Targeting of the HER2/HER3 signaling axis overcomes ligand‐mediated resistance to trastuzumab in HER2‐positive breast cancer by Satomi Watanabe, Kimio Yonesaka, Junko Tanizaki, Yoshikane Nonagase, Naoki Takegawa, Koji Haratani, Hisato Kawakami, Hidetoshi Hayashi, Masayuki Takeda, Junji Tsurutani, Kazuhiko Nakagawa

“…The anti‐HER2 antibody pertuzumab and anti‐HER3 antibody patritumab both target this heregulin–HER3‐HER2 complex in different ways. This study examined the anticancer efficacy of dual HER2 and HER3 blockade in trastuzumab‐resistant HER2‐positive breast cancer. …”
Get full text

Segmented evolution and exploration targets of the Cambrian platform margin in the Manxi area, Tarim Basin by Zongquan Hu, Fan Feng, Chengming Fang, Zicheng Cao, Tieyi Wang, Kangkang Guo, Yang Li, Shi Wang

“…In this segment, the Shayilike Formation transgressive deposits and the high-energy mound-shoal complexes along the platform margin of the Wusonggeer Formation constitute the optimal reservoir - cap rock assemblage, establishing this segment as the most promising target for hydrocarbon exploration in the platform margin.…”
Get full text

The effect of electroslag remelting on the cleanliness of CrNiMoWMnV ultrahigh-strength steels by Ali M., Porter D., Kömi J., Heikkinen E.P., Eissa M., El Faramawy H., Mattar T.

“…The NMIs were classified into four major classes: oxides, sulphides, nitrides, and complex multiphase inclusions. ESR brings about large changes in the area percentages, number densities, maximum equivalent circle diameters, and the chemical composition of the various NMIs. …”
Get full text

Quantifying the potential value of entomological data collection for programmatic decision-making on malaria control in sub-Saharan African settings by Nora Schmit, Hillary M. Topazian, Matteo Pianella, Giovanni D. Charles, Peter Winskill, Penelope A. Hancock, Ellie Sherrard-Smith, Katharina Hauck, Thomas S. Churcher, Azra C. Ghani

“…Abstract Background The availability of many tools for malaria control leads to complex decisions regarding the most cost-effective intervention package based on local epidemiology. …”
Get full text

improving Pain mAnagement for childreN and young people attendeD by Ambulance (PANDA): protocol for a realist review. [version 3; peer review: 2 approved, 1 approved with reservati... by Paul Leighton, Georgette Eaton, Georgie Nicholls, Kacper Sumera, Marishona Ortega, Jessica Hodgson, Michael Baliousis, Aloysius Niroshan Siriwardena, Despina Laparidou, Bill Lord, Sarah Redsell, Gregory Adam Whitley, Tatiana Bujor

“…Approximately 20% of these suffer acute pain caused by illness or injury. Pain is a highly complex sensory and emotional experience. The intersection between acute pain, unwell CYP and the unpredictable pre-hospital environment is convoluted. …”
Get full text

Simulating the ENSO impact on the distribution and fate of floating litter particles in the Northern South China Sea by Ke Pang, Ke Pang, Ke Pang, Yang Feng, Yang Feng, Yang Feng, Youchang Zheng, Youchang Zheng, Youchang Zheng, Chao Fang, Xiangrong Xu, Xiangrong Xu

“…However, the transport of floating litter after release is difficult to predict due to the complex hydrodynamic conditions caused by the climate variability. …”
Get full text

Impact of introducing transnasal endoscopy on expanding diagnostic endoscopy services by Nigel Trudgill, Hasan Haboubi, Jeff Turner, Laura Munglani, Tom Crosby, Ben Thomas Crosby, Karen Wright, Kay Charles, Wendy Evans, Megan Mathias, Stevie Davies, Badr Abdalla

“…TNE was identified as having a key role in facilitating complex cases, previously failed via the TOE route with a success rate in 11/12 (91.7%) of such cases. …”
Get full text

Evaluation of the dynamics of fattening of lactating cows of the newly created Ukrainian red dairy breed by Liliya Roman, Olena Bezaltychna, Serhiy Vyrvykyshka, Artem Iovenko, Tetyana Pushkar

“…Based on an industrial dairy complex-reproducer for breeding cattle of the Ukrainian red dairy breed, a scientific and industrial study was conducted to assess the dynamics of fattening of lactating cows (n=391) using a modified eye-measured scoring scale and an innovative methodological Model Cow approach to comparing the findings with the visualisation. …”
Get full text

Evaluation of exo-long noncoding RNA MALAT1 in OSCC in comparison to dysplastic and normal: A cross-sectional study by Ramya Sekar, Selvaraj Jayaraman, VishnuPriya Veeraraghavan, Kalaiselvi Krishnamoorthy, Shubhra Chauhan Aramanai, Sathan Raj Natarajan

“…Conclusion: MALAT1 stands out as a key player in the complex landscape of OSCC pathogenesis, impacting tumorigenesis, metastasis, and treatment outcomes through multifaceted molecular mechanisms. …”
Get full text

Reinnervation of Free Nipple Grafts Associated With Improved Erection Function by Katya Remy, MD, Seth E. Fruge, MD, Ian L. McCulloch, MD, Kristyn Vicente, BA, Makayla Kochheiser, BA, Katherine H. Carruthers, MD, William G. Austen, Jr, MD, Lisa Gfrerer, MD, PhD, Ian L. Valerio, MD

“…This study aimed to evaluate the effect of nerve preservation and reconstruction with targeted nipple–areola complex reinnervation (TNR) on NE following gender-affirming mastectomy with free nipple grafting. …”
Get full text

Effect of ISPAD Anaerobic Digestion on Ammonia Volatilization from Soil Applied Swine Manure by Susan King, Michael Schwalb, David Giard, Joann Whalen, Suzelle Barrington

“…Lower volatile solids content improving manure infiltration into the soil and a more complex ionic solution explain the effect of the ISPAD manure advantages. …”
Get full text

High clinical utility of long-read sequencing for precise diagnosis of congenital adrenal hyperplasia in 322 probands by Yunpeng Wang, Gaohui Zhu, Danhua Li, Yu Pan, Rong Li, Ting Zhou, Aiping Mao, Libao Chen, Jing Zhu, Min Zhu

“…The clinical utility of L-LRS could help to provide precision therapy to CAH patients, advance the life-long management of this complex disease and promote our understanding of CAH.…”
Get full text

The multi-omics signatures of telomere length in childhood by Congrong Wang, Dries S. Martens, Mariona Bustamante, Rossella Alfano, Michelle Plusquin, Lea Maitre, John Wright, Rosemary R. C. McEachan, Johanna Lepeule, Remy Slama, Marina Vafeiadi, Leda Chatzi, Regina Grazuleviciene, Kristine B. Gutzkow, Hector Keun, Eva Borràs, Eduard Sabidó, Angel Carracedo, Georgia Escarami, Augusto Anguita-Ruiz, Dolors Pelegrí-Sisó, Juan R. Gonzalez, Martine Vrijheid, Tim S. Nawrot

“…Abstract Background Telomere length is an important indicator of biological age and a complex multi-factor trait. To date, the telomere interactome for comprehending the high-dimensional biological aspects linked to telomere regulation during childhood remains unexplored. …”
Get full text

MP-LLAVRec: an agricultural product recommendation algorithm based on LLAVA and user modal preference by Peishan Li, Peishan Li, Peishan Li, Lutao Gao, Lutao Gao, Lutao Gao, Lilian Zhang, Lilian Zhang, Lilian Zhang, Lin Peng, Lin Peng, Lin Peng, Chunhui Bai, Chunhui Bai, Chunhui Bai, Linnan Yang, Linnan Yang, Linnan Yang

“…It consisted of three main components: (1) LLAVA data enhancement, which introduced a multimodal macromodel to improve the understanding of node attributes; (2) agricultural product association relationship fusion, which constructed and improved the complex association network structure among products to ensure that the system can better understand the substitution relationship, complementary relationship, and implied consumption logic among products; (3) user modal preference feature extraction block, which deeply mined the interaction data between consumers and products, and advanced the effective user feature information from the correspondence between global user representations and local modal user representations.Results and DiscussionWe conduct experiments on a real dataset from Amazon's large-scale e-commerce platform to verify the effectiveness of MP-LLAVRec. …”
Get full text

Infections, autoimmunity and immunodeficiencies are the leading etiologies of non-cystic fibrosis bronchiectasis in adults from the southwest of Colombia. by Andrés F. Zea-Vera, Carlos Andrés Rodríguez, Sebastián Giraldo, Mario Alejandro Chacón, Luis Fernando Guerrero, Ricardo Mosquera, Raúl Andrés Vallejo, Fabio Samir Vargas, María Andrea García, María A. Rengifo, Anilza Bonelo, Maximiliano Parra

“…Non-cystic fibrosis bronchiectasis is a complex medical condition with multiple etiologies, characterized by chronic productive cough and radiologic evidence of airway lumen dilation and wall thickening. …”
Get full text

Neuronal Transdifferentiation Potential of Human Mesenchymal Stem Cells from Neonatal and Adult Sources by a Small Molecule Cocktail by Lorena V. Cortés-Medina, Herminia Pasantes-Morales, Alejandro Aguilera-Castrejon, Arturo Picones, Cesar O. Lara-Figueroa, Enoch Luis, Juan Jose Montesinos, Victor A. Cortés-Morales, M. P. De la Rosa Ruiz, Erika Hernández-Estévez, Laura C. Bonifaz, Marco Antonio Alvarez-Perez, Gerardo Ramos-Mandujano

“…The addition of neurotrophic factors to the ICFRYA cocktail significantly increased the number of cells with complex neuron-like morphology and increased the number of cells positive for mature neuronal markers in BM- and UCB-MSCs. …”
Get full text

Correlation Between <i>Cryptococcus</i> Infection and the Nasal Mycobiota in a Population of Free-Ranging Koalas (<i>Phascolarctos cinereus</i>) in New South Wales, Australia by Andrew S. McPherson, Sophie L. Haworth, Alex Kan, Luisa Monteiro de Miranda, Mark B. Krockenberger

“…Cryptococcosis is a fungal disease in humans and animals, caused by the <i>Cryptococcus neoformans</i> and <i>Cryptococcus gattii</i> species complexes. Clinical cryptococcosis primarily manifests as upper respiratory tract disease; however, dissemination to other organs, particularly the brain, can occur. …”
Get full text

Managerial thinking in neonatal care: a qualitative study of place of care decision-making for preterm babies born at 27–31 weeks gestation in England by Neena Modi, Elizabeth S Draper, Miaoqing Yang, Sarah E Seaton, Kelvin Dawson, Vasiliki Bountziouka, Oliver Rivero-Arias, Thillagavathie Pillay, Natalie Armstrong, Alexis Paton, Elaine Boyle, Victor L Banda, Caroline Cupit, Bradley Manktelow, Abdul Qader T Ismail

“…Two were neonatal intensive care units and four were local neonatal units.Participants Clinical staff (n=15) working in neonatal units, and people present in neonatal units during periods of observation.Results In the context of real-world neonatal practice, with multiple (and rapidly-evolving) uncertainties relating to mothers, babies and unit/network capacity, ‘best place of care’ protocols were only one element of much more complex decision-making processes. Staff often made judgements from a less-than-ideal starting point, and were forced to respond to evolving clinical and organisational factors. …”
Get full text

Immune microenvironment spatial landscapes of tertiary lymphoid structures in gastric cancer by Yi Xie, Haoxin Peng, Yajie Hu, Keren Jia, Jiajia Yuan, Dan Liu, Yanyan Li, Xujiao Feng, Jian Li, Xiaotian Zhang, Yu Sun, Lin Shen, Yang Chen

“…However, understanding the complex and diverse immune microenvironment within TLS requires comprehensive analysis. …”
Get full text

A service ecosystems perspective to explore social prescribing value co-creation for vulnerable young people in NEET situation by Isabel Farina, Daniela Sangiorgi, Cristina Masella, Ilaria Simonelli, Regina Alves, Maria J. Marques, Sonia Dias, Carina Dantas, Sabrina Herzog, Sara Paternoster, Emanuele Torri, Marcello Bertotti

“…Discussion This research illustrates how social prescribing is not a linear path but rather a complex intervention with multiple interacting elements across ecosystem layers. …”
Get full text