Polygenic prediction of human longevity on the supposition of pervasive pleiotropy by M. Reza Jabalameli, Jhih-Rong Lin, Quanwei Zhang, Zhen Wang, Joydeep Mitra, Nha Nguyen, Tina Gao, Mark Khusidman, Sanish Sathyan, Gil Atzmon, Sofiya Milman, Jan Vijg, Nir Barzilai, Zhengdong D. Zhang

“…We tracked allele frequency changes as a function of viability across different age bins and prioritized 34 variants with an immediate implication on lipid metabolism, body mass index (BMI), and cognitive performance, among other traits, revealed by PheWAS analysis in the UK Biobank. Given the highly complex and non-linear interactions between the genetic determinants of longevity, we reasoned that a composite polygenic score would approximate a substantial portion of the variance in lifespan and developed the integrated longevity genetic scores (iLGSs) for distinguishing exceptional survival. …”
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Assessing Four Decades of Land Use and Land Cover Change: Policy Impacts and Environmental Dynamics in the Min River Basin, Fujian, China by Weixuan Huang, Anil Shrestha, Yifan Xie, Jianwu Yan, Jingxin Wang, Futao Guo, Yuee Cao, Guangyu Wang

“…Thus, this study highlights the complex relationship between different land use land cover policies, as some policies had synergistic effects between the policies and positive outcomes, while other policies showed conflicting outcomes. …”
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YHSeqY3000 panel captures all founding lineages in the Chinese paternal genomic diversity database by Mengge Wang, Shuhan Duan, Qiuxia Sun, Kaijun Liu, Yan Liu, Zhiyong Wang, Xiangping Li, Lanhai Wei, Yunhui Liu, Shengjie Nie, Kun Zhou, 10K_CPGDP consortium, Yongxin Ma, Huijun Yuan, Bing Liu, Lan Hu, Chao Liu, Guanglin He

“…This panel is intended to provide a new tool for forensic complex pedigree search and paternal biogeographical ancestry inference, as well as explore the general patterns of the fine-scale paternal evolutionary history of ethnolinguistically diverse Chinese populations. …”
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Seabed Acoustic Mapping Revealing an Uncharted Habitat of Circular Depressions Along the Southeast Brazilian Outer Shelf by Ana Carolina Lavagnino, Marcos Daniel Leite, Tarcila Franco, Pedro Smith Menandro, Fernanda Vedoato Vieira, Geandré Carlos Boni, Alex Cardoso Bastos

“…In Brazil, especially on the Espírito Santo Continental Shelf, high-resolution seabed mapping has revealed an unknown complex seascape. Circular depressions (CDs) were mapped for the first time in the Costa das Algas Marine Protection Area. …”
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Biomarker combinations from different modalities predict early disability accumulation in multiple sclerosis by Vinzenz Fleischer, Tobias Brummer, Muthuraman Muthuraman, Muthuraman Muthuraman, Falk Steffen, Milena Heldt, Maria Protopapa, Muriel Schraad, Gabriel Gonzalez-Escamilla, Sergiu Groppa, Stefan Bittner, Frauke Zipp

“…ObjectiveEstablishing biomarkers to predict multiple sclerosis (MS) disability accrual has been challenging using a single biomarker approach, likely due to the complex interplay of neuroinflammation and neurodegeneration. …”
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Safety, feasibility and initial efficacy of an app-facilitated telerehabilitation (AFTER) programme for COVID-19 survivors: a pilot randomised study by Kristine M Erlandson, Jacob John Capin, Amy Nordon-Craft, Sarah E Jolley, Jennifer E Stevens-Lapsley, Mary Morrow, Meghan Connors, Kristine Hare, Samantha MaWhinney, Michelle Rauzi, Sheryl Flynn

“…Both groups demonstrated clinically meaningful improvement in secondary outcomes with no statistically significant differences between groups.Conclusion Fully remote telerehabilitation was safe, feasible, had high adherence for COVID-19 recovery, and may apply to other medically complex patients including those with barriers to access care. …”
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Influence of environmental variables and anthropogenic activities on soda-saline lakes chemistry in northern Tanzania: A remote sensing and GIS approach by Azaria Stephano Lameck, Brian Rotich, Abdalrahman Ahmed, Harison K. Kipkulei, Peto Akos, Emil Boros

“…This study underscores the complex interplay between environmental variables and human activities in shaping the chemistry of soda-saline lakes.…”
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Prevalence, aetiology, and service mapping of dementia in rural Uganda. Part of DEPEND Uganda (Dementia Epidemiology, unmet Need and co-Developing Solutions in Uganda). [version 2;... by Joseph Mugisha, Nicholas J Ashton, Claire J Steves, Racheal Alinaitwe, Josephine Prynn, Tunde Peto, Beatrice Kimono, Martin Prince

“…People with dementia have complex needs benefiting from multi-dimensional support. …”
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Isolation and Characterization of Indigenous <i>Acetobacter</i> Strains from Cashew Apple and Their Potential Use in Vinegar Production by Yaya Anianhou Ouattara, Doudjo Soro, Kouakou Romain Fossou, Ahou Cinthia Ines Yebouet, Ismael Abraham Cissé, Dogbo Marius Akissi, Adolphe Zézé, Emmanuel Assidjo, Kouassi Benjamin Yao

“…Phenotypic and phylogenetic analysis revealed that four of them, namely OYA2, OYA6, OYA9, and OYA10, belong to the <i>A. tropicalis</i>/<i>A. senegalensis</i> species complex with 99.7% or 100% similarity. The fifth strain, OYA7, being similar (99.7%) to <i>A. syzygii</i>. …”
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Distinct mechanisms of electroacupuncture and manual acupuncture in modulating hypothalamic GnRH–tanycyte unit function of polycystic ovary syndrome by Yu Wang, Yicong Wang, Yuning Chen, Wenhan Lu, Xiaoyu Tong, Jiajia Li, Wenhao Gao, Rui Huang, Wei Hu, Yi Feng

“…Abstract Background Polycystic ovary syndrome (PCOS) is a complex neuroendocrine disorder characterized by dysregulation of the hypothalamus. …”
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Liposomal Formulation of Hydroxychloroquine Can Inhibit Autophagy In Vivo by Wieslawa H. Dragowska, Jagbir Singh, Mohamed Wehbe, Malathi Anantha, Katarina Edwards, Sharon M. Gorski, Marcel B. Bally, Ada W. Y. Leung

“…<b>Methods:</b> We developed two liposomal formulations of HCQ: a pH-loaded formulation and a formulation based on copper complexation. The pharmacokinetics of each formulation was evaluated in CD1 mice following intravenous administration. …”
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PreciPalm: An Intelligent System for Calculating Macronutrient Status and Fertilizer Recommendations for Oil Palm on Mineral Soils Based on a Precision Agriculture Approach by Kudang Boro Seminar, Harry Imantho, null Sudradjat, Sudirman Yahya, Sirojul Munir, Indra Kaliana, Fajar Mei Haryadi, Awalia Noor Baroroh, null Supriyanto, Gani Cahyo Handoyo, Arif Kurnia Wijayanto, Cecep Ijang Wahyudin, null Liyantono, Rhavif Budiman, Achmad Bakir Pasaman, Dwi Rusiawan, null Sulastri

“…The measurement of the macronutrient values of an oil palm plantation is a complex and tedious task, particularly when dealing with large plantation areas. …”
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β-Fructofuranosidase and β –D-Fructosyltransferase from New Aspergillus carbonarius PC-4 Strain Isolated from Canned Peach Syrup: Effect of Carbon and Nitrogen Sources on Enzyme Pr... by Gustavo Carvalho do Nascimento, Ryhára Dias Batista, Claudia Cristina Auler do Amaral Santos, Ezequiel Marcelino da Silva, Fabrício Coutinho de Paula, Danylo Bezerra Mendes, Deyla Paula de Oliveira, Alex Fernando de Almeida

“…Pineapple crown was the best complex carbon source for invertase (6.71 U/mL after 3 days of cultivation) and FTase production (14.60 U/mL after 5 days of cultivation). …”
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Structure of Spatial Correlation Network and Influencing Factors of Urban-Rural Integration in China by Wang Kai, Liu Meilun, Tan Jiaxin, Gan Chang

“…Spatially, it showed a decreasing gradient from east to west, but the gap between the interprovincial urban-rural integration level gradually narrowed, with obvious spatial non-equilibrium. 2) China's urban-rural integration spatial association network became increasingly dense, complex, and close, and the main linkage flows of urban-rural integration occurred between geographically neighboring provinces and cities, such as Shanghai-Jiangsu, Shanghai-Zhejiang, and Beijing-Tianjin. …”
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Computational Modeling and Experimental Investigation of CO₂-Hydrocarbon System Within Cross-Scale Porous Media by Feiyu Chen, Linghui Sun, Bowen Li, Xiuxiu Pan, Boyu Jiang, Xu Huo, Zhirong Zhang, Chun Feng

“…CO₂ flooding plays a crucial role in enhancing oil recovery and achieving carbon reduction targets, particularly in unconventional reservoirs with complex pore structures. The phase behavior of CO₂ and hydrocarbons at different scales significantly affects oil recovery efficiency, yet its underlying mechanisms remain insufficiently understood. …”
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Septoriablotch epidemic process on spring wheat varieties by E. Yu. Toropova, O. A. Kazakova, V. V. Piskarev

“…A differen tiated manifestation of resistance to Septorialeaf and ear disease has been established. Some varieties show complex resistance, combining reduced susceptibility to Septorialeaf and ear disease. …”
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The Impact of Exposure to Indoor Pollutants on Allergy and Lung Inflammation among School Children in Selangor, Malaysia: An Evaluation Using Factor Analysis by Khairul Nizam Mohd Isa, Zailina Hashim, Juliana Jalaludin, Dan Norbäck, Mohammed Abdulrazzaq Jabbar, Jamal Hisham Hashim

“…Linear mixed model, two-levels multiple logistic regression, PCA and SPC were applied to determine the complex relationship between respiratory symptoms, personal factors, FeNO levels and atmospheric indoor pollutants. 20.6% of students reported daytime breathlessness and 55.5% reported having rhinitis in the last 12 months. …”
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ON THE SPECIFICS OF TEACHING, SCHOOLS AND INTELLECTUAL CENTERS OF PALESTINE OF LATE ANTIQUITY by Zhanna M. Sukhova, Irina Yu. Vashcheva

“…Finally, the ability to engage in intellectual debates required the presence of libraries: one of the most famous and largest libraries in Palestine – the Caesarean library, which appeared at a historically important and complex moment, i.e. during the era of persecutions.…”
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A systematic review of military-to-civilian transition, The role of gender. by Alexandria Smith, Laura Rafferty, Bethany Croak, Neil Greenberg, Rafiyah Khan, Victoria Langston, Marie-Louise Sharp, Anne Stagg, Nicola Fear, Sharon Stevelink

“…<h4>Background</h4>The military-to-civilian transition can be a challenging period for many service members; however, recent research suggests that female ex-service personnel (veterans) confront additional complexities during reintegration into civilian life. …”
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Chromosomal analysis and short-term outcome of prenatally diagnosed congenital heart disease by Marcellino Verbeke, Laurens Hannes, Koen Devriendt, Kris Van den Bogaert, Bjorn Cools, Luc De Catte, Marc Gewillig, Jeroen Breckpot

“…This retrospective chart review was aimed at finding markers for short-term outcome prediction of prenatally-diagnosed complex CHD, focusing in particular on the impact of CHD category, of CHD severity score and of prenatal or postnatal diagnosis of ECA or chromosomal anomalies on 4 primary outcomes: termination of pregnancy (TOP), intrauterine fetal demise, neonatal mortality and 1-year-survival rate. …”
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