Germinal Center B Cells are Uniquely Targeted by Antibody-Suppressor CXCR5+CD8+ T Cells by Jason M. Zimmerer, PhD, Sachi Chaudhari, BS, Kavya Koneru, BS, Jing L. Han, MD, PhD, Mahmoud Abdel-Rasoul, MA, Hope Uwase, MA, Tai Yi, MD, Christopher K. Breuer, MD, Ginny L. Bumgardner, MD, PhD

“…The reduction of TFH-cell quantity was dependent on CD8+ TAb-supp cell–mediated major histocompatibility complex-I-dependent cytotoxic killing of GC B cells. …”
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People’s knowledge, attitudes, and conflicts with carnivores in central hills, Sri Lanka by Ashan Thudugala, Hem Bahadur Katuwal, Nalindra Laxman, Vishwa Dushmantha, Ravindi Menikrama, Harsha Dissanayake, Chameera Dilshan, Ru-Chuan He, Rui-Chang Quan

“…Our study highlights the complex nature of human-carnivore interactions and emphasizes the need for educating people about carnivores. …”
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Decoding the anomalies: a genome-based analysis of Bacillus cereus group strains closely related to Bacillus anthracis by Thuto Gomolemo Magome, Marius Surleac, Marius Surleac, Ayesha Hassim, Cornelius Carlos Bezuidenhout, Henriette van Heerden, Kgaugelo Edward Lekota

“…IntroductionThe Bacillus cereus group encompasses a complex group of closely related pathogenic and non-pathogenic bacterial species. …”
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Challenges and enablers for scaling up interventions targeting non-communicable diseases: a qualitative study applying the Consolidated Framework for Implementation Research to 19... by Josefien van Olmen, Peter Delobelle, Meena Daivadanam, Hassan Haghparast-Bidgoli, Maria Lazo-Porras, J Jaime Miranda, Yuan Li, Rohina Joshi, Amanda G Thrift, Rajesh Vedanthan, Gina Agarwal, Mark D Huffman, Kerstin Klipstein-Grobusch, Naomi Levitt, Dike Ojji, Feng J He, Kamran Siddiqi, Pascal Geldsetzer, Puhong Zhang, Milena Soriano Marcolino, Lal B Rawal, Brian Oldenburg, Helena Teede, Josephine Birungi, Edwin Wouters, Abha Shrestha, Ari Probandari, Mayowa Owolabi, Vilma Irazola, Andrea Beratarrechea, Keiko Nakamura, Gindo Tampubolon, Zulma Ortiz, Violet Naanyu, Jaap Koot, Anusha Ramani-Chander, Stephen Sherwood, Monika Martens, Gade Waqa, Maria Eugenia Esandi, Sujarwoto Sujarwoto, Laura Antonietti, Jan-Walter De Neve, Sayoki G Mfinanga, Antonio Luiz Pinho Ribeiro

“…COVID-19 provided both challenges and opportunities and these varied depending on the intervention characteristics and study objectives.Conclusion Researchers supporting the scale-up of complex interventions targeting NCDs need to leverage on existing trusting relationships and foster equitable stakeholder partnerships through research. …”
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Relation Between Humor Styles and Psychopathological Symptoms in Healthcare Professionals: A Cross-Sectional Study by Miriam Leñero-Cirujano, Héctor González-Ordi, Juan Ignacio Torres-González, Jacinto Gómez-Higuera, Sergi Piñar-Rodríguez, Elena López-Bermejo Minaya, Gregorio Jesús Alcalá-Albert, Álvaro Carmona-Pestaña, María Nieves Moro-Tejedor

“…<b>Background/Objectives</b>: Being a healthcare professional often involves exposure to complex situations that can contribute to the development of psychological problems. …”
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Exploring ketogenic diet resistance in glucose transporter type 1 deficiency syndrome: A comprehensive review and critical appraisal by Raffaele Falsaperla, Vincenzo Sortino, Gerhard Josef Kluger, Thomas Herberhold, Andrea Rüegger, Pasquale Striano, Martino Ruggieri, Joerg Klepper, Georgia Ramantani

“…Large‐scale multicenter studies, facilitated through international collaborations like the European Network for Therapy in Rare Epilepsies (NETRE), hold promise in elucidating the complexities of this patient population and developing personalized therapeutic approaches. …”
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Adipose tissue may not be a major player in the inflammatory pathogenesis of Autism Spectrum Disorder by Baojiang Wang, Yueyuan Qin, Yong Chen, Xiujie Zheng, Yanjuan Chen, Juan Zhao, Feng Zhang, Shan Duan

“…Purpose: Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder increasingly recognized for its strong association with chronic inflammation. …”
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Fluoride exposure, personal susceptibility and osteoarticular degeneration: Evidence from farmers in the Yellow River Basin of Henan Province by Zichen Feng, Long Sun, Shu Niu, Bin Liu, Ruijie Ba, Guoqing Wang, Qing Sun, Chunxiang Li, Yan Wang, Fangfang Yu, Guoyu Zhou, Yue Ba

“…Genetic susceptibility analysis showed that the CG genotype of calcitonin related polypeptide alpha (CALCA) rs1553005 loci was related to higher OAD risk (OR=1.959; 95 %CI: 1.003, 3.825), whereas higher methylation status of GNAS complex locus (GNAS) (OR=0.617; 95 %CI: 0.410, 0.929) and TC genotype of rs7121 loci (OR=0.569; 95 %CI: 0.371, 0.871) showed protective effect on OAD. …”
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A Cause Analysis of the High-Content Nitrogen and Low-Content Hydrocarbon in Shale Gas: A Case Study of the Early Cambrian in Xiuwu Basin, Yangtze Region by Yizhou Huang, Kun Zhang, Zhenxue Jiang, Yan Song, Shu Jiang, Chengzao Jia, Weiwei Liu, Ming Wen, Xuelian Xie, Tianlin Liu, Xin Li, Xin Wang, Xiaoxue Liu, Ye Zhang, Ling Tang

“…The study of nitrogen concentration in shale gas contributes to solve the question that how shale gas diffuses in complex tectonic areas, which helps to figure out the preservation requirements and accumulation mechanisms of shale gas and avoid exploration crisis. …”
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Outcomes of psychiatric interviews and self-rated symptom scales in people on sick leave for common mental disorders: an observational study by Cecilia Björkelund, Dominique Hange, Jeanette Westman, Anna Nager, Jonas Hällgren, Ingmarie Skoglund, Sandra af Winklerfelt Hammarberg, Anna Finnes

“…More severe symptoms were associated with longer sick leave.Conclusion Diagnoses on sick leave certificates did not reflect the complex and overlapping nature of the diagnoses found in the structured psychiatric interviews. …”
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Role of Intraplate Strike-Slip Earthquakes in Accommodating Convergence Across the Eastern Himalayan Plate Boundary System by Dibyajyoti Chaudhuri, Rupak Banerjee, Ajay Kumar, Shubham Sharma, Supriyo Mitra

“…The strike-slip earthquakes beneath Indo-Burma probably occur due to a complex interplay between the trench-normal slab-pull forces and lateral-shear forces set up by the strike-parallel components of the interplate-coupling resistance and the mantle-drag forces.…”
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Should we consider microbiota-based interventions as a novel therapeutic strategy for schizophrenia? A systematic review and meta-analysis by Lucas Hassib, Alexandre Kanashiro, João Francisco Cordeiro Pedrazzi, Bárbara Ferreira Vercesi, Sayuri Higa, Íris Arruda, Yago Soares, Adriana de Jesus de Souza, Alceu Afonso Jordão, Francisco Silveira Guimarães, Frederico Rogério Ferreira

“…Its etiology is multifactorial, involving a complex interplay of genetic, neurobiological, and environmental factors, and its neurobiology is associated with abnormalities in different neurotransmitter systems. …”
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Molecular Phylogenetics and Estimation of Evolutionary Divergence and Biogeography of the Family Cordycipitaceae (Ascomycota, Hypocreales) by Huili Pu, Jiao Yang, Nemat O. Keyhani, Lixia Yang, Minhai Zheng, Chenghao Qiu, Yuchen Mao, Junya Shang, Yongsheng Lin, Chengjie Xiong, Longbing Lin, Pengyu Lai, Yanbin Huang, Xin Yuan, Huiling Liang, Longfei Fan, Xiaoli Ma, Chunjin Qiu, Junzhi Qiu

“…The Cordycipitaceae family of insecticidal fungi is widely distributed in nature, is the most complex in the order Hypocreales (Ascomycota), with members displaying a diversity of morphological characteristics and insect host ranges. …”
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Differences in soil Cd immobilization and blockage of rice Cd uptake by biochar derived from crop residue and bone − A 2-year field experiment by Zhongjun Xue, Fengfeng Sui, Yanjie Qi, Siyu Pan, Ning Wang, Rongjun Bian, Stephen Joseph, Xuhui Zhang, Lianqing Li, Genxing Pan

“…Higher Si content in rice root in RHB treatment may promote complexation and deposition of Si hemicellulose-bound Cd in the root cell walls. …”
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A harmonized dataset relating alternative farmer management practices to crop yield, soil organic carbon stock, nitrous oxide emissions, and nitrate leaching generated using IPCC m... by Roberta Calone, Angela Fiore, Guido Pellis, Maria Luz Cayuela, Gabriele Mongiano, Alessandra Lagomarsino, Simone Bregaglio

“…These practices exhibit complex, non-linear interrelationships that affect crop productivity, water quality, and non-carbon dioxide greenhouse gases (GHG) emissions, possibly offsetting their benefits regarding soil organic carbon (SOC) sequestration. …”
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Comparative Study on the Reservoir Characteristics and Development Technologies of Two Typical Karst Weathering-Crust Carbonate Gas Reservoirs in China by Haijun Yan, Ailin Jia, Fankun Meng, Qinyu Xia, Wei Xu, Qingfu Feng, Wenjun Luo, Xinyu Li, Xun Zhu, Yicheng Liu

“…For Jingbian gas field, it is a lithological-stratigraphic reservoir developed in a westward monocline and multiple rows of nose-fold structures, and is a stable craton basin with simple palaeognomy distribution and stable connectivity, which has complex gas-water distribution. However, for Anyue gas field, it is a lithological-structural reservoir with multiple tectonic high points and multiple fault systems, and is biological dune beach facies under extensional setting with highly differentiated inside of the block in palaeognomy characteristics, which has limited connectivity and tectonic side water is in a local area. …”
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Evaluation of nutrient loads conveyed to the deep subalpine lakes of Northern Italy through their main tributaries by Paolo Dezuanni, Paolo Dezuanni, Diego Copetti, Claudia Dresti, Nicolò Pella, Nicolò Pella, Fabio Buzzi, Andrea Fenocchi, Andrea Fenocchi

“…Proper watershed management practices must be put into action to effectively oppose eutrophication. Because of the complexities and the multiple layers of stakeholders involved in this process, the only factual way to evaluate improvements in watershed nutrient management is to directly estimate nutrient loads at watershed closing sections through available data from environmental monitoring. …”
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Macro-environment oscillation notably up risk of water quality degradation: A case study in Shanxi Reservoir, China by Wangwei Cai, Jihong Xia, Zewen Liu, Jiayi Zu, Shuyi Ji, Yue Wang, Qihua Wang

“…However, the mechanism of macro-environment affect water quality risk still is unclear. Water quality is a complex system which should be able to adapt to small fluctuation of macro-environment, but turn into deterioration under significant macro-environment oscillation. …”
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High-resolution Cryo-EM Structure Determination of a-Synuclein—A Prototypical Amyloid Fibril by Juan Sanchez, Joshua Pierson, Collin Borcik, Chad Rienstra, Elizabeth Wright

“…The physiological role of a-synuclein (a-syn), an intrinsically disordered presynaptic neuronal protein, is believed to impact the release of neurotransmitters through interactions with the SNARE complex. However, under certain cellular conditions that are not well understood, a-syn will self-assemble into β-sheet-rich fibrils that accumulate and form insoluble neuronal inclusions. …”
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Dynamics of ecosystem service values in the Tarim River Basin by Mengxin Sun, Mengxin Sun, Xin Shen, Xin Shen, Hailiang Xu, Hailiang Xu, Ai Shajiang·Aili, Ai Shajiang·Aili

“…Interactions between climate and socioeconomic development complicate the dynamics of land use and ESV.DiscussionThe results indicate that while government policies and climate change significantly influence land use and ESV in the Tarim River Basin, socioeconomic factors are increasingly impactful. The complex interactions between climate and socioeconomic development have important implications for ecosystem management and decision-making. …”
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