In Silico Identification of New Anti-SARS-CoV-2 Main Protease (Mpro) Molecules with Pharmacokinetic Properties from Natural Sources Using Molecular Dynamics (MD) Simulations and Hi... by Harrison Onyango, Patrick Odhiambo, David Angwenyi, Patrick Okoth

“…This candidate drug was used to perform MD simulations, and the outcomes revealed that ZINC000072307130 formed a stable complex with the viral main protease. Consequently, ZINC000072307130 emerges as a potential anti-SARS-CoV-2 Mpro inhibitor for the production of new COVID 19 drugs.…”
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Who is to blame for the ‘problem’ of teenage pregnancy? Narratives of blame in two South African communities by Zoe Duby, Brittany Bunce, Chantal Fowler, Kate Bergh, Kim Jonas, Nevilene Slingers, Catherine Mathews, Fareed Abdullah

“…There is an urgent need to shift away from the individualised moralistic shaming of pregnant AGYW, towards a recognition of a complex interplay of multilevel factors that enable or constrain AGYW’s agency. …”
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Accuracy of Large Language Models for Infective Endocarditis Prophylaxis in Dental Procedures by Paak Rewthamrongsris, Jirayu Burapacheep, Vorapat Trachoo, Thantrira Porntaveetus

“…Conclusion: LLMs like GPT-4o show promise for retrieving AHA-IE guideline information, achieving up to 80% accuracy. However, complex medical questions may still pose a challenge. …”
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Health IT Implementation and the Impact of the COVID-19 Pandemic on Clinician-IT Dynamics: Qualitative Study by Adeola Bamgboje-Ayodele, Adrian Boscolo, Mitchell Burger, Owen Hutchings, Miranda Shaw, Tim Shaw, Amina Tariq, Sundresan Naicker, Steven McPhail, Melissa Baysari

“…Health IT implementation is difficult at the best of times, due to complex sociotechnical challenges that vary across contexts and settings; however, it is currently unclear how the pandemic impacted health IT implementation processes. …”
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Mono-allelic epigenetic regulation of polycistronic transcription initiation by RNA polymerase II in Trypanosoma brucei by Rudo Kieft, Laura Cliffe, Haidong Yan, Robert J. Schmitz, Stephen L. Hajduk, Robert Sabatini

“…Trypanosoma brucei brucei is unable to infect humans because of its susceptibility to an innate immune complex, trypanosome lytic factor (TLF) in the circulation of humans. …”
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The effect of depth data and upper limb impairment on lightweight monocular RGB human pose estimation models by Gloria-Edith Boudreault-Morales, Cesar Marquez-Chin, Xilin Liu, José Zariffa

“…The models were modified to include depth data as an input using three different fusion techniques: an early fusion method, a simple intermediate fusion method (using concatenation), and a complex intermediate fusion method (using specific fusion blocks, additional convolutional layers, and concatenation). …”
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Multidimension Analysis of the Prognostic Value, Immune Regulatory Function, and ceRNA Network of LY6E in Individuals with Colorectal Cancer by Ting Li, Weidong Liu, Chun Wang, Man Wang, Wenjia Hui, Jiajie Lu, Feng Gao

“…Lymphocyte antigen 6 complex, locus E (LY6E) is abnormally expressed in several cancers and is associated with poor outcomes. …”
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Assessing the impact of sewage and wastewater on antimicrobial resistance in nearshore Antarctic biofilms and sediments by Melody S Clark, Benjamin H Gregson, Carla Greco, Harisree Paramel Nair, Marlon Clark, Claire Evans, Kevin A. Hughes, Kudzai Hwengwere, Marcus Leung, Lloyd S Peck, Caray A. Walker, William Chow

“…Our data show that AMR in the Antarctic marine environment is far more complex than previously thought. Thus, more work is required to understand the true extent of the Antarctic microbiota biodiversity, their associated resistomes and the impact that human activities have on the Antarctic environment.…”
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A deep learning-based method for the intelligent identification of the quantity of coals flushed out during borehole hydraulic flushing by Xiaojun LI, Mingyang ZHAO, Miao LI

“…Besides, these results serve as a valuable reference for achieving intelligent advances in complex underground coal mine scenarios such as drilling sites for gas drainage.…”
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The clinical application and anatomical analysis of proximal peroneal artery perforator in free fibula flap based on CTA by Yitong Zhao, Danwei Xiang, Lina Song, Zhujiajun Cui, Xingwu Zheng, Tianyu Zhang, Huihui Yang, Yongzhen Fu, Qilin Liu

“…Abstract Background The vascularized free fibular flap is increasingly recognized as the standard technique for the repair of complex soft tissue and hard tissue defects in oral and maxillofacial surgery. …”
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Understanding ICU Nursing Knowledge, Perceived Barriers, and Facilitators of Sepsis Recognition and Management: A Cross-Sectional Study by Katherine A. Kissel, MN, RN, Karla D. Krewulak, PhD, Thérèse G. Poulin, BSc, Ken Kuljit S. Parhar, MD, MSc, Daniel J. Niven, MD, PhD, Vanessa M. Doiron, MScHQ, RN, Kirsten M. Fiest, PhD

“…Future research and improvement initiatives should use a theory-informed approach to overcome the pervasive, complex challenges impeding timely sepsis recognition and management.…”
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Sex-specific associations between estimated glucose disposal rate and cognitive decline in middle-aged and older adults in China: a longitudinal cohort study by Chun Luo, Shuang Han, Xiaoying Shen, Hao Wu, Jianqing Zhou, Bingyang Liu

“…Given the high prevalence of dementia and its substantial economic burden in China, large-scale longitudinal studies are essential to elucidate the complex relationship between IR and cognitive function.MethodsThis longitudinal cohort study included 8,734 middle-aged and older adults (median age: 58 years; 53.6% females) from the China Health and Retirement Longitudinal Study (CHARLS), followed from 2011 to 2018. …”
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An Analysis of the Gear Meshing Characteristics of the Main Planetary Gear Trains of Helicopters Undergoing Shafting Position Changes by Li Xuejun, Jiang Lingli, Hua Dengrong, Yin Daoxuan, Yang Dalian

“…The complex three-shaft three-reducer structural designs of helicopter transmission systems are prone to changes in the relative positions of shafting under the conditions of main rotor and tail rotor loads. …”
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Healthcare workers’ perspectives on trauma and mental health access for Rohingya refugees in Cox’s Bazar by Lindsey Green, Linda Kaljee, Shahanoor Akter Chowdhury, Thomas McHale, Ranit Mishori, Ranit Mishori, Dahlia Fateen, Nima Sheth

“…Detailing the limited mental health infrastructure and structural barriers facing Rohingya refugees in Bangladesh, the findings underscore the urgent need for trauma-informed interventions that address the complex psychological consequences of systemic violence and displacement. …”
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Obesity in pregnancy: infant health service utilisation and costs on the NHS by Ronan A Lyons, Ashrafunnesa Khanom, Sinead T Brophy, Kelly L Morgan, Muhammad A Rahman, Rebecca A Hill

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L-shaped association between dietary iron intake and HPV infection: a cross-sectional analysis based on national health and nutrition examination survey 2005–2016 by Xiaotong Chen, Haiwei Chen, Yuling Chen, Lixin Tang, Jiaqi Liu, Yu-Hua Ou

“…Additionally, we implemented smooth curve fitting and threshold effect analysis, to delineate the complex, nonlinear association between iron intake and HPV infection. …”
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The dynamics of lowland river sections of Danube and Tisza in the Carpathian basin by Imre M. Jánosi, Imre M. Jánosi, István Zsuffa, István Zsuffa, Tibor Bíró, Boglárka O. Lakatos, Boglárka O. Lakatos, András Szöllősi-Nagy, Zsolt Hetesi, Zsolt Hetesi

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Strength training in pregnancy. Systematic review of benefits and risks by Karol Demel, Antoni Kantor, Jakub Król, Łukasz Bialic, Monika Dziedzic, Sebastian Polok, Adriana Potoczek, Justyna Talaska, Marta Godyń, Dorota Zatłoka-Mazur

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Analysis of the structure and function of the tomato <i>Solanum lycopersicum</i> L. MADS-box gene <i>SlMADS5</i> by A. V. Nezhdanova, M. A. Slugina, E. A. Dyachenko, A. M. Kamionskaya, E. Z. Kochieva, A. V. Shchennikova

“…The E-proteins SEPALLATA are the central hub of the MADS-complexes, which determine the identity of the floral organs. …”
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A Review of Human Studies Assessing the Efficacy of Cannabidiol for Anxiety Disorders by Kuba Borys Romańczuk, Katarzyna Kamińska-Omasta, Bartosz Omasta, Olga Krupa, Paulina Dorota Pietrukaniec, Zofia Martyna Wójcik, Kinga Furtak, Szymon Przemysław Stolarczyk, Magdalena Agata Czerska, Daria Rybak

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