Trauma surgical skill sustainment at the University of Chicago AMEDD Military-Civilian Trauma Team Training Site: an observation report by Priya Prakash, Kenneth Wilson, Jennifer Cone, Selwyn O Rogers, Andrew Benjamin, Timothy P Plackett, Nicholas Jaszczak, David A Hampton

“…The AMEDD experience provided a deployment-relevant case mix with an emphasis on complex vascular injury repairs.…”
Get full text

Methodical approaches to identification of effective wheat genes providing broad-spectrum resistance against fungal diseases by E. S. Skolotneva, I. N. Leonova, E. Yu. Bukatich, E. A.  Salina

“…Among the pathogenic complex of the common wheat there is a causal agent of leaf and stem diseases: (rusts and powdery mildew), which has economic importan ce for most of the Russian regions. …”
Get full text

Polymorphism of the <i> FaOMT </i> and <i> FaFADl </i> genes for fruit flavor volatiles in strawberry varieties and wild species from the genetic collection of the Michurin Federal... by A. S. Lyzhin, I. V. Luk’yanchuk, E. V. Zhbanova

“…The key volatile compounds of the aromatic complex of strawberry fruit are mesifurane (fruity and caramel aromas) and y-decalactone (fruity, sweet, or peachy aroma). …”
Get full text

Impacts of Tax Laws on the Performance of Small and Medium Enterprises: A Case Study of Kabale Municipality Kabale District. by Abaasa, Ruth

“…The results aligned well with theoretical expectations, with 70 (47%) of respondents agreeing that tax laws are often complex and challenging for SMEs to navigate, requiring time, expertise, and sometimes external assistance from tax professionals or accountants. …”
Get full text

Influence of Mobile Money Crowding and Financial Service Delivery in Kabale Municipality: A Case Study of Mtn Uganda Kabale Branch. by Ahimbisibwe, Blair

“…The study findings revealed the challenges faced by mobile money transfer services and this included security of financial transactions being executed from some remote locations, money transfer relies entirely on the strength of the network, compliance with diverse regulations can be complex and time-consuming, lack of interoperability between different mobile money platforms and financial institutions. …”
Get full text

Preliminary investigation on the establishment of a new meibomian gland obstruction model and gene expression by Ming Sun, Huanmin Cheng, Zheng Yang, Jiangqin Tang, Shengshu Sun, Zhanglin Liu, Shaozhen Zhao, Lijie Dong, Yue Huang

“…Abstract Meibomian gland dysfunction is a chronic ocular surface disease with a complex pathogenesis, whose main clinical manifestations are meibomian gland obstruction or/and lipid abnormalities. …”
Get full text

The impact of biofeedback in enhancing chronic pain rehabilitation: A systematic review of mechanisms and outcomes by Andrea Calderone, Vincenza Maura Mazzurco Masi, Rosaria De Luca, Antonio Gangemi, Mirjam Bonanno, Daniela Floridia, Francesco Corallo, Giovanni Morone, Angelo Quartarone, Maria Grazia Maggio, Rocco Salvatore Calabrò

“…This condition, characterized by persistent pain, muscle stiffness, and emotional distress, often results in a complex interplay of physical and psychological factors that exacerbate symptoms and hinder recovery. …”
Get full text

Single-cell RNA sequencing and AlphaFold 3 insights into cytokine signaling and its role in uveal melanoma by Hongyan Sun, Cunzi Li, Zuhui Pu, Zuhui Pu, Ying Lu, Ying Lu, Zijing Wu, Zijing Wu, Lan Zhou, Lan Zhou, Hongzhan Lin, Yumo Wang, Tao Zi, Lisha Mou, Lisha Mou, Ming-ming Yang

“…T-cell population analysis revealed complex developmental pathways and interaction networks in UVM. …”
Get full text

Inflammatory adhesion mediates myocardial segmental necroptosis induced by mixed lineage kinase domain-like protein in acute myocardial infarction by Lijiang Wei, Naifu Wan, Wentong Zhu, Chenchen Liu, Zeyu Chen, Wuwei Rong, Lujun Zhang, Meifeng Xie, Yueqi Qin, Ting Sun, Qing Jing, Ankang Lyu

“…Abstract Purpose Cardiomyocyte death is a major cytopathologic response in acute myocardial infarction (AMI) and involves complex inflammatory interactions. Although existing reports indicating that mixed lineage kinase domain-like protein (MLKL) is involved in macrophage necroptosis and inflammasome activation, the downstream mechanism of MLKL in necroptosis remain poorly characterized in AMI. …”
Get full text

Characteristics of tongue coating microbiota in diabetic and non-diabetic kidney patients receiving hemodialysis by Qiang Luo, Siyuan Chu, Yongqun Wu, Lingling Jin, Rui Liu, Yulin Xu, Yina Yu, Yawei Jin, Luckress Ornelle Edouarda Phyfamin Houndekon, Heshen Hu, Yvchen Zou, Hao Huang, Haimin Chen

“…Network analysis revealed a less complex interaction relationship among the tongue coating bacterial microbiota of nonDM_HD and DM_HD. …”
Get full text

Gibberellin-3 induced dormancy and suppression of flower bud formation in pitaya (Hylocereus polyrhizus) by Kamran Shah, Xiaoyue Zhu, Tiantian Zhang, Jiayi Chen, Jiaxuan Chen, Yonghua Qin

“…Abstract Background Flowering is a complex, finely regulated process involving multiple phytohormones and transcription factors. …”
Get full text

Correlation Between Systemic Inflammation, Gut Microbiome Dysbiosis and Postoperative Complications After the Modified Whipple Procedure by Gelu Mihai Breaza, Florin Emil Hut, Octavian Cretu, Simona-Alina Abu-Awwad, Ahmed Abu-Awwad, Laurențiu Vasile Sima, Radu Gheorghe Dan, Cristina Ana-Maria Dan, Raluca Maria Closca, Flavia Zara

“…(1) Background: The modified Whipple procedure, or pylorus-preserving pancreaticoduodenectomy, is a complex surgical intervention used to treat pancreatic head tumors. …”
Get full text

Molecular-genetic pathways of hepatitis C virus regulation of the expression of cellular factors PREB and PLA2G4C, which play an important role in virus replication by E. L. Mishchenko, A. A. Makarova, E. A. Antropova, A. S. Venzel, T. V. Ivanisenko, P. S. Demenkov, V. A. Ivanisenko

“…It is known that the host factors PREB (prolactin regulatory element binding) and PLA2G4C (cytosolic phospholipase A2 gamma) are important for the functioning of the viral replicase complex and the formation of the platforms of HCV genome replication. …”
Get full text

Galectin-3 secreted by triple-negative breast cancer cells regulates T cell function by Annat Raiter, Yael Barhum, Julia Lipovetsky, Chen Menachem, Sharona Elgavish, Shmuel Ruppo, Yehudit Birger, Shai Izraeli, Orna Steinberg-Shemer, Rinat Yerushalmi

“…We recently demonstrated that Galectin-3 (Gal-3) binding protein/Gal-3 complex secreted by TNBC cells induces immunosuppression, through inhibiting CD45 signaling in T cells. …”
Get full text

mTORC2 Activation Mediated by Mesenchymal Stem Cell-Secreted Hepatocyte Growth Factors for the Recovery of Lipopolysaccharide-Induced Vascular Endothelial Barrier by Shan-Shan Meng, Feng-Mei Guo, Li-Li Huang, Ying-Zi Huang, Jian-Feng Xie, Cong-Shan Yang, Hai-Bo Qiu, Yi Yang

“…The mTOR protein kinase has two distinct multiprotein complexes mTORC1 and mTORC2 that regulate different branches of the mTOR network. …”
Get full text

Human_SNP_TATAdb: a database of SNPs that statistically significantly change the affinity of the TATA-binding protein to human gene promoters: genome-wide analysis and use cases by S. V. Filonov, N. L. Podkolodnyy, O. A. Podkolodnaya, N. N. Tverdokhleb, P. M. Ponomarenko, D. A. Rasskazov, A. G. Bogomolov, M. P. Ponomarenko

“…The Institute of Cytology and Genetics SB RAS (ICG) has developed a method for predicting TBP affinity for gene promoters based on a three-step binding mechanism: (1) TBP slides along DNA, (2) TBP stops at the binding site, and (3) the TBP-promoter complex is fixed due to DNA helix bending. The method showed a high correlation of theoretical predictions with measured values during repeated experimental testing by independent groups of researchers. …”
Get full text

Validation of a Questionnaire Assessing Pregnant Women’s Perspectives on Addressing the Psychological Challenges of Childbirth by Mihaela Corina Radu, Mihai Sebastian Armean, Razvan Daniel Chivu, Justin Aurelian, Melania Elena Pop-Tudose, Loredana Sabina Cornelia Manolescu

“…Introduction: Pregnant women’s experiences and concerns regarding childbirth are complex, necessitating a multidimensional and personalized approach in maternal care. …”
Get full text

Genetic Polymorphisms of Toll-like receptors 2 and 9 as Susceptibility Factors for the Development of Ankylosing Spondylitis and Psoriatic Arthritis by Camila F. Oliveira-Toré, Amarilis G. Moraes, Gabriela F. Martinez, Janisleya S. F. Neves, Luciana C. Macedo, Marco A. Rocha-Loures, Marília G. Quirino, Hugo V. Alves, Ana M. Sell, Jeane E. L. Visentainer

“…Ankylosing spondylitis (AS) and psoriatic arthritis (PsA) are classified as spondyloarthritis (SpA), a group of inflammatory rheumatic diseases with complex genetic etiology. Toll-like receptors (TLRs) have an important role in the mechanism of innate immunity and may influence inflammatory responses. …”
Get full text

TLR7: A Key Prognostic Biomarker and Immunotherapeutic Target in Lung Adenocarcinoma by Feiming Hu, Chenchen Hu, Yuanli He, Yuanjie Sun, Chenying Han, Xiyang Zhang, Lingying Yu, Daimei Shi, Yubo Sun, Junqi Zhang, Dongbo Jiang, Shuya Yang, Kun Yang

“…However, understanding its dynamic immune and stromal modulation remains a complex challenge. <b>Methods:</b> We utilized the ESTIMATE algorithm to evaluate the immune and stromal components of the LUAD TME from the TCGA database. …”
Get full text

The association between hair cortisol and burnout is moderated by age, psychosocial, and immunological markers by Patrick D. Gajewski, Peter Bröde, Maren Claus, Klaus Golka, Jan G. Hengstler, Carsten Watzl, Edmund Wascher, Stephan Getzmann

“…Conclusions: The present findings shed light on the complex interaction between burnout symptoms and work ability, chronic stress, personality, and the endocrinological and immunological responses across the working lifespan. …”
Get full text