Epicardially Placed Bioengineered Cardiomyocyte Xenograft in Immune-Competent Rat Model of Heart Failure by Ikeotunye Royal Chinyere, Pierce Bradley, Joshua Uhlorn, Joshua Eason, Saffie Mohran, Giuliana G. Repetti, Sherry Daugherty, Jen Watson Koevary, Steven Goldman, Jordan J. Lancaster

“…In vitro, engineered grafts exhibited responsiveness to beta-adrenergic receptor agonism/antagonism and SERCA inhibition and elicited complex molecular profiles. Conclusions. This hiPSC-CM-derived cardiac graft improved systolic and diastolic cardiac function in immune-competent CHF rats. …”
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Laser powder bed fusion of Ti6Al4V using low-cost high efficiency 450 nm diode point melting by Alkim Aydin, Erhan Cetin, S. Can Erman, Kamran Mumtaz

“…Laser Powder Bed Fusion (LPBF) is a commonly used Additive Manufacturing (AM) method for the production of geometrically complex metal components that are used in high-value sectors. …”
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Uncovering molecular mechanisms of soybean response to 12C6+ heavy ion irradiation through integrated transcriptomic and metabolomic profiling by Honglei Ren, Bixian Zhang, Chunlei Zhang, Xiulin Liu, Xueyang Wang, Fengyi Zhang, Kezhen Zhao, Rongqiang Yuan, Ahmed M. Abdelghany, Sobhi F. Lamlom

“…These findings elucidate soybeans' complex molecular reactions to ionizing radiation, helping us understand how radiation-induced genetic and metabolic alterations affect plant growth.…”
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Physical, Textural, Rheological, and Sensory Characteristics of Amaranth-Based Wheat Flour Bread by Sahreen Nasir, Farhana Mehraj Allai, Murtaza Gani, Shaiq Ganaie, Khalid Gul, Aabida Jabeen, Darakshan Majeed

“…Rheological parameters like complex viscosity, loss modulus, and storage modulus were also observed in all dough samples. …”
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Determining the mechanism of Shuxuening injection against liver cirrhosis through network pharmacology and animal experiments by Qiyao Liu, Tingyu Zhang, Yongan Ye, Xin Sun, Huan Xia, Xu Cao, Xiaoke Li, Wenying Qi, Yue Chen, Xiaobin Zao

“…A protein–protein interaction (PPI) network was constructed using the Search Tool for the Retrieval of Interacting Genes/Proteins (STRING), and hub genes were identified using Molecular Complex Detection (MCODE). LC was induced in rats and mice via intraperitoneal injections of diethylnitrosamine and carbon tetrachloride (CCl4) for 12 weeks. …”
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Gut microbiota modulation via fecal microbiota transplantation mitigates hyperoxaluria and calcium oxalate crystal depositions induced by high oxalate diet by Lingyue An, Shujue Li, Zhenglin Chang, Min Lei, Zhican He, Peng Xu, Shike Zhang, Zheng Jiang, Muhammad Sarfaraz Iqbal, Xinyuan Sun, Hongxing Liu, Xiaolu Duan, Wenqi Wu

“…These findings provide insights on the complex connection between secondary hyperoxaluria caused by high dietary oxalate and disruptions in gut microbiota, offering promising avenues for targeted therapeutic strategies.…”
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Increased Phenotype Severity Associated with Splice-Site Variants in a Hungarian Pediatric Neurofibromatosis 1 Cohort: A Retrospective Study by Klára Veres, Benedek Nagy, Zsófia Ember, Judit Bene, Kinga Hadzsiev, Márta Medvecz, László Szabó, Zsuzsanna Zsófia Szalai

“…<b>Background:</b> Neurofibromatosis type 1 (NF1) is a complex neurocutaneous disorder caused by pathogenic variants in the <i>NF1</i> gene. …”
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A novel virulent core genome multilocus sequence type CT 11424 of Listeria monocytogenes isolate causing stillbirth in Bangladesh by Muntasir Alam, Md Saiful Islam, M. Ishrat Jahan, Arpita Shyama Deb, Afruna Rahman, Zahidul Islam, Atique Iqbal Chowdhury, Kazi Munisul Islam, Mohammad Zahid Hossain, Dilruba Ahmed, Shams El Arifeen, Emily S. Gurley, Mustafizur Rahman

“…It belonged to ST 308, Serotype 4b, Clonal Complex 1, and Phylogenetic Lineage 1. Key L. monocytogenes virulence genes facilitating the crossing of the placental barrier, including full-length inlA, LIPI-1, and LIPI-3, were detected. …”
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Completion of the Central Italy daily precipitation instrumental data series from 1951 to 2019 by Gamal AbdElNasser Allam Abouzied, Guoqiang Tang, Simon Michael Papalexiou, Martyn P. Clark, Eleonora Aruffo, Piero Di Carlo

“…However, precipitation data frequently lack complete series, especially at daily and sub‐daily precipitation stations, which are usually large, bulky, and complex. To address this, gap filling is commonly used to produce complete hydrometeorological data series without missing values. …”
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Prevalence and influencing factors of regular physical activity among community-dwelling adults in Shaanxi province, 2018: an analysis of surveillance data by Yali TAO, Rina SA, Weihua WANG, Meng WU, Rong LIU, Lin QIU

“…MethodsPhysical activity data of 5 964 permanent residents aged 18 years or older were collected from the China Chronic Diseases and Risk Factors Surveillance Program dataset conducted in 10 districts/counties/prefectures of Shaanxi province in 2018. Complex weight processing and unconditional multivariate logistic regression models were used in the data analysis to investigate the prevalence and main influencing factors of regular physical activity among the participants. …”
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Universal conditional networks (UniCoN) for multi-age embryonic cartilage segmentation with Sparsely annotated data by Nishchal Sapkota, Yejia Zhang, Zihao Zhao, Maria Jose Gomez, Yuhan Hsi, Jordan A. Wilson, Kazuhiko Kawasaki, Greg Holmes, Meng Wu, Ethylin Wang Jabs, Joan T. Richtsmeier, Susan M. Motch Perrine, Danny Z. Chen

“…Tackling this segmentation task with deep learning (DL) methods is laborious due to the big burden of manual image annotation, expensive due to the high acquisition costs of 3D micro-CT images, and difficult due to embryonic cartilage’s complex and rapidly changing shapes. While DL approaches have been proposed to automate cartilage segmentation, most such models have limited accuracy and generalizability, especially across data from different embryonic age groups. …”
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A novel peptide encoded by circSRCAP confers resistance to enzalutamide by inhibiting the ubiquitin-dependent degradation of AR-V7 in castration-resistant prostate cancer by Xiannan Meng, Qingxuan Wu, Chengsong Cao, Wendong Yang, Sufang Chu, Hongjun Guo, Suhua Qi, Jin Bai

“…The AR/AR-V7 protein is regulated by the E3 ubiquitin ligase STUB1 and a complex involving HSP70, but the precise mechanism remains unclear. …”
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Defining indicators for disease burden, health outcomes, policies and barriers and facilitators to health services for migrant populations in the Middle East and North African regi... by Charles Agyemang, Ali Ardalan, Farah Seedat, Bouchra Assarag, Nuria Casamitjana, Kolitha Wickramage, Sally Hargreaves, Ana Requena-Mendez, Fouad M Fouad, Dominik Zenner, Anna Deal, Stella Evangelidou, Wafa Saidi, Chiaki Ito, Oumnia Bouaddi, Moudrick Abdellatifi, Alba Cuxart-Graell, Hassan Edries, Eman Elafef, Taha Maatoug, Anissa Ouahchi, Liv Mathilde Pampiri, Sara Arias, Adel Abdelkhalek, Ahmed Hamed Arisha, Ibrahim Ahmed Bani, Aasmaa Chaoui, Wafa Chemao-Elfihri, Kenza Hassouni, Mahmoud Hilali, Mohamed Khalis, Wejdene Mansour, Ali Mtiraoui, MENA Migrant Health Working Group, Asad Adam, Adnene Ben Haj Aissa, Salma Altyib, Hanen Ben Belgacem, Imane Belkhammar, Thomas Calvot, Luciana Ceretti, Nelly Chavassieux, Hassan Chrifi, Mohamed Douagi, Algdail Elnil, Gonzalo Fanjul, Ahmed Hamed, Abdedayem Khelifi, Lora Makhlouf, Maissa Mokni, Davide Olchini, Tarik Oufkir, Nasong Park, Giuseppe Raffa, Sandra Santafé, Alice Sironi, Fatma Temimi, Zeineb Turki

“…Introduction The Middle East and North African (MENA) region is characterised by high and complex migration flows, yet little is known about the health of migrant populations, their levels of underimmunisation and access to healthcare provision. …”
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Five-year Variations in Air Pollutant Emissions with Ultra-low Emission Retrofits in a 660 MW Coal-fired Power Unit by Zhiyong Li, Zhuangzhuang Ren, Chengjing Cao, Chen Liu, Zhen Zhai, Jixiang Liu, Ziyi Zhan, Changtao Huang, Lan Chen, Hongdan Yuan

“…What’s more, the ULE transformation weaken the correlation between pollutant emissions (in mg m−3) and corresponding removal efficiencies of control devices, evidencing the pollutant emissions received complex impacts from coal components, emission control technologies and devices, and so on. …”
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Tumor CEMIP drives immune evasion of colorectal cancer via MHC-I internalization and degradation by Ying Zhu, Jiao Li, Tao Zhang, Lei Zhao, Min Jin, Jinghua Ren, Jing Tang, Haihong Wang, Zhenyu Lin, Qing Liang, Ruiqi Li, Biying Zhang, Qingling Hua, Guojie Xu, Jiayuan Chen, Lanqing Wang, Dejun Zhang, Dandan Yu

“…Background Loss of major histocompatibility complex class I (MHC-I) in tumor cells limits the use of immune checkpoint blockade (ICB) in colorectal cancer. …”
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Functionalization of sawdust biochar using Mg-Fe-LDH and sodium dodecyl sulfonate enhanced its stability and immobilization capacity for Cd and Pb in contaminated water and soil by Xin Pan, Shaoping Kuang, Xiao Wang, Habib Ullah, Zepeng Rao, Esmat F. Ali, Qumber Abbas, Sang Soo Lee, Sabry M. Shaheen

“…The higher removal/immobilization efficiency of MSB could be attributed to its alkalinity, and the enhanced synergistic interactions including surface precipitation, ion exchange, complexation, and hydrogen bonding. The resistance to carbon loss by H2O2, thermal recalcitrance index R 50, and degree of graphitization in MSB were significantly improved compared to SB, indicating a more stable carbon fraction sequestered in MSB following aging in soil. …”
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Integrating microplastic research in sustainable agriculture: Challenges and future directions for food production by Marcelo Illanes, María-Trinidad Toro, Mauricio Schoebitz, Nelson Zapata, Diego A. Moreno, María Dolores López-Belchí

“…Furthermore, machine learning algorithms can be employed to analyze complex datasets, enhancing our ability to predict the impacts of MPs on plant health and crop performance under different environmental conditions. …”
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The clean analysis process of Mn2+ for industries: a comparative study on direct determination of high-concentration Mn2+ in solution using spectrophotometry by Yanli Xu, Fuyuan Xu, Yong Liu, Guangbin Zhu, Ying Chen, Ning Duan

“…Traditional detection method like potassium periodate spectrophotometry (PPS) method is limited to low concentrations and involve complex processes that contribute to secondary pollution. …”
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Sources analysis and risk assessment of heavy metals in soil in a polymetallic mining area in southeastern Hubei based on Monte Carlo simulation by Jing Wang, Bo Wang, Qibin Zhao, Jinnan Cao, Xiao Xiao, Di Zhao, Zhenya Chen, Di Wu

“…The main findings are as follows: (1) Among the heavy metals present in the soil, copper (Cu) has the highest average concentration at 278.54 mg/kg, followed by zinc (Zn) at 161.16 mg/kg, chromium (Cr) at 75.23 mg/kg, nickel (Ni) at 30.38 mg/kg, arsenic (As) at 22.53 mg/kg, cadmium (Cd) at 0.76 mg/kg, and mercury (Hg) at 0.14 mg/kg; (2) The distribution of heavy metal concentrations exhibits significant regional variations, with the spatial pattern of pollution indicating that TLS is more affected than JLS, as evidenced by the Pollution Load Index (PLI) values; (3) Three potential sources of heavy metals were identified: natural sources, anthropogenic activities (including industrial production and agricultural practices), and atmospheric deposition (both dry and wet); (4) While severe contamination levels of specific metals such as copper and cadmium are observed in JLS and TLS soils, the overall contamination is mild, suggesting complex contamination dynamics; (5) Cadmium poses a moderate to high ecological risk, being the most sensitive factor in the comprehensive ecological risk assessment with a contribution rate of 65.2 %; (6) The concentrations of heavy metals in the soil present certain health risks, with children being more vulnerable than adults. …”
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Synthesis of Nanocrystalline Mn-Doped Bi₂Te₃ Thin Films via Magnetron Sputtering by Joshua Bibby, Angadjit Singh, Emily Heppell, Jack Bollard, Barat Achinuq, Sarah J. Haigh, Gerrit van der Laan, Thorsten Hesjedal

“…Additionally, the incorporation of Mn ions within the van der Waals gap and substitutional doping on Bi sites contributes to the observed complex magnetic properties. Intriguingly, a decrease in magnetic moment per Mn was observed with increasing Mn concentration, which is consistent with the formation of the intrinsic magnetic topological insulator <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><msub><mi>MnBi</mi><mn>2</mn></msub><msub><mi>Te</mi><mn>4</mn></msub></mrow></semantics></math></inline-formula>.…”
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