatic pathogens, and the in vivo effects on the gut microbiome and metabolome of tilapia. …”
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Dynamic selectout and voting-based federated learning for enhanced medical image analysis by Saeed Iqbal, Adnan N Qureshi, Musaed Alhussein, Khursheed Aurangzeb, Atif Mahmood, Saaidal Razalli Bin Azzuhri

“…When these agents work together in the system, it is imperative to tackle the complexities of distributed deep learning. We suggest a novel approach that uses a voting mechanism and dynamic SelectOut inside the FL framework to address these problems. …”
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Pulmonary granuloma formation during latent Cryptococcus neoformans infection in C3HeB/FeJ mice involves progression through three immunological phases by Jovany J. Betancourt, Minna Ding, J. Marina Yoder, Issa Mutyaba, Hannah M. Atkins, Gabriela De la Cruz, David B. Meya, Kirsten Nielsen

“…These findings highlight a complex series of immune changes that occur during the establishment of granulomas that control C. neoformans in the lungs and lay the foundation for studies to identify critical beneficial immune responses to Cryptococcus infections.IMPORTANCECryptococcus neoformans is a fungal pathogen that disseminates from the lungs to the brain to cause fatal disease. …”
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Mycotoxilogical monitoring. Part 2. Wheat, barley, oat and maize grain by G. P. Kononenko, A. A. Burkin, Ye. V. Zotova

“…The maize grains demonstrated the whole complex of the tested fusarium toxins with the prevalence of T-2 toxin, deoxynivalenol, zearalenone and fumonisins; and the maximal amounts of these mycotoxins by several times exceeded the accepted regulatory levels. …”
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Comparative effect of atorvastatin and risperidone on modulation of TLR4/NF-κB/NOX-2 in a rat model of valproic acid-induced autism by Eman A. E. Farrag, Mona H. Askar, Zienab Abdallah, Safinaz M. Mahmoud, Eman A. Abdulhai, Eman Abdelrazik, Eman Mohamad El Nashar, Faten Mohammed Alasiri, Asma Nasser Saeed Alqahtani, Mamdouh Eldesoqui, Ali M. Eldib, Alshimaa Magdy

“…Abstract Background Autism spectrum disorder (ASD) is a complex neurodevelopmental condition that is significantly increasing, resulting in severe distress. …”
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NCAPD3-mediated ferroptosis of 2,3,5,4’-Tetrahydroxystilbene-2-O-β-D-glucoside inhibits proliferation in T47D cells by Jianfen Shen, Shuo Zhang, Shuo Zhang, Yan Song, Yan Song, Leiming Yang, Leiming Yang, Qi Huang, Qi Huang, Pengyu Wang, Pengyu Wang, Youzhi Zhang, Youzhi Zhang

“…ObjectiveNon-SMC condensin II complex subunit D3 (NCAPD3) has recently been demonstrated as a crucial oncogenic factor, nevertheless, the biological role of NCAPD3 in the pathogenesis of breast cancer has not been elucidated. …”
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